EA199900503A1 - Днк, кодирующая активные дельта-эндотоксины чешуекрылых насекомых, и ее использование - Google Patents

Днк, кодирующая активные дельта-эндотоксины чешуекрылых насекомых, и ее использование

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Publication number
EA199900503A1
EA199900503A1 EA199900503A EA199900503A EA199900503A1 EA 199900503 A1 EA199900503 A1 EA 199900503A1 EA 199900503 A EA199900503 A EA 199900503A EA 199900503 A EA199900503 A EA 199900503A EA 199900503 A1 EA199900503 A1 EA 199900503A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
nucleic acid
disclosed
endotoxins
modified
Prior art date
Application number
EA199900503A
Other languages
English (en)
Inventor
Джеймс А. Баум
Эми Джелен Гилмер
Энн-Мари Меттас
Original Assignee
Экоджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Экоджен, Инк. filed Critical Экоджен, Инк.
Publication of EA199900503A1 publication Critical patent/EA199900503A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
    • B41M5/00—Duplicating or marking methods; Sheet materials for use therein
    • B41M5/26—Thermography ; Marking by high energetic means, e.g. laser otherwise than by burning, and characterised by the material used
    • B41M5/382—Contact thermal transfer or sublimation processes
    • B41M5/392—Additives, other than colour forming substances, dyes or pigments, e.g. sensitisers, transfer promoting agents
    • B41M5/395—Macromolecular additives, e.g. binders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/075—Bacillus thuringiensis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S428/00—Stock material or miscellaneous articles
    • Y10S428/913—Material designed to be responsive to temperature, light, moisture
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S428/00—Stock material or miscellaneous articles
    • Y10S428/914—Transfer or decalcomania
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pest Control & Pesticides (AREA)
  • Optics & Photonics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Insects & Arthropods (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Раскрываются новые модифицированные синтетическими методами фрагменты нуклеиновой кислоты В. tHuringiensis, кодирующие δ-эндотоксины, обладающие инсектицидной активностью против чешуекрылых насекомых. Раскрываются также синтетические кристаллические белки, кодируемые указанными последовательностями нуклеиновых кислот. Раскрываются также методы создания и использования таких генов и белков, а также методы осуществления рекомбинантной экспрессии и трансформации подходящих клеток-хозяев. Аспектами изобретения также являются трансформированные хозяйские клетки и трансгенные растения, экспрессирующие модифицированный эндотоксин. Раскрываются также методы модификации, изменения и мутагенеза специфических петлевых участков между α спиралями в домене 1 таких кристаллических белков, включая CrylC, для получения сконструированных генетическими методами рекомбинантных генов cry*, а также кодируемых ими белков, которые обладают улучшенной инсектицидной активностью. В предпочтительных вариантах реализации изобретения раскрываются новые аминокислотные фрагменты CrylC* и модифицированные последовательности нуклеиновой кислоты cry 1C*, которые их кодируют.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900503A 1996-11-27 1997-11-26 Днк, кодирующая активные дельта-эндотоксины чешуекрылых насекомых, и ее использование EA199900503A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/757,536 US5942664A (en) 1996-11-27 1996-11-27 Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants
PCT/US1997/022181 WO1998023641A1 (en) 1996-11-27 1997-11-26 Dna encoding lepidopteran-active delta-endotoxins and its use

Publications (1)

Publication Number Publication Date
EA199900503A1 true EA199900503A1 (ru) 2000-02-28

Family

ID=25048194

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900503A EA199900503A1 (ru) 1996-11-27 1997-11-26 Днк, кодирующая активные дельта-эндотоксины чешуекрылых насекомых, и ее использование

Country Status (17)

