EA015779B1 - Соединения для ингибирования митоза - Google Patents

Соединения для ингибирования митоза Download PDF

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Publication number
EA015779B1
EA015779B1 EA200970486A EA200970486A EA015779B1 EA 015779 B1 EA015779 B1 EA 015779B1 EA 200970486 A EA200970486 A EA 200970486A EA 200970486 A EA200970486 A EA 200970486A EA 015779 B1 EA015779 B1 EA 015779B1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
cancer
compound
aigoga
kinase
Prior art date
Application number
EA200970486A
Other languages
English (en)
Russian (ru)
Other versions
EA200970486A1 (ru
Inventor
Кристофер Ф. Клэйборн
Тодд Б. Селлс
Стефен Г. Страуд
Original Assignee
Милленниум Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39315133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA015779(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Милленниум Фармасьютикалз, Инк. filed Critical Милленниум Фармасьютикалз, Инк.
Publication of EA200970486A1 publication Critical patent/EA200970486A1/ru
Publication of EA015779B1 publication Critical patent/EA015779B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EA200970486A 2006-11-16 2007-11-14 Соединения для ингибирования митоза EA015779B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16
PCT/US2007/023948 WO2008063525A1 (en) 2006-11-16 2007-11-14 Compounds for inhibiting mitotic progression

Publications (2)

Publication Number Publication Date
EA200970486A1 EA200970486A1 (ru) 2009-10-30
EA015779B1 true EA015779B1 (ru) 2011-12-30

Family

ID=39315133

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970486A EA015779B1 (ru) 2006-11-16 2007-11-14 Соединения для ингибирования митоза

Country Status (34)

Country Link
US (7) US8026246B2 (enExample)
EP (4) EP2086981B1 (enExample)
JP (3) JP5102839B2 (enExample)
KR (2) KR101342014B1 (enExample)
CN (2) CN101547924B (enExample)
AR (1) AR064246A1 (enExample)
AT (1) ATE556076T1 (enExample)
AU (1) AU2007322046B2 (enExample)
BR (1) BRPI0718803B8 (enExample)
CA (1) CA2669680C (enExample)
CL (1) CL2007003244A1 (enExample)
CR (3) CR10782A (enExample)
CY (1) CY1112828T1 (enExample)
DK (2) DK2086981T3 (enExample)
EA (1) EA015779B1 (enExample)
ES (3) ES2384123T3 (enExample)
GE (1) GEP20125459B (enExample)
HR (2) HRP20120490T1 (enExample)
IL (1) IL198690A0 (enExample)
MA (1) MA30988B1 (enExample)
MX (3) MX348568B (enExample)
MY (1) MY153243A (enExample)
NO (1) NO343338B1 (enExample)
NZ (3) NZ611898A (enExample)
PH (1) PH12012502057B1 (enExample)
PL (2) PL2497772T3 (enExample)
PT (2) PT2086981E (enExample)
RS (2) RS52313B (enExample)
SG (2) SG10201503350TA (enExample)
SI (2) SI2086981T1 (enExample)
TW (1) TWI401255B (enExample)
UA (1) UA94129C2 (enExample)
WO (1) WO2008063525A1 (enExample)
ZA (1) ZA200903279B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221158B2 (en) 2015-09-09 2019-03-05 Icahn School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
US10759790B2 (en) 2015-09-09 2020-09-01 Ichan School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents

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WO2010065134A1 (en) * 2008-12-05 2010-06-10 Millennium Pharmaceuticals, Inc. 5, 7-dihydro- 6h-pyrimido [ 5, 4-d] [ 1 ] benzazepin-6-thiones as plk inhibitors
ES2468391T3 (es) * 2008-12-22 2014-06-16 Millennium Pharmaceuticals, Inc. Combinación de inhibidores de cinasas Aurora y anticuerpos anti-CD20
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) * 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
EP2536279A4 (en) * 2010-02-19 2013-07-24 Millennium Pharm Inc CRYSTALLINE FORMS OF SODIUM 4 - {[9-CHLORO-7- (2-FLUORO-6-METHOXYPHENYL) -5H-PYRIMIDO [5,4-D] [2] BENZAZEPHIN-2YL] AMINO} -2-METHOXYBENZOATE
US20120107304A1 (en) 2010-04-27 2012-05-03 Boehringer Ingelheim International Gmbh Combination therapy in treatment of oncological and fibrotic diseases
US9085582B2 (en) * 2010-06-22 2015-07-21 Glaxosmithkline Llc Benzotriazolodiazepine compounds inhibitors of bromodomains
UY34114A (es) 2011-06-03 2013-01-03 Millennium Pharm Inc Combinación de inhibidores de mek e inhibidores selectivos de la quiinasa aurora a
US20130303519A1 (en) * 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN103772391A (zh) * 2012-10-23 2014-05-07 杨子娇 一类治疗房角狭窄的化合物及其用途
EP2976086B1 (en) * 2013-03-22 2020-10-14 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
WO2015085289A1 (en) 2013-12-06 2015-06-11 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd30 antibodies
CA2972076A1 (en) * 2014-12-23 2016-06-30 Millennium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
EP3324976A4 (en) 2015-07-21 2019-03-27 Millennium Pharmaceuticals, Inc. ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS
JP6591036B2 (ja) 2016-02-26 2019-10-16 公益財団法人がん研究会 Hp1の機能に着目した抗癌剤のスクリーニング方法及び評価系
EA201892075A1 (ru) 2016-03-15 2019-04-30 Оризон Дженомикс, С.А. Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей
JP6188986B1 (ja) * 2017-03-23 2017-08-30 株式会社ノエビア 時計遺伝子発現量調整剤及びエラスチン産生促進剤
WO2019195658A1 (en) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Sting levels as a biomarker for cancer immunotherapy
WO2020049208A1 (es) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
WO2021041532A1 (en) 2019-08-26 2021-03-04 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
JP2025511697A (ja) 2022-04-07 2025-04-16 イーライ リリー アンド カンパニー Kras g12c阻害剤を作製するための方法
CA3247183A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company TREATMENT METHOD INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS
WO2024006424A1 (en) 2022-06-30 2024-01-04 Eli Lilly And Company Kras g12c inhibitor for treating cancer
WO2025075211A1 (en) 2023-10-03 2025-04-10 Takeda Pharmaceutical Company Limited Alisertib and paclitaxel for treating small cell lung cancer
WO2025245045A1 (en) 2024-05-21 2025-11-27 The Regents Of The University Of California Methods of treating lung cancer

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221158B2 (en) 2015-09-09 2019-03-05 Icahn School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
US10759790B2 (en) 2015-09-09 2020-09-01 Ichan School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents

Also Published As

Publication number Publication date
GEP20125459B (en) 2012-03-26
NZ597252A (en) 2013-06-28
EP2497772B1 (en) 2014-10-29
EP2944639A1 (en) 2015-11-18
EP2497772A1 (en) 2012-09-12
NO343338B1 (no) 2019-02-04
SG176443A1 (en) 2011-12-29
EP2497773A1 (en) 2012-09-12
CN103483343B (zh) 2016-06-01
NO20091864L (no) 2009-06-15
HK1217699A1 (en) 2017-01-20
PL2497772T3 (pl) 2015-05-29
US20150166545A1 (en) 2015-06-18
ES2384123T3 (es) 2012-06-29
PT2497772E (pt) 2015-02-05
US20110312942A1 (en) 2011-12-22
KR101342014B1 (ko) 2013-12-19
US20210214361A1 (en) 2021-07-15
KR20090091173A (ko) 2009-08-26
TWI401255B (zh) 2013-07-11
EP2086981A1 (en) 2009-08-12
CR10782A (es) 2009-06-24
TW200829589A (en) 2008-07-16
EP2944639B1 (en) 2017-01-04
EP2086981B1 (en) 2012-05-02
PL2086981T3 (pl) 2012-09-28
EP2497773B1 (en) 2015-02-25
CY1112828T1 (el) 2016-02-10
MX348568B (es) 2017-06-20
BRPI0718803B8 (pt) 2021-05-25
KR20110113210A (ko) 2011-10-14
CA2669680C (en) 2012-04-10
JP2012006965A (ja) 2012-01-12
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
CL2007003244A1 (es) 2008-04-04
US20190031662A1 (en) 2019-01-31
US20080167292A1 (en) 2008-07-10
SG10201503350TA (en) 2015-06-29
SI2086981T1 (sl) 2012-12-31
BRPI0718803B1 (pt) 2020-11-17
JP2014055166A (ja) 2014-03-27
CN101547924B (zh) 2013-09-25
US11958855B2 (en) 2024-04-16
NZ611898A (en) 2015-01-30
HK1175778A1 (en) 2013-07-12
AU2007322046B2 (en) 2012-04-05
SI2497772T1 (sl) 2015-03-31
WO2008063525A1 (en) 2008-05-29
ES2537451T3 (es) 2015-06-08
CR20140544A (es) 2015-01-12
CR20140154A (es) 2014-07-23
KR101110458B1 (ko) 2012-03-13
DK2497772T3 (en) 2015-01-19
EA200970486A1 (ru) 2009-10-30
CN103483343A (zh) 2014-01-01
IL198690A0 (en) 2010-02-17
JP5452811B2 (ja) 2014-03-26
MX343391B (es) 2016-11-04
DK2086981T3 (da) 2012-08-06
ES2528793T3 (es) 2015-02-12
HRP20150047T1 (en) 2015-03-13
PH12012502057B1 (en) 2018-10-24
NZ577042A (en) 2012-03-30
US20240400567A1 (en) 2024-12-05
HK1134672A1 (en) 2010-05-07
HRP20120490T1 (hr) 2012-07-31
AR064246A1 (es) 2009-03-25
US9765076B2 (en) 2017-09-19
US20110312943A1 (en) 2011-12-22
MA30988B1 (fr) 2009-12-01
JP2010510215A (ja) 2010-04-02
BRPI0718803A2 (pt) 2013-12-03
RS53788B1 (sr) 2015-06-30
AU2007322046A1 (en) 2008-05-29
MY153243A (en) 2015-01-29
ATE556076T1 (de) 2012-05-15
US9988384B2 (en) 2018-06-05
CA2669680A1 (en) 2008-05-29
UA94129C2 (ru) 2011-04-11
HK1175777A1 (en) 2013-07-12
ZA200903279B (en) 2010-07-28
PH12012502057A1 (en) 2015-09-14
US10836766B2 (en) 2020-11-17
CN101547924A (zh) 2009-09-30
JP5102839B2 (ja) 2012-12-19
RS52313B (sr) 2012-12-31
US8026246B2 (en) 2011-09-27

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