JP2011505850A - Ｓｍタンパク質ベースの分泌操作 - Google Patents

Ｓｍタンパク質ベースの分泌操作 Download PDF

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Publication number
JP2011505850A
JP2011505850A JP2010538474A JP2010538474A JP2011505850A JP 2011505850 A JP2011505850 A JP 2011505850A JP 2010538474 A JP2010538474 A JP 2010538474A JP 2010538474 A JP2010538474 A JP 2010538474A JP 2011505850 A JP2011505850 A JP 2011505850A
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Prior art keywords
protein
cell
expression
sly1
cho
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JP2010538474A
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Japanese (ja)
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JP2011505850A5 (enExample
Inventor
カウフマン，ヒット
ベッカー，エリク
フローリン，ローレ
フッセンエガー，マルティン
ペン，レン−ワン
スタッズ，ジョーイ・エム
Original Assignee
ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
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Application filed by ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト filed Critical ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
Publication of JP2011505850A publication Critical patent/JP2011505850A/ja
Publication of JP2011505850A5 publication Critical patent/JP2011505850A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010538474A 2007-12-20 2008-12-19 Ｓｍタンパク質ベースの分泌操作 Pending JP2011505850A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07150254 2007-12-20
EP08152829 2008-03-17
PCT/EP2008/010882 WO2009080299A1 (en) 2007-12-20 2008-12-19 Sm-protein based secretion engineering

Publications (2)

Publication Number Publication Date
JP2011505850A true JP2011505850A (ja) 2011-03-03
JP2011505850A5 JP2011505850A5 (enExample) 2011-12-15

Family

ID=40344722

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010538474A Pending JP2011505850A (ja) 2007-12-20 2008-12-19 Ｓｍタンパク質ベースの分泌操作

Country Status (14)

Country Link
US (1) US20090247609A1 (enExample)
EP (1) EP2225389A1 (enExample)
JP (1) JP2011505850A (enExample)
KR (1) KR20100099190A (enExample)
CN (1) CN101903529A (enExample)
AR (1) AR069958A1 (enExample)
AU (1) AU2008340652A1 (enExample)
BR (1) BRPI0821389A2 (enExample)
CA (1) CA2709645A1 (enExample)
EA (1) EA201000945A1 (enExample)
IL (1) IL205239A0 (enExample)
NZ (1) NZ586037A (enExample)
TW (1) TW200932907A (enExample)
WO (1) WO2009080299A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504382A (ja) * 2014-12-19 2018-02-15 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー 細胞内のＢｏＮＴ／Ｅの生物学的活性を決定するための手段及び方法
JP2023513395A (ja) * 2020-01-20 2023-03-30 イーブイ、セル、バイオテック、（コアンチョウ）、カンパニー、リミテッド 小胞及びその使用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012107634A (ru) 2009-09-18 2013-10-27 Селексис С.А. Способы и продукты для увеличенной экспрессии и процессинга трансгена
TW201823460A (zh) * 2012-05-29 2018-07-01 美商再生元醫藥公司 生產細胞株增強子
HUE043103T2 (hu) 2013-02-01 2019-08-28 Selexis Sa Fokozott transzgén expresszió és processzálás
CN106554973B (zh) * 2015-09-30 2020-05-22 北京吉尚立德生物科技有限公司 一种cho细胞分泌能力评价系统
WO2023155881A1 (en) * 2022-02-18 2023-08-24 Tsinghua University Methods for regulating secretion via migrasomes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08501695A (ja) * 1992-10-06 1996-02-27 バルティオン テクニリーネン トゥトキムスケスクス 組換え真核細胞による分泌タンパク質の増大された産生
WO2004042052A1 (en) * 2002-11-08 2004-05-21 The University Of Queensland Modulating tnf (alpha) secretion

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1003889A1 (en) * 1997-08-05 2000-05-31 Chiron Corporation NOVEL $i(PICHIA PASTORIS) GENE SEQUENCES AND METHODS FOR THEIR USE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08501695A (ja) * 1992-10-06 1996-02-27 バルティオン テクニリーネン トゥトキムスケスクス 組換え真核細胞による分泌タンパク質の増大された産生
WO2004042052A1 (en) * 2002-11-08 2004-05-21 The University Of Queensland Modulating tnf (alpha) secretion

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN5010015965; ＴＯＯＮＥＮ　ＲＵＵＤ　Ｆ　Ｇ: 'ＶＥＳＩＣＬＥ　ＴＲＡＦＦＩＣＫＩＮＧ：　ＰＬＥＡＳＵＲＥ　ＡＮＤ　ＰＡＩＮ　ＦＲＯＭ　ＳＭ　ＧＥＮＥＳ' ＴＲＥＮＤＳ　ＩＮ　ＣＥＬＬ　ＢＩＯＬＯＧＹ Ｖ１３　Ｎ４, 200304, Ｐ１７７-１８６ *
JPN5010015968; ＧＡＬＬＷＩＴＺ: 'ＴＨＥ　ＲＩＤＤＬＥ　ＯＦ　ＴＨＥ　ＳＥＣ１／ＭＵＮＣ-１８　ＰＲＯＴＥＩＮＳ　-　ＮＥＷ　ＴＷＩＳＴＳ　ＡＤＤＥＤ　ＴＯ　ＴＨＥＩＲ　ＩＮＴＥＲＡＣＴＩＯＮＳ　ＷＩＴＨ　ＳＮＡＲＥＳ' ＴＲＥＮＤＳ　ＩＮ　ＢＩＯＣＨＥＭＩＣＡＬ　ＳＣＩＥＮＣＥＳ Ｖ２８　Ｎ３, 200303, Ｐ１１３-１１６, ＥＬＳＥＶＩＥＲ *
JPN6013048897; Ｄｉａｂｅｔｅｓ ５２, 2003, ｐ．１９１０-１９１７ *
JPN6013048900; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ． ２８２　（４５）, 200711, ｐ．３２６１３-３２６２２ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504382A (ja) * 2014-12-19 2018-02-15 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー 細胞内のＢｏＮＴ／Ｅの生物学的活性を決定するための手段及び方法
JP2023513395A (ja) * 2020-01-20 2023-03-30 イーブイ、セル、バイオテック、（コアンチョウ）、カンパニー、リミテッド 小胞及びその使用
JP7778377B2 (ja) 2020-01-20 2025-12-02 イーブイ、セル、バイオテック、（コアンチョウ）、カンパニー、リミテッド 小胞及びその使用

Also Published As

Publication number Publication date
BRPI0821389A2 (pt) 2015-06-16
AR069958A1 (es) 2010-03-03
EA201000945A1 (ru) 2011-02-28
CN101903529A (zh) 2010-12-01
CA2709645A1 (en) 2009-07-02
TW200932907A (en) 2009-08-01
WO2009080299A8 (en) 2010-04-15
US20090247609A1 (en) 2009-10-01
AU2008340652A1 (en) 2009-07-02
EP2225389A1 (en) 2010-09-08
IL205239A0 (en) 2010-11-30
WO2009080299A1 (en) 2009-07-02
NZ586037A (en) 2012-08-31
KR20100099190A (ko) 2010-09-10

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