EA031730B1 - Антитела к cd52 - Google Patents

Info

Publication number

EA031730B1

EA031730B1 EA201591796A EA201591796A EA031730B1 EA 031730 B1 EA031730 B1 EA 031730B1 EA 201591796 A EA201591796 A EA 201591796A EA 201591796 A EA201591796 A EA 201591796A EA 031730 B1 EA031730 B1 EA 031730B1

Authority

EA

Eurasian Patent Office

Prior art keywords

antibody

seq

ser

antibodies

antigen

Prior art date

2013-03-15

Links

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• 102000013135 CD52 Antigen Human genes 0.000 claims abstract description 143
• 108010065524 CD52 Antigen Proteins 0.000 claims abstract description 143
• 230000027455 binding Effects 0.000 claims abstract description 127
• 150000007523 nucleic acids Chemical class 0.000 claims abstract description 122
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 106
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 106
• 239000012634 fragment Substances 0.000 claims abstract description 89
• 239000000427 antigen Substances 0.000 claims abstract description 75
• 108091007433 antigens Proteins 0.000 claims abstract description 75
• 102000036639 antigens Human genes 0.000 claims abstract description 75
• 239000013598 vector Substances 0.000 claims abstract description 38
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 22
• 201000011510 cancer Diseases 0.000 claims abstract description 19
• 208000023275 Autoimmune disease Diseases 0.000 claims abstract description 15
• 108090000623 proteins and genes Proteins 0.000 claims description 131
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 127
• 102000004169 proteins and genes Human genes 0.000 claims description 123
• 210000004027 cell Anatomy 0.000 claims description 92
• 238000000034 method Methods 0.000 claims description 75
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 69
• 238000011282 treatment Methods 0.000 claims description 54
• 101000980814 Homo sapiens CAMPATH-1 antigen Proteins 0.000 claims description 48
• 102000043738 human CD52 Human genes 0.000 claims description 47
• 201000006417 multiple sclerosis Diseases 0.000 claims description 38
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 37
• 230000014509 gene expression Effects 0.000 claims description 31
• 241000282414 Homo sapiens Species 0.000 claims description 29
• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 28
• 239000000203 mixture Substances 0.000 claims description 20
• 239000002773 nucleotide Substances 0.000 claims description 20
• 125000003729 nucleotide group Chemical group 0.000 claims description 20
• 239000003814 drug Substances 0.000 claims description 16
• 238000002360 preparation method Methods 0.000 claims description 13
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 9
• 229940027941 immunoglobulin g Drugs 0.000 claims description 8
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 7
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 7
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 6
• 239000004472 Lysine Substances 0.000 claims description 6
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 6
• 229910052739 hydrogen Inorganic materials 0.000 claims description 6
• 230000033115 angiogenesis Effects 0.000 claims description 5
• 238000003556 assay Methods 0.000 claims description 5
• 230000002401 inhibitory effect Effects 0.000 claims description 5
• 239000003937 drug carrier Substances 0.000 claims description 4
• 229910052731 fluorine Inorganic materials 0.000 claims description 4
• 229910052717 sulfur Inorganic materials 0.000 claims description 4
• 229910052727 yttrium Inorganic materials 0.000 claims description 4
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 3
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 3
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 3
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 3
• 210000004899 c-terminal region Anatomy 0.000 claims description 3
• 229910052740 iodine Inorganic materials 0.000 claims description 3
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
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