EA034893B1 - Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний - Google Patents

Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний Download PDF

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Publication number
EA034893B1
EA034893B1 EA201690093A EA201690093A EA034893B1 EA 034893 B1 EA034893 B1 EA 034893B1 EA 201690093 A EA201690093 A EA 201690093A EA 201690093 A EA201690093 A EA 201690093A EA 034893 B1 EA034893 B1 EA 034893B1
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Eurasian Patent Office
Prior art keywords
compound
pharmaceutically acceptable
formula
treatment
acceptable salt
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EA201690093A
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English (en)
Russian (ru)
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EA201690093A1 (ru
Inventor
Дэвид Крейг Мак Гоуен
Серж Мария Алоисиус Питерс
Стефан Жюльен Ласт
Вернер Эмбрехтс
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
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Publication of EA201690093A1 publication Critical patent/EA201690093A1/ru
Publication of EA034893B1 publication Critical patent/EA034893B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA201690093A 2013-06-27 2014-06-26 Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний EA034893B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13174108 2013-06-27
PCT/EP2014/063467 WO2014207082A1 (en) 2013-06-27 2014-06-26 Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases

Publications (2)

Publication Number Publication Date
EA201690093A1 EA201690093A1 (ru) 2016-04-29
EA034893B1 true EA034893B1 (ru) 2020-04-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA202090258A EA202090258A3 (ru) 2013-06-27 2014-06-26 Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний
EA201690093A EA034893B1 (ru) 2013-06-27 2014-06-26 Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний

Family Applications Before (1)

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EA202090258A EA202090258A3 (ru) 2013-06-27 2014-06-26 Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний

Country Status (25)

Country Link
US (2) US10385054B2 (OSRAM)
EP (1) EP3030563B1 (OSRAM)
JP (2) JP6763769B2 (OSRAM)
KR (1) KR102311234B1 (OSRAM)
CN (2) CN109369643B (OSRAM)
AU (2) AU2014301089B2 (OSRAM)
BR (1) BR112015032546B1 (OSRAM)
CA (1) CA2913028C (OSRAM)
CL (1) CL2015003686A1 (OSRAM)
DK (1) DK3030563T3 (OSRAM)
EA (2) EA202090258A3 (OSRAM)
ES (1) ES2645950T3 (OSRAM)
HR (1) HRP20171720T1 (OSRAM)
HU (1) HUE037125T2 (OSRAM)
IL (3) IL242655B (OSRAM)
MX (2) MX361527B (OSRAM)
MY (1) MY176142A (OSRAM)
NO (1) NO3030563T3 (OSRAM)
PH (1) PH12015502780A1 (OSRAM)
PL (1) PL3030563T3 (OSRAM)
PT (1) PT3030563T (OSRAM)
SG (2) SG10201803331PA (OSRAM)
SI (1) SI3030563T1 (OSRAM)
UA (1) UA117590C2 (OSRAM)
WO (1) WO2014207082A1 (OSRAM)

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