PT2497772E - Composto para inibir a progressão mitótica - Google Patents

Composto para inibir a progressão mitótica Download PDF

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Publication number
PT2497772E
PT2497772E PT121531313T PT12153131T PT2497772E PT 2497772 E PT2497772 E PT 2497772E PT 121531313 T PT121531313 T PT 121531313T PT 12153131 T PT12153131 T PT 12153131T PT 2497772 E PT2497772 E PT 2497772E
Authority
PT
Portugal
Prior art keywords
compound
mitotic progression
inhibiting mitotic
inhibiting
progression
Prior art date
Application number
PT121531313T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39315133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2497772(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of PT2497772E publication Critical patent/PT2497772E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT121531313T 2006-11-16 2007-11-14 Composto para inibir a progressão mitótica PT2497772E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16

Publications (1)

Publication Number Publication Date
PT2497772E true PT2497772E (pt) 2015-02-05

Family

ID=39315133

Family Applications (2)

Application Number Title Priority Date Filing Date
PT121531313T PT2497772E (pt) 2006-11-16 2007-11-14 Composto para inibir a progressão mitótica
PT07867449T PT2086981E (pt) 2006-11-16 2007-11-14 Compostos para inibir a progressão mitótica

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT07867449T PT2086981E (pt) 2006-11-16 2007-11-14 Compostos para inibir a progressão mitótica

Country Status (34)

Country Link
US (7) US8026246B2 (enExample)
EP (4) EP2086981B1 (enExample)
JP (3) JP5102839B2 (enExample)
KR (2) KR101110458B1 (enExample)
CN (2) CN103483343B (enExample)
AR (1) AR064246A1 (enExample)
AT (1) ATE556076T1 (enExample)
AU (1) AU2007322046B2 (enExample)
BR (1) BRPI0718803B8 (enExample)
CA (1) CA2669680C (enExample)
CL (1) CL2007003244A1 (enExample)
CR (3) CR10782A (enExample)
CY (1) CY1112828T1 (enExample)
DK (2) DK2086981T3 (enExample)
EA (1) EA015779B1 (enExample)
ES (3) ES2528793T3 (enExample)
GE (1) GEP20125459B (enExample)
HR (2) HRP20120490T1 (enExample)
IL (1) IL198690A0 (enExample)
MA (1) MA30988B1 (enExample)
MX (3) MX2009004670A (enExample)
MY (1) MY153243A (enExample)
NO (1) NO343338B1 (enExample)
NZ (3) NZ577042A (enExample)
PH (1) PH12012502057B1 (enExample)
PL (2) PL2497772T3 (enExample)
PT (2) PT2497772E (enExample)
RS (2) RS52313B (enExample)
SG (2) SG10201503350TA (enExample)
SI (2) SI2497772T1 (enExample)
TW (1) TWI401255B (enExample)
UA (1) UA94129C2 (enExample)
WO (1) WO2008063525A1 (enExample)
ZA (1) ZA200903279B (enExample)

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RS50568B8 (sr) 2004-05-14 2019-08-30 Millennium Pharm Inc Jedinjenja i postupci za inhibiciju mitotičke progresije inhibiranjem aurora kinaze
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
US7998952B2 (en) * 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof
MX2011006725A (es) * 2008-12-22 2011-09-15 Millennium Pharm Inc Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) * 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
CN102770024A (zh) * 2010-02-19 2012-11-07 米伦纽姆医药公司 4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式
US20120107304A1 (en) 2010-04-27 2012-05-03 Boehringer Ingelheim International Gmbh Combination therapy in treatment of oncological and fibrotic diseases
US9085582B2 (en) * 2010-06-22 2015-07-21 Glaxosmithkline Llc Benzotriazolodiazepine compounds inhibitors of bromodomains
AR086656A1 (es) 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
US20130303519A1 (en) * 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN103772391A (zh) * 2012-10-23 2014-05-07 杨子娇 一类治疗房角狭窄的化合物及其用途
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
US10335494B2 (en) 2013-12-06 2019-07-02 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-CD30 antibodies
JP2018502089A (ja) * 2014-12-23 2018-01-25 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｒａｆ阻害剤及びａｕｒｏｒａキナーゼ阻害剤の組み合わせ
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
EP3347355B1 (en) 2015-09-09 2022-07-13 Icahn School of Medicine at Mount Sinai Heterotricyclic sulfonamides as anti-cancer agents
US10221158B2 (en) 2015-09-09 2019-03-05 Icahn School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
WO2017146253A1 (ja) 2016-02-26 2017-08-31 公益財団法人がん研究会 Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
JP6188986B1 (ja) * 2017-03-23 2017-08-30 株式会社ノエビア 時計遺伝子発現量調整剤及びエラスチン産生促進剤
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
WO2020049208A1 (es) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
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WO2025075211A1 (en) 2023-10-03 2025-04-10 Takeda Pharmaceutical Company Limited Alisertib and paclitaxel for treating small cell lung cancer
WO2025245045A1 (en) 2024-05-21 2025-11-27 The Regents Of The University Of California Methods of treating lung cancer

