EA199900907A1 - 4,4-дизамещенные 3,4-дигидро-2(1н)-хиназолиноны, полезные в качестве ингибиторов обратной транскриптазы вич - Google Patents
4,4-дизамещенные 3,4-дигидро-2(1н)-хиназолиноны, полезные в качестве ингибиторов обратной транскриптазы вичInfo
- Publication number
- EA199900907A1 EA199900907A1 EA199900907A EA199900907A EA199900907A1 EA 199900907 A1 EA199900907 A1 EA 199900907A1 EA 199900907 A EA199900907 A EA 199900907A EA 199900907 A EA199900907 A EA 199900907A EA 199900907 A1 EA199900907 A1 EA 199900907A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dihydro
- inhibitors
- useful
- hiv reverse
- transpriptase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Настоящее изобретение относится к 4,4-дизамещенным 3,4-дигидро-2(1Н)-хиназолинонам формулы (I)или их стереоизомерным формам, смесям стереомерных форм или их фармацевтически приемлемым солям, которые полезны в качестве ингибиторов обратной транскриптазы ВИЧ, и к их фармацевтическим композициям и диагностическим наборам, содержащим их, и способам применения их для лечения вирусной инфекции или в качестве тест-стандарта или реагента.Отчет о международном поиске опубликован 1999.01.14.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83854097A | 1997-04-09 | 1997-04-09 | |
US7132298P | 1998-01-14 | 1998-01-14 | |
PCT/US1998/006733 WO1998045276A2 (en) | 1997-04-09 | 1998-04-07 | 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199900907A1 true EA199900907A1 (ru) | 2000-04-24 |
EA001991B1 EA001991B1 (ru) | 2001-10-22 |
Family
ID=26752095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900907A EA001991B1 (ru) | 1997-04-09 | 1998-04-07 | 4,4-дизамещенные 3,4-дигидро-2(1н)-хиназолиноны, полезные в качестве ингибиторов обратной транскриптазы вич |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0973753A2 (ru) |
JP (1) | JP2002504095A (ru) |
KR (1) | KR20010006146A (ru) |
CN (1) | CN1252063A (ru) |
AR (1) | AR012340A1 (ru) |
AU (1) | AU734928B2 (ru) |
BR (1) | BR9808513A (ru) |
CA (1) | CA2284996A1 (ru) |
EA (1) | EA001991B1 (ru) |
EE (1) | EE9900452A (ru) |
HR (1) | HRP980143A2 (ru) |
HU (1) | HUP0001446A3 (ru) |
IL (1) | IL132188A0 (ru) |
NO (1) | NO314936B1 (ru) |
NZ (1) | NZ500592A (ru) |
PL (1) | PL336305A1 (ru) |
SK (1) | SK137899A3 (ru) |
TW (1) | TW587078B (ru) |
WO (1) | WO1998045276A2 (ru) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002509922A (ja) * | 1998-03-27 | 2002-04-02 | デュポン ファーマシューティカルズ カンパニー | 4,4−二置換−3,4−ジヒドロ−2(1h)−キナゾリンチオン誘導体、それらの調製法、およびhiv逆転写酵素阻害剤としてのそれらの使用 |
AU6508899A (en) | 1998-10-13 | 2000-05-01 | Du Pont Pharmaceuticals Company | Selective eradication of virally-infected cells by combined use of a cytotoxic agent and an antiviral agent |
AU1821900A (en) * | 1998-11-19 | 2000-06-05 | Du Pont Pharmaceuticals Company | Process for the preparation of quinazolinones |
WO2000029390A1 (en) * | 1998-11-19 | 2000-05-25 | Du Pont Pharmaceuticals Company | Crystalline (-)-6- chloro-4- cyclopropylethynyl- 4-trifluoromethyl- 3,4-dihydro- 2(1h)-quinazolinone |
US6175009B1 (en) | 1999-11-18 | 2001-01-16 | Dupont Pharmaceuticals Company | Process for the preparation of quinazolinones |
DE60023025T2 (de) * | 1999-11-23 | 2006-07-13 | Smithkline Beecham Corp. | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren |
US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
CA2403230A1 (en) * | 2000-03-23 | 2001-09-27 | Lilian A. Radesca | Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors |
US6555686B2 (en) * | 2000-03-23 | 2003-04-29 | Bristol-Myers Squibb Pharma | Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors |
ZA200300255B (en) | 2000-07-20 | 2004-09-28 | Bristol Myers Squibb Pharma Co | Tricyclic 2-pyridone compounds useful as HIV reverse transcriptase inhibitors. |
US6596729B2 (en) | 2000-07-20 | 2003-07-22 | Bristol-Myers Squibb Company | Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
EP1575583A1 (en) * | 2002-12-16 | 2005-09-21 | Boehringer Ingelheim Pharmaceuticals Inc. | Treatment of hiv infection through combined administration of tipranavir and capravirine |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | METHOD AND APPARATUS PROVIDING A VARIABLE USER INTERFACE |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
EP1751546A2 (en) | 2004-05-20 | 2007-02-14 | Albatros Technologies GmbH & Co. KG | Printable hydrogel for biosensors |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR MANUFACTURING A DEVICE FOR SAMPLING LIQUIDS |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
