EA023559B1 - Аналоги инсулина человека с пролонгированной терапевтической активностью, стабильные в кислой среде - Google Patents
Аналоги инсулина человека с пролонгированной терапевтической активностью, стабильные в кислой среде Download PDFInfo
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- EA023559B1 EA023559B1 EA201170149A EA201170149A EA023559B1 EA 023559 B1 EA023559 B1 EA 023559B1 EA 201170149 A EA201170149 A EA 201170149A EA 201170149 A EA201170149 A EA 201170149A EA 023559 B1 EA023559 B1 EA 023559B1
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- Eurasian Patent Office
- Prior art keywords
- denotes
- insulin
- group
- formula
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL385586A PL219335B1 (pl) | 2008-07-04 | 2008-07-04 | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| PCT/PL2009/050010 WO2010002283A2 (en) | 2008-07-04 | 2009-07-04 | New insulin analogues of prolonged activity |
Publications (2)
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| EA201170149A1 EA201170149A1 (ru) | 2011-06-30 |
| EA023559B1 true EA023559B1 (ru) | 2016-06-30 |
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| EA201170149A EA023559B1 (ru) | 2008-07-04 | 2009-07-04 | Аналоги инсулина человека с пролонгированной терапевтической активностью, стабильные в кислой среде |
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| EP (2) | EP2321344A2 (enExample) |
| JP (1) | JP2011526886A (enExample) |
| CN (1) | CN102083855A (enExample) |
| CA (1) | CA2729938C (enExample) |
| EA (1) | EA023559B1 (enExample) |
| PL (2) | PL219335B1 (enExample) |
| WO (1) | WO2010002283A2 (enExample) |
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| US10100098B2 (en) | 2006-12-13 | 2018-10-16 | Stelis Biopharma Private Limited | Insulin production methods and proinsulin constructs |
| PL2370461T3 (pl) | 2008-12-15 | 2014-03-31 | Zealand Pharma As | Analogi glukagonu |
| MX2011006313A (es) | 2008-12-15 | 2011-09-27 | Zealand Pharma As | Analogos de glucagon. |
| US8642540B2 (en) | 2008-12-15 | 2014-02-04 | Zealand Pharma A/S | Glucagon analogues |
| PL2370462T3 (pl) | 2008-12-15 | 2015-01-30 | Zealand Pharma As | Analogi glukagonu |
| US9156901B2 (en) | 2009-07-13 | 2015-10-13 | Ditte Riber | Acylated glucagon analogues |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| AU2011269430A1 (en) | 2010-06-24 | 2013-01-10 | Zealand Pharma A/S | Glucagon analogues |
| AR085086A1 (es) | 2011-01-20 | 2013-09-11 | Zealand Pharma As | Uso de analogos de glucagon acilados |
| WO2012115638A1 (en) * | 2011-02-23 | 2012-08-30 | Elona Biotechnologies | Glargine proinsulin compositions and methods of producing glargine insulin analogs therefrom |
| IN2014MN02304A (enExample) | 2012-05-03 | 2015-08-07 | Zealand Pharma As | |
| PL222975B1 (pl) * | 2012-05-23 | 2016-09-30 | Inst Biotechnologii I Antybiotyków | Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny |
| US9624287B2 (en) | 2012-07-17 | 2017-04-18 | Case Western Reserve University | O-linked carbohydrate-modified insulin analogues |
| DK2877200T3 (da) * | 2012-07-17 | 2019-08-12 | Univ Case Western Reserve | O-bundne carbonhydratmodificerede insulinanaloger |
| CN109456400A (zh) | 2012-07-23 | 2019-03-12 | 西兰制药公司 | 胰高血糖素类似物 |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| EP2945643A4 (en) * | 2013-01-15 | 2017-04-26 | Phasebio Pharmaceuticals, Inc. | Therapeutic agents, compositions, and methods for glycemic control |
| CN103981242A (zh) * | 2013-02-07 | 2014-08-13 | 华凌科技有限公司 | 胰岛素的制备方法 |
| WO2014122651A1 (en) * | 2013-02-07 | 2014-08-14 | Valin Technologies Ltd. | Process for preparing insulin |
| WO2014122653A1 (en) * | 2013-02-07 | 2014-08-14 | Valin Technologies Ltd. | Process for preparing insulin |
| CN103981243A (zh) * | 2013-02-07 | 2014-08-13 | 华凌科技有限公司 | 胰岛素的制备方法 |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| RS57632B1 (sr) | 2013-10-17 | 2018-11-30 | Zealand Pharma As | Acilovani analozi glukagona |
| JP2017503474A (ja) | 2013-11-06 | 2017-02-02 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン−ｇｌｐ−１−ｇｉｐトリプルアゴニスト化合物 |
| CN105849122B (zh) | 2013-11-06 | 2021-04-30 | 西兰制药公司 | Gip-glp-1双重激动剂化合物及方法 |
| TWI705973B (zh) | 2014-10-29 | 2020-10-01 | 丹麥商西蘭製藥公司 | Ｇｉｐ促效劑化合物及方法 |
| PL3283507T3 (pl) | 2015-04-16 | 2020-05-18 | Zealand Pharma A/S | Acylowany analog glukagonu |
| PL239062B1 (pl) * | 2016-01-22 | 2021-11-02 | Inst Biotechnologii I Antybiotykow | Sposób wytwarzania insuliny i jej pochodnych |
| UY37490A (es) * | 2016-11-21 | 2018-06-29 | Univ Case Western Reserve | Análogos de insulina de acción rápida de estabilidad mejorada. |
