EA200501817A1 - Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции - Google Patents

Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции

Info

Publication number
EA200501817A1
EA200501817A1 EA200501817A EA200501817A EA200501817A1 EA 200501817 A1 EA200501817 A1 EA 200501817A1 EA 200501817 A EA200501817 A EA 200501817A EA 200501817 A EA200501817 A EA 200501817A EA 200501817 A1 EA200501817 A1 EA 200501817A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dislipidemia
treating atherosclerosis
pharmaceutical compositions
related conditions
administered
Prior art date
Application number
EA200501817A
Other languages
English (en)
Other versions
EA009744B1 (ru
Inventor
Кан Чэн
Джерард Уотерс М.
Кэтлин М. Меттерс
Гэри О`Нил
Original Assignee
Мерк Энд Ко., Инк.
Мерк Фросст Кэнада Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33476734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200501817(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Энд Ко., Инк., Мерк Фросст Кэнада Лтд. filed Critical Мерк Энд Ко., Инк.
Publication of EA200501817A1 publication Critical patent/EA200501817A1/ru
Publication of EA009744B1 publication Critical patent/EA009744B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Описан способ лечения атеросклероза, где никотиновая кислота или еще один агонист рецептора никотиновой кислоты вводят больному в сочетании с антагонистом рецептора DP. Антагонист рецептора DP вводят с целью снижения, профилактики или устранения гиперемии, которая может возникнуть.
EA200501817A 2003-05-15 2004-05-13 Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции EA009744B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47066503P 2003-05-15 2003-05-15
PCT/US2004/014980 WO2004103370A1 (en) 2003-05-15 2004-05-13 Method of treating atherosclerosis, dyslipidemias and related conditions and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
EA200501817A1 true EA200501817A1 (ru) 2006-06-30
EA009744B1 EA009744B1 (ru) 2008-04-28

Family

ID=33476734

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200501817A EA009744B1 (ru) 2003-05-15 2004-05-13 Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции
EA200702674A EA011895B1 (ru) 2003-05-15 2004-05-13 Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200702674A EA011895B1 (ru) 2003-05-15 2004-05-13 Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции

Country Status (45)

