EA200100792A1 - Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств - Google Patents

Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств

Info

Publication number
EA200100792A1
EA200100792A1 EA200100792A EA200100792A EA200100792A1 EA 200100792 A1 EA200100792 A1 EA 200100792A1 EA 200100792 A EA200100792 A EA 200100792A EA 200100792 A EA200100792 A EA 200100792A EA 200100792 A1 EA200100792 A1 EA 200100792A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrido
imidazo
phosphodiesterase
pyrasinones
medicine
Prior art date
Application number
EA200100792A
Other languages
English (en)
Russian (ru)
Inventor
Норберт Хефген
Штефан Селеньи
Маркс Дегенхард
Уте Эгерланд
Original Assignee
Арцнаймиттельверк Дрезден Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999102082 external-priority patent/DE19902082A1/de
Priority claimed from DE1999161302 external-priority patent/DE19961302A1/de
Application filed by Арцнаймиттельверк Дрезден Гмбх filed Critical Арцнаймиттельверк Дрезден Гмбх
Publication of EA200100792A1 publication Critical patent/EA200100792A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA200100792A 1999-01-20 2000-01-14 Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств EA200100792A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999102082 DE19902082A1 (de) 1999-01-20 1999-01-20 Verwendung von Imidazo[1,5-a]-pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erectiler Dysfunktion und Verfahren zu deren Herstellung
DE1999161302 DE19961302A1 (de) 1999-12-18 1999-12-18 Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
PCT/EP2000/000260 WO2000043392A2 (de) 1999-01-20 2000-01-14 Verwendung von imidazo[1,5-a]-pyrido[3,2-e]-pyrazinonen als arzneimittel

Publications (1)

Publication Number Publication Date
EA200100792A1 true EA200100792A1 (ru) 2002-10-31

Family

ID=26051406

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100792A EA200100792A1 (ru) 1999-01-20 2000-01-14 Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств

Country Status (23)

Country Link
EP (1) EP1144410A2 (ko)
JP (1) JP2002535330A (ko)
KR (1) KR20010101603A (ko)
CN (1) CN1344268A (ko)
AR (1) AR022318A1 (ko)
AU (1) AU2291200A (ko)
BG (1) BG105714A (ko)
BR (1) BR0007613A (ko)
CA (1) CA2296224A1 (ko)
CO (1) CO5190700A1 (ko)
CZ (1) CZ20012627A3 (ko)
EA (1) EA200100792A1 (ko)
EE (1) EE200100377A (ko)
HU (1) HUP0105132A3 (ko)
ID (1) ID29790A (ko)
IL (1) IL144156A0 (ko)
IS (1) IS5987A (ko)
LT (1) LT2001078A (ko)
LV (1) LV12793B (ko)
NO (1) NO20013334L (ko)
SK (1) SK10322001A3 (ko)
TR (1) TR200102121T2 (ko)
WO (1) WO2000043392A2 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
JP2005513060A (ja) * 2001-12-17 2005-05-12 アルタナ　ファルマ　アクチエンゲゼルシャフト 選択的ｐｄｅ５阻害剤の新規使用
US6916345B2 (en) 2002-02-12 2005-07-12 L'oreal S.A. 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres
FR2835741B1 (fr) * 2002-02-12 2006-05-05 Oreal Nouveaux coupleurs 6-alcoxy-2,3-diaminopyridine utiles pour la teinture des fibres keratiniques
DE10325813B4 (de) 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
CN101106997A (zh) * 2004-08-17 2008-01-16 约翰·霍普金斯大学 Pde5抑制剂组合物及治疗心脏病征候的方法
EP2103613B1 (en) * 2006-12-13 2016-02-17 ASKA Pharmaceutical Co., Ltd. Quinoxaline derivative
JP2011505366A (ja) 2007-11-30 2011-02-24 ワイス・エルエルシー ホスホエステラーゼ１０の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ［１，５−ａ］ピラジン
US20090143361A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
CN106905324B (zh) 2011-10-10 2018-09-25 H.隆德贝克有限公司 具有咪唑并吡嗪酮骨架的pde9抑制剂
EP2807163B1 (en) 2012-01-26 2017-03-22 H. Lundbeck A/S Pde9 inhibitors with imidazo triazinone backbone
JP5842640B2 (ja) * 2012-01-31 2016-01-13 株式会社東洋新薬 ホスホジエステラーゼ３阻害剤
WO2016022836A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
WO2016022825A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
DK3303339T3 (da) 2015-07-07 2021-04-12 H Lundbeck As Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme
JP2021526134A (ja) 2018-05-25 2021-09-30 イマラ インク． ６−［（３Ｓ，４Ｓ）−４−メチル−ｌ−（ピリミジン−２−イルメチル）ピロリジン−３−イル］−３−テトラヒドロピラン−４−イル−７Ｈ−イミダゾ［ｌ，５−Ａ］ピラジン−８−オンの一水和物および結晶形態

