CN102202648B - 包含脱支淀粉的阴道小丸 - Google Patents
包含脱支淀粉的阴道小丸 Download PDFInfo
- Publication number
- CN102202648B CN102202648B CN200980142499.7A CN200980142499A CN102202648B CN 102202648 B CN102202648 B CN 102202648B CN 200980142499 A CN200980142499 A CN 200980142499A CN 102202648 B CN102202648 B CN 102202648B
- Authority
- CN
- China
- Prior art keywords
- starch
- piller
- compositions
- vagina
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Description
小丸 | 穹窿 | 阴道中部 | 入口 | 总计 |
志愿者1 | 0.70 | 0.25 | 0.04 | 0.99 |
志愿者2 | 0.49 | 0.10 | 0.10 | 0.69 |
志愿者3 | 0.15 | 0.02 | 0.00 | 0.17 |
志愿者4 | 0.14 | 0.01 | 0.00 | 0.15 |
志愿者5 | 0.34 | 0.13 | 0.02 | 0.49 |
平均 | 0.37 | 0.10 | 0.03 | 0.50 |
粉末 | 穹窿 | 阴道中部 | 入口 | 总计 |
志愿者1 | 0.30 | 0.05 | 0.00 | 0.35 |
志愿者2 | 0.04 | 0.00 | 0.00 | 0.04 |
志愿者3 | 0.47 | 0.15 | 0.17 | 0.79 |
志愿者4 | 0.01 | 0.04 | 0.02 | 0.07 |
志愿者5 | 0.82 | 0.00 | 0.00 | 0.82 |
平均 | 0.33 | 0.05 | 0.04 | 0.41 |
粉末 | 穹窿 | 阴道中部 | 入口 | 总计 |
志愿者1 | 0.07 | 0.01 | 0.00 | 0.08 |
志愿者2 | 0.00 | 0.00 | 0.00 | 0.00 |
志愿者3 | 0.05 | 0.02 | 0.00 | 0.07 |
志愿者4 | 0.03 | 0.03 | 0.00 | 0.06 |
志愿者5 | 0.29 | 0.08 | 0.00 | 0.37 |
平均 | 0.09 | 0.03 | 0.00 | 0.12 |
Claims (8)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10778408P | 2008-10-23 | 2008-10-23 | |
US61/107,784 | 2008-10-23 | ||
PCT/US2009/061662 WO2010048389A2 (en) | 2008-10-23 | 2009-10-22 | Pharmaceutical pellets comprising modified starch and therapeutic applications therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102202648A CN102202648A (zh) | 2011-09-28 |
CN102202648B true CN102202648B (zh) | 2014-07-23 |
Family
ID=42118112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980142499.7A Expired - Fee Related CN102202648B (zh) | 2008-10-23 | 2009-10-22 | 包含脱支淀粉的阴道小丸 |
Country Status (9)
Country | Link |
---|---|
US (2) | US20100105784A1 (zh) |
EP (1) | EP2344121B1 (zh) |
JP (1) | JP5608167B2 (zh) |
KR (1) | KR20110073618A (zh) |
CN (1) | CN102202648B (zh) |
BR (1) | BRPI0919869A2 (zh) |
RU (1) | RU2519715C2 (zh) |
TW (1) | TWI500429B (zh) |
WO (1) | WO2010048389A2 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2477884T3 (es) | 2008-08-19 | 2014-07-18 | Xenoport, Inc. | Profármacos de hidrogenofumarato de metilo, composiciones farmacéuticas de los mismos y procedimientos de uso |
SG194725A1 (en) * | 2011-05-02 | 2013-12-30 | Aptalis Pharmatech Inc | Rapid dissolve tablet compositions for vaginal administration |
CA2882713A1 (en) | 2012-08-22 | 2014-02-27 | Xenoport, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
WO2014031897A1 (en) | 2012-08-22 | 2014-02-27 | Xenoport, Inc. | Oral dosage forms having a high loading of (n,n- diethylcarbamoyl)methyl methyl|(2e)but-2-ene-1,4-dioate |
WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
TW201516020A (zh) | 2013-09-06 | 2015-05-01 | Xenoport Inc | (n,n-二乙基胺甲醯基)甲基(2e)丁-2-烯-1,4-二酸甲酯之晶形、合成方法及用途 |
US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
EP3787656A1 (en) * | 2018-05-04 | 2021-03-10 | The Procter & Gamble Company | Compositions and methods for treating vaginal dryness |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101024084A (zh) * | 2005-05-02 | 2007-08-29 | 国家淀粉及化学投资控股公司 | 脱支淀粉在挤压-滚圆药丸中的用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
CH678697A5 (zh) * | 1989-04-03 | 1991-10-31 | Warner Lambert Co | |
US5468286A (en) * | 1989-10-25 | 1995-11-21 | National Starch And Chemical Investment Holding Corporation | Enzymatically debranched starches as tablet excipients |
US5281276A (en) * | 1992-03-25 | 1994-01-25 | National Starch And Chemical Investment Holding Corporation | Process for making amylase resistant starch from high amylose starch |
US5260068A (en) * | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
NL9201195A (nl) * | 1992-07-03 | 1994-02-01 | Tno | Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat. |
