HRP20190699T1 - Naprava za dopremu lijeka za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca - Google Patents
Naprava za dopremu lijeka za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca Download PDFInfo
- Publication number
- HRP20190699T1 HRP20190699T1 HRP20190699TT HRP20190699T HRP20190699T1 HR P20190699 T1 HRP20190699 T1 HR P20190699T1 HR P20190699T T HRP20190699T T HR P20190699TT HR P20190699 T HRP20190699 T HR P20190699T HR P20190699 T1 HRP20190699 T1 HR P20190699T1
- Authority
- HR
- Croatia
- Prior art keywords
- analgesia
- local
- drug delivery
- delivery device
- anesthesia
- Prior art date
Links
- 230000036592 analgesia Effects 0.000 title claims 13
- 210000005036 nerve Anatomy 0.000 title claims 9
- 238000012377 drug delivery Methods 0.000 title claims 8
- 238000002690 local anesthesia Methods 0.000 title claims 8
- 241000282412 Homo Species 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 239000012907 medicinal substance Substances 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 230000003187 abdominal effect Effects 0.000 claims 2
- SIEYLFHKZGLBNX-UHFFFAOYSA-N bupivacaine hydrochloride (anhydrous) Chemical compound [Cl-].CCCC[NH+]1CCCCC1C(=O)NC1=C(C)C=CC=C1C SIEYLFHKZGLBNX-UHFFFAOYSA-N 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 239000000515 collagen sponge Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000013373 fibrillar collagen Human genes 0.000 claims 2
- 108060002894 fibrillar collagen Proteins 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 210000000115 thoracic cavity Anatomy 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 206010002091 Anaesthesia Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 238000011538 abdominal hysterectomy Methods 0.000 claims 1
- 230000037005 anaesthesia Effects 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 238000001647 drug administration Methods 0.000 claims 1
- 238000002350 laparotomy Methods 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 238000011477 surgical intervention Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (14)
1. Naprava za dopremu lijeka pogodna za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca na određenom mjestu kod potrebitog čovjeka ili životinje, naprava obuhvaća matricu od fibrilarnog kolagena; i barem jednu ljekovitu tvar, najmanje jedna ljekovita tvar je sadržajno homogeno raspršena u matrici kolagena, pri čemu naprava za dopremu lijeka sadrži jednu ili nekoliko liofiliziranih kolagen spužvi koje ukupno sadrže 250 mg ili 200 mg anhidridnog bupivakain hidroklorida.
2. Naprava za dopremu lijeka iz patentnog zahtjeva 1, pri čemu čovjek ili životinja kad je u potrebi za lokalnom analgezijom, lokalnom anestezijom, ili blokadom živca nakon gastrointestinalne (GI) operacije, naprava za dopremu lijeka sadrži mnoštvo spužvi koje ukupno sadrže 200 mg bupivakain hidroklorida, pri čemu spužve imaju površinu od 100 cm2 i dubinu ili debljinu od 0.5 cm.
3. Naprava iz patentnih zahtjeva 1-2, pri čemu je analgezija omogućena bez nuspojava povezanih s toksičnosti naprave za dopremu lijeka.
4. Naprava iz patentnih zahtjeva 1-3, pri čemu naprava umanjuje pacijentovu potrebu za sustavnom analgezijom.
5. Uporaba naprave za dopremu lijeka koja sadrži matricu od fibrilarnog kolagena; i barem jednu ljekovitu tvar, najmanje jedna ljekovita tvar je sadržajno homogeno raspršena u matrici kolagena, za proizvodnju lijeka za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca kod potrebitog čovjeka ili životinje, analgezija, anestezija ili blokada živca obuhvaća davanje lijeka na određeno mjesto kod potrebitog čovjeka ili životinje pri čemu naprava za primjenu lijeka sadrži jednu ili nekoliko liofiliziranih kolagen spužvi koje ukupno sadrže 250 mg ili 200 mg anhidridnog bupivakain hidroklorida.
6. Uporaba u skladu s patentnim zahtjevom 5, pri čemu se najmanje jedna spužva postavlja pored mjesta operativnog zahvata, najmanje se jedna spužva postavlja preko reza u stijenku tjelesne šupljine i najmanje se jedna spužva postavlja između obloge i kože oko reza.
7. Uporaba u skladu s patentnim zahtjevom 6, pri čemu je uporaba za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca kod čovjeka nakon laparotomije.
8. Uporaba u skladu s patentnim zahtjevima 6-7, pri čemu je uporaba za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca kod čovjeka nakon ortopedskog, abdominalnog, ginekološkog ili torakalnog operativnog zahvata.