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
ID29790A (id) 2001-10-11
EP1144410A2 (de) 2001-10-17
KR20010101603A (ko) 2001-11-14
LV12793B (lv) 2002-05-20
CO5190700A1 (es) 2002-08-29
CZ20012627A3 (cs) 2002-01-16
LT2001078A (en) 2002-08-26
BR0007613A (pt) 2001-10-30
IL144156A0 (en) 2002-05-23
SK10322001A3 (sk) 2002-07-02
LV12793A (lv) 2002-02-20
JP2002535330A (ja) 2002-10-22
NO20013334D0 (no) 2001-07-05
CA2296224A1 (en) 2000-07-20
CN1344268A (zh) 2002-04-10
AU2291200A (en) 2000-08-07
TR200102121T2 (tr) 2002-01-21
AR022318A1 (es) 2002-09-04
HUP0105132A2 (hu) 2002-05-29
NO20013334L (no) 2001-07-05
EE200100377A (et) 2002-10-15
BG105714A (en) 2002-02-28
WO2000043392A3 (de) 2000-09-28
HUP0105132A3 (en) 2002-12-28
WO2000043392A2 (de) 2000-07-27
IS5987A (is) 2001-06-29

Similar Documents

Publication Publication Date Title
EA200100792A1 (ru) Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств
MY140872A (en) 5,7-diaminopyrazolo[4,3-d]pyrimidines with pde-5 inhibitory activity, compositions containing such derivatives and the use of such derivatives in the treatment of hypertension and other disorders
ATE297208T1 (de) Tablette mit verlängerter wirkstoffabgabe zur behandlung der parkinsonkrankheit
EA200501253A1 (ru) Производные пиразоло[1,5-a][1,3,5]триазина в качестве лигандов каннабиноидных рецепторов
EA200200208A1 (ru) Синергитическая композиция
EA200100721A1 (ru) Производное габапентина для предупреждения и лечения висцеральной боли
WO2001087038A3 (en) β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE
CR10191A (es) Derivados de pirazolo (3,4d) pirimidina. (divisional)
EA200300219A1 (ru) Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
EA200600190A1 (ru) Производные пиримидин-2,4-диона в качестве антагонистов рецептора гонадотропин-высвобождающего гормона
JPH09512834A (ja) 勃起機能不全の治療のためのｃＧＭＰ−ＰＤＥ阻害薬
EA200400735A1 (ru) 3-β-D-РИБОФУРАНОЗИЛТИАЗОЛО[4,5-d]ПИРИМИДИННУКЛЕОЗИДЫ И ИХ ПРИМЕНЕНИЯ
TR199801755T2 (xx) Pirimido(5,4-D)pirimidinler, bu bile�ikleri i�eren farmas�tik maddeler.
EA200400135A1 (ru) Применение производных амидинов для лечения амилоидоза
DK0779888T3 (da) Pyrimido[5,4-d]pyrimidiner, lægemidler indeholdende disse forbindelser, anvendelse deraf og fremgangsmåder til fremstilling
PL373414A1 (en) 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands
EA200600209A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[3,4-c]ПИРАЗОЛА, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ КАК ИНГИБИТОРЫ КИНАЗЫ
EA200501690A1 (ru) Композиция, включающая ингибитор pde4 и ингибитор pde5
NO20024364D0 (no) Anvendelse av pyrido [3,2-E]-pyrazinoner som inhibitorer av fosfodiesterase 5 for behandling av erektil dysfunksjon
NZ542866A (en) Compositions and methods for the therapy of inflammatory bowel disease
EA199900161A1 (ru) Производные пиридазино [4,5-в]-хинолин-5-оксида, их получение и применение в качестве антагонистов глицина
NO20013645D0 (no) Anvendelse av pyridazino[4,5-b]indol-1-acetamid-derivater for fremstilling av medisiner for behandling av sykdommer relatert tildysfunksjonen av perifere benzodiazepinreseptorer
EA200200883A1 (ru) Производные пирано[2,3-с]имидазо[1,2-а]пиридина для лечения заболеваний желудочно-кишечного тракта
EA200300048A1 (ru) Энантиомер 1,2-аннелированного хиназолина, ингибирующий фарнезилтрансферазу
NO20062883L (no) Fosfodiesterase-V-inhibitorpreparater