EA201071053A1 - Кристаллическое производное бензимидазола - Google Patents

Кристаллическое производное бензимидазола

Info

Publication number
EA201071053A1
EA201071053A1 EA201071053A EA201071053A EA201071053A1 EA 201071053 A1 EA201071053 A1 EA 201071053A1 EA 201071053 A EA201071053 A EA 201071053A EA 201071053 A EA201071053 A EA 201071053A EA 201071053 A1 EA201071053 A1 EA 201071053A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzimidazole
methyl
crystal derivative
derivative
crystal
Prior art date
Application number
EA201071053A
Other languages
English (en)
Other versions
EA017064B1 (ru
Inventor
Хидео Хасимото
Тадаси Ураи
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40577894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201071053(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201071053A1 publication Critical patent/EA201071053A1/ru
Publication of EA017064B1 publication Critical patent/EA017064B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предлагается кристаллический (R)-2-[[[3-метил-4-(2,2,2-трифторэтокси)-2-пиридинил]метил]сульфинил]-lH-бензимидазол, порошковая рентгенограмма которого содержит характеристические пики для межплоскостных расстояний (d) 10,06±0,2; 8,70±0,2; 6,57±0,2; 5,59±0,2 и 4,00±0,2 Å. В настоящем изобретении предлагается стабильное противоязвенное лекарственное средство, обладающее лучшей всасываемостью.
EA201071053A 2008-03-10 2009-03-09 Кристаллическое производное бензимидазола EA017064B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008059342 2008-03-10
PCT/JP2009/054970 WO2009113696A1 (en) 2008-03-10 2009-03-09 Crystal of benzimidazole compound

Publications (2)

Publication Number Publication Date
EA201071053A1 true EA201071053A1 (ru) 2011-04-29
EA017064B1 EA017064B1 (ru) 2012-09-28

Family

ID=40577894

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071053A EA017064B1 (ru) 2008-03-10 2009-03-09 Кристаллическое производное бензимидазола

Country Status (30)

