BR0112606A - Compostos tricìclicos 2-piridona úteis como inibidores de transcriptase inversa de hiv - Google Patents

Compostos tricìclicos 2-piridona úteis como inibidores de transcriptase inversa de hiv

Info

Publication number
BR0112606A
BR0112606A BR0112606-7A BR0112606A BR0112606A BR 0112606 A BR0112606 A BR 0112606A BR 0112606 A BR0112606 A BR 0112606A BR 0112606 A BR0112606 A BR 0112606A
Authority
BR
Brazil
Prior art keywords
pyridone
transcriptase inhibitors
reverse transcriptase
hiv reverse
compounds useful
Prior art date
Application number
BR0112606-7A
Other languages
English (en)
Inventor
James D Rodgers
Haisheng Wang
Mona Patel
Argyrios Arvanitis
Anthony J Cocuzza
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of BR0112606A publication Critical patent/BR0112606A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"COMPOSTOS TRICìCLICOS 2-PIRIDONA úTEIS COMO INIBIDORES DE TRANSCRIPTASE INVERSA DE HIV". A presente invenção se refere aos compostos 2-piridona tricíclicos da fórmula (I): ou formas estereoisoméricas, misturas estereoisoméricas ou formas de sal farmaceuticamente aceitáveis dos mesmos, que são úteis como inibidores de transcriptase inversa de HIV e às composições farmacêuticas e kits de diagnóstico compreendendo os mesmos para tratamento de infecção por vírus ou como um padrão de ensaio ou reagente.
BR0112606-7A 2000-07-20 2001-07-20 Compostos tricìclicos 2-piridona úteis como inibidores de transcriptase inversa de hiv BR0112606A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21953200P 2000-07-20 2000-07-20
US28485601P 2001-04-19 2001-04-19
PCT/US2001/022827 WO2002008226A2 (en) 2000-07-20 2001-07-20 Tricyclic 2-pyridone compounds useful as hiv reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
BR0112606A true BR0112606A (pt) 2004-06-29

Family

ID=26913986

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112606-7A BR0112606A (pt) 2000-07-20 2001-07-20 Compostos tricìclicos 2-piridona úteis como inibidores de transcriptase inversa de hiv

Country Status (23)

Country Link
US (1) US6596729B2 (pt)
EP (1) EP1303515A2 (pt)
JP (1) JP2004532793A (pt)
KR (1) KR20030065454A (pt)
CN (1) CN1464878A (pt)
AR (1) AR031861A1 (pt)
AU (1) AU2001280641A1 (pt)
BG (1) BG107439A (pt)
BR (1) BR0112606A (pt)
CA (1) CA2418194A1 (pt)
EE (1) EE200300027A (pt)
HU (1) HUP0302862A2 (pt)
IL (1) IL153683A0 (pt)
IS (1) IS6690A (pt)
LT (1) LT2003003A (pt)
LV (1) LV13024B (pt)
MX (1) MXPA03000434A (pt)
NO (1) NO20030248L (pt)
PL (1) PL365958A1 (pt)
SI (1) SI21139A (pt)
SK (1) SK392003A3 (pt)
WO (1) WO2002008226A2 (pt)
YU (1) YU3203A (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
TW200306192A (en) 2002-01-18 2003-11-16 Bristol Myers Squibb Co Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
CN100554245C (zh) * 2002-08-09 2009-10-28 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
CA2513527C (en) * 2003-02-07 2012-08-14 Janssen Pharmaceutica N.V. Pyrimidine derivatives for the prevention of hiv infection
EP1758911A1 (en) * 2004-05-17 2007-03-07 Tibotec Pharmaceuticals Ltd. 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700673A (en) * 1971-02-12 1972-10-24 Morton Norwich Products Inc 3-4-dihydrobenzo(b) (1,7)naphthyridin-1(2h)-ones
GB9023289D0 (en) 1990-10-25 1990-12-05 Ici Plc Herbicides
IL102764A0 (en) 1991-08-16 1993-01-31 Merck & Co Inc Quinazoline derivatives,and pharmaceutical compositions containing them
AU2436792A (en) * 1991-08-16 1993-03-16 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
AU1046895A (en) 1993-11-05 1995-05-23 Merck & Co., Inc. New quinazolines as inhibitors of hiv reverse transcriptase
DE4344452A1 (de) 1993-12-24 1995-06-29 Hoechst Ag Aza-4-iminochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung
ID18046A (id) 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd Senyawa siklik campuran, pembuatan dan penngunaannya.
CA2268953A1 (en) 1996-10-02 1998-04-09 Du Pont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
HRP980143A2 (en) 1997-04-09 1999-02-28 Soo Sung Ko 4,4-disubstituted-3,4-dihydro-2 (1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
US6593337B1 (en) 1999-10-19 2003-07-15 Bristol-Myers Squibb Pharma Company Tricyclic compounds useful as HIV reverse transcriptase inhibitors

Also Published As

Publication number Publication date
PL365958A1 (en) 2005-01-24
SI21139A (sl) 2003-08-31
YU3203A (sh) 2006-01-16
IS6690A (is) 2003-01-17
CN1464878A (zh) 2003-12-31
NO20030248L (no) 2003-03-17
SK392003A3 (en) 2003-10-07
IL153683A0 (en) 2003-07-06
JP2004532793A (ja) 2004-10-28
LT2003003A (en) 2003-11-25
CA2418194A1 (en) 2002-01-31
WO2002008226A2 (en) 2002-01-31
KR20030065454A (ko) 2003-08-06
WO2002008226A3 (en) 2002-06-20
MXPA03000434A (es) 2003-06-24
HUP0302862A2 (hu) 2003-12-29
AU2001280641A1 (en) 2002-02-05
US6596729B2 (en) 2003-07-22
US20020107261A1 (en) 2002-08-08
EP1303515A2 (en) 2003-04-23
EE200300027A (et) 2004-10-15
AR031861A1 (es) 2003-10-08
LV13024B (en) 2003-10-20
BG107439A (bg) 2003-09-30
NO20030248D0 (no) 2003-01-17

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]