Country Link
US (4) US20040229844A1 (ru)
EP (3) EP2116244B1 (ru)
JP (2) JP4637833B2 (ru)
KR (2) KR100806008B1 (ru)
CN (3) CN100441184C (ru)
AR (1) AR041089A1 (ru)
AU (2) AU2004240597B2 (ru)
BR (1) BRPI0410273A (ru)
CA (1) CA2525772C (ru)
CL (1) CL2004001056A1 (ru)
CO (1) CO5630034A2 (ru)
CR (2) CR8047A (ru)
CY (2) CY1109476T1 (ru)
DE (1) DE602004022036D1 (ru)
DK (2) DK2116244T3 (ru)
DO (1) DOP2004000907A (ru)
EA (2) EA009744B1 (ru)
EC (1) ECSP056156A (ru)
ES (2) ES2328148T3 (ru)
GE (2) GEP20105025B (ru)
GT (1) GT200400098A (ru)
HK (1) HK1092722A1 (ru)
HN (1) HN2004000171A (ru)
HR (2) HRP20090424T1 (ru)
IL (1) IL171962A (ru)
IS (1) IS2708B (ru)
JO (1) JO2564B1 (ru)
MA (1) MA27835A1 (ru)
ME (1) MEP60108A (ru)
MX (1) MXPA05012272A (ru)
MY (1) MY140639A (ru)
NO (1) NO20055957L (ru)
NZ (2) NZ543399A (ru)
PA (1) PA8603201A1 (ru)
PE (1) PE20050552A1 (ru)
PL (2) PL2116244T3 (ru)
PT (2) PT2116244E (ru)
RS (3) RS52731B (ru)
SG (1) SG153667A1 (ru)
SI (2) SI1624871T1 (ru)
TN (1) TNSN05290A1 (ru)
TW (2) TWI341199B (ru)
UA (1) UA89615C2 (ru)
WO (1) WO2004103370A1 (ru)
ZA (1) ZA200508288B (ru)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094830A2 (en) * 2001-05-23 2002-11-28 Merck Frosst Canada & Co. DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
EP1603585A2 (en) * 2003-03-14 2005-12-14 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74
TWI258478B (en) 2003-10-31 2006-07-21 Arena Pharm Inc Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
US7019022B2 (en) * 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
ES2523796T1 (es) 2004-10-08 2014-12-01 Forward Pharma A/S Composición farmacéutica de liberación controlada que comprende éster de ácido fumárico
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8165517B2 (en) * 2005-01-19 2012-04-24 The Trustees Of The University Of Pennsylvania Methods for identifying inhibitors of vascular injury
CA2598273A1 (en) * 2005-02-17 2006-08-24 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
AU2006214286A1 (en) * 2005-02-18 2006-08-24 Arena Pharmaceuticals, Inc. Methods and compositions for the treatment of lipid-associated disorders
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
EP1885726B1 (en) * 2005-05-17 2016-12-14 Merck Sharp & Dohme Corp. Ortho-condensed 2-pyridinone derivatives as nicotinic acid receptor agonists for the treatment of dyslipidemia
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US20090258862A1 (en) * 2005-08-29 2009-10-15 Colletti Steven L Niacin receptor agonists, compositions containing such compounds and methods of treatment
RU2008112313A (ru) * 2005-09-01 2009-10-10 Эррэй Биофарма Инк. (Us) Соединения ингибиторы raf и способы их применения
EP1940382A2 (en) * 2005-10-07 2008-07-09 Aditech Pharma AB Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
CA2634940A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
JP2009521445A (ja) * 2005-12-21 2009-06-04 シェーリング コーポレイション Ｈ３アンタゴニスト／逆アゴニストと食欲抑制剤との組み合わせ
CA2637717A1 (en) * 2006-01-20 2007-08-02 Schering Corporation Heterocycles as nicotinic acid receptor agonists for the treatment of dyyslipidemia
US20090069275A1 (en) * 2006-02-17 2009-03-12 Rocca Jose G Low flush niacin formulation
WO2008033464A2 (en) * 2006-09-15 2008-03-20 Schering Corporation Azetidinone derivatives for the treatment of disorders of the lipid metabolism
EP2091534A1 (en) * 2006-09-15 2009-08-26 Schering Corporation Azetidinone derivatives and methods of use thereof
CA2663434A1 (en) 2006-09-15 2008-03-20 Schering Corporation Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders
WO2008039882A1 (en) * 2006-09-30 2008-04-03 Sanofi-Aventis U.S. Llc A combination of niacin and a prostaglandin d2 receptor antagonist
WO2008097535A2 (en) * 2007-02-08 2008-08-14 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
US20090076117A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched laropiprant
CN101559058B (zh) * 2008-04-16 2011-07-20 北京本草天源药物研究院 一种治疗血脂异常的药物组合物
RU2010151944A (ru) * 2008-05-20 2012-06-27 Серенис Терапьютикс С.А. (Fr) Ниацин и нспвс для комбинированной терапии
WO2010030360A1 (en) 2008-09-11 2010-03-18 Arena Pharmaceuticals, Inc. 3H-IMIDAZO[4,5-b]PYRIDIN-5-OL DERIVATIVES USEFUL IN THE TREATMENT OF GPR81 RECEPTOR DISORDERS
US20110165239A1 (en) * 2008-09-24 2011-07-07 Laman Alani Pharmaceutical compositions of atorvastatin
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
DK2564839T3 (en) 2009-01-09 2016-07-25 Forward Pharma As A pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
MX2012010038A (es) 2010-03-16 2012-10-01 Aventis Pharma Inc Una pirimidina sustituida como un antagonista del receptor de la prostaglandina d2.
EP2547672A1 (en) 2010-03-16 2013-01-23 Aventis Pharmaceuticals Inc. Substituted pyrimidines as prostaglandin d2 receptor antagonists

