EA201270475A1 - Комбинация - Google Patents

Комбинация

Info

Publication number
EA201270475A1
EA201270475A1 EA201270475A EA201270475A EA201270475A1 EA 201270475 A1 EA201270475 A1 EA 201270475A1 EA 201270475 A EA201270475 A EA 201270475A EA 201270475 A EA201270475 A EA 201270475A EA 201270475 A1 EA201270475 A1 EA 201270475A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutically acceptable
acceptable salt
treatment
relates
combinations
Prior art date
Application number
EA201270475A
Other languages
English (en)
Inventor
Курт Р. Оджер
Кертис Эрл Бахман
Тона М. Джилмер
Джеймс Г. мл. Греджер
Джоел Дэвид Грешок
Сильви Лакерр
Ли Лю
Шэннон Рене Моррис
Original Assignee
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ГЛЭКСОСМИТКЛАЙН ЭлЭлСи filed Critical ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
Publication of EA201270475A1 publication Critical patent/EA201270475A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Настоящее изобретение относится к способу лечения рака у млекопитающего и к фармацевтическим комбинациям, используемым при таком лечении. В частности, способ относится к новой комбинации, включающей ингибитор МЕК: N-{3-[3-циклопропил-5-[(2-фтор-4-йодофенил)амино]-6,8-диметил-2,4,7-триоксо-3,4,6,7-тетрагидропиридо[4,3-d]пиримидин-1(2Н)-ил]фенил}ацетамид или его фармацевтически приемлемую соль или сольват, и ингибитор PI3 киназы: 2,4-дифтор-N-{2-(метилокси)-5-[4-(4-пиридазинил)-6-хинолинил]-3-пиридинил}бензолсульфонамид, или его фармацевтически приемлемую соль, к фармацевтическим композициям, включающим их, и к способам применения таких комбинаций при лечении рака.
EA201270475A 2009-09-28 2010-09-28 Комбинация EA201270475A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24626509P 2009-09-28 2009-09-28
US38573810P 2010-09-23 2010-09-23
PCT/US2010/050495 WO2011038380A2 (en) 2009-09-28 2010-09-28 Combination

Publications (1)

Publication Number Publication Date
EA201270475A1 true EA201270475A1 (ru) 2012-11-30

Family

ID=43796526

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270475A EA201270475A1 (ru) 2009-09-28 2010-09-28 Комбинация

Country Status (13)

Country Link
US (1) US20120245180A1 (ru)
EP (1) EP2482819A4 (ru)
JP (1) JP2013505962A (ru)
KR (1) KR20120099217A (ru)
CN (1) CN102665719A (ru)
AU (1) AU2010298020B8 (ru)
BR (1) BR112012006968A2 (ru)
CA (1) CA2775874A1 (ru)
EA (1) EA201270475A1 (ru)
IL (1) IL218846A0 (ru)
MX (1) MX2012003779A (ru)
WO (1) WO2011038380A2 (ru)
ZA (1) ZA201202258B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI505828B (zh) * 2010-12-20 2015-11-01 葛蘭素史克智慧財產（第二）有限公司 新穎醫藥組成物
RU2015132907A (ru) * 2013-01-09 2017-02-14 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Комбинация
EP2986611B1 (en) * 2013-04-18 2019-02-06 Shanghai Fochon Pharmaceutical Co. Ltd Certain protein kinase inhibitors
WO2018126192A1 (en) * 2016-12-30 2018-07-05 Children's Medical Center Corporation Map2k1 (mek1) as a therapeutic target for arteriovenous malformations and associated disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
RU2364596C2 (ru) 2004-06-11 2009-08-20 Джапан Тобакко Инк. ПРОИЗВОДНЫЕ 5-АМИНО-2,4,7-ТРИОКСО-3,4,7,8-ТЕТРАГИДРО-2Н-ПИРИДО[2,3-d] ПИРИМИДИНА, ОБЛАДАЮЩИЕ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ
US7666901B2 (en) * 2004-10-13 2010-02-23 Wyeth Analogs of 17-hydroxywortmannin as PI3K inhibitors
PE20080038A1 (es) 2006-04-11 2008-02-22 Smithkline Beecham Corp Derivados de tiazolidinadiona como inhibidores de la pi3 quinasa
CN101528231A (zh) * 2006-08-16 2009-09-09 埃克塞利希斯股份有限公司 在癌症的治疗中使用pi3k和mek调控剂
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa

Also Published As

Publication number Publication date
MX2012003779A (es) 2012-06-01
AU2010298020B2 (en) 2013-09-12
EP2482819A4 (en) 2013-02-20
CN102665719A (zh) 2012-09-12
JP2013505962A (ja) 2013-02-21
US20120245180A1 (en) 2012-09-27
WO2011038380A3 (en) 2011-09-15
BR112012006968A2 (pt) 2019-09-24
AU2010298020A1 (en) 2012-04-19
EP2482819A2 (en) 2012-08-08
KR20120099217A (ko) 2012-09-07
AU2010298020A8 (en) 2013-10-10
IL218846A0 (en) 2012-06-28
AU2010298020B8 (en) 2013-10-10
ZA201202258B (en) 2012-10-31
CA2775874A1 (en) 2011-03-31
WO2011038380A2 (en) 2011-03-31

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