Country Link
US (11) US5942664A (ru)
EP (1) EP0942929A1 (ru)
JP (1) JP2001506490A (ru)
CN (1) CN1245502A (ru)
AP (1) AP9901542A0 (ru)
AR (1) AR010662A1 (ru)
AU (1) AU745431B2 (ru)
BR (1) BR9713555A (ru)
CA (1) CA2272847A1 (ru)
CO (1) CO4930292A1 (ru)
EA (1) EA199900503A1 (ru)
ID (1) ID23695A (ru)
IL (1) IL130082A0 (ru)
OA (1) OA11258A (ru)
TR (1) TR199901179T2 (ru)
WO (1) WO1998023641A1 (ru)
ZA (1) ZA9710431B (ru)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942664A (en) * 1996-11-27 1999-08-24 Ecogen, Inc. Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants
CA2219247C (en) 1997-10-23 2006-12-05 Mold-Masters Limited Injection molding apparatus having a melt bore through the front end of the pin
AUPP058797A0 (en) * 1997-11-28 1997-12-18 Commonwealth Scientific And Industrial Research Organisation Novel gene
US6060594A (en) 1997-12-18 2000-05-09 Ecogen, Inc. Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins
CZ302074B6 (cs) * 1998-08-19 2010-09-29 Monsanto Technology Llc Rostlinné expresní vektory, transformované rostlinné bunky a zpusob pro zlepšení genové exprese v rostlinách
US6251604B1 (en) * 1999-08-13 2001-06-26 Genopsys, Inc. Random mutagenesis and amplification of nucleic acid
US6501009B1 (en) 1999-08-19 2002-12-31 Monsanto Technology Llc Expression of Cry3B insecticidal protein in plants
AR025349A1 (es) 1999-08-23 2002-11-20 Mycogen Corp Metodos para controlar las plagas del gusano gris
CN1390259A (zh) 1999-09-15 2003-01-08 孟山都技术有限公司 对鳞翅目昆虫有活性的苏云金芽孢杆菌δ内毒素组合物及其使用方法
US7279547B2 (en) * 2000-02-10 2007-10-09 University Of Connecticut Insecticidal compounds and methods for selection thereof
WO2001059146A1 (en) * 2000-02-10 2001-08-16 University Of Connecticut Insecticidal compounds and methods for selection thereof
US7605304B2 (en) 2000-10-24 2009-10-20 E.I. Du Pont De Nemours And Company Genes encoding novel bacillus thuringiensis proteins with pesticidal activity against coleopterans
US20090241217A9 (en) * 2001-05-22 2009-09-24 Jingrui Wu Yield-improved transgenic plants
US20030208789A1 (en) * 2002-05-03 2003-11-06 Stefan Jansens Wound-inducible expression in plants
US20040091505A1 (en) * 2002-06-26 2004-05-13 E.I Du Pont De Nemours And Company Genes encoding proteins with pesticidal activity
US7462760B2 (en) * 2002-06-26 2008-12-09 Pioneer Hi-Bred International, Inc. Genes encoding plant protease-resistant pesticidal proteins and method of their use
CN1681923B (zh) 2002-07-18 2010-06-02 孟山都技术有限公司 利用人工的多核苷酸及其组合物来减少转基因沉默的方法
ATE412054T1 (de) * 2003-02-20 2008-11-15 Athenix Corp Delta-endotoxin gene und verfahren zu ihrer verwendung
AU2013203135B2 (en) * 2003-02-20 2016-05-12 Athenix Corporation Delta-endotoxin genes and methods for their use
US7351881B2 (en) * 2003-02-20 2008-04-01 Athenix Corporation AXMI-008, a delta-endotoxin gene and methods for its use
US7355099B2 (en) 2003-02-20 2008-04-08 Athenix Corporation AXMI-004, a delta-endotoxin gene and methods for its use
US7294760B2 (en) 2003-03-28 2007-11-13 Monsanto Technology Llc Plant promoters for use in early seed development
WO2005021718A2 (en) 2003-08-25 2005-03-10 Monsanto Technology Llc Tubulin regulatory elements for use in plants
US7309785B1 (en) 2003-10-03 2007-12-18 Dow Agrosciences Llc Modified chimeric Cry35 proteins
US7524810B1 (en) 2003-10-03 2009-04-28 Dow Agrosciences Llc Modified Cry34 proteins
BRPI0417735A (pt) 2003-12-16 2007-04-03 Monsanto Technology Llc composições protéicas e gênicas inseticidas secretadas a partir de bacillus thuringiensis e seus usos
US7371848B2 (en) 2004-01-20 2008-05-13 Monsanto Technology Llc Chimeric promoters comprising a caulimovirus promoter enhancer for use in plants
EP3388521A1 (en) 2004-02-27 2018-10-17 Dow AgroSciences LLC High efficiency peptide production in plant cells
US7109173B1 (en) 2004-03-16 2006-09-19 Wilbert Gamble Transport of nucleotides, oligonucleotides and polynucleotides into the cytoplasm and nucleus of cells by peptides
AR048685A1 (es) * 2004-04-09 2006-05-17 Monsanto Technology Llc Metodos para el control de infestaciones de insectos en plantas.
