EA200900087A1 - Применение гидрофильной матрицы, содержащей производное полиакриловой кислоты, простой эфир целлюлозы и дезинтегрирующий агент, в производстве медикаментов для лечения заболеваний женских гениталий - Google Patents
Применение гидрофильной матрицы, содержащей производное полиакриловой кислоты, простой эфир целлюлозы и дезинтегрирующий агент, в производстве медикаментов для лечения заболеваний женских гениталийInfo
- Publication number
- EA200900087A1 EA200900087A1 EA200900087A EA200900087A EA200900087A1 EA 200900087 A1 EA200900087 A1 EA 200900087A1 EA 200900087 A EA200900087 A EA 200900087A EA 200900087 A EA200900087 A EA 200900087A EA 200900087 A1 EA200900087 A1 EA 200900087A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- treatment
- acid derivative
- polyacrylic acid
- cellulose
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 5
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229920002125 Sokalan® Polymers 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000004584 polyacrylic acid Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 229920002678 cellulose Polymers 0.000 title 1
- 239000001913 cellulose Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 208000004926 Bacterial Vaginosis Diseases 0.000 abstract 1
- 208000005448 Trichomonas Infections Diseases 0.000 abstract 1
- 206010044620 Trichomoniasis Diseases 0.000 abstract 1
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 abstract 1
- 239000000227 bioadhesive Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229920003086 cellulose ether Polymers 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
- 208000013464 vaginal disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Описывается гидрофильная матрица, которая содержит а) по меньшей мере одно производное полиакриловой кислоты в предпочтительном количестве 0,5-40%; b) по меньшей мере один простой эфир целлюлозы в предпочтительном количестве 30-90% и с) по меньшей мере один дезинтегрирующий агент в предпочтительном количестве 2-50% массы матрицы. Эта матрица применяется в сочетании по меньшей мере с одним приемлемым в фармакологии действующим компонентом для изготовления твердых биоадгезивных лекарственных средств с регулируемым высвобождением для лечения вагинальных заболеваний, таких как вульвовагинальный кандидоз, бактериальный вагинит или трихомоноз. Матрица применяется в твердых образованиях в количестве 5-60%, предпочтительно 20-40%, а действующий компонент в количестве 2-70%, предпочтительно 5-50% массы лекарственного средства.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06116269A EP1872775A1 (en) | 2006-06-29 | 2006-06-29 | Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders |
PCT/EP2007/056185 WO2008000683A1 (en) | 2006-06-29 | 2007-06-21 | Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200900087A1 true EA200900087A1 (ru) | 2009-06-30 |
EA018257B1 EA018257B1 (ru) | 2013-06-28 |
Family
ID=37433668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200900087A EA018257B1 (ru) | 2006-06-29 | 2007-06-21 | Применение гидрофильной матрицы, содержащей полимер полиакриловой кислоты, простой эфир целлюлозы и дезинтегрирующий агент, для лечения заболеваний женских гениталий |
Country Status (25)
Country | Link |
---|---|
US (1) | US8865201B2 (ru) |
EP (2) | EP1872775A1 (ru) |
JP (1) | JP5205374B2 (ru) |
KR (1) | KR101443149B1 (ru) |
CN (2) | CN101478951A (ru) |
AR (1) | AR061771A1 (ru) |
