CN102083855A - 活性延长的新胰岛素类似物 - Google Patents

活性延长的新胰岛素类似物 Download PDF

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Publication number
CN102083855A
CN102083855A CN2009801261044A CN200980126104A CN102083855A CN 102083855 A CN102083855 A CN 102083855A CN 2009801261044 A CN2009801261044 A CN 2009801261044A CN 200980126104 A CN200980126104 A CN 200980126104A CN 102083855 A CN102083855 A CN 102083855A
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CN
China
Prior art keywords
general formula
insulin
b32arg
b31arg
group represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN2009801261044A
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English (en)
Chinese (zh)
Inventor
W·斯瓦温斯基
P·博罗维奇
A·普罗辛尼奇扎克
J·米科瓦伊奇克
T·格拉宾斯基
D·库日诺加
D·米基维奇-西格瓦
A·舞伊托维奇-克拉维茨
M·杰林斯基
M·凯希克-布罗达卡
V·亚当切夫斯卡-切库达
I·索科沃夫斯卡
G·普罗辛尼奇扎克
D·斯塔德尼克
J·安托西克
J·普什佐霍
J·贝尔纳特
T·帕夫卢科维奇
J·斯滕波尼夫斯基
M·博吉尔
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INST BIOTECHNOLOGII I ANTYBIOT
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INST BIOTECHNOLOGII I ANTYBIOT
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Application filed by INST BIOTECHNOLOGII I ANTYBIOT filed Critical INST BIOTECHNOLOGII I ANTYBIOT
Publication of CN102083855A publication Critical patent/CN102083855A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801261044A 2008-07-04 2009-07-04 活性延长的新胰岛素类似物 Pending CN102083855A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL385586 2008-07-04
PL385586A PL219335B1 (pl) 2008-07-04 2008-07-04 Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
PCT/PL2009/050010 WO2010002283A2 (en) 2008-07-04 2009-07-04 New insulin analogues of prolonged activity

Publications (1)

Publication Number Publication Date
CN102083855A true CN102083855A (zh) 2011-06-01

Family

ID=41130257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801261044A Pending CN102083855A (zh) 2008-07-04 2009-07-04 活性延长的新胰岛素类似物

Country Status (8)

Country Link
US (2) US8618048B2 (enExample)
EP (2) EP2321344A2 (enExample)
JP (1) JP2011526886A (enExample)
CN (1) CN102083855A (enExample)
CA (1) CA2729938C (enExample)
EA (1) EA023559B1 (enExample)
PL (2) PL219335B1 (enExample)
WO (1) WO2010002283A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105025919A (zh) * 2013-01-15 2015-11-04 费斯生物制药公司 用于血糖控制的治疗剂、组合物和方法
CN110198722A (zh) * 2016-11-21 2019-09-03 卡斯西部储备大学 稳定性增强的快速作用的胰岛素类似物

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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US10100098B2 (en) 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
PL2370461T3 (pl) 2008-12-15 2014-03-31 Zealand Pharma As Analogi glukagonu
MX2011006313A (es) 2008-12-15 2011-09-27 Zealand Pharma As Analogos de glucagon.
US8642540B2 (en) 2008-12-15 2014-02-04 Zealand Pharma A/S Glucagon analogues
PL2370462T3 (pl) 2008-12-15 2015-01-30 Zealand Pharma As Analogi glukagonu
US9156901B2 (en) 2009-07-13 2015-10-13 Ditte Riber Acylated glucagon analogues
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
AU2011269430A1 (en) 2010-06-24 2013-01-10 Zealand Pharma A/S Glucagon analogues
AR085086A1 (es) 2011-01-20 2013-09-11 Zealand Pharma As Uso de analogos de glucagon acilados
WO2012115638A1 (en) * 2011-02-23 2012-08-30 Elona Biotechnologies Glargine proinsulin compositions and methods of producing glargine insulin analogs therefrom
IN2014MN02304A (enExample) 2012-05-03 2015-08-07 Zealand Pharma As
PL222975B1 (pl) * 2012-05-23 2016-09-30 Inst Biotechnologii I Antybiotyków Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
DK2877200T3 (da) * 2012-07-17 2019-08-12 Univ Case Western Reserve O-bundne carbonhydratmodificerede insulinanaloger
CN109456400A (zh) 2012-07-23 2019-03-12 西兰制药公司 胰高血糖素类似物
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
CN103981242A (zh) * 2013-02-07 2014-08-13 华凌科技有限公司 胰岛素的制备方法
WO2014122651A1 (en) * 2013-02-07 2014-08-14 Valin Technologies Ltd. Process for preparing insulin
WO2014122653A1 (en) * 2013-02-07 2014-08-14 Valin Technologies Ltd. Process for preparing insulin
CN103981243A (zh) * 2013-02-07 2014-08-13 华凌科技有限公司 胰岛素的制备方法
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
RS57632B1 (sr) 2013-10-17 2018-11-30 Zealand Pharma As Acilovani analozi glukagona
JP2017503474A (ja) 2013-11-06 2017-02-02 ジーランド ファーマ アクティーゼルスカブ グルカゴン−ｇｌｐ−１−ｇｉｐトリプルアゴニスト化合物
CN105849122B (zh) 2013-11-06 2021-04-30 西兰制药公司 Gip-glp-1双重激动剂化合物及方法
TWI705973B (zh) 2014-10-29 2020-10-01 丹麥商西蘭製藥公司 Ｇｉｐ促效劑化合物及方法
PL3283507T3 (pl) 2015-04-16 2020-05-18 Zealand Pharma A/S Acylowany analog glukagonu
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
KR102666154B1 (ko) * 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
BR112021011156A2 (pt) 2018-12-11 2021-10-26 Sanofi Conjugados de insulina
WO2021081335A1 (en) * 2019-10-24 2021-04-29 University Of Utah Research Foundation Novel mini-insulin with extended c-terminal a chain