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535326A (en) * 1967-03-06 1970-10-20 Sumitomo Chemical Co Certain tetrahydro carboline derivatives
BE787444A (fr) * 1971-08-13 1973-02-12 Hoffmann La Roche Composes polycycliques
US4009181A (en) * 1973-01-22 1977-02-22 Hoffmann-La Roche Inc. Cyclopenta[b]indole-2-carboxylic acids and derivatives thereof
US4057559A (en) * 1973-10-01 1977-11-08 American Home Products Corporation Carbazole acetic acid derivatives
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
JPS6352514B2 (ru) 1977-09-30 1988-10-19 Rca Corp
US4342767A (en) 1980-01-23 1982-08-03 Merck & Co., Inc. Hypocholesteremic fermentation products
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US5021447A (en) * 1986-01-23 1991-06-04 Merck Frosst Canada, Inc. Tetrahydrocarbazole 1-alkanoic acids and pharmaecutical compositions
US4808608A (en) * 1986-01-23 1989-02-28 Merck & Co., Inc. Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
US4940719A (en) * 1986-03-27 1990-07-10 Merck Frosst Canada, Inc. Tetrahydrocarbazole esters, pharmaceutical compositions and use
US4775680A (en) * 1987-07-21 1988-10-04 Merck & Co., Inc. Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
US5190972A (en) * 1992-01-27 1993-03-02 The University Of Melbourne Method of combatting cyclosporine organ toxicity with prostaglandin analogs
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
EP0821587A4 (en) * 1995-04-19 1999-05-19 Lipoprotein Technologies Inc COMPOSITIONS, KITS AND METHODS FOR ADMINISTERING ANTILIPEMICS AND MEDICINES AGAINST PLATELET AGGREGATION
DK0877750T3 (da) 1995-10-31 2002-07-15 Schering Corp Som hypocholesterolemiske midler velegnede, sukkersubstituerede 2-azetidinoner
WO1997016424A1 (en) 1995-11-02 1997-05-09 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-([phenyl or 4-fluorophenyl])-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinone
CZ288545B6 (cs) 1995-12-22 2001-07-11 Kowa Company, Ltd. Stabilizovaná farmaceutická kompozice na bázi kyseliny (E)-3,5-dihydroxy-7-[4´-4´´-fluorfenyl-2´-cyklopropylchinolin-3´-yl]-6-heptenové
US5739321A (en) 1996-05-31 1998-04-14 Schering Corporation 3-hydroxy γ-lactone based enantionselective synthesis of azetidinones
US5886171A (en) 1996-05-31 1999-03-23 Schering Corporation 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
US5756470A (en) 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US20010006644A1 (en) * 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
US6469035B1 (en) * 1997-07-31 2002-10-22 Eugenio A. Cefali Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid
PT1017390E (pt) * 1997-07-31 2007-07-24 Kos Life Sciences Inc Comprimido revestido que compreende ácido nicotínico ou um composto metabolizado a ácido nicotínico sob uma forma de libertação prolongada, e um revestimento que contém um inibidor da hmg-coa-redutase sob uma forma de libertação imediata.
RU2247722C2 (ru) * 1997-10-27 2005-03-10 Др. Редди`З Лабораториз Лимитед Производные арилкарбоновых кислот, способы их получения, фармацевтическая композиция на их основе, способы лечения и предупреждения различных заболеваний, промежуточные соединения и способы их получения
US6133001A (en) 1998-02-23 2000-10-17 Schering Corporation Stereoselective microbial reduction for the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-Hydroxy-3-(4-fluorophenyl)propyl)]-4(S)-(4 -hydroxyphenyl)-2-azetidinone
US5919672A (en) 1998-10-02 1999-07-06 Schering Corporation Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
EP1137634B1 (en) 1998-12-07 2005-06-15 Schering Corporation Process for the synthesis of azetidinones
IL143944A0 (en) 1998-12-23 2002-04-21 Searle Llc Combinations for cardiovascular indications
CN1249250C (zh) 1999-04-05 2006-04-05 先灵公司 用于制备1－(4－氟苯基)－3(R)－[3(S)－羟基－3－(4－氟苯基)丙基]－4(S)－(4－羟苯基)－2－β丙内酰胺的立体选择性微生物还原反应
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
IT1306141B1 (it) * 1999-05-17 2001-05-30 Giampiero Valletta Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche.
CN1179945C (zh) 2000-03-09 2004-12-15 小野药品工业株式会社 吲哚衍生物、其制备方法及用途
US20010047027A1 (en) * 2000-04-12 2001-11-29 Marc Labelle Prostaglandin D2 receptor antagonists
JP2002008186A (ja) * 2000-06-23 2002-01-11 Mitsubishi Heavy Ind Ltd 車種識別装置
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
JP3889563B2 (ja) * 2000-09-13 2007-03-07 三洋電機株式会社 映像信号処理回路
EP1377834A2 (en) 2001-04-11 2004-01-07 Glaxo Group Limited Medicaments which are modulators of hm74 and/or hm74a activity
WO2002094830A2 (en) 2001-05-23 2002-11-28 Merck Frosst Canada & Co. DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
EP1424335A4 (en) 2001-09-07 2005-11-16 Ono Pharmaceutical Co INDOLE DERIVATIVES
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
BR0308518A (pt) 2002-03-19 2005-02-22 Ono Pharmaceutical Co Compostos ácidos carboxìlicos e drogas contendo os compostos como o ingrediente ativo
EP1513519B1 (en) * 2002-06-03 2009-02-18 Novartis AG The use of substituted cyanopyrrolidines for treating hyperlipidemia
US7019022B2 (en) * 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
JP4129960B2 (ja) * 2005-07-01 2008-08-06 タキゲン製造株式会社 ステー

