EA200870528A1 - Композиции и способы ингибирования экспрессии гена pcsk9 - Google Patents

Композиции и способы ингибирования экспрессии гена pcsk9

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Publication number
EA200870528A1
EA200870528A1 EA200870528A EA200870528A EA200870528A1 EA 200870528 A1 EA200870528 A1 EA 200870528A1 EA 200870528 A EA200870528 A EA 200870528A EA 200870528 A EA200870528 A EA 200870528A EA 200870528 A1 EA200870528 A1 EA 200870528A1
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Prior art keywords
expression
methods
dsrna
pcsk9
pcsk9 gene
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EA200870528A
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English (en)
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EA015676B1 (ru
Inventor
Памела Тан
Биргит Брамлаге
Мария Франк-Каменетски
Кевин Фитцжеральд
Акин Акинк
Виктор Е. Котелянски
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Элнилэм Фармасьютикалз, Инк.
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Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA200870528A1 publication Critical patent/EA200870528A1/ru
Publication of EA015676B1 publication Critical patent/EA015676B1/ru

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Abstract

Настоящее изобретение относится к двухцепочечной рибонуклеиновой кислоте (дцРНК) для ингибирования экспрессии гена пропротеин-конвертазы субтилизин-кексина 9 (PCSK9), где указанная дцРНК включает в себя антисмысловую цепь, имеющую нуклеотидную последовательность длиной менее чем в 30 нуклеотидов, обычно 19-25 нуклеотидов, и, по существу, комплементарную по меньшей мере части гена PCSK9. Настоящее изобретение относится также к фармацевтической композиции, содержащей дцРНК в комбинации с фармацевтически приемлемым носителем, и к способам лечения заболеваний, вызываемых экспрессией гена PCSK9, с использованием указанной фармацевтической композиции.
EA200870528A 2006-05-11 2007-05-10 Композиции и способы ингибирования экспрессии гена pcsk9 EA015676B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US79945806P 2006-05-11 2006-05-11
US81720306P 2006-06-27 2006-06-27
US84008906P 2006-08-25 2006-08-25
US82991406P 2006-10-18 2006-10-18
US90113407P 2007-02-13 2007-02-13
PCT/US2007/068655 WO2007134161A2 (en) 2006-05-11 2007-05-10 Compositions and methods for inhibiting expression of the pcsk9 gene

Publications (2)

Publication Number Publication Date
EA200870528A1 true EA200870528A1 (ru) 2009-06-30
EA015676B1 EA015676B1 (ru) 2011-10-31

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EA200870528A EA015676B1 (ru) 2006-05-11 2007-05-10 Композиции и способы ингибирования экспрессии гена pcsk9
EA201100907A EA020840B1 (ru) 2006-05-11 2007-05-14 Композиции и способы ингибирования экспрессии гена pcsk9

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US (9) US7605251B2 (ru)
EP (8) EP3249052B1 (ru)
JP (4) JP5570806B2 (ru)
KR (2) KR101320916B1 (ru)
CN (2) CN103614375A (ru)
AU (2) AU2007249329C1 (ru)
CA (2) CA2915441A1 (ru)
EA (2) EA015676B1 (ru)
ES (2) ES2392478T3 (ru)
HK (1) HK1183910A1 (ru)
IL (3) IL195181A (ru)
NZ (2) NZ587616A (ru)
PL (2) PL3578656T3 (ru)
SG (1) SG171676A1 (ru)
WO (1) WO2007134161A2 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2640258C2 (ru) * 2011-09-13 2017-12-27 Аффирис Аг Вакцина

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