EA017582B1 - Лечение метастатической стадии рака предстательной железы дегареликсом - Google Patents

Лечение метастатической стадии рака предстательной железы дегареликсом Download PDF

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Publication number
EA017582B1
EA017582B1 EA200901074A EA200901074A EA017582B1 EA 017582 B1 EA017582 B1 EA 017582B1 EA 200901074 A EA200901074 A EA 200901074A EA 200901074 A EA200901074 A EA 200901074A EA 017582 B1 EA017582 B1 EA 017582B1
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EA
Eurasian Patent Office
Prior art keywords
subject
degarelix
treatment
level
days
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EA200901074A
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English (en)
Russian (ru)
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EA200901074A1 (ru
Inventor
Бо-Эрик Перссон
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Ферринг Интернэшнл Сентер С.А.
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Application filed by Ферринг Интернэшнл Сентер С.А. filed Critical Ферринг Интернэшнл Сентер С.А.
Publication of EA200901074A1 publication Critical patent/EA200901074A1/ru
Publication of EA017582B1 publication Critical patent/EA017582B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EA200901074A 2008-02-11 2009-02-10 Лечение метастатической стадии рака предстательной железы дегареликсом EA017582B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2774108P 2008-02-11 2008-02-11
EP08250703 2008-02-29
US14795609P 2009-01-28 2009-01-28
PCT/IB2009/000370 WO2009101533A1 (en) 2008-02-11 2009-02-10 Treatment of metastatic stage prostate cancer with degarelix

Publications (2)

Publication Number Publication Date
EA200901074A1 EA200901074A1 (ru) 2010-04-30
EA017582B1 true EA017582B1 (ru) 2013-01-30

Family

ID=39718285

Family Applications (4)

Application Number Title Priority Date Filing Date
EA200901074A EA017582B1 (ru) 2008-02-11 2009-02-10 Лечение метастатической стадии рака предстательной железы дегареликсом
EA201300742A EA026521B1 (ru) 2008-02-11 2009-02-10 СПОСОБ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ АНТАГОНИСТОМ ГОНАДОТРОПИН-ВЫСВОБОЖДАЮЩЕГО ГОРМОНА (GnRH) ДЕГАРЕЛИКСОМ
EA201300741A EA036695B1 (ru) 2008-02-11 2009-02-10 Применение композиции, содержащей дегареликс, для лечения рака предстательной железы у субъекта, имеющего повышенный уровень холестерина
EA200901075A EA020543B1 (ru) 2008-02-11 2009-02-10 СПОСОБ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ АНТАГОНИСТОМ ГОНАДОТРОПИН-ВЫСВОБОЖДАЮЩЕГО ГОРМОНА (GnRH) ДЕГАРЕЛИКСОМ

Family Applications After (3)

Application Number Title Priority Date Filing Date
EA201300742A EA026521B1 (ru) 2008-02-11 2009-02-10 СПОСОБ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ АНТАГОНИСТОМ ГОНАДОТРОПИН-ВЫСВОБОЖДАЮЩЕГО ГОРМОНА (GnRH) ДЕГАРЕЛИКСОМ
EA201300741A EA036695B1 (ru) 2008-02-11 2009-02-10 Применение композиции, содержащей дегареликс, для лечения рака предстательной железы у субъекта, имеющего повышенный уровень холестерина
EA200901075A EA020543B1 (ru) 2008-02-11 2009-02-10 СПОСОБ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ АНТАГОНИСТОМ ГОНАДОТРОПИН-ВЫСВОБОЖДАЮЩЕГО ГОРМОНА (GnRH) ДЕГАРЕЛИКСОМ

Country Status (25)