EP1788861B1 (en) 2004-08-24 2017-04-12 Monsanto Technology, LLC Adenylate translocator protein gene non-coding regulatory elements for use in plants
BRPI0515302A (pt) 2004-09-14 2008-07-15 Monsanto Technology Llc moléculas promotoras para uso em plantas
CA2598307C (en) 2005-02-26 2014-12-30 Basf Plant Science Gmbh Expression cassettes for seed-preferential expression in plants
US8034994B2 (en) 2005-04-19 2011-10-11 Basf Plant Science Gmbh Starchy-endosperm and/or germinating embryo-specific expression in mono-cotyledonous plants
US7790873B2 (en) 2005-05-10 2010-09-07 Basf Plant Science Gmbh Expression cassettes for seed-preferential expression in plants
WO2007027828A2 (en) * 2005-08-30 2007-03-08 Phyllom Llc Insect resistant transgenic turf grass
US8993846B2 (en) 2005-09-06 2015-03-31 Monsanto Technology Llc Vectors and methods for improved plant transformation efficiency
WO2007098042A2 (en) 2006-02-17 2007-08-30 Monsanto Technology Llc Chimeric regulatory sequences comprising introns from dicotyledons for plant gene expression
AU2007228981B2 (en) * 2006-03-21 2012-10-04 BASF Agricultural Solutions Seed US LLC Novel genes encoding insecticidal proteins
WO2008011584A2 (en) * 2006-07-21 2008-01-24 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis toxin with anti-lepidopteran activity
WO2008073877A2 (en) * 2006-12-08 2008-06-19 Pioneer Hi-Bred International, Inc. Novel bacillus thuringiensis crystal polypeptides, polynucleotides, and compositions thereof
EP2074219B1 (en) 2007-02-16 2013-11-20 BASF Plant Science GmbH Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants
US7838729B2 (en) 2007-02-26 2010-11-23 Monsanto Technology Llc Chloroplast transit peptides for efficient targeting of DMO and uses thereof
US8609936B2 (en) 2007-04-27 2013-12-17 Monsanto Technology Llc Hemipteran-and coleopteran active toxin proteins from Bacillus thuringiensis
WO2008145406A1 (en) * 2007-06-01 2008-12-04 Bayer Bioscience N.V. Novel genes encoding insecticidal proteins
WO2009036234A1 (en) * 2007-09-14 2009-03-19 Athenix Corporation Synthetic axmi-004 delta-endotoxin genes and methods for their use
ES2562908T3 (es) 2008-04-07 2016-03-09 Monsanto Technology Llc Elementos reguladores de plantas y sus usos
JP2011526150A (ja) 2008-06-25 2011-10-06 アテニックス・コーポレーション 毒素遺伝子およびその使用法
EP2379724B1 (en) 2008-12-23 2015-01-21 Athenix Corporation Axmi-150 delta-endotoxin gene and methods for its use
US20120277117A1 (en) 2009-02-27 2012-11-01 Adel Zayed Hydroponic apparatus and methods of use
WO2011003901A1 (en) 2009-07-10 2011-01-13 Basf Plant Science Company Gmbh Expression cassettes for endosperm-specific expression in plants
TWI486126B (zh) * 2009-07-30 2015-06-01 Taiwan Agricultural Chemicals And Toxic Substances Res Inst Council Of Agricult 一種拮抗害蟲之新穎蘇力菌菌株
AU2010278843B2 (en) * 2009-07-31 2016-05-19 BASF Agricultural Solutions Seed US LLC Axmi-192 family of pesticidal genes and methods for their use
US8937214B2 (en) 2009-10-23 2015-01-20 Monsanto Technology Llc Methods and compositions for expression of transgenes in plants
CN102051337B (zh) * 2009-10-27 2013-06-19 行政院农业委员会农业药物毒物试验所 一种拮抗害虫的新颖苏云金杆菌菌株
BR112012013156A2 (pt) 2009-12-03 2017-06-13 Basf Plant Science Co Gmbh cassete de expressão, vetor, célula horpedeira, tecido de planta transgênica e método para a produção de um tecido de planta transgênica
JP5969921B2 (ja) 2009-12-16 2016-08-17 ダウ アグロサイエンシィズ エルエルシー 抵抗性昆虫の対応のためのＣｒｙ１Ｂｅと組み合わせたＣｒｙ１Ｄａの使用
AR079500A1 (es) * 2009-12-16 2012-02-01 Dow Agrosciences Llc Uso combinado de proteinas cry1ca y cry1fa para el manejo de la resistencia de insectos
US20120317682A1 (en) * 2009-12-16 2012-12-13 Dow Agrosciences Llc Combined use of vip3ab and cry1fa for management of resistant insects
SI2512225T1 (sl) * 2009-12-16 2017-12-29 Dow Agrosciences, Llc Uporaba Vip3Ab v kombinaciji s Cry1Ca za obvladovanje rezistentnih insektov