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
WO2004111244A2 (en) * 2003-06-17 2004-12-23 Sembiosys Genetics Inc. Methods for the production of insulin in plants
WO2006096079A2 (en) * 2005-03-10 2006-09-14 Instytut Biotechnologii I Antybiotykow Pharmaceutical composition comprising a biosynthetic analog of human insulin, and its use in the treatment of diabetes mellitus.
WO2008049931A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins

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DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
US5434247A (en) * 1986-10-10 1995-07-18 Board Of Regents, The University Of Texas System Peptides for inducing monocyte cytotoxicity in diagnostics
US5135736A (en) * 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK0547544T3 (da) * 1991-12-18 1997-09-08 Hoechst Ag Fremgangsmåde til fremstilling af insulinholdige opløsninger.
BR9306042A (pt) 1992-02-28 1997-11-18 Autoimmune Inc Método para tratar uma doença auto-immune em um mamifero e formas de dosagens farmacêuticas oral e inalável
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DK1141014T3 (da) * 1999-01-06 2005-04-11 Genentech Inc Insulinlignende vækstfaktor (IGF) i mutantvariant
US6777207B2 (en) * 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
PL213561B1 (pl) 2004-01-09 2013-03-29 Inst Biotechnologii I Antybiotykow Sposób otrzymywania plazmidu, plazmid oraz zastosowania
US7893197B2 (en) * 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
US7947645B2 (en) * 2004-09-02 2011-05-24 Cognosci, Inc. APO E analogs and methods for their use
US7511118B2 (en) * 2005-06-17 2009-03-31 Mannkind Corporation PSMA peptide analogues
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
US20090099065A1 (en) * 2006-03-13 2009-04-16 Novo Nordisk A/S Acylated Single Chain Insulin
CN101573133B (zh) * 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
US5506202A (en) * 1988-12-29 1996-04-09 Hoechst Aktiengesellschaft Insulin derivatives, a process for the preparation thereof, the use thereof, and a pharmaceutical formulation containing them
WO2004111244A2 (en) * 2003-06-17 2004-12-23 Sembiosys Genetics Inc. Methods for the production of insulin in plants
WO2006096079A2 (en) * 2005-03-10 2006-09-14 Instytut Biotechnologii I Antybiotykow Pharmaceutical composition comprising a biosynthetic analog of human insulin, and its use in the treatment of diabetes mellitus.
WO2008049931A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105025919A (zh) * 2013-01-15 2015-11-04 费斯生物制药公司 用于血糖控制的治疗剂、组合物和方法
CN110198722A (zh) * 2016-11-21 2019-09-03 卡斯西部储备大学 稳定性增强的快速作用的胰岛素类似物

Also Published As

Publication number Publication date
CA2729938C (en) 2018-11-06
US20110136736A1 (en) 2011-06-09
EP2371853B1 (en) 2017-09-13
EP2321344A2 (en) 2011-05-18
EA201170149A1 (ru) 2011-06-30
US20140121353A1 (en) 2014-05-01
EP2371853A3 (en) 2012-10-03
WO2010002283A9 (en) 2011-01-20
WO2010002283A2 (en) 2010-01-07
US8618048B2 (en) 2013-12-31
PL385586A1 (pl) 2010-01-18
PL2371853T3 (pl) 2018-06-29
EP2371853A2 (en) 2011-10-05
EA023559B1 (ru) 2016-06-30
PL219335B1 (pl) 2015-04-30
WO2010002283A3 (en) 2010-04-29
JP2011526886A (ja) 2011-10-20
CA2729938A1 (en) 2010-01-07

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110601