MX2008016508A - Uso de una matriz hidrofilica que contiene un derivado de acido poliacrilico, un eter de celulosa y un desintegrante para la elaboracion de un medicamento para tratar trastornos genitales femeninos. - Google Patents

Uso de una matriz hidrofilica que contiene un derivado de acido poliacrilico, un eter de celulosa y un desintegrante para la elaboracion de un medicamento para tratar trastornos genitales femeninos.

Info

Publication number
MX2008016508A
MX2008016508A MX2008016508A MX2008016508A MX2008016508A MX 2008016508 A MX2008016508 A MX 2008016508A MX 2008016508 A MX2008016508 A MX 2008016508A MX 2008016508 A MX2008016508 A MX 2008016508A MX 2008016508 A MX2008016508 A MX 2008016508A
Authority
MX
Mexico
Prior art keywords
disintegrant
acid derivative
polyacrylic acid
cellulose ether
matrix
Prior art date
Application number
MX2008016508A
Other languages
English (en)
Inventor
Federico Mailland
Stefano De Luigi Bruschi
Original Assignee
Polichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polichem Sa filed Critical Polichem Sa
Publication of MX2008016508A publication Critical patent/MX2008016508A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una matriz hidrofilica es mostrada, la cual comprende: a) al menos un derivado de ácido poliacrilico en cantidades preferidas de 0.5-40%, b) al menos un éter celulosa en cantidades preferidas de 30-90% y c) al menos un desintegrante en cantidades preferidas de 2-50%, con relación al peso de la matriz. La matriz es utilizada en combinación con al menos un principio activo farmacéuticamente aceptable para elaboración de formulaciones de liberación controlada de bioadhesivo sólido para el tratamiento de disfunciones vaginales, tales como candidiasis vulvovaginal, vaginosis bacterial o tricomoniasis. La matriz es utilizada en formulaciones sólidas en cantidades de aproximadamente 5-60%, preferiblemente 20-40%, y el principio activo en cantidades de aproximadamente 2-70%, preferiblemente 5-50% con relación al peso de la formulación.
MX2008016508A 2006-06-29 2007-06-21 Uso de una matriz hidrofilica que contiene un derivado de acido poliacrilico, un eter de celulosa y un desintegrante para la elaboracion de un medicamento para tratar trastornos genitales femeninos. MX2008016508A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116269A EP1872775A1 (en) 2006-06-29 2006-06-29 Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders
PCT/EP2007/056185 WO2008000683A1 (en) 2006-06-29 2007-06-21 Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders

Publications (1)

Publication Number Publication Date
MX2008016508A true MX2008016508A (es) 2009-04-22

Family

ID=37433668

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008016508A MX2008016508A (es) 2006-06-29 2007-06-21 Uso de una matriz hidrofilica que contiene un derivado de acido poliacrilico, un eter de celulosa y un desintegrante para la elaboracion de un medicamento para tratar trastornos genitales femeninos.

Country Status (25)

Country Link
US (1) US8865201B2 (es)
EP (2) EP1872775A1 (es)
JP (1) JP5205374B2 (es)
KR (1) KR101443149B1 (es)
CN (2) CN101478951A (es)
AR (1) AR061771A1 (es)
AT (1) ATE455534T1 (es)
BR (1) BRPI0713298A2 (es)
CA (1) CA2652226C (es)
CO (1) CO6140022A2 (es)
CY (1) CY1109910T1 (es)
DE (1) DE602007004486D1 (es)
DK (1) DK2032123T3 (es)
EA (1) EA018257B1 (es)
ES (1) ES2339069T3 (es)
HK (1) HK1128587A1 (es)
HR (1) HRP20100159T1 (es)
MA (1) MA30597B1 (es)
MX (1) MX2008016508A (es)
NO (1) NO20090095L (es)
PL (1) PL2032123T3 (es)
PT (1) PT2032123E (es)
RS (1) RS51279B (es)
SI (1) SI2032123T1 (es)
WO (1) WO2008000683A1 (es)

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ES2344673B1 (es) 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
EP2163240A1 (en) * 2008-09-12 2010-03-17 Universita' Degli Studi Di Genova A method for the production of bioadhesive compact matrices
CN102202648B (zh) * 2008-10-23 2014-07-23 汉高公司 包含脱支淀粉的阴道小丸
ES2344675B1 (es) * 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
EP2243482A1 (en) * 2009-04-20 2010-10-27 Polichem SA Use of nifuratel to treat infections caused by atopobium species
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
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US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
KR102335160B1 (ko) * 2013-10-22 2021-12-03 쎄러퓨틱스엠디, 인코퍼레이티드 질내 삽입형 에스트라다이올 약제학적 조성물 및 방법
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. 天然の併用ホルモン補充療法剤及び療法
CN105796520A (zh) * 2014-12-29 2016-07-27 四川滇虹医药开发有限公司 一种缓释型硝酸布康唑直压片剂及其制备方法
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EP3435977A4 (en) 2016-04-01 2019-10-16 Therapeuticsmd, Inc. PHARMACEUTICAL COMPOSITION OF STEROID HORMONE
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11026883B2 (en) * 2016-10-13 2021-06-08 Catalent U.K. Swindon Zydis Limited Lyophilized pharmaceutical compositions for vaginal delivery
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CN109010320B (zh) * 2018-09-18 2021-09-14 浙江汇能生物股份有限公司 一种双释型聚卡波非钙颗粒剂及制备方法和畜禽中的应用
CN114129530A (zh) * 2021-12-08 2022-03-04 南京康川济医药科技有限公司 一种黄体酮缓释组合物及其制备方法

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Also Published As

Publication number Publication date
SI2032123T1 (sl) 2010-04-30
EP2032123A1 (en) 2009-03-11
US20110091555A1 (en) 2011-04-21
BRPI0713298A2 (pt) 2012-04-17
NO20090095L (no) 2009-01-07
HK1128587A1 (en) 2009-10-30
JP2009541419A (ja) 2009-11-26
CA2652226C (en) 2014-08-12
WO2008000683A1 (en) 2008-01-03
KR20090033341A (ko) 2009-04-02
MA30597B1 (fr) 2009-07-01
JP5205374B2 (ja) 2013-06-05
EA018257B1 (ru) 2013-06-28
US8865201B2 (en) 2014-10-21
CN101478951A (zh) 2009-07-08
AR061771A1 (es) 2008-09-17
RS51279B (sr) 2010-12-31
CY1109910T1 (el) 2014-09-10
CO6140022A2 (es) 2010-03-19
DE602007004486D1 (de) 2010-03-11
CA2652226A1 (en) 2008-01-03
DK2032123T3 (da) 2010-03-08
ATE455534T1 (de) 2010-02-15
EA200900087A1 (ru) 2009-06-30
ES2339069T3 (es) 2010-05-14
EP2032123B1 (en) 2010-01-20
PL2032123T3 (pl) 2010-06-30
KR101443149B1 (ko) 2014-09-23
PT2032123E (pt) 2010-04-07
EP1872775A1 (en) 2008-01-02
CN103071157A (zh) 2013-05-01
HRP20100159T1 (hr) 2010-05-31

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