MXPA03000434A - Compuestos de 2-piridona triciclicos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih). - Google Patents
Compuestos de 2-piridona triciclicos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih).Info
- Publication number
- MXPA03000434A MXPA03000434A MXPA03000434A MXPA03000434A MXPA03000434A MX PA03000434 A MXPA03000434 A MX PA03000434A MX PA03000434 A MXPA03000434 A MX PA03000434A MX PA03000434 A MXPA03000434 A MX PA03000434A MX PA03000434 A MXPA03000434 A MX PA03000434A
- Authority
- MX
- Mexico
- Prior art keywords
- tricyclic
- reverse transcriptase
- hiv reverse
- pyridone compounds
- compounds useful
- Prior art date
Links
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title abstract 2
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a compuestos de 2-piridona tricíclicos de la formula (I): (ver formula) o formas estereoisomérica, mezclas estereoisoméricas, o formas de sal farmacéuticamente aceptable del mismo, que son °tiles como inhibidores de la transcriptasa inversa del VIH, y a composiciones farmacéuticas y kit(s) de diagnostico que comprenden el mismo, y métodos para usar el mismo para el tratamiento de una infeccion viral o como un estándar o reactivo de ensayo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21953200P | 2000-07-20 | 2000-07-20 | |
| US28485601P | 2001-04-19 | 2001-04-19 | |
| PCT/US2001/022827 WO2002008226A2 (en) | 2000-07-20 | 2001-07-20 | Tricyclic 2-pyridone compounds useful as hiv reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03000434A true MXPA03000434A (es) | 2003-06-24 |
Family
ID=26913986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03000434A MXPA03000434A (es) | 2000-07-20 | 2001-07-20 | Compuestos de 2-piridona triciclicos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih). |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6596729B2 (es) |
| EP (1) | EP1303515A2 (es) |
| JP (1) | JP2004532793A (es) |
| KR (1) | KR20030065454A (es) |
| CN (1) | CN1464878A (es) |
| AR (1) | AR031861A1 (es) |
| AU (1) | AU2001280641A1 (es) |
| BG (1) | BG107439A (es) |
| BR (1) | BR0112606A (es) |
| CA (1) | CA2418194A1 (es) |
| EE (1) | EE200300027A (es) |
| HU (1) | HUP0302862A2 (es) |
| IL (1) | IL153683A0 (es) |
| IS (1) | IS6690A (es) |
| LT (1) | LT2003003A (es) |
| LV (1) | LV13024B (es) |
| MX (1) | MXPA03000434A (es) |
| NO (1) | NO20030248L (es) |
| PL (1) | PL365958A1 (es) |
| SI (1) | SI21139A (es) |
| SK (1) | SK392003A3 (es) |
| WO (1) | WO2002008226A2 (es) |
| YU (1) | YU3203A (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
| US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| TW200306192A (en) | 2002-01-18 | 2003-11-16 | Bristol Myers Squibb Co | Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors |
| AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| JP4822707B2 (ja) * | 2002-08-09 | 2011-11-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ４−［［４−［［４−（２−シアノエテニル）−２，６−ジメチルフェニル］アミノ］−２−ピリミジニル］アミノ］ベンゾニトリルの製造方法 |
| US20070021449A1 (en) | 2003-02-07 | 2007-01-25 | Jan Heeres | Pyrimidine derivatives for the prevention of hiv infection |
| TW200607503A (en) | 2004-05-17 | 2006-03-01 | Tibotec Pharm Ltd | 1-heterocyclyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3700673A (en) * | 1971-02-12 | 1972-10-24 | Morton Norwich Products Inc | 3-4-dihydrobenzo(b) (1,7)naphthyridin-1(2h)-ones |
| GB9023289D0 (en) | 1990-10-25 | 1990-12-05 | Ici Plc | Herbicides |
| AU2436792A (en) * | 1991-08-16 | 1993-03-16 | Merck & Co., Inc. | Quinazoline derivatives as inhibitors of hiv reverse transcriptase |
| IL102764A0 (en) | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
