EA028026B1 - Противовирусное соединение, содержащая его фармацевтическая композиция и способ лечения - Google Patents
Противовирусное соединение, содержащая его фармацевтическая композиция и способ лечения Download PDFInfo
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- EA028026B1 EA028026B1 EA201492002A EA201492002A EA028026B1 EA 028026 B1 EA028026 B1 EA 028026B1 EA 201492002 A EA201492002 A EA 201492002A EA 201492002 A EA201492002 A EA 201492002A EA 028026 B1 EA028026 B1 EA 028026B1
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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| PT1633766T (pt) | 2003-05-30 | 2019-06-04 | Gilead Pharmasset Llc | Análogos de nucleósido fluorado modificado |
| JP5905020B2 (ja) | 2010-11-17 | 2016-04-20 | ギリアド ファーマセット エルエルシー | 抗ウイルス化合物 |
| PT2907816T (pt) | 2011-11-16 | 2018-10-18 | Gilead Pharmasset Llc | Imidazolilimidazóis condensados como compostos antivirais |
| US20130309196A1 (en) | 2012-05-16 | 2013-11-21 | Gilead Sciences, Inc. | Antiviral compounds |
| US9233974B2 (en) * | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
| US20150064252A1 (en) * | 2013-08-27 | 2015-03-05 | Gilead Pharmasset Llc | Solid dispersion formulation of an antiviral compound |
| EP3650014B1 (en) | 2013-08-27 | 2021-10-06 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
| TW202014413A (zh) * | 2014-06-11 | 2020-04-16 | 美商基利法瑪席特有限責任公司 | 製備抗病毒化合物之方法 |
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| SG11201705069YA (en) | 2014-12-26 | 2017-07-28 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
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| CN107501280A (zh) * | 2017-09-05 | 2017-12-22 | 安徽华昌高科药业有限公司 | 一种维帕他韦的合成方法 |
| WO2019113462A1 (en) | 2017-12-07 | 2019-06-13 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
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| CN111018870B (zh) * | 2019-11-29 | 2021-07-23 | 南京正济医药研究有限公司 | 一种维帕他韦中间体的制备方法 |
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| WO2010096777A1 (en) * | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| WO2012068234A2 (en) * | 2010-11-17 | 2012-05-24 | Gilead Sciences, Inc. | Antiviral compounds |
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| XIAOFAN ZHENG; THOMAS W. HUDYMA; SCOTT W. MARTIN; CARL BERGSTROM; MIN DING; FENG HE; JEFFREY ROMINE; MICHAEL A. POSS; JOHN F. KADO: "Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 21, no. 10, 17 March 2011 (2011-03-17), AMSTERDAM, NL, pages 2925 - 2929, XP028199550, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2011.03.067 * |
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