EA200501265A1 - Производные пиримидина для профилактики вич-инфекции - Google Patents
Производные пиримидина для профилактики вич-инфекцииInfo
- Publication number
- EA200501265A1 EA200501265A1 EA200501265A EA200501265A EA200501265A1 EA 200501265 A1 EA200501265 A1 EA 200501265A1 EA 200501265 A EA200501265 A EA 200501265A EA 200501265 A EA200501265 A EA 200501265A EA 200501265 A1 EA200501265 A1 EA 200501265A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- prevention
- hiv infection
- pyrimidine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Изобретение относится к применению соединения при производстве лекарственного средства для профилактики ВИЧ-инфекции при половом акте и связанном с ним близком контакте между партнерами, где соединение представляет собой соединение формулы (I), его N-оксид, фармацевтически приемлемую аддитивную соль, четвертичный амин и стереохимически изомерную форму, где кольцо, включающее -a=a-a=a- и -b=b-b=b-, представляет собой фенил, пиридил, пиримидинил, пиразинил, пиридазинил; а также к содержащим его композициям.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0301291 | 2003-02-07 | ||
PCT/EP2004/001011 WO2004069812A1 (en) | 2003-02-07 | 2004-02-04 | Pyrimidine derivatives for the prevention of hiv infection |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200501265A1 true EA200501265A1 (ru) | 2006-02-24 |
EA011164B1 EA011164B1 (ru) | 2009-02-27 |
Family
ID=32842658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501265A EA011164B1 (ru) | 2003-02-07 | 2004-02-04 | Производные пиримидина для профилактики вич-инфекции |
Country Status (22)
Country | Link |
---|---|
US (2) | US20070021449A1 (ru) |
EP (1) | EP1597237B1 (ru) |
JP (2) | JP5602333B2 (ru) |
KR (2) | KR20110132482A (ru) |
CN (2) | CN1747937A (ru) |
AP (1) | AP2065A (ru) |
AU (1) | AU2004210081B2 (ru) |
BR (1) | BRPI0407329A (ru) |
CA (1) | CA2513527C (ru) |
CL (1) | CL2004000192A1 (ru) |
EA (1) | EA011164B1 (ru) |
ES (1) | ES2598404T3 (ru) |
HR (1) | HRP20050688B1 (ru) |
IL (1) | IL170114A (ru) |
MX (1) | MXPA05008364A (ru) |
MY (1) | MY176490A (ru) |
NO (1) | NO334178B1 (ru) |
NZ (1) | NZ541902A (ru) |
PL (1) | PL227577B1 (ru) |
UA (1) | UA80601C2 (ru) |
WO (1) | WO2004069812A1 (ru) |
ZA (1) | ZA200506253B (ru) |
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-
2004
- 2004-02-04 BR BR0407329-0A patent/BRPI0407329A/pt not_active Application Discontinuation
- 2004-02-04 JP JP2006501729A patent/JP5602333B2/ja not_active Expired - Lifetime
- 2004-02-04 PL PL378144A patent/PL227577B1/pl unknown
- 2004-02-04 NZ NZ541902A patent/NZ541902A/en not_active IP Right Cessation
- 2004-02-04 AP AP2005003366A patent/AP2065A/en active
- 2004-02-04 WO PCT/EP2004/001011 patent/WO2004069812A1/en active Application Filing
- 2004-02-04 CN CNA2004800034604A patent/CN1747937A/zh active Pending
- 2004-02-04 CN CN2011100443222A patent/CN102151270A/zh active Pending
- 2004-02-04 KR KR1020117026076A patent/KR20110132482A/ko not_active Application Discontinuation
- 2004-02-04 ES ES04707937.1T patent/ES2598404T3/es not_active Expired - Lifetime
- 2004-02-04 CL CL200400192A patent/CL2004000192A1/es unknown
- 2004-02-04 KR KR1020057013837A patent/KR101185048B1/ko active IP Right Grant
- 2004-02-04 US US10/544,735 patent/US20070021449A1/en not_active Abandoned
- 2004-02-04 AU AU2004210081A patent/AU2004210081B2/en not_active Expired
- 2004-02-04 EA EA200501265A patent/EA011164B1/ru unknown
- 2004-02-04 CA CA2513527A patent/CA2513527C/en not_active Expired - Lifetime
- 2004-02-04 EP EP04707937.1A patent/EP1597237B1/en not_active Expired - Lifetime
- 2004-02-04 MX MXPA05008364A patent/MXPA05008364A/es active IP Right Grant
- 2004-02-05 MY MYPI20040342A patent/MY176490A/en unknown
- 2004-04-02 UA UAA200508362A patent/UA80601C2/uk unknown
-
2005
- 2005-08-01 HR HRP20050688AA patent/HRP20050688B1/hr not_active IP Right Cessation
- 2005-08-04 IL IL170114A patent/IL170114A/en active IP Right Grant
- 2005-08-04 ZA ZA200506253A patent/ZA200506253B/xx unknown
- 2005-09-06 NO NO20054143A patent/NO334178B1/no not_active IP Right Cessation
-
2009
- 2009-09-25 US US12/567,051 patent/US8828982B2/en active Active
-
2014
- 2014-05-21 JP JP2014105248A patent/JP5799133B2/ja not_active Expired - Lifetime
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