EA019540B1 - Производные хинолина в качестве ингибиторов pi3 киназы - Google Patents

Производные хинолина в качестве ингибиторов pi3 киназы Download PDF

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Publication number
EA019540B1
EA019540B1 EA200971072A EA200971072A EA019540B1 EA 019540 B1 EA019540 B1 EA 019540B1 EA 200971072 A EA200971072 A EA 200971072A EA 200971072 A EA200971072 A EA 200971072A EA 019540 B1 EA019540 B1 EA 019540B1
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Prior art keywords
cancer
compound
treatment
inhibitors
cell
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EA200971072A
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English (en)
Russian (ru)
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EA200971072A1 (ru
Inventor
Николас Д. Адамс
Жоэлль Лоррейн Берджесс
Майкл Джерард Дарси
Карла А. Донателли
Стивен Дэвид Найт
Кеннет Аллен Ньюландер
Ланс Риджерс
Марта Сарпонг
Стэнли Дж. Шмидт
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Смитклайн Бичам Корпорейшн
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Publication of EA200971072A1 publication Critical patent/EA200971072A1/ru
Publication of EA019540B1 publication Critical patent/EA019540B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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EA200971072A 2007-05-18 2008-05-16 Производные хинолина в качестве ингибиторов pi3 киназы EA019540B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93876107P 2007-05-18 2007-05-18
PCT/US2008/063819 WO2008144463A1 (en) 2007-05-18 2008-05-16 Quinoline derivatives as pi3 kinase inhibitors

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