9. Uporaba u skladu s patentnim zahtjevom 8, pri čemu je uporaba za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca kod čovjeka nakon benignih abdominalnih ili torakalnih kirurških zahvata.
10. Uporaba u skladu s patentnim zahtjevom 9, pri čemu je uporaba za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca kod čovjeka nakon abdominalne histerektomije, miomektomije i kirurgije adneksa.
11. Naprava iz patentnih zahtjeva 1-4 ili uporaba iz patentnih zahtjeva 5-10 pri čemu spužve imaju dubinu od 0.5 cm.
12. Naprava iz patentnih zahtjeva 1-4 ili uporaba iz patentnih zahtjeva 5-10 pri čemu svaka spužva ima dužinu od 5 cm i širinu od 5 cm.
13. Uporaba iz patentnih zahtjeva 5-10 pri čemu je analgezija omogućena bez nuspojava povezanih s toksičnosti naprave za dopremu lijeka.
14. Uporaba iz patentnih zahtjeva 5-10 pri čemu naprava umanjuje pacijentovu potrebu za sustavnom analgezijom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/692,337 US20080241243A1 (en) | 2007-03-28 | 2007-03-28 | Drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
| IE2007/0220A IE85880B1 (en) | 2007-03-28 | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade | |
| EP16154811.0A EP3085363B1 (en) | 2007-03-28 | 2008-03-28 | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190699T1 true HRP20190699T1 (hr) | 2019-07-12 |
Family
ID=39540798
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160743TT HRP20160743T1 (hr) | 2007-03-28 | 2016-06-27 | Naprava za dopremu lijeka za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca |
| HRP20190699TT HRP20190699T1 (hr) | 2007-03-28 | 2019-04-15 | Naprava za dopremu lijeka za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160743TT HRP20160743T1 (hr) | 2007-03-28 | 2016-06-27 | Naprava za dopremu lijeka za omogućavanje lokalne analgezije, lokalne anestezije ili blokade živca |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP2139457B1 (hr) |
| JP (1) | JP5372905B2 (hr) |
| CY (2) | CY1117814T1 (hr) |
| DE (1) | DE202008018583U1 (hr) |
| DK (2) | DK2139457T3 (hr) |
| ES (2) | ES2718542T3 (hr) |
| HR (2) | HRP20160743T1 (hr) |
| HU (2) | HUE027803T2 (hr) |
| IE (1) | IES20080229A2 (hr) |
| LT (1) | LT3085363T (hr) |
| PL (2) | PL3085363T3 (hr) |
| PT (2) | PT3085363T (hr) |
| SI (2) | SI3085363T1 (hr) |
| TR (1) | TR201905174T4 (hr) |
| WO (1) | WO2008117268A2 (hr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47826E1 (en) | 2007-03-28 | 2020-01-28 | Innocoll Pharmaceuticals Limited | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage |
| JP2012507383A (ja) * | 2008-11-06 | 2012-03-29 | イノコル テクノロジーズ リミティッド | 薬剤送達インプラントおよびその作製のためのプロセス |
| US20100278895A1 (en) | 2009-04-30 | 2010-11-04 | Medtronic, Inc. | Antioxidants and antimicrobial accessories including antioxidants |
| US8911427B2 (en) | 2010-12-28 | 2014-12-16 | Medtronic, Inc. | Therapeutic agent reservoir delivery system |
| US9205150B2 (en) * | 2011-12-05 | 2015-12-08 | Incept, Llc | Medical organogel processes and compositions |
| PL3255106T3 (pl) | 2012-01-09 | 2019-09-30 | Innocoll Pharmaceuticals Limited | Zmodyfikowany kolagen |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| JP6363115B2 (ja) | 2013-02-28 | 2018-07-25 | ミラ ファーマ コーポレイション | 注射可能局所麻酔半固体製剤およびその組成物 |
| RU2561301C1 (ru) * | 2014-10-06 | 2015-08-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Омский государственный аграрный университет имени П.А. Столыпина" | Способ трансфеморальной блокады нервов мочевого пузыря у мелких животных |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| WO2022162640A1 (en) * | 2021-02-01 | 2022-08-04 | Massey University | Post-operative pain management |