CA2211778A1 (en) * | 1997-08-14 | 1999-02-14 | Francois Carriere | Preparation of pregelatinized high amylose starch and debranched starch useful as an excipient for controlled release of active agents |
WO1999053902A1 (en) * | 1998-04-22 | 1999-10-28 | Glasgow Caledonian University | Orally administrable compositions comprising cation cross-linked polysaccharide and a polymer digestible in the lower gastrointestinal tract |
US7262170B2 (en) * | 1998-04-26 | 2007-08-28 | Zhongming Zeng | Pharmaceutical composition for reducing vaginal acidity and treatment of vaginitis, and the use thereof |
US7238677B2 (en) * | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
US7276486B2 (en) * | 2004-03-15 | 2007-10-02 | Kimberly-Clark Worldwide, Inc. | Compositions for vaginal treatment |
US20050214364A1 (en) * | 2004-03-23 | 2005-09-29 | Hutman Herbert W | Products and methods for treating vaginal infections |
US8318230B2 (en) * | 2005-05-02 | 2012-11-27 | Henkel Ag & Co. Kgaa | Use of debranched starch in extrusion-spheronization pharmaceutical pellets |
EP1872775A1 (en) * | 2006-06-29 | 2008-01-02 | Polichem S.A. | Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders |
-
2009
- 2009-10-22 JP JP2011533328A patent/JP5608167B2/ja active Active
- 2009-10-22 KR KR1020117011716A patent/KR20110073618A/ko not_active Application Discontinuation
- 2009-10-22 BR BRPI0919869A patent/BRPI0919869A2/pt not_active IP Right Cessation
- 2009-10-22 WO PCT/US2009/061662 patent/WO2010048389A2/en active Application Filing
- 2009-10-22 RU RU2011120438/15A patent/RU2519715C2/ru not_active IP Right Cessation
- 2009-10-22 EP EP09744012.7A patent/EP2344121B1/en active Active
- 2009-10-22 CN CN200980142499.7A patent/CN102202648B/zh not_active Expired - Fee Related
- 2009-10-22 US US12/603,917 patent/US20100105784A1/en not_active Abandoned
- 2009-10-23 TW TW098136057A patent/TWI500429B/zh not_active IP Right Cessation
-
2012
- 2012-04-24 US US13/454,592 patent/US20120207823A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101024084A (zh) * | 2005-05-02 | 2007-08-29 | 国家淀粉及化学投资控股公司 | 脱支淀粉在挤压-滚圆药丸中的用途 |
Also Published As
Publication number | Publication date |
---|---|
JP2012506861A (ja) | 2012-03-22 |
TWI500429B (zh) | 2015-09-21 |
CN102202648A (zh) | 2011-09-28 |
WO2010048389A3 (en) | 2010-10-07 |
KR20110073618A (ko) | 2011-06-29 |
BRPI0919869A2 (pt) | 2015-12-15 |
EP2344121A2 (en) | 2011-07-20 |
WO2010048389A2 (en) | 2010-04-29 |
JP5608167B2 (ja) | 2014-10-15 |
US20120207823A1 (en) | 2012-08-16 |
EP2344121B1 (en) | 2017-07-12 |
RU2519715C2 (ru) | 2014-06-20 |
RU2011120438A (ru) | 2012-11-27 |
TW201021850A (en) | 2010-06-16 |
US20100105784A1 (en) | 2010-04-29 |
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PB01 | Publication | ||
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Owner name: HENKEL US IP LLC Free format text: FORMER OWNER: HENKEL CORP. Effective date: 20141127 |
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Effective date of registration: 20141127 Address after: American Connecticut Patentee after: Henkel U.S. Intellectual Property Limited Liability Company Address before: American Connecticut Patentee before: Henkel Corp. |
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Owner name: HENKEL CORP. Free format text: FORMER OWNER: HENKEL US IP LLC Effective date: 20150423 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20150423 Address after: Dusseldorf Patentee after: Henkel intellectual property Holdings Co.,Ltd Address before: American Connecticut Patentee before: Henkel U.S. Intellectual Property Limited Liability Company |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140723 Termination date: 20161022 |
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CF01 | Termination of patent right due to non-payment of annual fee |