CA2782554A1 (en) * 2009-12-16 2011-07-14 Dow Agrosciences Llc Modified cry1ca insecticidal cry proteins
JP5907892B2 (ja) * 2009-12-16 2016-04-26 ダウ アグロサイエンシィズ エルエルシー 抵抗性昆虫の対応のためのＣｒｙ１Ｂｅと組み合わせたＣｒｙ１Ａｂの使用
AR079505A1 (es) * 2009-12-16 2012-02-01 Dow Agrosciences Llc Uso de cry1da en combinacion con cry1ca para el manejo de insectos resistentes
NZ601096A (en) * 2009-12-16 2014-10-31 Dow Agrosciences Llc Combined use of cry1da and cry1fa proteins for insect resistance management
CN102753694A (zh) * 2009-12-16 2012-10-24 陶氏益农公司 组合使用Cry1Fa和Cry1Ab蛋白用于控制Cry抗性蔗螟和用于甘蔗中的昆虫抗性管理
WO2011084622A1 (en) 2009-12-16 2011-07-14 Dow Agrosciences Llc Combined use of cry1ca and cry1ab proteins for insect resistance management
BR122021001281B1 (pt) 2010-01-14 2022-03-03 Monsanto Technology Llc Molécula de dna compreendendo elementos reguladores de plantas
US8735560B1 (en) 2010-03-02 2014-05-27 Monsanto Technology Llc Multiple domain lepidopteran active toxin proteins
CN102250923B (zh) * 2010-05-19 2013-10-16 复旦大学 对鳞翅目害虫高抗性的cryIAc基因及其在甘蔗中的应用
AR082282A1 (es) * 2010-07-19 2012-11-28 Dow Agrosciences Llc Maiz con rendimiento y eficiencia de uso de nitrogeno aumentados
MX345696B (es) 2010-08-30 2017-02-10 Dow Agrosciences Llc Intensificador viral baciliforme de caña de azucar (vbca) y uso en la genomica funcional de la planta.
CN102094038A (zh) * 2010-12-08 2011-06-15 上海市农业科学院 一种转基因水稻Bt蛋白cry1c的原核表达及纯化方法
WO2012082325A1 (en) * 2010-12-13 2012-06-21 Syngenta Participations Ag Cry1i proteins and genes for insect control
KR102003175B1 (ko) 2011-03-25 2019-07-24 몬산토 테크놀로지 엘엘씨 식물 조절 요소 및 그의 용도
WO2012131619A1 (en) 2011-03-30 2012-10-04 Metahelix Life Sciences Limited A nucleotide sequence, expression cassette, transgenic events, cells and methods thereof
CN103748228B (zh) 2011-03-30 2017-02-15 墨西哥国立大学 突变型苏云金芽孢杆菌cry基因及其使用方法
EA031667B1 (ru) 2011-05-13 2019-02-28 Монсанто Текнолоджи Ллс Регуляторные элементы растений и их применение
CN103125516B (zh) * 2011-11-24 2014-12-17 华中农业大学 对南方根结线虫具有杀虫增效作用的蛋白组合物Cry6Aa/Cry55Aa及应用
CN102559554B (zh) * 2012-01-09 2013-06-05 东北农业大学 苏云金芽胞杆菌cry1Ca基因，表达蛋白及其应用
JP2015508668A (ja) 2012-02-29 2015-03-23 ダウ アグロサイエンシィズ エルエルシー サトウキビ桿状ウイルス（ｓｃｂｖ）エンハンサーおよび植物機能ゲノミクスにおけるその使用
US11692016B2 (en) 2012-03-09 2023-07-04 Vestaron Corporation High gene expression yeast strain
CN104411714A (zh) 2012-03-09 2015-03-11 韦斯塔隆公司 毒肽产生、植物中的肽表达和富含半胱氨酸的肽的组合
US9663793B2 (en) 2012-04-20 2017-05-30 Monsanto Technology, Llc Plant regulatory elements and uses thereof
CA2881787A1 (en) 2012-08-13 2014-02-20 University Of Georgia Research Foundation, Inc. Compositions and methods for increasing pest resistance in plants
KR20150060969A (ko) * 2012-10-05 2015-06-03 다우 아그로사이언시즈 엘엘씨 저항성 가을 거염벌레 곤충의 관리를 위한 조합에서의 Cry1Ea의 사용
US9783820B2 (en) 2012-10-15 2017-10-10 Pioneer Hi-Bred International, Inc. Methods and compositions to enhance activity of Cry endotoxins
US10968446B2 (en) 2012-11-01 2021-04-06 Massachusetts Institute Of Technology Directed evolution of synthetic gene cluster
CN108866076B (zh) 2012-12-19 2022-09-27 孟山都技术公司 植物调控元件及其用途
WO2014159434A1 (en) 2013-03-14 2014-10-02 Monsanto Technology Llc Plant regulatory elements and uses thereof
CR20200121A (es) 2013-03-14 2020-07-03 Monsanto Technology Llc Elementos regulatorios de planta y sus usos (divisional 2015-0554)
CA2902002C (en) 2013-03-14 2023-08-01 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
BR112015023709A2 (pt) 2013-03-15 2017-07-18 Pioneer Hi Bred Int polipeptídeo phi-4, polinucleotídeo, composição, método para inibir o crescimento, método para controlar uma população, planta, semente, cassete de expressão, método para expressar em uma planta um polinucleotídeo, método para proteger uma planta, proteína de fusão
CN103421840A (zh) * 2013-08-01 2013-12-04 华中农业大学 利用转基因技术提高油菜对鳞翅目害虫抗性的方法
MX359026B (es) 2013-08-16 2018-09-12 Pioneer Hi Bred Int Proteinas insecticidas y metodos de uso.