Also Published As

Publication number Publication date
NZ572515A (en) 2010-07-30
IS2708B (is) 2011-01-15
ES2392743T3 (es) 2012-12-13
PT2116244E (pt) 2012-11-02
AR041089A1 (es) 2005-05-04
MXPA05012272A (es) 2006-05-19
TNSN05290A1 (en) 2007-07-10
DK1624871T3 (da) 2009-11-16
WO2004103370A1 (en) 2004-12-02
MY140639A (en) 2010-01-15
IL171962A0 (en) 2006-04-10
PT1624871E (pt) 2009-09-07
HRP20120818T1 (hr) 2012-11-30
CN102526735A (zh) 2012-07-04
HN2004000171A (es) 2011-07-11
RS20120498A1 (en) 2013-08-30
CA2525772A1 (en) 2004-12-02
TW200503757A (en) 2005-02-01
AU2004240597B2 (en) 2011-01-06
DOP2004000907A (es) 2004-11-30
RS20050777A (sr) 2008-04-04
IS8071A (is) 2005-10-13
US20110118292A1 (en) 2011-05-19
BRPI0410273A (pt) 2006-05-16
RS52731B (sr) 2013-08-30
PA8603201A1 (es) 2005-02-04
TWI334354B (en) 2010-12-11
DE602004022036D1 (de) 2009-08-27
TW200803844A (en) 2008-01-16
DK2116244T3 (da) 2012-11-26
SG153667A1 (en) 2009-07-29
KR100806008B1 (ko) 2008-02-26
MA27835A1 (fr) 2006-04-03
AU2011200986B2 (en) 2012-11-08
ES2328148T3 (es) 2009-11-10
US20090233977A1 (en) 2009-09-17
JP2010077151A (ja) 2010-04-08
CN1787819A (zh) 2006-06-14
AU2004240597A1 (en) 2004-12-02
CR8047A (es) 2006-07-14
HRP20090424T1 (en) 2009-09-30
GT200400098A (es) 2005-03-03
EP2116244B1 (en) 2012-08-08
NZ543399A (en) 2009-02-28
EA011895B1 (ru) 2009-06-30
JO2564B1 (en) 2010-11-03
PL1624871T3 (pl) 2009-12-31
SI2116244T1 (sl) 2012-12-31
HK1092722A1 (en) 2007-02-16
US20040229844A1 (en) 2004-11-18
EP2286816A1 (en) 2011-02-23
KR20080003470A (ko) 2008-01-07
TWI341199B (en) 2011-05-01
US20100076002A1 (en) 2010-03-25
GEP20084569B (en) 2008-12-25
EA200702674A1 (ru) 2008-04-28
CN101559227A (zh) 2009-10-21
ZA200508288B (en) 2008-08-27
EP1624871A1 (en) 2006-02-15
KR20060012617A (ko) 2006-02-08
KR100960749B1 (ko) 2010-06-01
PL2116244T3 (pl) 2013-01-31
JP2006526030A (ja) 2006-11-16
CO5630034A2 (es) 2006-04-28
IL171962A (en) 2012-06-28
NO20055957L (no) 2006-02-14
AU2011200986A1 (en) 2011-03-31
MEP60108A (en) 2011-05-10
SI1624871T1 (sl) 2009-12-31
RS20120499A1 (en) 2013-08-30
CN100441184C (zh) 2008-12-10
CA2525772C (en) 2011-03-15
ECSP056156A (es) 2006-04-19
EA009744B1 (ru) 2008-04-28
EP1624871B1 (en) 2009-07-15
JP4637833B2 (ja) 2011-02-23
CN101559227B (zh) 2012-03-21
PE20050552A1 (es) 2005-08-06
CY1109476T1 (el) 2014-08-13
UA89615C2 (ru) 2010-02-25
GEP20105025B (en) 2010-06-25
EP2116244A1 (en) 2009-11-11
CR9808A (es) 2008-07-29
CY1113342T1 (el) 2016-06-22
CL2004001056A1 (es) 2005-03-28