| DE4320347A1 (de) | 1993-06-19 | 1994-12-22 | Boehringer Mannheim Gmbh | Quinazolin-Derivate und diese enthaltende Arzneimittel |
| AU1046895A (en) | 1993-11-05 | 1995-05-23 | Merck & Co., Inc. | New quinazolines as inhibitors of hiv reverse transcriptase |
| DE4344452A1 (de) | 1993-12-24 | 1995-06-29 | Hoechst Ag | Aza-4-iminochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung |
| ID18046A (id) | 1996-08-20 | 1998-02-19 | Takeda Chemical Industries Ltd | Senyawa siklik campuran, pembuatan dan penngunaannya. |
| ATE248826T1 (de) | 1996-10-02 | 2003-09-15 | Bristol Myers Squibb Pharma Co | 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv- reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung |
| HRP980143A2 (en) | 1997-04-09 | 1999-02-28 | Soo Sung Ko | 4,4-disubstituted-3,4-dihydro-2 (1h)-quinazolinones useful as hiv reverse transcriptase inhibitors |
| US6593337B1 (en) | 1999-10-19 | 2003-07-15 | Bristol-Myers Squibb Pharma Company | Tricyclic compounds useful as HIV reverse transcriptase inhibitors |
-
2001
- 2001-07-19 US US09/908,995 patent/US6596729B2/en not_active Expired - Lifetime
- 2001-07-20 YU YU3203A patent/YU3203A/sh unknown
- 2001-07-20 AU AU2001280641A patent/AU2001280641A1/en not_active Abandoned
- 2001-07-20 CN CN01815629A patent/CN1464878A/zh active Pending
- 2001-07-20 SI SI200120050A patent/SI21139A/sl not_active IP Right Cessation
- 2001-07-20 SK SK39-2003A patent/SK392003A3/sk unknown
- 2001-07-20 WO PCT/US2001/022827 patent/WO2002008226A2/en not_active Application Discontinuation
- 2001-07-20 MX MXPA03000434A patent/MXPA03000434A/es unknown
- 2001-07-20 AR ARP010103492A patent/AR031861A1/es unknown
- 2001-07-20 EP EP01959047A patent/EP1303515A2/en not_active Withdrawn
- 2001-07-20 JP JP2002514132A patent/JP2004532793A/ja active Pending
- 2001-07-20 EE EEP200300027A patent/EE200300027A/xx unknown
- 2001-07-20 KR KR10-2003-7000800A patent/KR20030065454A/ko not_active Application Discontinuation
- 2001-07-20 HU HU0302862A patent/HUP0302862A2/hu unknown
- 2001-07-20 PL PL01365958A patent/PL365958A1/xx not_active Application Discontinuation
- 2001-07-20 BR BR0112606-7A patent/BR0112606A/pt not_active Application Discontinuation
- 2001-07-20 CA CA002418194A patent/CA2418194A1/en not_active Abandoned
- 2001-07-20 IL IL15368301A patent/IL153683A0/xx unknown
-
2003
- 2003-01-06 BG BG107439A patent/BG107439A/bg unknown
- 2003-01-15 LT LT2003003A patent/LT2003003A/xx not_active Application Discontinuation
- 2003-01-17 IS IS6690A patent/IS6690A/is unknown
- 2003-01-17 NO NO20030248A patent/NO20030248L/no not_active Application Discontinuation
- 2003-02-18 LV LVP-03-16A patent/LV13024B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004532793A (ja) | 2004-10-28 |
| IL153683A0 (en) | 2003-07-06 |
| YU3203A (sh) | 2006-01-16 |
| US6596729B2 (en) | 2003-07-22 |
| NO20030248L (no) | 2003-03-17 |
| HUP0302862A2 (hu) | 2003-12-29 |
| IS6690A (is) | 2003-01-17 |
| AU2001280641A1 (en) | 2002-02-05 |
| PL365958A1 (en) | 2005-01-24 |
| BG107439A (bg) | 2003-09-30 |
| WO2002008226A3 (en) | 2002-06-20 |
| KR20030065454A (ko) | 2003-08-06 |
| US20020107261A1 (en) | 2002-08-08 |
| AR031861A1 (es) | 2003-10-08 |
| CN1464878A (zh) | 2003-12-31 |
| SI21139A (sl) | 2003-08-31 |
| WO2002008226A2 (en) | 2002-01-31 |
| CA2418194A1 (en) | 2002-01-31 |
| BR0112606A (pt) | 2004-06-29 |
| EE200300027A (et) | 2004-10-15 |
| LV13024B (en) | 2003-10-20 |
| NO20030248D0 (no) | 2003-01-17 |
| EP1303515A2 (en) | 2003-04-23 |
| LT2003003A (en) | 2003-11-25 |
| SK392003A3 (en) | 2003-10-07 |
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