| KR102666154B1 (ko) * | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| BR112021011156A2 (pt) | 2018-12-11 | 2021-10-26 | Sanofi | Conjugados de insulina |
| WO2021081335A1 (en) * | 2019-10-24 | 2021-04-29 | University Of Utah Research Foundation | Novel mini-insulin with extended c-terminal a chain |
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| EP0376156A2 (de) * | 1988-12-29 | 1990-07-04 | Hoechst Aktiengesellschaft | Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung |
| WO2004111244A2 (en) * | 2003-06-17 | 2004-12-23 | Sembiosys Genetics Inc. | Methods for the production of insulin in plants |
| WO2006096079A2 (en) * | 2005-03-10 | 2006-09-14 | Instytut Biotechnologii I Antybiotykow | Pharmaceutical composition comprising a biosynthetic analog of human insulin, and its use in the treatment of diabetes mellitus. |
| WO2008049931A1 (en) * | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
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|---|---|---|---|---|
| DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| US5434247A (en) * | 1986-10-10 | 1995-07-18 | Board Of Regents, The University Of Texas System | Peptides for inducing monocyte cytotoxicity in diagnostics |
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK0547544T3 (da) * | 1991-12-18 | 1997-09-08 | Hoechst Ag | Fremgangsmåde til fremstilling af insulinholdige opløsninger. |
| BR9306042A (pt) | 1992-02-28 | 1997-11-18 | Autoimmune Inc | Método para tratar uma doença auto-immune em um mamifero e formas de dosagens farmacêuticas oral e inalável |
| DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| DE19652713C2 (de) * | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| DK1141014T3 (da) * | 1999-01-06 | 2005-04-11 | Genentech Inc | Insulinlignende vækstfaktor (IGF) i mutantvariant |
| US6777207B2 (en) * | 1999-12-29 | 2004-08-17 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| PL213561B1 (pl) | 2004-01-09 | 2013-03-29 | Inst Biotechnologii I Antybiotykow | Sposób otrzymywania plazmidu, plazmid oraz zastosowania |
| US7893197B2 (en) * | 2004-08-25 | 2011-02-22 | Janssen Pharmaceutica N.V. | Relaxin-3 chimeric polypeptides and their preparation and use |
| US7947645B2 (en) * | 2004-09-02 | 2011-05-24 | Cognosci, Inc. | APO E analogs and methods for their use |
| US7511118B2 (en) * | 2005-06-17 | 2009-03-31 | Mannkind Corporation | PSMA peptide analogues |
| DE102005051366A1 (de) * | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
| US20090099065A1 (en) * | 2006-03-13 | 2009-04-16 | Novo Nordisk A/S | Acylated Single Chain Insulin |
| CN101573133B (zh) * | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
-
2008
- 2008-07-04 PL PL385586A patent/PL219335B1/pl unknown
-
2009
- 2009-07-04 US US13/002,520 patent/US8618048B2/en not_active Expired - Fee Related
- 2009-07-04 WO PCT/PL2009/050010 patent/WO2010002283A2/en not_active Ceased
- 2009-07-04 JP JP2011516197A patent/JP2011526886A/ja active Pending
- 2009-07-04 EP EP09773816A patent/EP2321344A2/en not_active Withdrawn
- 2009-07-04 CN CN2009801261044A patent/CN102083855A/zh active Pending
- 2009-07-04 EA EA201170149A patent/EA023559B1/ru not_active IP Right Cessation
- 2009-07-04 EP EP11003008.7A patent/EP2371853B1/en not_active Not-in-force
- 2009-07-04 CA CA2729938A patent/CA2729938C/en not_active Expired - Fee Related
- 2009-07-04 PL PL11003008T patent/PL2371853T3/pl unknown
-
2013
- 2013-11-26 US US14/090,496 patent/US20140121353A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0376156A2 (de) * | 1988-12-29 | 1990-07-04 | Hoechst Aktiengesellschaft | Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung |
| WO2004111244A2 (en) * | 2003-06-17 | 2004-12-23 | Sembiosys Genetics Inc. | Methods for the production of insulin in plants |
| WO2006096079A2 (en) * | 2005-03-10 | 2006-09-14 | Instytut Biotechnologii I Antybiotykow | Pharmaceutical composition comprising a biosynthetic analog of human insulin, and its use in the treatment of diabetes mellitus. |
| WO2008049931A1 (en) * | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102083855A (zh) | 2011-06-01 |
| CA2729938C (en) | 2018-11-06 |
| US20110136736A1 (en) | 2011-06-09 |
| EP2371853B1 (en) | 2017-09-13 |
| EP2321344A2 (en) | 2011-05-18 |
| EA201170149A1 (ru) | 2011-06-30 |
| US20140121353A1 (en) | 2014-05-01 |
| EP2371853A3 (en) | 2012-10-03 |
| WO2010002283A9 (en) | 2011-01-20 |
| WO2010002283A2 (en) | 2010-01-07 |
| US8618048B2 (en) | 2013-12-31 |
| PL385586A1 (pl) | 2010-01-18 |
| PL2371853T3 (pl) | 2018-06-29 |
| EP2371853A2 (en) | 2011-10-05 |
| PL219335B1 (pl) | 2015-04-30 |
| WO2010002283A3 (en) | 2010-04-29 |
| JP2011526886A (ja) | 2011-10-20 |
| CA2729938A1 (en) | 2010-01-07 |
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