| WO2022219179A1 (en) * | 2021-04-15 | 2022-10-20 | Innocoll Pharmaceuticals Limited | Drug-release implant for soft tissue surgery |
| IL310517A (en) * | 2021-07-28 | 2024-03-01 | Innocoll Pharm Ltd | Bupivacaine-collagen drug delivery implant and methods for its preparation and use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4125400C2 (de) * | 1991-07-31 | 2000-08-17 | Edwin Klaus | Verwendung von unlöslichem Kollagen zur Behandlung von degenerativen, nicht entzündlichen Gelenkprozessen |
| JPH08143449A (ja) * | 1994-11-17 | 1996-06-04 | Lederle Japan Ltd | 徐放性局所麻酔用注射剤 |
| US7119062B1 (en) * | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
| US20080124400A1 (en) * | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
| SI2767292T1 (sl) * | 2004-09-17 | 2017-01-31 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
| EP1793872B1 (en) * | 2004-09-30 | 2016-05-11 | Covalon Technologies Inc. | Non-adhesive elastic gelatin matrices |
-
2008
- 2008-03-28 JP JP2010500426A patent/JP5372905B2/ja active Active
- 2008-03-28 DE DE202008018583.1U patent/DE202008018583U1/de not_active Expired - Lifetime
- 2008-03-28 SI SI200832058T patent/SI3085363T1/sl unknown
- 2008-03-28 ES ES16154811T patent/ES2718542T3/es active Active
- 2008-03-28 IE IE20080229A patent/IES20080229A2/en not_active IP Right Cessation
- 2008-03-28 HU HUE08719893A patent/HUE027803T2/en unknown
- 2008-03-28 PT PT16154811T patent/PT3085363T/pt unknown
- 2008-03-28 PL PL16154811T patent/PL3085363T3/pl unknown
- 2008-03-28 WO PCT/IE2008/000035 patent/WO2008117268A2/en active Application Filing
- 2008-03-28 ES ES08719893.3T patent/ES2582368T3/es active Active
- 2008-03-28 HU HUE16154811A patent/HUE043185T2/hu unknown
- 2008-03-28 PT PT87198933T patent/PT2139457T/pt unknown
- 2008-03-28 LT LTEP16154811.0T patent/LT3085363T/lt unknown
- 2008-03-28 PL PL08719893.3T patent/PL2139457T3/pl unknown
- 2008-03-28 DK DK08719893.3T patent/DK2139457T3/en active
- 2008-03-28 TR TR2019/05174T patent/TR201905174T4/tr unknown
- 2008-03-28 DK DK16154811.0T patent/DK3085363T3/en active
- 2008-03-28 EP EP08719893.3A patent/EP2139457B1/en active Active
- 2008-03-28 EP EP16154811.0A patent/EP3085363B1/en active Active
- 2008-03-28 SI SI200831641A patent/SI2139457T1/sl unknown
-
2016
- 2016-06-27 HR HRP20160743TT patent/HRP20160743T1/hr unknown
- 2016-07-14 CY CY20161100677T patent/CY1117814T1/el unknown
-
2019
- 2019-04-12 CY CY20191100409T patent/CY1121568T1/el unknown
- 2019-04-15 HR HRP20190699TT patent/HRP20190699T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008117268A2 (en) | 2008-10-02 |
| WO2008117268A3 (en) | 2009-03-26 |
| HUE043185T2 (hu) | 2019-08-28 |
| SI3085363T1 (sl) | 2019-07-31 |
| EP2139457A2 (en) | 2010-01-06 |
| CY1117814T1 (el) | 2017-05-17 |
| EP3085363A1 (en) | 2016-10-26 |
| TR201905174T4 (tr) | 2019-05-21 |
| HRP20160743T1 (hr) | 2016-09-23 |
| LT3085363T (lt) | 2019-06-25 |
| CY1121568T1 (el) | 2020-05-29 |
| IES20080229A2 (en) | 2008-12-24 |
| PT2139457T (pt) | 2016-07-26 |
| DK3085363T3 (en) | 2019-04-29 |
| EP3085363B1 (en) | 2019-03-20 |
| EP2139457B1 (en) | 2016-05-04 |
| HUE027803T2 (en) | 2016-10-28 |
| DK2139457T3 (en) | 2016-07-25 |
| PL2139457T3 (pl) | 2016-11-30 |
| SI2139457T1 (sl) | 2016-09-30 |
| DE202008018583U1 (de) | 2016-03-14 |
| ES2718542T3 (es) | 2019-07-02 |
| JP5372905B2 (ja) | 2013-12-18 |
| PT3085363T (pt) | 2019-05-16 |
| PL3085363T3 (pl) | 2019-08-30 |
| JP2010522738A (ja) | 2010-07-08 |
| ES2582368T3 (es) | 2016-09-12 |
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