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JP2008520713A (ja) 2004-11-17 2008-06-19 ミイカナ セラピューティクス インコーポレイテッド キナーゼ阻害剤
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CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها

Also Published As

Publication number Publication date
US20080167292A1 (en) 2008-07-10
SG10201503350TA (en) 2015-06-29
JP5452811B2 (ja) 2014-03-26
MX348568B (es) 2017-06-20
EP2944639A1 (en) 2015-11-18
DK2086981T3 (da) 2012-08-06
US9988384B2 (en) 2018-06-05
TWI401255B (zh) 2013-07-11
AU2007322046A1 (en) 2008-05-29
CN101547924A (zh) 2009-09-30
CR20140544A (es) 2015-01-12
US20190031662A1 (en) 2019-01-31
TW200829589A (en) 2008-07-16
HK1175778A1 (en) 2013-07-12
CN103483343B (zh) 2016-06-01
NZ597252A (en) 2013-06-28
ATE556076T1 (de) 2012-05-15
SI2086981T1 (sl) 2012-12-31
IL198690A0 (en) 2010-02-17
EP2944639B1 (en) 2017-01-04
US20150166545A1 (en) 2015-06-18
CN101547924B (zh) 2013-09-25
EP2497772A1 (en) 2012-09-12
KR20090091173A (ko) 2009-08-26
SI2497772T1 (sl) 2015-03-31
UA94129C2 (ru) 2011-04-11
HK1175777A1 (en) 2013-07-12
EA015779B1 (ru) 2011-12-30
MA30988B1 (fr) 2009-12-01
PL2086981T3 (pl) 2012-09-28
CA2669680A1 (en) 2008-05-29
CA2669680C (en) 2012-04-10
US20210214361A1 (en) 2021-07-15
NZ611898A (en) 2015-01-30
CY1112828T1 (el) 2016-02-10
US20110312942A1 (en) 2011-12-22
PH12012502057A1 (en) 2015-09-14
WO2008063525A1 (en) 2008-05-29
US10836766B2 (en) 2020-11-17
ES2528793T3 (es) 2015-02-12
KR101342014B1 (ko) 2013-12-19
BRPI0718803B8 (pt) 2021-05-25
KR20110113210A (ko) 2011-10-14
CR10782A (es) 2009-06-24
AR064246A1 (es) 2009-03-25
RS53788B1 (sr) 2015-06-30
SG176443A1 (en) 2011-12-29
EP2086981B1 (en) 2012-05-02
JP5102839B2 (ja) 2012-12-19
US11958855B2 (en) 2024-04-16
HK1134672A1 (en) 2010-05-07
GEP20125459B (en) 2012-03-26
EP2497773B1 (en) 2015-02-25
NO20091864L (no) 2009-06-15
JP2014055166A (ja) 2014-03-27
EP2497772B1 (en) 2014-10-29
HRP20120490T1 (hr) 2012-07-31
CL2007003244A1 (es) 2008-04-04
MX343391B (es) 2016-11-04
EP2086981A1 (en) 2009-08-12
MY153243A (en) 2015-01-29
US8026246B2 (en) 2011-09-27
RS52313B (sr) 2012-12-31
AU2007322046B2 (en) 2012-04-05
US20110312943A1 (en) 2011-12-22
BRPI0718803A2 (pt) 2013-12-03
BRPI0718803B1 (pt) 2020-11-17
NO343338B1 (no) 2019-02-04
ES2384123T3 (es) 2012-06-29
US20240400567A1 (en) 2024-12-05
PH12012502057B1 (en) 2018-10-24
ZA200903279B (en) 2010-07-28
HRP20150047T1 (en) 2015-03-13
JP2012006965A (ja) 2012-01-12
ES2537451T3 (es) 2015-06-08
HK1217699A1 (en) 2017-01-20
JP2010510215A (ja) 2010-04-02
NZ577042A (en) 2012-03-30
DK2497772T3 (en) 2015-01-19
KR101110458B1 (ko) 2012-03-13
EP2497773A1 (en) 2012-09-12
CR20140154A (es) 2014-07-23
PL2497772T3 (pl) 2015-05-29
EA200970486A1 (ru) 2009-10-30
US9765076B2 (en) 2017-09-19
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
CN103483343A (zh) 2014-01-01

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