Similar Documents

Publication Publication Date Title
EA200501817A1 (ru) Способ лечения атеросклероза, дислипидемий и связанных с ними состояний и фармацевтические композиции
UA86621C2 (ru) Антагонисты рецептора глюкагона, их получение и терапевтическое применение
TW200733971A (en) CGRP peptide antagonists and conjugates
DE60038290D1 (de) Opioidantagonisthaltige zusammensetzung zur erhöhung der analgetischen wirksamkeit von tramadol und verringerung von ihre nebenwirkungen
WO2005107726A3 (en) Method for the treatment of back pain
TW200507849A (en) Methods for treating interleukin-6 related diseases
BR0313233A (pt) Composto, uso do mesmo, método de tratamento ou profilaxia de doenças, e, composição farmacêutica
DK1735278T3 (da) Histamin H3-receptormidler, fremstilling og terapeutiske anvendelser
DK1957484T3 (da) Glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser
EA200700118A1 (ru) Амидосоединения и их применение в качестве лекарственных средств
TW200738729A (en) Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
EA200400734A1 (ru) Способ и композиция для потенциирования действия опиатного анальгетика
EP1064966A3 (en) Combination of an 5HT1 receptor antagonist, caffeine and a cyclooxygenase-2 inhibitor for the treatment of migraine
ATE450503T1 (de) Pyrrolidinderivate als histamin-h3- rezeptorantagonisten
EA200802159A1 (ru) Введение агониста-антагониста пациентам с опиоидной зависимостью
EP1064948A3 (en) Combination of an 5HT1 receptor antagonist, caffeine and a cyclooxygenase-2 inhibitor for the treatment of migraine
EP1051995A3 (en) 5HT1 receptor agonists and a cox-2 inhibitor or NSAID for the treatment of migraine
EP1051994A3 (en) 5HT1 receptor agonists and a COX-2 inhibitor for the treatment of migraine
WO2006051413A8 (en) Azabenoxazoles for the treatment of cns disorders
UA93689C2 (ru) Фармацевтическая композиция ингибиторов дипептидилпептидазы
EA200701086A1 (ru) Производные изоксазола, их фармацевтические композиции и способ лечения невропатической боли
MA33284B1 (fr) Nouveaux sels pharmaceutiquement acceptables de 4-(1h-imidazol-4-ylmethyl) pyridine et leurs utilisations therapeutiques

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
TC4A Change in name of a patent proprietor in a eurasian patent
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU