EA200801426A1 - ПРОИЗВОДНЫЕ 2-АДАМАНТИЛМОЧЕВИНЫ В КАЧЕСТВЕ СЕЛЕКТИВНЫХ ИНГИБИТОРОВ 11β-HSD1 - Google Patents

ПРОИЗВОДНЫЕ 2-АДАМАНТИЛМОЧЕВИНЫ В КАЧЕСТВЕ СЕЛЕКТИВНЫХ ИНГИБИТОРОВ 11β-HSD1

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EA200801426A1
EA200801426A1 EA200801426A EA200801426A EA200801426A1 EA 200801426 A1 EA200801426 A1 EA 200801426A1 EA 200801426 A EA200801426 A EA 200801426A EA 200801426 A EA200801426 A EA 200801426A EA 200801426 A1 EA200801426 A1 EA 200801426A1
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EA
Eurasian Patent Office
Prior art keywords
hsd1
derivatives
adamantylm
urine
selective inhibitor
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EA200801426A
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English (en)
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EA017923B1 (ru
Inventor
Денис Карньято
Кристине Шарон
Иоганнес Глайтц
Дидье Роше
Бьёрн Хок
Original Assignee
Мерк Патент Гмбх
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Publication of EA200801426A1 publication Critical patent/EA200801426A1/ru
Publication of EA017923B1 publication Critical patent/EA017923B1/ru

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Abstract

Настоящее изобретение относится к производным 2-адамантилмочевины формулы I в качестве селективных ингибиторов фермента 11-бета-гидроксистероид-дегидрогеназа 1 типа (11β-HSD1) и к применению таких соединений для лечения и профилактики метаболического синдрома, диабета, резистентности к инсулину, ожирения, нарушений обмена липидов, глаукомы, остеопороза, расстройств познавательной способности, тревоги, депрессии, иммунных нарушений, гипертонии и других заболеваний и состояний.
EA200801426A 2005-12-16 2006-11-22 ПРОИЗВОДНЫЕ 2-АДАМАНТИЛМОЧЕВИНЫ В КАЧЕСТВЕ СЕЛЕКТИВНЫХ ИНГИБИТОРОВ 11β-HSD1 EA017923B1 (ru)

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EP05292724A EP1801098A1 (en) 2005-12-16 2005-12-16 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
PCT/EP2006/011156 WO2007068330A1 (en) 2005-12-16 2006-11-22 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS

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EA200801426A1 true EA200801426A1 (ru) 2008-10-30
EA017923B1 EA017923B1 (ru) 2013-04-30

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CA2633186C (en) 2014-08-12
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IL192053A (en) 2014-01-30
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