|
JP2610889B2
(ja)
|
1987-09-03 |
1997-05-14 |
日本臓器製薬株式会社 |
新規架橋アデニン誘導体
|
|
ES2232871T3
(es)
|
1996-07-03 |
2005-06-01 |
Sumitomo Pharmaceuticals Company, Limited |
Nuevos derivados de purina.
|
|
NZ333302A
(en)
|
1996-08-28 |
2000-08-25 |
Pfizer |
Substituted 6,5-hetero-bicyclic derivatives for the prevention or inhibition of a disorder that can be treated by antagonising corticotropin releasing factor
|
|
KR100517397B1
(ko)
|
1996-10-04 |
2005-09-29 |
교린 세이야꾸 가부시키 가이샤 |
피라졸로피리딜피리다지논 유도체 및 이를 포함하는 기관지 확장제
|
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6339089B2
(en)
|
1997-08-13 |
2002-01-15 |
Fujirebio Inc. |
Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
|
|
ES2205573T3
(es)
|
1997-11-28 |
2004-05-01 |
Sumitomo Pharmaceuticals Company, Limited |
Nuevo compuestos heterociclicos.
|
|
TW572758B
(en)
|
1997-12-22 |
2004-01-21 |
Sumitomo Pharma |
Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
|
|
US6187777B1
(en)
*
|
1998-02-06 |
2001-02-13 |
Amgen Inc. |
Compounds and methods which modulate feeding behavior and related diseases
|
|
CA2321153A1
(en)
|
1998-02-17 |
1999-08-19 |
Timothy D. Cushing |
Anti-viral pyrimidine derivatives
|
|
US6110929A
(en)
|
1998-07-28 |
2000-08-29 |
3M Innovative Properties Company |
Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
|
|
JP4342007B2
(ja)
|
1998-08-10 |
2009-10-14 |
大日本住友製薬株式会社 |
キナゾリン誘導体
|
|
JP4315300B2
(ja)
|
1998-08-10 |
2009-08-19 |
大日本住友製薬株式会社 |
新規なキナゾリン誘導体
|
|
ES2221414T3
(es)
|
1998-08-27 |
2004-12-16 |
Sumitomo Pharmaceuticals Company, Limited |
Derivados de pirimidina.
|
|
US6583148B1
(en)
|
1999-04-08 |
2003-06-24 |
Krenitsky Pharmaceuticals, Inc. |
Neurotrophic substituted pyrimidines
|
|
US6503908B1
(en)
|
1999-10-11 |
2003-01-07 |
Pfizer Inc |
Pharmaceutically active compounds
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
AU2002364211A1
(en)
|
2001-12-21 |
2003-07-15 |
Bayer Pharmaceuticals Corporation |
Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
|
|
TW200407143A
(en)
|
2002-05-21 |
2004-05-16 |
Bristol Myers Squibb Co |
Pyrrolotriazinone compounds and their use to treat diseases
|
|
US7091232B2
(en)
|
2002-05-21 |
2006-08-15 |
Allergan, Inc. |
4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
|
|
AU2003242252A1
(en)
|
2002-06-07 |
2003-12-22 |
Kyowa Hakko Kogyo Co., Ltd. |
Bicyclic pyrimidine derivatives
|
|
MXPA05003193A
(es)
|
2002-09-27 |
2005-06-08 |
Sumitomo Pharma |
Compuesto de adenina novedoso y uso del mismo.
|
|
US8455458B2
(en)
|
2002-10-16 |
2013-06-04 |
Arthrodynamic Technologies, Animal Health Division, Inc. |
Composition and method for treating connective tissue damage
|
|
MXPA05013922A
(es)
|
2003-06-20 |
2006-02-24 |
Coley Pharm Group Inc |
Antagonistas de receptor tipo toll de molecula pequena.
|
|
ES2342069T4
(es)
|
2003-09-05 |
2011-01-26 |
Anadys Pharmaceuticals, Inc. |
Ligandos de tlr7 para el tratamiento de la hepatitis c.