Country Link
US (17) US20090203623A1 (https=)
EP (7) EP2650012B1 (https=)
JP (12) JP5924866B2 (https=)
KR (8) KR20220009504A (https=)
CN (4) CN101998861A (https=)
AU (2) AU2009213751B2 (https=)
BR (2) BRPI0908127A2 (https=)
CA (3) CA2714445C (https=)
CY (3) CY1115561T1 (https=)
DK (3) DK2505204T3 (https=)
EA (4) EA017582B1 (https=)
ES (3) ES2532709T3 (https=)
HK (1) HK1198243A1 (https=)
HR (3) HRP20140665T1 (https=)
IL (3) IL207295A (https=)
JO (1) JOP20090061B1 (https=)
MX (2) MX2010008817A (https=)
NZ (4) NZ587057A (https=)
PL (3) PL2505204T3 (https=)
PT (3) PT2650012E (https=)
RU (2) RU2504393C2 (https=)
SI (3) SI2249859T1 (https=)
TW (2) TWI539959B (https=)
WO (2) WO2009101533A1 (https=)
ZA (1) ZA201005697B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
JO3525B1 (ar) * 2008-02-11 2020-07-05 Ferring Int Center Sa علاج سرطان البروستاتا في المرحلة النقيلية بدواء ديجاريليكس
TWI539959B (zh) * 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
MX2011011431A (es) * 2009-05-01 2012-02-23 Ferring Bv Composicion para el tratamiento de cancer de prostata.
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
FR2964323B1 (fr) * 2010-09-08 2012-11-09 Jean Pierre Raynaud Utilisation de la testosterone chez un patient en deficit androgenique et atteint d'un cancer de la prostate
LT2632934T (lt) 2010-10-27 2017-01-10 Ferring B.V. Degarelikso ir jo tarpinių darinių gamybos būdas
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
AU2012225232B2 (en) 2011-03-09 2016-05-12 Richard G. Pestell Prostate cancer cell lines, gene signatures and uses thereof
CN102204889B (zh) * 2011-05-23 2013-09-18 蚌埠丰原涂山制药有限公司 一种醋酸地加瑞克冻干粉针剂及其制备方法
WO2013104745A1 (en) * 2012-01-13 2013-07-18 Ferring Bv Pharmaceutical composition
JP6518585B2 (ja) 2012-05-14 2019-05-22 リチャード ジー. ペステル がんの治療のためのccr5の修飾薬の使用
PL4512390T1 (pl) 2012-06-01 2025-09-01 Ferring B.V. Wytwarzanie degareliksu
NZ744456A (en) 2012-09-26 2019-09-27 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
PL2900675T3 (pl) 2012-09-28 2019-08-30 Takeda Pharmaceutical Company Limited Sposób wytwarzania pochodnej tienopirymidyny
IL241595B2 (en) 2013-03-15 2025-10-01 Abbvie Inc Composition for use in methods of treating heavy menstrual bleeding associated with uterine fibroids
WO2014186608A1 (en) * 2013-05-15 2014-11-20 Adverse Events, Inc. System and method for surveillance and evaluation of safety risks associated with medical interventions
US10821152B2 (en) 2014-08-26 2020-11-03 Betanien Hospital Methods, agents and compositions for treatment of inflammatory conditions
AU2016261770B2 (en) * 2015-05-12 2022-06-02 Drexel University Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same
CN110248661A (zh) 2016-09-30 2019-09-17 梦欧文科学有限责任公司 前列腺癌的治疗
BR112019014192A2 (pt) * 2017-01-30 2020-02-11 Antev Limited Composição compreendendo pelo menos um antagonista de gnrh
US10702508B2 (en) 2017-10-16 2020-07-07 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
AU2018419533A1 (en) 2018-04-19 2020-11-12 Abbvie Inc. Methods of treating heavy menstrual bleeding
EP3829584A4 (en) * 2018-08-01 2022-06-08 Abbvie Inc. DOSAGE SCHEDULES FOR ELAGOLIX
RU2731002C1 (ru) * 2019-10-22 2020-08-26 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения рака предстательной железы
CN116407494B (zh) * 2023-03-02 2024-07-09 山东大学齐鲁医院 一种醋酸地加瑞克注射液及其制备方法、用途