AT (1) | ATE455534T1 (ru) |
BR (1) | BRPI0713298A2 (ru) |
CA (1) | CA2652226C (ru) |
CO (1) | CO6140022A2 (ru) |
CY (1) | CY1109910T1 (ru) |
DE (1) | DE602007004486D1 (ru) |
DK (1) | DK2032123T3 (ru) |
EA (1) | EA018257B1 (ru) |
ES (1) | ES2339069T3 (ru) |
HK (1) | HK1128587A1 (ru) |
HR (1) | HRP20100159T1 (ru) |
MA (1) | MA30597B1 (ru) |
MX (1) | MX2008016508A (ru) |
NO (1) | NO20090095L (ru) |
PL (1) | PL2032123T3 (ru) |
PT (1) | PT2032123E (ru) |
RS (1) | RS51279B (ru) |
SI (1) | SI2032123T1 (ru) |
WO (1) | WO2008000683A1 (ru) |
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ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
EP2163240A1 (en) * | 2008-09-12 | 2010-03-17 | Universita' Degli Studi Di Genova | A method for the production of bioadhesive compact matrices |
CN102202648B (zh) * | 2008-10-23 | 2014-07-23 | 汉高公司 | 包含脱支淀粉的阴道小丸 |
ES2344675B1 (es) * | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
EP2243482A1 (en) * | 2009-04-20 | 2010-10-27 | Polichem SA | Use of nifuratel to treat infections caused by atopobium species |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
KR102335160B1 (ko) * | 2013-10-22 | 2021-12-03 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 질내 삽입형 에스트라다이올 약제학적 조성물 및 방법 |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
CN105796520A (zh) * | 2014-12-29 | 2016-07-27 | 四川滇虹医药开发有限公司 | 一种缓释型硝酸布康唑直压片剂及其制备方法 |
EP3247347A4 (en) | 2015-01-23 | 2018-11-21 | Biocidium Biopharmaceuticals Inc. | Anti-bacterial compositions |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
EP3435977A4 (en) | 2016-04-01 | 2019-10-16 | Therapeuticsmd, Inc. | PHARMACEUTICAL COMPOSITION OF STEROID HORMONE |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US11026883B2 (en) * | 2016-10-13 | 2021-06-08 | Catalent U.K. Swindon Zydis Limited | Lyophilized pharmaceutical compositions for vaginal delivery |
GB201808567D0 (en) * | 2018-05-24 | 2018-07-11 | Douglas Pharmaceuticals Ltd | Pharmaceutical compositions |
CN109010320B (zh) * | 2018-09-18 | 2021-09-14 | 浙江汇能生物股份有限公司 | 一种双释型聚卡波非钙颗粒剂及制备方法和畜禽中的应用 |
CN114129530A (zh) * | 2021-12-08 | 2022-03-04 | 南京康川济医药科技有限公司 | 一种黄体酮缓释组合物及其制备方法 |
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US2379832A (en) * | 1936-06-02 | 1945-07-03 | Schering Corp | Process for the manufacture of unsaturated ketones of the cyclopentano polyhydro phenanthrene series |
CH202847A (de) * | 1937-06-26 | 1939-02-15 | Chem Ind Basel | Verfahren zur Darstellung von Acetylen-Derivaten der Cyclopentanopolyhydrophenanthren-Reihe. |
US2265976A (en) * | 1937-10-25 | 1941-12-09 | Schering Corp | Tertiary alcohols of the estrane series and their derivatives and a process for their manufacture |
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US6248358B1 (en) | 1998-08-25 | 2001-06-19 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets and methods of making and using the same |
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CZ2003199A3 (cs) * | 2000-06-23 | 2003-12-17 | Teva Pharmaceutical Industries Ltd. | Rychle expandující kompozice pro řízené uvolňování léčiva a retenci léčiva v žaludku a lékové formy obsahující tuto kompozici |
FR2813865B1 (fr) | 2000-09-08 | 2002-12-20 | Rexam Sofab | Dispositif a buse unique pour la distribution selective de deux produits |
EP1318790A4 (en) | 2000-09-19 | 2006-02-01 | Cima Labs Inc | PHARMACEUTICAL COMPOSITIONS FOR RECTAL AND VAGINAL ADMINISTRATION |
