EA201000945A1 - Конструирование системы секреции на основе sm-белков - Google Patents

Конструирование системы секреции на основе sm-белков

Info

Publication number
EA201000945A1
EA201000945A1 EA201000945A EA201000945A EA201000945A1 EA 201000945 A1 EA201000945 A1 EA 201000945A1 EA 201000945 A EA201000945 A EA 201000945A EA 201000945 A EA201000945 A EA 201000945A EA 201000945 A1 EA201000945 A1 EA 201000945A1
Authority
EA
Eurasian Patent Office
Prior art keywords
proteins
construction
system based
secretion system
expression
Prior art date
Application number
EA201000945A
Other languages
English (en)
Russian (ru)
Inventor
Хитто Кауфманн
Эрик Беккер
Лоре Флорин
Мартин Фуссенеггер
Рэньван Пэн
Джой М. Стадтс
Original Assignee
Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг filed Critical Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Publication of EA201000945A1 publication Critical patent/EA201000945A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EA201000945A 2007-12-20 2008-12-19 Конструирование системы секреции на основе sm-белков EA201000945A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07150254 2007-12-20
EP08152829 2008-03-17
PCT/EP2008/010882 WO2009080299A1 (en) 2007-12-20 2008-12-19 Sm-protein based secretion engineering

Publications (1)

Publication Number Publication Date
EA201000945A1 true EA201000945A1 (ru) 2011-02-28

Family

ID=40344722

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000945A EA201000945A1 (ru) 2007-12-20 2008-12-19 Конструирование системы секреции на основе sm-белков

Country Status (14)

Country Link
US (1) US20090247609A1 (enExample)
EP (1) EP2225389A1 (enExample)
JP (1) JP2011505850A (enExample)
KR (1) KR20100099190A (enExample)
CN (1) CN101903529A (enExample)
AR (1) AR069958A1 (enExample)
AU (1) AU2008340652A1 (enExample)
BR (1) BRPI0821389A2 (enExample)
CA (1) CA2709645A1 (enExample)
EA (1) EA201000945A1 (enExample)
IL (1) IL205239A0 (enExample)
NZ (1) NZ586037A (enExample)
TW (1) TW200932907A (enExample)
WO (1) WO2009080299A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013505013A (ja) 2009-09-18 2013-02-14 セレクシス エス．エー． 強化導入遺伝子発現およびプロセッシングの産物および方法
TW201823460A (zh) * 2012-05-29 2018-07-01 美商再生元醫藥公司 生產細胞株增強子
ES2717175T3 (es) 2013-02-01 2019-06-19 Selexis Sa Expresión mejorada de transgenes y procesamiento
CN107207586B (zh) 2014-12-19 2021-07-13 莫茨药物股份两合公司 用于测定BoNT/E在细胞中的生物活性的装置和方法
CN106554973B (zh) * 2015-09-30 2020-05-22 北京吉尚立德生物科技有限公司 一种cho细胞分泌能力评价系统
CN113134014B (zh) * 2020-01-20 2023-09-26 医微细胞生物技术(广州)有限公司 囊泡在制备血友病药物中的应用
WO2023155881A1 (en) * 2022-02-18 2023-08-24 Tsinghua University Methods for regulating secretion via migrasomes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI924494A0 (fi) * 1992-10-06 1992-10-06 Valtion Teknillinen Oekad produktion av avsoendrarde proteiner i eukaryotiska rekombinantceller
JP2001512684A (ja) * 1997-08-05 2001-08-28 カイロン コーポレイション 新規のｐｉｃｈｉａｐａｓｔｏｒｉｓ遺伝子配列およびそれらの使用方法
AU2002952550A0 (en) * 2002-11-08 2002-11-21 The University Of Queensland Modulating TNFalpha Secretion

Also Published As

Publication number Publication date
AU2008340652A1 (en) 2009-07-02
CN101903529A (zh) 2010-12-01
BRPI0821389A2 (pt) 2015-06-16
KR20100099190A (ko) 2010-09-10
WO2009080299A1 (en) 2009-07-02
IL205239A0 (en) 2010-11-30
NZ586037A (en) 2012-08-31
US20090247609A1 (en) 2009-10-01
CA2709645A1 (en) 2009-07-02
TW200932907A (en) 2009-08-01
WO2009080299A8 (en) 2010-04-15
EP2225389A1 (en) 2010-09-08
JP2011505850A (ja) 2011-03-03
AR069958A1 (es) 2010-03-03

Similar Documents

Publication Publication Date Title
EA201000945A1 (ru) Конструирование системы секреции на основе sm-белков
MX2015012361A (es) Metodos de fabricacion para controlar el contenido de lisina c-terminal, galactosa y acido sialico en proteinas recombinantes.
MX376623B (es) Cultivo celular metabolicamente optimizado.
MY186219A (en) Production of proteins in glutamine-free cell culture media
BR122019022434B8 (pt) método para cultivar células de mamífero que secretam proteína heteróloga em um sobrenadante de cultura celular
MX348739B (es) Metodo para purificar soluciones de inmunoglobulina.
MX2018002121A (es) Elaboracion de fosfatasas alcalinas.
MX2013003681A (es) Ácidos nucleicos manipulados y métodos de uso de los mismos.
EA201492185A1 (ru) Способ получения рекомбинантной идуронат-2-сульфатазы
MX2010007729A (es) Vectores de expresion de mamifero mejorados y uso de los mismos.
TR201900213T4 (tr) Bir sürekli hücre kültüründe bir polipeptit veya ilişkin virüsün üretim metodu.
EP2536821A4 (en) IMPROVING THE EFFECT OF FE-S-BUNDLE REQUIRING PROTEINS
AR062069A1 (es) Replegado de proteinas recombinantes
MX2019003427A (es) Composiciones para cultivo celular y metodos para la produccion de polipeptidos.
WO2007096192A3 (en) Production of biologically active proteins
BR112017018149A2 (pt) célula hospedeira recombinante, método para produzir uma proteína de interesse recombinante, sistema de expressão, e, processos para fabricar uma formulação de proteína estável e para reduzir a atividade de esterase em uma formulação de proteína.
WO2013091661A3 (en) Proteolytic resistant protein affinity tag
MX2013005853A (es) Enzimas de fusion que tienen actividad de n-acetilglucosaminil transferasa.
MY192068A (en) Purification of iduronate-2-sulfatase
ATE426674T1 (de) Stoffwechselanderungen in garungen zur produktion rekombinanter proteine
WO2013163654A3 (en) Nucleic acids, cells, and methods for producing secreted proteins
EA202091349A1 (ru) Способы культивирования клеток
MY184387A (en) Improved surface display of functional proteins in a broad range of gram negative bacteria
DK1495112T3 (da) Cellekulturmedium
DK1897939T3 (da) Mikroorganismestamme til produktion af rekombinante proteiner