|
|
JPWO2005092892A1
(ja)
|
2004-03-26 |
2008-02-14 |
大日本住友製薬株式会社 |
8−オキソアデニン化合物
|
|
US8012964B2
(en)
|
2004-03-26 |
2011-09-06 |
Dainippon Sumitomo Pharma Co., Ltd. |
9-substituted 8-oxoadenine compound
|
|
WO2007084413A2
(en)
|
2004-07-14 |
2007-07-26 |
Ptc Therapeutics, Inc. |
Methods for treating hepatitis c
|
|
US7923554B2
(en)
|
2004-08-10 |
2011-04-12 |
Janssen Pharmaceutica N.V. |
HIV inhibiting 1,2,4-triazin-6-one derivatives
|
|
JP2008519083A
(ja)
|
2004-11-09 |
2008-06-05 |
エフ.ホフマン−ラ ロシュ アーゲー |
アミノキナゾリン化合物
|
|
US7498409B2
(en)
|
2005-03-24 |
2009-03-03 |
Schering Corporation |
Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
|
|
EA200702235A1
(ru)
|
2005-05-04 |
2008-04-28 |
Пфайзер Лимитед |
Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с
|
|
WO2006122003A2
(en)
*
|
2005-05-05 |
2006-11-16 |
Ardea Biosciences, Inc. |
Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv
|
|
AR054122A1
(es)
|
2005-05-12 |
2007-06-06 |
Tibotec Pharm Ltd |
Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas
|
|
US7994360B2
(en)
|
2005-05-16 |
2011-08-09 |
Xtl Biopharmaceuticals Ltd. |
Benzofuran compounds
|
|
EP1924564B1
(en)
|
2005-09-01 |
2016-11-09 |
F.Hoffmann-La Roche Ag |
Diaminopyrimidines as p2x3 and p2x2/3 modulators
|
|
EP1939198A4
(en)
|
2005-09-22 |
2012-02-15 |
Dainippon Sumitomo Pharma Co |
NEW ADENINE CONNECTION
|
|
WO2007056208A2
(en)
|
2005-11-02 |
2007-05-18 |
Cytovia, Inc. |
N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
|
US20090182140A1
(en)
|
2005-12-02 |
2009-07-16 |
Mitsubishi Tanabe Pharma Corporation |
Alicyclic Heterocyclic Compound
|
|
JP2009528989A
(ja)
|
2006-02-17 |
2009-08-13 |
ファイザー・リミテッド |
Tlr7変調剤としての3−デアザプリン誘導体
|
|
US9259426B2
(en)
|
2006-07-20 |
2016-02-16 |
Gilead Sciences, Inc. |
4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
US8673929B2
(en)
|
2006-07-20 |
2014-03-18 |
Gilead Sciences, Inc. |
4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
|
|
ES2571028T3
(es)
|
2006-12-07 |
2016-05-23 |
Genentech Inc |
Compuestos inhibidores de fosfoinositida 3-cinasa y métodos de uso
|
|
CN103224506A
(zh)
|
2006-12-20 |
2013-07-31 |
P.安杰莱蒂分子生物学研究所 |
抗病毒的吲哚
|
|
JP5425642B2
(ja)
|
2007-02-07 |
2014-02-26 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
合成tlrアゴニストの結合体およびそのための使用
|
|
JP2008222557A
(ja)
*
|
2007-03-08 |
2008-09-25 |
Kotobuki Seiyaku Kk |
ピロロ[3,2−d]ピリミジン誘導体及びこれを有効成分とする医薬組成物
|
|
JP5480637B2
(ja)
|
2007-03-19 |
2014-04-23 |
アストラゼネカ・アクチエボラーグ |
Toll様受容体(tlr7)モジュレーターとしての9−置換−8−オキソ−アデニン化合物
|
|
TW200902018A
(en)
*
|
2007-03-20 |
2009-01-16 |
Dainippon Sumitomo Pharma Co |
Novel adenine compound
|
|
WO2008114819A1
(ja)
|
2007-03-20 |
2008-09-25 |
Dainippon Sumitomo Pharma Co., Ltd. |
新規アデニン化合物
|
|
WO2008147697A1
(en)
|
2007-05-22 |
2008-12-04 |
Boehringer Ingelheim International Gmbh |
Benzimidazolone chymase inhibitors
|
|
MX2009013832A
(es)
|
2007-06-29 |
2010-03-10 |
Gilead Sciences Inc |
Derivados de purina y su uso como moduladores del receptor 7 similar a un puente.
|
|
MX2010001650A
(es)
|
2007-08-10 |
2010-08-02 |
Glaxosmithkline Llc |
Entidades quimicas biciclicas que contienen nitrogeno para el tratamiento de infecciones virales.