WO2002076426A2 (en) * | 2001-03-27 | 2002-10-03 | Galen (Chemicals) Limited | Intravaginal drug delivery devices for the administration of an antimicrobial agent |
US6899890B2 (en) * | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
CN1302764C (zh) | 2005-01-10 | 2007-03-07 | 凌沛学 | 一种妇科用药阴道凝胶片 |
-
2006
- 2006-06-29 EP EP06116269A patent/EP1872775A1/en not_active Withdrawn
-
2007
- 2007-06-21 BR BRPI0713298-0A patent/BRPI0713298A2/pt not_active IP Right Cessation
- 2007-06-21 AT AT07730288T patent/ATE455534T1/de active
- 2007-06-21 RS RSP-2010/0045A patent/RS51279B/sr unknown
- 2007-06-21 EA EA200900087A patent/EA018257B1/ru not_active IP Right Cessation
- 2007-06-21 JP JP2009517127A patent/JP5205374B2/ja not_active Expired - Fee Related
- 2007-06-21 CA CA2652226A patent/CA2652226C/en not_active Expired - Fee Related
- 2007-06-21 DE DE602007004486T patent/DE602007004486D1/de active Active
- 2007-06-21 DK DK07730288.3T patent/DK2032123T3/da active
- 2007-06-21 EP EP07730288A patent/EP2032123B1/en active Active
- 2007-06-21 SI SI200730193T patent/SI2032123T1/sl unknown
- 2007-06-21 CN CNA2007800239858A patent/CN101478951A/zh active Pending
- 2007-06-21 CN CN2013100083584A patent/CN103071157A/zh active Pending
- 2007-06-21 ES ES07730288T patent/ES2339069T3/es active Active
- 2007-06-21 MX MX2008016508A patent/MX2008016508A/es active IP Right Grant
- 2007-06-21 PL PL07730288T patent/PL2032123T3/pl unknown
- 2007-06-21 WO PCT/EP2007/056185 patent/WO2008000683A1/en active Application Filing
- 2007-06-21 US US12/308,786 patent/US8865201B2/en not_active Expired - Fee Related
- 2007-06-21 PT PT07730288T patent/PT2032123E/pt unknown
- 2007-06-21 KR KR1020087032076A patent/KR101443149B1/ko not_active IP Right Cessation
- 2007-06-29 AR ARP070102948A patent/AR061771A1/es unknown
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2008
- 2008-12-24 CO CO08136879A patent/CO6140022A2/es unknown
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2009
- 2009-01-07 NO NO20090095A patent/NO20090095L/no not_active Application Discontinuation
- 2009-01-22 MA MA31583A patent/MA30597B1/fr unknown
- 2009-05-05 HK HK09104134.0A patent/HK1128587A1/xx not_active IP Right Cessation
-
2010
- 2010-03-18 HR HR20100159T patent/HRP20100159T1/hr unknown
- 2010-03-19 CY CY20101100256T patent/CY1109910T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI2032123T1 (sl) | 2010-04-30 |
EP2032123A1 (en) | 2009-03-11 |
US20110091555A1 (en) | 2011-04-21 |
BRPI0713298A2 (pt) | 2012-04-17 |
NO20090095L (no) | 2009-01-07 |
HK1128587A1 (en) | 2009-10-30 |
JP2009541419A (ja) | 2009-11-26 |
CA2652226C (en) | 2014-08-12 |
WO2008000683A1 (en) | 2008-01-03 |
KR20090033341A (ko) | 2009-04-02 |
MA30597B1 (fr) | 2009-07-01 |
JP5205374B2 (ja) | 2013-06-05 |
EA018257B1 (ru) | 2013-06-28 |
US8865201B2 (en) | 2014-10-21 |
CN101478951A (zh) | 2009-07-08 |
AR061771A1 (es) | 2008-09-17 |
RS51279B (sr) | 2010-12-31 |
CY1109910T1 (el) | 2014-09-10 |
CO6140022A2 (es) | 2010-03-19 |
DE602007004486D1 (de) | 2010-03-11 |
CA2652226A1 (en) | 2008-01-03 |
DK2032123T3 (da) | 2010-03-08 |
ATE455534T1 (de) | 2010-02-15 |
ES2339069T3 (es) | 2010-05-14 |
EP2032123B1 (en) | 2010-01-20 |
MX2008016508A (es) | 2009-04-22 |
PL2032123T3 (pl) | 2010-06-30 |
KR101443149B1 (ko) | 2014-09-23 |
PT2032123E (pt) | 2010-04-07 |
EP1872775A1 (en) | 2008-01-02 |
CN103071157A (zh) | 2013-05-01 |
HRP20100159T1 (hr) | 2010-05-31 |
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