Country Link
US (1) US8222422B2 (ru)
EP (1) EP2262790B1 (ru)
JP (3) JP2011513202A (ru)
KR (1) KR20100123758A (ru)
CN (1) CN102026994B (ru)
AR (1) AR070972A1 (ru)
AU (1) AU2009224247B2 (ru)
BR (1) BRPI0909651A2 (ru)
CA (1) CA2671369C (ru)
CL (1) CL2009000547A1 (ru)
CO (1) CO6300956A2 (ru)
CR (1) CR11707A (ru)
DO (1) DOP2010000274A (ru)
EA (1) EA017064B1 (ru)
EC (1) ECSP10010531A (ru)
ES (1) ES2638463T3 (ru)
GE (1) GEP20125649B (ru)
IL (1) IL207867A0 (ru)
LT (1) LT2262790T (ru)
MA (1) MA32215B1 (ru)
MX (1) MX2010009641A (ru)
MY (1) MY150833A (ru)
NZ (1) NZ588379A (ru)
PE (1) PE20091680A1 (ru)
PT (1) PT2262790T (ru)
TW (1) TWI447110B (ru)
UA (1) UA103189C2 (ru)
UY (1) UY31695A (ru)
WO (1) WO2009113696A1 (ru)
ZA (1) ZA201006754B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011004387A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd Process for the preparation of dexlansoprazole polymorphic forms
CN102108077B (zh) * 2009-12-23 2013-09-25 江苏豪森医药集团有限公司 制备右兰索拉唑的方法
US20130197232A1 (en) * 2010-01-29 2013-08-01 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of dexlansoprazole
CN104447695A (zh) * 2013-11-22 2015-03-25 广东东阳光药业有限公司 一种苯并咪唑化合物的水合物
SI3305291T1 (sl) 2015-06-08 2021-08-31 Hk Inno.N Corporation Uporabe benzimidazolnega derivata za nočno izločanje kisline
MX2019006206A (es) * 2016-11-29 2019-08-14 Censa Pharmaceuticals Inc Polimorfos de sepiapterina y sales de los mismos.
CN106866631A (zh) * 2017-04-06 2017-06-20 山东裕欣药业有限公司 一种右旋兰索拉唑晶型及制备方法
WO2019046849A1 (en) 2017-09-01 2019-03-07 Censa Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING SEPAPTERINE AND USES THEREOF
JP2021526134A (ja) 2018-05-25 2021-09-30 イマラ インク． ６−［（３Ｓ，４Ｓ）−４−メチル−ｌ−（ピリミジン−２−イルメチル）ピロリジン−３−イル］−３−テトラヒドロピラン−４−イル−７Ｈ−イミダゾ［ｌ，５−Ａ］ピラジン−８−オンの一水和物および結晶形態
JPWO2020013330A1 (ja) * 2018-07-13 2021-06-24 協和発酵バイオ株式会社 ユーコミン酸の非溶媒和物結晶及びその製造方法
CN113376273B (zh) * 2021-06-02 2023-03-17 国药集团精方（安徽）药业股份有限公司 一种清心莲子饮hplc特征图谱的检测方法及该特征图谱的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
DK171989B1 (da) 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
DE4035455A1 (de) 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
SE504459C2 (sv) 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) 1994-11-28 1995-01-11 Astra Ab Resolution
HRP960232A2 (en) 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
TW385306B (en) * 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
CN1238694A (zh) 1996-11-22 1999-12-15 普罗克特和甘保尔公司 治疗肠胃病用的含铋和nsaid的组合物
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
ES2150808T3 (es) * 1997-08-08 2000-12-01 Aventis Pharma Gmbh Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico.
WO1999038512A1 (en) 1998-01-30 1999-08-05 Sepracor Inc. S-lansoprazole compositions and methods
EP1056456A4 (en) 1998-01-30 2006-10-25 Sepracor Inc R-LANSOPRAZOL COMPOSITIONS AND TREATMENTS THEREFOR
WO1999056698A2 (en) 1998-05-06 1999-11-11 Københavns Universitet Treatment of celiac disease
JP3283252B2 (ja) * 1999-06-17 2002-05-20 武田薬品工業株式会社 ベンズイミダゾール化合物の結晶
TWI275587B (en) 1999-06-17 2007-03-11 Takeda Chemical Industries Ltd A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
JP4327424B2 (ja) * 2000-05-15 2009-09-09 武田薬品工業株式会社 結晶の製造法
JP3374314B2 (ja) * 2000-05-15 2003-02-04 武田薬品工業株式会社 結晶の製造法
ES2511774T3 (es) * 2000-05-15 2014-10-23 Takeda Pharmaceutical Company Limited Formas cristalinas de (R)-lansoprazol
JP4160293B2 (ja) * 2000-12-01 2008-10-01 武田薬品工業株式会社 結晶の製造法
US7285668B2 (en) * 2000-12-01 2007-10-23 Takeda Pharmaceutical Company Limited Process for the crystallization of (R)- or (S)-lansoprazole
AU2003273000A1 (en) 2002-10-16 2004-05-04 Takeda Pharmaceutical Company Limited Stable solid preparations
JP4749660B2 (ja) * 2002-10-16 2011-08-17 武田薬品工業株式会社 安定な固形製剤
JP2011507977A (ja) 2007-12-31 2011-03-10 武田薬品工業株式会社 （ｒ）−２−［［［３−メチル−４−（２，２，２−トリフルオロエトキシ）−２−ピリジニル］メチル］スルフィニル］−１ｈ−ベンズイミダゾールの溶媒和物結晶形

Also Published As

Publication number Publication date
ES2638463T3 (es) 2017-10-20
UY31695A (es) 2009-11-10
US8222422B2 (en) 2012-07-17
US20110046183A1 (en) 2011-02-24
CR11707A (es) 2010-11-04
ZA201006754B (en) 2011-11-30
JP2011513202A (ja) 2011-04-28
CA2671369A1 (en) 2009-09-10
JP2014015477A (ja) 2014-01-30
MA32215B1 (fr) 2011-04-01
TWI447110B (zh) 2014-08-01
PT2262790T (pt) 2017-07-18
CA2671369C (en) 2011-05-10
TW200938531A (en) 2009-09-16
AU2009224247A2 (en) 2010-10-28
LT2262790T (lt) 2017-08-25
CN102026994A (zh) 2011-04-20
JP2015163623A (ja) 2015-09-10
AU2009224247B2 (en) 2013-12-12
EP2262790B1 (en) 2017-06-07
CL2009000547A1 (es) 2010-05-07
EA017064B1 (ru) 2012-09-28
WO2009113696A1 (en) 2009-09-17
AU2009224247A1 (en) 2009-09-17
DOP2010000274A (es) 2010-09-30
EP2262790A1 (en) 2010-12-22
ECSP10010531A (es) 2010-11-30
MX2010009641A (es) 2010-09-22
PE20091680A1 (es) 2009-11-16
MY150833A (en) 2014-02-28
GEP20125649B (en) 2012-09-25
UA103189C2 (ru) 2013-09-25
CO6300956A2 (es) 2011-07-21
AR070972A1 (es) 2010-05-19
BRPI0909651A2 (pt) 2015-09-22
KR20100123758A (ko) 2010-11-24
CN102026994B (zh) 2014-05-07
IL207867A0 (en) 2010-12-30
NZ588379A (en) 2012-07-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU