KR20100099190A - Ｓｍ-단백질 기반의 분비 조작 - Google Patents

Ｓｍ-단백질 기반의 분비 조작 Download PDF

Info

Publication number
KR20100099190A
KR20100099190A KR1020107013514A KR20107013514A KR20100099190A KR 20100099190 A KR20100099190 A KR 20100099190A KR 1020107013514 A KR1020107013514 A KR 1020107013514A KR 20107013514 A KR20107013514 A KR 20107013514A KR 20100099190 A KR20100099190 A KR 20100099190A
Authority
KR
South Korea
Prior art keywords
protein
cell
expression
seq
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020107013514A
Other languages
English (en)
Korean (ko)
Inventor
히토 카우프만
에릭 베커
로레 플로린
마르틴 푸쎄네거
렌-방 펭
조이 엠. 스터츠
Original Assignee
베링거 잉겔하임 파르마 게엠베하 운트 코 카게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 filed Critical 베링거 잉겔하임 파르마 게엠베하 운트 코 카게
Publication of KR20100099190A publication Critical patent/KR20100099190A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107013514A 2007-12-20 2008-12-19 Ｓｍ-단백질 기반의 분비 조작 Ceased KR20100099190A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07150254 2007-12-20
EP07150254.6 2007-12-20
EP08152829 2008-03-17
EP08152829.1 2008-03-17

Publications (1)

Publication Number Publication Date
KR20100099190A true KR20100099190A (ko) 2010-09-10

Family

ID=40344722

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107013514A Ceased KR20100099190A (ko) 2007-12-20 2008-12-19 Ｓｍ-단백질 기반의 분비 조작

Country Status (14)

Country Link
US (1) US20090247609A1 (enExample)
EP (1) EP2225389A1 (enExample)
JP (1) JP2011505850A (enExample)
KR (1) KR20100099190A (enExample)
CN (1) CN101903529A (enExample)
AR (1) AR069958A1 (enExample)
AU (1) AU2008340652A1 (enExample)
BR (1) BRPI0821389A2 (enExample)
CA (1) CA2709645A1 (enExample)
EA (1) EA201000945A1 (enExample)
IL (1) IL205239A0 (enExample)
NZ (1) NZ586037A (enExample)
TW (1) TW200932907A (enExample)
WO (1) WO2009080299A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102575264A (zh) 2009-09-18 2012-07-11 瑟莱克斯公司 增加的转基因表达和加工的产品和方法
TW201823460A (zh) * 2012-05-29 2018-07-01 美商再生元醫藥公司 生產細胞株增強子
DK2951309T3 (en) 2013-02-01 2019-04-23 Selexis Sa INCREASED TRANSGEN EXPRESSION AND PROCESSING
KR102514666B1 (ko) 2014-12-19 2023-03-27 메르츠 파마 게엠베하 운트 코. 카가아 세포에서 BoNT/E의 생물학적 활성의 결정을 위한 수단 및 방법
CN106554973B (zh) * 2015-09-30 2020-05-22 北京吉尚立德生物科技有限公司 一种cho细胞分泌能力评价系统
CN113134014B (zh) * 2020-01-20 2023-09-26 医微细胞生物技术(广州)有限公司 囊泡在制备血友病药物中的应用
WO2023155881A1 (en) * 2022-02-18 2023-08-24 Tsinghua University Methods for regulating secretion via migrasomes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI924494A0 (fi) * 1992-10-06 1992-10-06 Valtion Teknillinen Oekad produktion av avsoendrarde proteiner i eukaryotiska rekombinantceller
JP2001512684A (ja) * 1997-08-05 2001-08-28 カイロン コーポレイション 新規のｐｉｃｈｉａｐａｓｔｏｒｉｓ遺伝子配列およびそれらの使用方法
AU2002952550A0 (en) * 2002-11-08 2002-11-21 The University Of Queensland Modulating TNFalpha Secretion

Also Published As

Publication number Publication date
IL205239A0 (en) 2010-11-30
US20090247609A1 (en) 2009-10-01
WO2009080299A1 (en) 2009-07-02
CN101903529A (zh) 2010-12-01
EA201000945A1 (ru) 2011-02-28
EP2225389A1 (en) 2010-09-08
AU2008340652A1 (en) 2009-07-02
JP2011505850A (ja) 2011-03-03
BRPI0821389A2 (pt) 2015-06-16
AR069958A1 (es) 2010-03-03
CA2709645A1 (en) 2009-07-02
WO2009080299A8 (en) 2010-04-15
NZ586037A (en) 2012-08-31
TW200932907A (en) 2009-08-01

Similar Documents

Publication Publication Date Title
Leskov et al. Synthesis and functional analyses of nuclear clusterin, a cell death protein
US8221999B2 (en) Protein production
KR101812348B1 (ko) 단백질의 생산 방법
Chung et al. Effect of doxycycline‐regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells
Ha et al. Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures
US20220064690A1 (en) CELL ENGINEERING USING RNAs
AU2009200829A1 (en) Methods vectors plasmids and methods for increasing expression of recombinant polypeptides
CA2577073C (en) Systems and methods for protein production employing polypeptides functional in unfolded protein response pathway
US11549108B2 (en) Mammalian cells for producing a secreted protein
US20090247609A1 (en) Sm-protein based secretion engineering
US9340592B2 (en) CHO/CERT cell lines
US20110281301A1 (en) The secretory capacity in host cells
KR20250079008A (ko) 신규 트랜스포사제 시스템
US9315565B2 (en) Method for producing protein
HK1146088A (en) Sm-protein based secretion engineering
US20090018099A1 (en) Protein production
US20120190065A1 (en) Combinatorial engineering
Venables Interactions of RBM, a candidate human spermatogenesis factor
HK1164937A (en) Combinatorial engineering
HK1136314B (en) Improvement of protein production
Exchange et al. Ragged Red Fibres

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100618

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20131218

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20150312

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20150528

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20150312

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I