BR112016005543B1 (pt) 2013-09-13 2022-03-08 Pioneer Hi-Bred International, Inc Polipeptídeo pip-72 recombinante, construto de dna, método de obtenção de planta transgênica, célula hospedeira, composição, proteína de fusão, método para controlar uma população de praga de inseto, método para inibir o crescimento ou matar uma praga de inseto, método para controlar uma infestação de insetos em uma planta transgênica, método para identificar em uma amostra biológica uma sequência de nucleotídeos, método para identificar em uma amostra um polipeptídeo pip-72
CN103667340A (zh) * 2013-12-05 2014-03-26 华中农业大学 一种可稳定遗传的抗虫转基因玉米的构建方法
CN103773776B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1C毒素独特型单链抗体与应用
EP3102592B1 (en) 2014-02-07 2020-05-20 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2015120270A1 (en) 2014-02-07 2015-08-13 Pioneer Hi Bred International, Inc. Insecticidal proteins and methods for their use
US9957524B2 (en) 2014-03-28 2018-05-01 Monsanto Technology Llc Pesticidal toxin proteins active against coleopteran insects
WO2016000237A1 (en) 2014-07-03 2016-01-07 Pioneer Overseas Corporation Plants having enhanced tolerance to insect pests and related constructs and methods involving insect tolerance genes
WO2016044092A1 (en) 2014-09-17 2016-03-24 Pioneer Hi Bred International Inc Compositions and methods to control insect pests
CA2963480A1 (en) 2014-10-15 2016-04-21 Pioneer Hi-Bred International, Inc. Insecticidal polypeptides having broad spectrum activity and uses thereof
EP3207144B1 (en) 2014-10-16 2019-05-01 Monsanto Technology LLC Lepidopteran-active cry1da1 amino acid sequence variant proteins
SG10201913870RA (en) 2014-10-16 2020-03-30 Monsanto Technology Llc Novel chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests
WO2016061206A1 (en) 2014-10-16 2016-04-21 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
US10487123B2 (en) * 2014-10-16 2019-11-26 Monsanto Technology Llc Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests
WO2016061392A1 (en) 2014-10-16 2016-04-21 Monsanto Technology Llc Proteins toxic or inhibitory to lepidopteran insects
US10920208B2 (en) 2014-10-22 2021-02-16 President And Fellows Of Harvard College Evolution of proteases
US11130964B2 (en) 2014-11-20 2021-09-28 Monsanto Technology Llc Insect inhibitory proteins
CN107109417B (zh) 2014-11-20 2021-01-15 孟山都技术公司 新型昆虫抑制性蛋白
EA038923B1 (ru) 2015-03-11 2021-11-10 Пайонир Хай-Бред Интернэшнл, Инк. Инсектицидная днк-конструкция и способы её применения
US11519011B2 (en) 2015-03-26 2022-12-06 The Texas A&M University System Conversion of lignin into bioplastics and lipid fuels
CN104744576B (zh) * 2015-04-16 2020-07-03 中国农业科学院植物保护研究所 对舞毒蛾有杀虫活性的Bt蛋白及其应用
US11299729B2 (en) 2015-04-17 2022-04-12 President And Fellows Of Harvard College Vector-based mutagenesis system
CN108064233B (zh) 2015-05-19 2022-07-15 先锋国际良种公司 杀昆虫蛋白及其使用方法
MX2017016119A (es) 2015-06-16 2018-03-07 Pioneer Hi Bred Int Composiciones y metodos para controlar plagas de insectos.