|
|
KR101174201B1
(ko)
|
2007-08-28 |
2012-08-16 |
아이알엠 엘엘씨 |
키나제 억제제로서의 2-비페닐아미노-4-아미노피리미딘 유도체
|
|
WO2009030998A1
(en)
|
2007-09-05 |
2009-03-12 |
Coley Pharmaceutical Group, Inc. |
Pyrimidine compounds as toll-like receptor (tlr) agonists
|
|
PE20091236A1
(es)
*
|
2007-11-22 |
2009-09-16 |
Astrazeneca Ab |
Derivados de pirimidina como immunomoduladores de tlr7
|
|
CN101910177B
(zh)
|
2007-12-24 |
2013-08-28 |
泰博特克药品公司 |
作为丙型肝炎病毒抑制剂的大环吲哚
|
|
WO2009099650A2
(en)
|
2008-02-07 |
2009-08-13 |
Carson Dennis A |
Treatment of bladder diseases with a tlr7 activator
|
|
WO2009134624A1
(en)
|
2008-04-28 |
2009-11-05 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
|
WO2009157560A1
(ja)
|
2008-06-27 |
2009-12-30 |
京セラ株式会社 |
ユーザインタフェース生成装置
|
|
US8946239B2
(en)
|
2008-07-10 |
2015-02-03 |
Duquesne University Of The Holy Spirit |
Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
|
|
UY31982A
(es)
|
2008-07-16 |
2010-02-26 |
Boehringer Ingelheim Int |
Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
|
|
CA2760766A1
(en)
|
2009-05-21 |
2010-11-25 |
Nicholas James Bennett |
Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
|
|
US8637525B2
(en)
|
2009-07-31 |
2014-01-28 |
Bristol-Myers Squibb Company |
Compounds for the reduction of beta-amyloid production
|
|
TWI468402B
(zh)
|
2009-07-31 |
2015-01-11 |
必治妥美雅史谷比公司 |
降低β-類澱粉生成之化合物
|
|
WO2011049987A2
(en)
|
2009-10-20 |
2011-04-28 |
Eiger Biopharmaceuticals, Inc. |
Azaindazoles to treat flaviviridae virus infection
|
|
SG10201406813RA
(en)
|
2009-10-22 |
2014-11-27 |
Gilead Sciences Inc |
Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
|
|
KR101094446B1
(ko)
|
2009-11-19 |
2011-12-15 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노[3,2-d]피리미딘 화합물
|
|
JP2013032290A
(ja)
|
2009-11-20 |
2013-02-14 |
Dainippon Sumitomo Pharma Co Ltd |
新規縮合ピリミジン誘導体
|
|
DE102010040233A1
(de)
|
2010-09-03 |
2012-03-08 |
Bayer Schering Pharma Aktiengesellschaft |
Bicyclische Aza-Heterocyclen und ihre Verwendung
|
|
WO2012067269A1
(en)
|
2010-11-19 |
2012-05-24 |
Dainippon Sumitomo Pharma Co., Ltd. |
Aminoalkoxyphenyl compounds and their use in the treatment of disease
|
|
WO2012066335A1
(en)
|
2010-11-19 |
2012-05-24 |
Astrazeneca Ab |
Phenol compounds als toll -like receptor 7 agonists
|
|
PH12013502033A1
(en)
|
2011-04-08 |
2014-01-06 |
Janssen Sciences Ireland Uc |
Pyrimidine derivatives for the treatment of viral infections
|
|
US8916575B2
(en)
|
2011-05-18 |
2014-12-23 |
Janssen R&D Ireland |
Quinazoline derivatives for the treatment of viral infections and further diseases
|
|
EP2776439B1
(en)
|
2011-11-09 |
2018-07-04 |
Janssen Sciences Ireland UC |
Purine derivatives for the treatment of viral infections
|
|
DK2812331T3
(en)
|
2012-02-08 |
2019-04-08 |
Janssen Sciences Ireland Unlimited Co |
PIPERIDINOPYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS
|
|
US9296701B2
(en)
|
2012-04-24 |
2016-03-29 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
|
WO2014009509A1
(en)
|
2012-07-13 |
2014-01-16 |
Janssen R&D Ireland |
Macrocyclic purines for the treatment of viral infections
|
|
MX369417B
(es)
|
2012-08-10 |
2019-11-07 |
Janssen Sciences Ireland Uc |
Derivados de alquilpirimidina para el tratamiento de infecciones víricas y otras enfermedades.
|
|
EP2712866A1
(en)
|
2012-10-01 |
2014-04-02 |
Centre National de la Recherche Scientifique (CNRS) |
1,2,4-triazine derivatives for the treatment of viral infections
|
|
NZ705360A
(en)
|
2012-10-05 |
2018-11-30 |
Janssen Sciences Ireland Uc |
Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
|
|
US9499549B2
(en)
*
|
2012-10-10 |
2016-11-22 |
Janssen Sciences Ireland Uc |
Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases
|
|
UA118341C2
(uk)
|
2012-11-16 |
2019-01-10 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Гетероциклічні заміщені похідні 2-амінохіназоліну для лікування вірусних інфекцій
|
|
UA118751C2
(uk)
|
2013-02-21 |
2019-03-11 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Похідні 2-амінопіримідину для лікування вірусних інфекцій
|
|
BR112015024411B1
(pt)
|
2013-03-29 |
2022-02-22 |
Janssen Sciences Ireland Uc |
Desaza-purinonas macrocíclicas para o tratamento de infeções virais e composição farmacêutica que os compreende
|
|
NO3030563T3
(OSRAM)
*
|
2013-06-27 |
2018-01-06 |
|
|
|
CA2913691C
(en)
|
2013-07-30 |
2022-01-25 |
Janssen Sciences Ireland Uc |
Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
|
|
US9701661B2
(en)
|
2014-07-11 |
2017-07-11 |
Northwestern University |
2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
|