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
ZA735680B (en) * 1972-09-21 1974-07-31 Hoffmann La Roche Polypeptides
US4072668A (en) 1973-11-06 1978-02-07 The Salk Institute For Biological Studies LH-RH Analogs
DE2862341D1 (en) 1977-12-26 1983-11-24 Ihara Chemical Ind Co Process for producing aromatic monocarboxylic acid
US5296468A (en) 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
DE69214818T2 (de) 1991-04-25 1997-02-27 Romano S.-Cergue Deghenghi LHRH-Antagonisten
EP0556034B2 (en) 1992-02-12 2004-07-21 Daikyo Gomu Seiko Ltd. A medical instrument
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
SI9300468A (en) 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
JP3688381B2 (ja) 1995-03-10 2005-08-24 株式会社東芝 光ディスク原盤露光装置
US6379669B1 (en) 1995-08-04 2002-04-30 Akhouri A. Sinha Targeting of organs by immunoconjugates
US5710246A (en) 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
US5821230A (en) * 1997-04-11 1998-10-13 Ferring Bv GnRH antagonist decapeptides
US5977302A (en) 1997-11-20 1999-11-02 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of GnRH peptides
FR2776520B1 (fr) 1998-03-25 2000-05-05 Sod Conseils Rech Applic Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation
CN1243543C (zh) 1998-07-20 2006-03-01 派普泰克有限公司 生物植入物配方
CN100500692C (zh) * 2000-03-14 2009-06-17 赞塔里斯有限公司 新型lhrh拮抗剂,其制备方法和药物用途
US20040198706A1 (en) 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US20020103131A1 (en) 2001-01-26 2002-08-01 Jacobson Jill D. Prevention of diabetes by administration of GnRH antagonists
WO2002098897A2 (en) * 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
GB0117057D0 (en) 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20070015713A1 (en) 2005-07-14 2007-01-18 Voyager Pharmaceutical Corporation Methods for treating prostate cancer
US20060234918A1 (en) * 2001-12-19 2006-10-19 Voyager Pharmaceutical Corporation Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors
SE0104463D0 (sv) 2001-12-29 2001-12-29 Carlbiotech Ltd As Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
CN1411803A (zh) 2002-08-29 2003-04-23 四川大学 制备前体脂质体的方法及其装置
BRPI0314546B8 (pt) 2002-09-27 2021-05-25 Zentaris Gmbh composição de gel farmacêutico compreendendo peptídeos farmaceuticamente atvos com liberação sustentada, método para a produção dos mesmos kit.
GB0223367D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Therapeutic treatment
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
EP1674082A1 (de) 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
WO2006069779A1 (en) 2004-12-30 2006-07-06 F. Hoffmann-La Roche Ag Preparing of peptides with excellent solubility
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
WO2007130809A2 (en) 2006-05-06 2007-11-15 Volodymyr Brodskyy An automatic injectable drug mixing device
EP1891964A1 (en) 2006-08-08 2008-02-27 AEterna Zentaris GmbH Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits
EP1967202A1 (en) 2007-03-05 2008-09-10 AEterna Zentaris GmbH Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
IL182922A0 (en) 2007-05-02 2007-09-20 Medimop Medical Projects Ltd Automatic liquid drug reconstitution apparatus
US8283331B2 (en) 2007-10-09 2012-10-09 Children's Medical Center Corporation Methods to regulate miRNA processing by targeting Lin-28
CA2711984A1 (en) 2008-01-15 2009-07-23 Abbott Gmbh & Co. Kg Powdered protein compositions and methods of making same
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
ES2589322T3 (es) 2008-02-11 2016-11-11 Safety Syringes, Inc. Jeringa con protector de seguridad de aguja y clip para evitar la liberación del protector durante un proceso de reconstitución
WO2010121835A1 (en) 2009-04-24 2010-10-28 Polypeptide Laboratories A/S Method for the manufacture of degarelix
MX2011011431A (es) 2009-05-01 2012-02-23 Ferring Bv Composicion para el tratamiento de cancer de prostata.
TW201043221A (en) 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
WO2011066386A1 (en) 2009-11-25 2011-06-03 Novetide, Ltd. Process for production of degarelix
IT1399892B1 (it) 2010-03-15 2013-05-09 Spi Tecno Srl Sistema per l illuminazione pubblica
ES2385240B1 (es) 2010-07-26 2013-09-23 Gp-Pharm, S.A. Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata.
LT2632934T (lt) 2010-10-27 2017-01-10 Ferring B.V. Degarelikso ir jo tarpinių darinių gamybos būdas
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
CN102204889B (zh) 2011-05-23 2013-09-18 蚌埠丰原涂山制药有限公司 一种醋酸地加瑞克冻干粉针剂及其制备方法
KR20140063602A (ko) 2011-07-15 2014-05-27 훼링 비.브이. 피코설페이트 조성물을 투여하여 대장내시경의 시술 시기를 조절하는 방법
PL4512390T1 (pl) 2012-06-01 2025-09-01 Ferring B.V. Wytwarzanie degareliksu

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BOCCON-GIBOD ET AL.: "Optimising Hormone Therapy in Advanced Disease" EUROPEAN UROLOGY SUPPLEMENTS, XX, XX, vol. 4, no. 8, 1 November 2005 (2005-11-01), pages 21-29, XP005112815 ISSN: 1569-9056 abstract page 23, column 1, paragraph 3, page 27, column 2, paragraph 2 *
BOYLE ET AL.: "Treatment of hormone sensitive prostate cancer" EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, vol. 3, no. 3, 1 October 2005 (2005-10-01), pages 331-338, XP005130027 ISSN: 1359-6349, page 334, column 2, paragraph 3 - page 336, column 2, paragraph 3 *
DEBRUYNE FRANS M.J.: "Gonadotropin-releasing hormone antagonist in the management of prostate cancer". REVIEWS IN UROLOGY 2004, vol. 6 Suppl 7, 2004, pages S25-S32, XP002527257 ISSN: 1523-6161 abstract page S27, column 2, paragraph 1 - page S29, column 3, paragraph 3 *
DEGARELIX STUDY GROUP TAMMELA ET AL.: "904Degarelix - a phase 11 multicentre, randomized dose-escalating study testing a novel gnrh receptor blocker in prostate cancer patients" EUROPEAN UROLOGY SUPPLEMENTS, XX, XX, vol. 4, no. 3, 1 March 2005 (2005-03-01), page 228, XP005007365 ISSN: 1569-9056 abstract *
DOEHN CHRISTIAN ET AL.: "Drug evaluation: Degarelix - a potential new therapy for prostate cancer". IDRUGS: THE INVESTIGATIONAL DRUGS JOURNAL AUG 2006, vol. 9, no. 8, August 2006 (2006-08), pages 565-572, XP009105353 ISSN: 1369-7056, page 567, column 1, paragraph 4 - page 569, column 1, paragraph 1 *
GITTELMAN ET AL.: "MP-08.21: A multicentre, randomised one year dose-finding study of degarelix, a gonadotrophin-releasing hormone (GnRH) receptor blocker, in prostate cancer patients" UROLOGY, BELLE MEAD, NJ, US, vol. 70, no. 3, 1 September 2007 (2007-09-01), pages 83-84, XP022248654 ISSN: 0090-4295 abstract *
GONZALEZ-BARCENA D. ET AL.: "Luteinizing hormone-releasing hormone antagonist cetrorelix as primary single therapy in patients with advanced prostatic cancer and paraplegia due to metastatic invasion of spinal cord". UROLOGY FEB 1995, vol. 45, no. 2, February 1995 (1995-02), pages 275-281, XP002527258 ISSN: 0090-4295 abstract page 277, column 2, paragraph 1 - page 279, column 1, paragraph 1 *
HUIRNE J.A. ET AL.: "Gonadotropin-releasing-hormone-receptor antagonists" LANCET THE, LANCET LIMITED. LONDON, GB, vol. 358, no. 9295, 24 November 2001 (2001-11-24), pages 1793-1803, XP004805574 ISSN: 0140-6736 abstract page 1796, column 1, paragraph 1, page 1796, column 2, paragraph 3, page 1799, column 2, paragraph 4 *
IVERSEN ET AL.: "MP-08.18" UROLOGY, BELLE MEAD, NJ, US, vol. 68, 1 November 2006 (2006-11-01), page 102, XP005709326 ISSN: 0090-4295 abstract *
MONGIAT-ARTUS P. ET AL.: "Role of Luteinising Hormone Releasing Hormone (LHRH) Agonists and Hormonal Treatment in the Management of Prostate Cancer" EUROPEAN UROLOGY SUPPLEMENTS, XX, XX, vol. 4, no. 5, 1 July 2005 (2005-07-01), pages 4-13, XP004926296 ISSN: 1569-9056 abstract page 10, column 2, paragraphs 3, 4 *
VAN POPPEL H. ET AL.: "23 LONG-TERM EVALUATION OF DEGARELIX, A GONADOTROPHIN-RELEASING HORMONE (GNRH) RECEPTOR BLOCKER, INVESTIGATED IN A MULTICENTRE RANDOMISED STUDY IN PROSTATE CANCER (CAP) PATIENTS" EUROPEAN UROLOGY SUPPLEMENTS, XX, XX, vol. 6, no. 2, 1 March 2007 (2007-03-01), page 28, XP022686644 ISSN: 1569-9056 [retrieved on 2007-03-01] abstract *

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