CN115418357A (zh) 2015-07-13 2022-12-02 皮沃特生物公司 改良植物性状的方法及组合物
WO2017015559A2 (en) 2015-07-23 2017-01-26 President And Fellows Of Harvard College Evolution of bt toxins
US10612011B2 (en) 2015-07-30 2020-04-07 President And Fellows Of Harvard College Evolution of TALENs
EP3943602A1 (en) 2015-08-06 2022-01-26 Pioneer Hi-Bred International, Inc. Plant derived insecticidal proteins and methods for their use
US10155960B2 (en) 2015-08-27 2018-12-18 Monsanto Technology Llc Insect inhibitory proteins
US11236347B2 (en) 2015-08-28 2022-02-01 Pioneer Hi-Bred International, Inc. Ochrobactrum-mediated transformation of plants
BR112018004633A2 (pt) * 2015-09-09 2018-10-23 Syngenta Participations Ag composições e métodos para detecção de proteínas
JP2018537119A (ja) 2015-10-05 2018-12-20 マサチューセッツ インスティテュート オブ テクノロジー リファクターされたｎｉｆクラスターを使用する窒素固定
WO2017105987A1 (en) 2015-12-18 2017-06-22 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
AU2017229608B2 (en) 2016-03-11 2022-12-01 Monsanto Technology Llc Plant regulatory elements and uses thereof
RU2018137045A (ru) * 2016-04-14 2020-05-14 Пайонир Хай-Бред Интернэшнл, Инк. Инсектицидные полипептиды, обладающие улучшенным спектром активности, и пути их применения
US11028407B2 (en) 2016-04-19 2021-06-08 Pioneer Hi-Bred International, Inc. Insecticidal combinations of polypeptides having improved activity spectrum and uses thereof
CN105693856A (zh) * 2016-04-25 2016-06-22 江苏省农业科学院 一种单克隆抗体及其分泌该单克隆抗体的细胞株、制备方法与应用
WO2017192560A1 (en) 2016-05-04 2017-11-09 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
NZ748198A (en) 2016-05-24 2023-05-26 Monsanto Technology Llc Plant regulatory elements and uses thereof
BR112018076047A2 (pt) 2016-06-16 2019-03-26 Pioneer Hi Bred Int elemento de silenciamento, construto de dna, cassete de expressão, célula hospedeira, composição, célula vegetal, planta ou parte de planta, semente transgênica, método para controlar um inseto-praga de planta e kit
EP3475430B1 (en) 2016-06-24 2022-06-01 Pioneer Hi-Bred International, Inc. Plant regulatory elements and methods of use thereof
US20190359992A1 (en) 2016-06-28 2019-11-28 Cellectis Altering expression of gene products in plants through targeted insertion of nucleic acid sequences
CA3026113A1 (en) 2016-07-01 2018-01-04 Pioneer Hi-Bred International, Inc. Insecticidal proteins from plants and methods for their use
WO2018013333A1 (en) 2016-07-12 2018-01-18 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
CN106834234B (zh) * 2016-09-09 2020-08-07 中国农业科学院植物保护研究所 检测Cry1Ie蛋白的单克隆抗体杂交瘤细胞株、单克隆抗体及其应用
CN109952024B (zh) * 2016-10-10 2023-11-03 孟山都技术公司 新型昆虫抑制蛋白
JP2020500009A (ja) 2016-10-21 2020-01-09 ベスタロン コーポレイション 切断可能ペプチドならびにそれを含む殺虫性タンパク質及び殺線虫性タンパク質
WO2018084936A1 (en) 2016-11-01 2018-05-11 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CN110088123B (zh) 2016-12-14 2023-10-20 先锋国际良种公司 杀昆虫蛋白及其使用方法
WO2018118811A1 (en) 2016-12-22 2018-06-28 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CN110799474B (zh) 2017-01-12 2022-07-26 皮沃特生物公司 用于改良植物性状的方法及组合物
WO2018140214A1 (en) 2017-01-24 2018-08-02 Pioneer Hi-Bred International, Inc. Nematicidal protein from pseudomonas
CN106674334B (zh) * 2017-02-08 2020-09-01 金陵科技学院 一种结合Cry2Ad的环七肽及其编码基因和应用
MX2019009371A (es) 2017-02-08 2019-09-23 Pionner Hi Bred Int Inc Combinaciones insecticidas de proteinas insecticidas derivadas de plantas y metodos para su uso.
CA3063200A1 (en) 2017-05-11 2018-11-15 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
US20200308598A1 (en) 2017-05-26 2020-10-01 Pioneer Hi-Bred International, Inc. Insecticidal polypeptides having improved activity spectrum and uses thereof
WO2019010164A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College EVOLUTION OF ARNT SYNTHÉTASES
US11624130B2 (en) 2017-09-18 2023-04-11 President And Fellows Of Harvard College Continuous evolution for stabilized proteins
WO2019074598A1 (en) 2017-10-13 2019-04-18 Pioneer Hi-Bred International, Inc. VIRUS-INDUCED GENETIC SILENCING TECHNOLOGY FOR THE CONTROL OF INSECTS IN MAIZE
US10264787B1 (en) 2017-11-28 2019-04-23 BIOVECBLOK s.r.l. Natural mosquito larvicide
US10306894B1 (en) 2017-11-28 2019-06-04 BIOVECBLOK s.r.l. Natural mosquito repellant
US20200332311A1 (en) 2018-01-12 2020-10-22 The Texas A&M University System Increasing plant bioproduct yield
WO2019165245A1 (en) 2018-02-22 2019-08-29 Zymergen Inc. Method for creating a genomic library enriched for bacillus and identification of novel cry toxins
CN108314711B (zh) * 2018-02-28 2021-05-28 吉林省农业科学院 一种具有免疫原性的cry1C重组蛋白、分离的核酸分子及其应用
WO2019169150A1 (en) 2018-03-02 2019-09-06 Pioneer Hi-Bred International, Inc. Plant health assay
US20210015109A1 (en) 2018-03-02 2021-01-21 Zymergen Inc. Insecticidal protein discovery platform and insecticidal proteins discovered therefrom
BR102018009263A8 (pt) * 2018-05-07 2023-01-31 Embrapa Pesquisa Agropecuaria Molécula de ácido nucleico cry1da códon-otimizada, construção de ácido nucleico, vetor, célula hospedeira, célula vegetal, planta transgênica, método para transformar uma célula, método para produzir uma planta transgênica, método de controle de pragas invertebradas de plantas de cultivo e usos da molécula de ácido nucleico
BR112020023800A2 (pt) 2018-05-22 2021-02-23 Pioneer Hi-Bred International, Inc. elementos reguladores de planta e métodos de uso dos mesmos
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
MX2020013875A (es) 2018-06-27 2021-08-11 Pivot Bio Inc Composiciones agricolas que comprenden microbios remodelados de fijacion de nitrogeno.
BR112021003797A2 (pt) 2018-08-29 2021-05-25 Pioneer Hi-Bred International, Inc. proteínas inseticidas e métodos para seu uso
CN110283232B (zh) * 2019-06-12 2021-01-05 江西中藻生物科技股份有限公司 结合Cry1Da蛋白的多肽分子及其应用
CN110294790B (zh) * 2019-06-12 2021-01-05 江西中藻生物科技股份有限公司 Cry1Da蛋白的多肽配体分子及其应用
WO2021076346A1 (en) 2019-10-18 2021-04-22 Pioneer Hi-Bred International, Inc. Maize event dp-202216-6 and dp-023211-2 stack
WO2021221690A1 (en) 2020-05-01 2021-11-04 Pivot Bio, Inc. Modified bacterial strains for improved fixation of nitrogen
TW202142114A (zh) 2020-02-04 2021-11-16 美商陶氏農業科學公司 具有殺有害生物效用之組成物及與其相關之方法
EP4143211A2 (en) 2020-05-01 2023-03-08 Pivot Bio, Inc. Modified bacterial strains for improved fixation of nitrogen
EP4182466A2 (en) 2020-07-14 2023-05-24 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2022035649A1 (en) 2020-08-10 2022-02-17 Pioneer Hi-Bred International, Inc. Plant regulatory elements and methods of use thereof
WO2022125639A1 (en) 2020-12-08 2022-06-16 Monsanto Technology Llc Modified plant-associated bacteria and methods of their use
EP4262400A1 (en) 2020-12-21 2023-10-25 Monsanto Technology LLC Novel insect inhibitory proteins
UY39585A (es) 2020-12-23 2022-07-29 Monsanto Technology Llc Proteínas que exhiben actividad inhibidora de insectos frente a plagas con importancia agrícola de plantas de cultivo y semillas
AU2021412979A1 (en) 2020-12-31 2023-07-06 Monsanto Technology Llc Novel insect inhibitory proteins
AR125216A1 (es) 2021-03-26 2023-06-28 Flagship Pioneering Innovations Vii Llc Producción de polirribonucleótidos circulares en un sistema eucariota
EP4314289A1 (en) 2021-03-26 2024-02-07 Flagship Pioneering Innovations VII, LLC Production of circular polyribonucleotides in a prokaryotic system
TW202300650A (zh) 2021-03-26 2023-01-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 真核系統中環狀多核糖核苷酸的產生
CA3218556A1 (en) 2021-07-02 2023-01-05 Pivot Bio, Inc. Genetically-engineered bacterial strains for improved fixation of nitrogen
AU2022375817A1 (en) 2021-11-01 2024-05-09 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
WO2023141540A2 (en) 2022-01-20 2023-07-27 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
WO2023156906A1 (en) 2022-02-15 2023-08-24 Futuragene Israel Ltd A bacillus thuringiensis pesticidal protein (bt pp) combination useful for plant protection
TW202345696A (zh) 2022-05-18 2023-12-01 美商科迪華農業科技有限責任公司 具有殺有害生物效用之組成物及與其相關的方法
WO2024052856A1 (en) 2022-09-09 2024-03-14 Friedrich Alexander Universität Erlangen-Nürnberg Plant regulatory elements and uses thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479279A (en) * 1892-07-19 Ore-concentrator
US4448885A (en) * 1981-04-27 1984-05-15 Board Of The Regents Of The University Of Washington Bacillus thuringiensis crystal protein in Escherichia coli
US4467036A (en) * 1981-11-12 1984-08-21 The Board Of Regents Of The University Of Washington Bacillus thuringiensis crystal protein in Escherichia coli
US4467203A (en) * 1981-10-19 1984-08-21 Panametrics, Inc. Low noise amplifier and method for energy biased radiation sensitive receiver
US5380831A (en) * 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US5567600A (en) * 1983-09-26 1996-10-22 Mycogen Plant Sciences, Inc. Synthetic insecticidal crystal protein gene
DE3346138A1 (de) * 1983-12-21 1985-07-11 Boehringer Mannheim Gmbh, 6800 Mannheim Bacillus thuringiensis var. tenebrionis sowie ein insektizid wirkendes, hieraus erhaeltliches praeparat bzw. toxin sowie deren verwendung zur bekaempfung von coleoptera
BR8600161A (pt) * 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
GB8526774D0 (en) * 1985-10-30 1985-12-04 Sandoz Ltd Bacillus thuringiensis hybrids
US5024837A (en) * 1987-05-06 1991-06-18 Donovan William P Coleopteran active microorganisms, related insecticide compositions and methods for their production and use
JP3177237B2 (ja) * 1987-06-10 2001-06-18 アンステイテユ・パストウール 鱗翅類に対して幼虫殺虫活性を有するポリペプチドをコードするヌクレオチド配列
FR2616444B1 (fr) * 1987-06-10 1990-03-02 Pasteur Institut Sequences nucleotidiques codant pour des polypeptides dotes d'une activite larvicide vis-a-vis de lepidopteres
US4910016A (en) * 1987-08-03 1990-03-20 Mycogen Corporation Novel Bacillus thuringiensis isolate
EP0413019B1 (en) * 1989-02-24 2001-10-04 Monsanto Technology LLC Synthetic plant genes and method for preparation
GB8910624D0 (en) * 1989-05-09 1989-06-21 Ici Plc Bacterial strains
EP0400246A1 (en) * 1989-05-31 1990-12-05 Plant Genetic Systems, N.V. Prevention of Bt resistance development
US5126133A (en) * 1989-06-27 1992-06-30 Mycogen Corporation Bacillus thuringiensis isolate active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins
US5188960A (en) * 1989-06-27 1993-02-23 Mycogen Corporation Bacillus thuringiensis isolate active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins
EP0528857B1 (en) * 1990-04-26 2002-01-30 Aventis CropScience N.V. New bacillus thuringiensis strain and its gene encoding insecticidal toxin
US5589382A (en) * 1990-07-27 1996-12-31 Mycogen Corporation Bacillus thuringiensis genes encoding nematode-active toxins
EP0602064B1 (en) * 1991-08-02 1998-12-16 Mycogen Corporation Novel microorganism and insecticide
US5843744A (en) * 1993-07-08 1998-12-01 Ecogen Inc. Bacillus thuringiensis Tn5401 proteins
US5441884A (en) * 1993-07-08 1995-08-15 Ecogen Inc. Bacillus thuringiensis transposon TN5401
US5322687A (en) * 1993-07-29 1994-06-21 Ecogen Inc. Bacillus thuringiensis cryet4 and cryet5 toxin genes and proteins toxic to lepidopteran insects
GB9318207D0 (en) * 1993-09-02 1993-10-20 Sandoz Ltd Improvements in or relating to organic compounds
US5659123A (en) * 1994-08-26 1997-08-19 Plant Genetic Systems, N.V. Diabrotica toxins
US5942664A (en) * 1996-11-27 1999-08-24 Ecogen, Inc. Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants

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