CN102060786A (zh) * | 2011-01-20 | 2011-05-18 | 天津大学 | 4-(取代-1,3-二炔基)-4-(三氟甲基)-3,4-二氢取代喹唑啉-2-酮类化合物及其制备方法和应用 |
DK2694101T3 (en) * | 2011-04-06 | 2017-01-09 | Biovaxim Ltd | Pharmaceutical compositions for the prevention and / or treatment of HIV disease in humans |
WO2013175417A1 (en) | 2012-05-24 | 2013-11-28 | Novartis Ag | Pyrrolopyrrolidinone compounds |
US9403827B2 (en) | 2013-01-22 | 2016-08-02 | Novartis Ag | Substituted purinone compounds |
EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
US9890166B2 (en) | 2013-05-27 | 2018-02-13 | Novartis Ag | Imidazopyrrolidine derivatives and their use in the treatment of disease |
EA028175B1 (ru) | 2013-05-28 | 2017-10-31 | Новартис Аг | Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания |
AU2014272700B2 (en) | 2013-05-28 | 2016-12-01 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease |
EA029269B1 (ru) | 2013-11-21 | 2018-02-28 | Новартис Аг | Производные пирролопирролона и их применение для лечения заболеваний |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL102764A0 (en) * | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
AU2436792A (en) * | 1991-08-16 | 1993-03-16 | Merck & Co., Inc. | Quinazoline derivatives as inhibitors of hiv reverse transcriptase |
WO1993022292A1 (en) * | 1992-05-07 | 1993-11-11 | Merck & Co., Inc. | New quinazolines as inhibitors of hiv reverse transcriptase |
US5663169A (en) * | 1992-08-07 | 1997-09-02 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
DE4320347A1 (de) * | 1993-06-19 | 1994-12-22 | Boehringer Mannheim Gmbh | Quinazolin-Derivate und diese enthaltende Arzneimittel |
GB2281297A (en) * | 1993-08-27 | 1995-03-01 | Merck & Co Inc | Quinazoline compounds |
WO1995012583A1 (en) * | 1993-11-05 | 1995-05-11 | Merck & Co., Inc. | New quinazolines as inhibitors of hiv reverse transcriptase |
US5434152A (en) * | 1993-11-08 | 1995-07-18 | Merck & Co., Inc. | Asymmetric synthesis of (S)-(-)-6-chloro-4- cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone |
-
1998
- 1998-03-19 HR HR60/071,322A patent/HRP980143A2/hr not_active Application Discontinuation
- 1998-04-06 AR ARP980101558A patent/AR012340A1/es not_active Application Discontinuation
- 1998-04-07 CN CN98803974A patent/CN1252063A/zh active Pending
- 1998-04-07 EP EP98913401A patent/EP0973753A2/en not_active Withdrawn
- 1998-04-07 BR BR9808513-1A patent/BR9808513A/pt not_active IP Right Cessation
- 1998-04-07 CA CA002284996A patent/CA2284996A1/en not_active Abandoned
- 1998-04-07 IL IL13218898A patent/IL132188A0/xx unknown
- 1998-04-07 AU AU67960/98A patent/AU734928B2/en not_active Ceased
- 1998-04-07 NZ NZ500592A patent/NZ500592A/en unknown
- 1998-04-07 EE EEP199900452A patent/EE9900452A/xx unknown
- 1998-04-07 HU HU0001446A patent/HUP0001446A3/hu unknown
- 1998-04-07 SK SK1378-99A patent/SK137899A3/sk unknown
- 1998-04-07 KR KR1019997009225A patent/KR20010006146A/ko not_active Application Discontinuation
- 1998-04-07 PL PL98336305A patent/PL336305A1/xx unknown
- 1998-04-07 JP JP54297198A patent/JP2002504095A/ja active Pending
- 1998-04-07 EA EA199900907A patent/EA001991B1/ru not_active IP Right Cessation
- 1998-04-07 WO PCT/US1998/006733 patent/WO1998045276A2/en not_active Application Discontinuation
- 1998-04-15 TW TW087105365A patent/TW587078B/zh active
-
1999
- 1999-10-08 NO NO19994904A patent/NO314936B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EE9900452A (et) | 2000-04-17 |
SK137899A3 (en) | 2000-05-16 |
NO994904L (no) | 1999-12-01 |
EP0973753A2 (en) | 2000-01-26 |
HUP0001446A3 (en) | 2001-11-28 |
BR9808513A (pt) | 2000-05-23 |
HUP0001446A2 (hu) | 2001-05-28 |
HRP980143A2 (en) | 1999-02-28 |
JP2002504095A (ja) | 2002-02-05 |
KR20010006146A (ko) | 2001-01-26 |
IL132188A0 (en) | 2001-03-19 |
PL336305A1 (en) | 2000-06-19 |
TW587078B (en) | 2004-05-11 |
WO1998045276A3 (en) | 1999-01-14 |
AR012340A1 (es) | 2000-10-18 |
CA2284996A1 (en) | 1998-10-15 |
WO1998045276A2 (en) | 1998-10-15 |
EA001991B1 (ru) | 2001-10-22 |
NZ500592A (en) | 2001-09-28 |
AU6796098A (en) | 1998-10-30 |
AU734928B2 (en) | 2001-06-28 |
NO994904D0 (no) | 1999-10-08 |
CN1252063A (zh) | 2000-05-03 |
NO314936B1 (no) | 2003-06-16 |
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PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |