EA199800973A1 - Полипептид белка-106 наружной мембраны moraxella catarrhalis, последовательность гена и их применение - Google Patents

Полипептид белка-106 наружной мембраны moraxella catarrhalis, последовательность гена и их применение

Info

Publication number
EA199800973A1
EA199800973A1 EA199800973A EA199800973A EA199800973A1 EA 199800973 A1 EA199800973 A1 EA 199800973A1 EA 199800973 A EA199800973 A EA 199800973A EA 199800973 A EA199800973 A EA 199800973A EA 199800973 A1 EA199800973 A1 EA 199800973A1
Authority
EA
Eurasian Patent Office
Prior art keywords
omp106
polypeptide
polypeptides
catarrhalis
membrane
Prior art date
Application number
EA199800973A
Other languages
English (en)
Other versions
EA002743B1 (ru
Inventor
Кеннет Такер
Лаура Плосила
Original Assignee
Антекс Байолоджикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Антекс Байолоджикс, Инк. filed Critical Антекс Байолоджикс, Инк.
Publication of EA199800973A1 publication Critical patent/EA199800973A1/ru
Publication of EA002743B1 publication Critical patent/EA002743B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Данное изобретение описывает полипептид белка-106 (ОМР106) наружной мембраны Moraxella catarrhalis, произведенные из ОМР106 полипептиды, нуклеотидные последовательности, кодирующие эти полипептиды, и антитела, которые специфически связывают полипептид ОМР106 и/или произведенные из ОМР106 полипептиды. Также описаны иммуногенные, профилактические или терапевтические композиции, в том числе вакцины, содержащие полипептид ОМР106 и/или произведенные из ОМР106 полипептиды. Данное изобретение дополнительно описывает способы индукции иммунных ответов на M.catarrhalis и полипептид ОМР106 и произведенные из ОМР106 полипептиды M.catarrhalis в животных.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800973A 1996-05-03 1997-04-28 Полипептид белка-106 наружной мембраны moraxella catarrhalis, днк, его кодирующие, и их применение EA002743B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/642,712 US7341727B1 (en) 1996-05-03 1996-05-03 M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
PCT/US1997/007679 WO1997041731A1 (en) 1996-05-03 1997-04-28 Moraxella catarrhalis outer membrane protein-106 polypeptide, gene sequence and uses thereof

Publications (2)

Publication Number Publication Date
EA199800973A1 true EA199800973A1 (ru) 1999-06-24
EA002743B1 EA002743B1 (ru) 2002-08-29

Family

ID=24577687

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800973A EA002743B1 (ru) 1996-05-03 1997-04-28 Полипептид белка-106 наружной мембраны moraxella catarrhalis, днк, его кодирующие, и их применение

Country Status (26)

Country Link
US (6) US7341727B1 (ru)
EP (1) EP0900025B1 (ru)
JP (2) JP4401437B2 (ru)
CN (2) CN1222618C (ru)
AR (1) AR006999A1 (ru)
AT (1) ATE244016T1 (ru)
AU (1) AU723528B2 (ru)
BG (1) BG64832B1 (ru)
BR (1) BR9711090A (ru)
CA (1) CA2253636C (ru)
CZ (1) CZ298034B6 (ru)
DE (1) DE69723254T2 (ru)
EA (1) EA002743B1 (ru)
EE (1) EE04684B1 (ru)
ES (1) ES2202624T3 (ru)
GE (1) GEP20022695B (ru)
HK (2) HK1021299A1 (ru)
HU (1) HU223004B1 (ru)
NO (2) NO324816B1 (ru)
NZ (1) NZ332896A (ru)
PL (3) PL189375B1 (ru)
SK (1) SK284812B6 (ru)
TW (1) TW541314B (ru)
UA (1) UA68332C2 (ru)
WO (1) WO1997041731A1 (ru)
ZA (1) ZA973809B (ru)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335018B1 (en) * 1995-05-01 2002-01-01 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US6440425B1 (en) * 1995-05-01 2002-08-27 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US7341727B1 (en) * 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
AUPO652897A0 (en) 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
GB9714276D0 (en) * 1997-07-08 1997-09-10 Univ Dundee Peptides and related compounds
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
GB9808720D0 (en) 1998-04-23 1998-06-24 Smithkline Beecham Biolog Novel compounds
GB9810084D0 (en) 1998-05-11 1998-07-08 Cortecs Uk Ltd Proteins
US6627728B1 (en) 1998-05-12 2003-09-30 Smithkline Beecham Biologicals S.A. Compounds from moraxella catarrhalis
GB9810193D0 (en) * 1998-05-12 1998-07-08 Smithkline Beecham Biolog Novel compounds
GB9810285D0 (en) 1998-05-13 1998-07-15 Smithkline Beecham Biolog Novel compounds
US6541616B1 (en) 1998-10-01 2003-04-01 Antex Biologics Inc. Moraxella catarrhalis protein, gene sequence and uses thereof
AR022963A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Biolog Vacuna
US6673910B1 (en) 1999-04-08 2004-01-06 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to M. catarrhalis for diagnostics and therapeutics
EP1185658B1 (en) * 1999-05-24 2008-06-04 GlaxoSmithKline Biologicals S.A. Novel compounds from moraxella catarrhalis
GB9915031D0 (en) * 1999-06-25 1999-08-25 Smithkline Beecham Biolog Novel compounds
GB9921691D0 (en) * 1999-09-14 1999-11-17 Smithkline Beecham Sa Novel compounds
CA2383081A1 (en) * 1999-09-14 2001-03-22 Smithkline Beecham Biologicals S.A. Polypeptides from moraxella (branhamella) catarrhalis
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
SE0102410D0 (sv) * 2001-07-04 2001-07-04 Arne Forsgren Novel surface exposed immunoglobulin D-binding protein from moraxella catarrhalis
US20060034854A1 (en) 2002-08-02 2006-02-16 Berthet Francois-Xavier J Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
IL308456A (en) 2005-04-08 2024-01-01 Wyeth Llc A multivalent pneumomuroral protein-polysaccharide conjugate preparation
CN100357318C (zh) * 2005-10-11 2007-12-26 中山大学 美人鱼发光杆菌外膜蛋白w和编码序列及其制备方法和应用
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CA2816182C (en) 2005-12-22 2018-02-20 Glaxosmithkline Biologicals S.A. Pneumococcal polysaccharide conjugate vaccine
ZA200805602B (en) 2006-01-17 2009-12-30 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein E; pE)
WO2008000028A1 (en) * 2006-06-27 2008-01-03 Oral Health Australia Pty Ltd Porphyromonas gingivalis polypeptides useful in the prevention of periodontal disease
KR101579947B1 (ko) 2007-06-26 2015-12-28 글락소스미스클라인 바이오로지칼즈 에스.에이. 스트렙토코쿠스 뉴모니애 캡슐 다당류 컨쥬게이트를 포함하는 백신
AU2008274907B2 (en) 2007-07-12 2014-11-13 Oral Health Australia Pty Ltd Immunology treatment for biofilms
DK2175851T3 (da) 2007-07-12 2013-07-15 Oral Health Australia Pty Ltd Biofilmbehandling
US8642046B2 (en) * 2007-10-09 2014-02-04 Tufts University Cholera vaccines
ES2633738T3 (es) 2008-08-29 2017-09-25 Oral Health Australia Pty Ltd Prevención, tratamiento y diagnóstico de la infección por p. gingivales
US8140041B2 (en) * 2009-08-27 2012-03-20 Mediatek Inc. Tunable capacitive device with linearization technique employed therein
ES2366735B1 (es) * 2009-10-08 2012-09-13 Fundación Pública Andaluza Para La Gestión De La Investigación En Salud De Sevilla Vacuna frente a acinetobacter baumannii.
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
JP2013521770A (ja) 2010-03-10 2013-06-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン組成物
JP6002659B2 (ja) 2010-04-13 2016-10-05 セルデックス・セラピューティクス・インコーポレイテッド ヒトｃｄ２７に結合する抗体およびその使用
US8501197B2 (en) 2010-04-30 2013-08-06 The Research Foundation for The State of New York Compositions and methods for stimulating immune response against Moraxella catarrhalis
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
EP2689253B1 (en) 2011-03-22 2021-03-10 Cyvek, Inc. Microfluidic devices and methods of manufacture
RU2481401C2 (ru) * 2011-07-15 2013-05-10 Государственное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГОУ ВПО УГМА Минздравсоцразвития России) СПОСОБ ВЫЯВЛЕНИЯ β-ЛАКТАМАЗОПРОДУЦИРУЮЩИХ ОКСИДАЗОПОЗИТИВНЫХ ГРАМОТРИЦАТЕЛЬНЫХ ДИПЛОКОККОВ, ПОДОЗРИТЕЛЬНЫХ НА ПРИНАДЛЕЖНОСТЬ К MORAХELLA (BRANCHAMELLA) CATARRHALIS
KR102070469B1 (ko) 2012-03-08 2020-01-28 싸이벡, 아이엔씨 미세유체 분석 어셈블리 및 제조방법
US11210432B2 (en) * 2013-08-20 2021-12-28 Janus Technologies, Inc. Method and apparatus for selectively snooping and capturing data for secure computer interfaces
EP3268037B1 (en) 2015-03-09 2022-08-31 Celldex Therapeutics, Inc. Cd27 agonists
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
EA201892362A1 (ru) 2016-04-18 2019-04-30 Селлдекс Терапьютикс, Инк. Агонистические антитела, которые связываются с cd40 человека, и варианты их применения
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
IE20190086A1 (en) 2017-05-30 2019-12-25 Glaxosmithkline Biologicals Sa Novel methods for manufacturing an adjuvant
WO2019106192A1 (en) 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Saponin purification
SG11202010011RA (en) 2018-04-17 2020-11-27 Celldex Therapeutics Inc Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs
BR112021000965A2 (pt) 2018-08-07 2021-04-27 Glaxosmithkline Biologicals S.A. processos e vacinas
CN111157735B (zh) * 2018-11-07 2023-02-07 广州万孚生物技术股份有限公司 凝集性卡他莫拉菌单克隆抗体及其制备方法和应用
US20220339282A1 (en) 2018-11-29 2022-10-27 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
WO2020123444A1 (en) 2018-12-11 2020-06-18 Celldex Therapeutics, Inc. Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy
EP3980044A1 (en) 2019-06-05 2022-04-13 GlaxoSmithKline Biologicals SA Saponin purification
CN111778226B (zh) * 2020-07-21 2022-04-05 东北师范大学 一种水稻耐碱胁迫相关的质膜H+-ATPase蛋白及其应用
JP2024515560A (ja) 2021-04-09 2024-04-10 セルデックス セラピューティクス インコーポレイテッド Ｉｌｔ４に対する抗体、二重特異性の抗ｉｌｔ４／ｐｄ－ｌ１抗体、およびそれらの使用方法
WO2023077521A1 (en) 2021-11-08 2023-05-11 Celldex Therapeutics, Inc Anti-ilt4 and anti-pd-1 bispecific constructs
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
WO2024017827A1 (en) 2022-07-19 2024-01-25 Glaxosmithkline Biologicals Sa Continuous process for vaccine production

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675176A (en) * 1983-12-12 1987-06-23 Norden Laboratories Moraxella bovis protease vaccine
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
US5552146A (en) * 1991-08-15 1996-09-03 Board Of Regents, The University Of Texas System Methods and compositions relating to useful antigens of Moraxella catarrhalis
US5607846A (en) 1994-05-17 1997-03-04 Research Foundation Of State University Of New York Vaccine for moraxella catarrhalis
US6440425B1 (en) 1995-05-01 2002-08-27 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US6335018B1 (en) 1995-05-01 2002-01-01 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
US7341727B1 (en) * 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
GB9809683D0 (en) 1998-05-06 1998-07-01 Smithkline Beecham Biolog Novel compounds
GB9812163D0 (en) 1998-06-05 1998-08-05 Smithkline Beecham Biolog Novel compounds

Also Published As

Publication number Publication date
EA002743B1 (ru) 2002-08-29
CN1800359A (zh) 2006-07-12
EE9800373A (et) 1999-04-15
ES2202624T3 (es) 2004-04-01
PL189995B1 (pl) 2005-10-31
US20020177200A1 (en) 2002-11-28
JP2000510696A (ja) 2000-08-22
AU723528B2 (en) 2000-08-31
PL189375B1 (pl) 2005-07-29
US20080145916A1 (en) 2008-06-19
DE69723254T2 (de) 2004-04-22
ATE244016T1 (de) 2003-07-15
SK150998A3 (en) 1999-05-07
CA2253636C (en) 2003-04-22
CN1223549A (zh) 1999-07-21
NO985113D0 (no) 1998-11-02
CN1222618C (zh) 2005-10-12
UA68332C2 (en) 2004-08-16
NO20063711L (no) 1998-12-28
HK1095358A1 (en) 2007-05-04
DE69723254D1 (de) 2003-08-07
JP4401437B2 (ja) 2010-01-20
US7341727B1 (en) 2008-03-11
EE04684B1 (et) 2006-08-15
US20100021492A1 (en) 2010-01-28
US7128910B2 (en) 2006-10-31
NO324816B1 (no) 2007-12-10
US6214981B1 (en) 2001-04-10
CN100415871C (zh) 2008-09-03
EP0900025A1 (en) 1999-03-10
CZ352498A3 (cs) 1999-06-16
US7914795B2 (en) 2011-03-29
WO1997041731A1 (en) 1997-11-13
AR006999A1 (es) 1999-10-13
SK284812B6 (sk) 2005-12-01
NZ332896A (en) 2000-05-26
ZA973809B (en) 1997-12-01
PL189374B1 (pl) 2005-07-29
US7576179B2 (en) 2009-08-18
CZ298034B6 (cs) 2007-05-30
EP0900025A4 (en) 2000-01-05
CA2253636A1 (en) 1997-11-13
HU223004B1 (hu) 2004-03-01
EP0900025B1 (en) 2003-07-02
JP2008161194A (ja) 2008-07-17
US20070087019A1 (en) 2007-04-19
BG102983A (en) 2000-05-31
HUP9902695A2 (hu) 1999-12-28
NO985113L (no) 1998-12-28
TW541314B (en) 2003-07-11
GEP20022695B (en) 2002-05-27
HUP9902695A3 (en) 2001-02-28
BG64832B1 (bg) 2006-06-30
PL330935A1 (en) 1999-06-07
AU3118097A (en) 1997-11-26
BR9711090A (pt) 1999-08-17
HK1021299A1 (en) 2000-06-09

Similar Documents

Publication Publication Date Title
EA199800973A1 (ru) Полипептид белка-106 наружной мембраны moraxella catarrhalis, последовательность гена и их применение
DK35593D0 (da) Polypeptid kodet af lav-dna-sekvens
ATE300616T1 (de) Gnrh-leukotoxin-chimäre
DE69936105D1 (de) Menschliche tslp nukleinsäuren und polypeptide
DK0574466T3 (da) Udtrykkelse af rekombinante proteiner i svækkede bakterier
ATE337399T1 (de) Zusammensetzungen zur immuntherapie und diagnose von tuberculosis
MX9702714A (es) Produccion de peptidos en plantas como fusiones de proteinas con revestimiento viral.
ATE364083T1 (de) Immunogene zusammensetzungen gegen eine helicobacterinfektion, verwendung von polypeptiden in diesen zusammensetzungen und nukleinsäurendie besagte polypeptide kodieren
ES2100960T3 (es) Estructura proteica de la toxina vegetal gelonina.
FR2692282B1 (fr) Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications.
EA200100395A1 (ru) Фармацевтическая композиция, содержащая фрагменты днк, кодирующей антигенный белок, обладающая противоопухолевым действием
ATE312923T1 (de) Moraxella catarrhalis basb034 polypeptide und verwendungen davon
ATE354657T1 (de) Basb019 proteine und gene aus moraxella catarrhalis, antigene, antikörper, und verwendungen
PE20010239A1 (es) Gen derivado de lawsonia y polipeptidos, peptidos y proteinas de hemolisina relacionados y sus usos
DK1082435T3 (da) Proteiner og gener fra Moraxella catarrhalis, antigener, antistoffer og anvendelser
BR0012740A (pt) Compostos para tratamento de distúrbios do sistema infeccioso e imune e métodos para seu emprego
DK43991A (da) Allele varianter af plasmodium falciparum merozoitoverfladeantigen

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU