KR101110458B1 - 유사분열 진행을 억제하기 위한 화합물 - Google Patents

유사분열 진행을 억제하기 위한 화합물 Download PDF

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Publication number
KR101110458B1
KR101110458B1 KR1020097012501A KR20097012501A KR101110458B1 KR 101110458 B1 KR101110458 B1 KR 101110458B1 KR 1020097012501 A KR1020097012501 A KR 1020097012501A KR 20097012501 A KR20097012501 A KR 20097012501A KR 101110458 B1 KR101110458 B1 KR 101110458B1
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group
aliphatic
cancer
aryl
ring
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Korean (ko)
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KR20090091173A (ko
Inventor
크리스토퍼 에프. 클래이본
토드 비. 셀스
스티븐 지. 스트로우드
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밀레니엄 파머슈티컬스 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020097012501A 2006-11-16 2007-11-14 유사분열 진행을 억제하기 위한 화합물 Active KR101110458B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16
US60/859,340 2006-11-16
PCT/US2007/023948 WO2008063525A1 (en) 2006-11-16 2007-11-14 Compounds for inhibiting mitotic progression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117022355A Division KR101342014B1 (ko) 2006-11-16 2007-11-14 유사분열 진행을 억제하기 위한 화합물

Publications (2)

Publication Number Publication Date
KR20090091173A KR20090091173A (ko) 2009-08-26
KR101110458B1 true KR101110458B1 (ko) 2012-03-13

Family

ID=39315133

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097012501A Active KR101110458B1 (ko) 2006-11-16 2007-11-14 유사분열 진행을 억제하기 위한 화합물
KR1020117022355A Active KR101342014B1 (ko) 2006-11-16 2007-11-14 유사분열 진행을 억제하기 위한 화합물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117022355A Active KR101342014B1 (ko) 2006-11-16 2007-11-14 유사분열 진행을 억제하기 위한 화합물

Country Status (34)

Country Link
US (7) US8026246B2 (enExample)
EP (4) EP2497773B1 (enExample)
JP (3) JP5102839B2 (enExample)
KR (2) KR101110458B1 (enExample)
CN (2) CN101547924B (enExample)
AR (1) AR064246A1 (enExample)
AT (1) ATE556076T1 (enExample)
AU (1) AU2007322046B2 (enExample)
BR (1) BRPI0718803B8 (enExample)
CA (1) CA2669680C (enExample)
CL (1) CL2007003244A1 (enExample)
CR (3) CR10782A (enExample)
CY (1) CY1112828T1 (enExample)
DK (2) DK2086981T3 (enExample)
EA (1) EA015779B1 (enExample)
ES (3) ES2384123T3 (enExample)
GE (1) GEP20125459B (enExample)
HR (2) HRP20120490T1 (enExample)
IL (1) IL198690A0 (enExample)
MA (1) MA30988B1 (enExample)
MX (3) MX348568B (enExample)
MY (1) MY153243A (enExample)
NO (1) NO343338B1 (enExample)
NZ (3) NZ611898A (enExample)
PH (1) PH12012502057B1 (enExample)
PL (2) PL2497772T3 (enExample)
PT (2) PT2086981E (enExample)
RS (2) RS52313B (enExample)
SG (2) SG10201503350TA (enExample)
SI (2) SI2086981T1 (enExample)
TW (1) TWI401255B (enExample)
UA (1) UA94129C2 (enExample)
WO (1) WO2008063525A1 (enExample)
ZA (1) ZA200903279B (enExample)

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AR086656A1 (es) * 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
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JP6955485B2 (ja) 2015-09-09 2021-10-27 アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ 抗がん剤としての複素環式の限定された三環系スルホンアミド
JP6966425B2 (ja) 2015-09-09 2021-11-17 アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai 抗がん剤としての複素環式の限定された三環系スルホンアミド
WO2017146253A1 (ja) 2016-02-26 2017-08-31 公益財団法人がん研究会 Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
JP6188986B1 (ja) * 2017-03-23 2017-08-30 株式会社ノエビア 時計遺伝子発現量調整剤及びエラスチン産生促進剤
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KR20250027777A (ko) 2022-06-30 2025-02-27 일라이 릴리 앤드 캄파니 암을 치료하기 위한 kras g12c 억제제
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JP5452811B2 (ja) 2014-03-26
HK1134672A1 (en) 2010-05-07
BRPI0718803B1 (pt) 2020-11-17
PT2497772E (pt) 2015-02-05
ZA200903279B (en) 2010-07-28
MX348568B (es) 2017-06-20
RS53788B1 (sr) 2015-06-30
KR20090091173A (ko) 2009-08-26
BRPI0718803B8 (pt) 2021-05-25
PL2086981T3 (pl) 2012-09-28
WO2008063525A1 (en) 2008-05-29
IL198690A0 (en) 2010-02-17
DK2086981T3 (da) 2012-08-06
EP2086981A1 (en) 2009-08-12
AR064246A1 (es) 2009-03-25
ES2528793T3 (es) 2015-02-12
PH12012502057A1 (en) 2015-09-14
EP2944639A1 (en) 2015-11-18
MA30988B1 (fr) 2009-12-01
US20150166545A1 (en) 2015-06-18
MY153243A (en) 2015-01-29
HRP20120490T1 (hr) 2012-07-31
MX343391B (es) 2016-11-04
SI2086981T1 (sl) 2012-12-31
KR101342014B1 (ko) 2013-12-19
US9765076B2 (en) 2017-09-19
US20240400567A1 (en) 2024-12-05
US20210214361A1 (en) 2021-07-15
US20190031662A1 (en) 2019-01-31
CR10782A (es) 2009-06-24
NZ577042A (en) 2012-03-30
NO343338B1 (no) 2019-02-04
NZ611898A (en) 2015-01-30
SI2497772T1 (sl) 2015-03-31
US8026246B2 (en) 2011-09-27
EP2497772A1 (en) 2012-09-12
NO20091864L (no) 2009-06-15
PL2497772T3 (pl) 2015-05-29
CL2007003244A1 (es) 2008-04-04
AU2007322046A1 (en) 2008-05-29
HK1175777A1 (en) 2013-07-12
RS52313B (sr) 2012-12-31
US10836766B2 (en) 2020-11-17
GEP20125459B (en) 2012-03-26
EP2497773A1 (en) 2012-09-12
US20110312943A1 (en) 2011-12-22
JP5102839B2 (ja) 2012-12-19
EA200970486A1 (ru) 2009-10-30
EP2497773B1 (en) 2015-02-25
US20080167292A1 (en) 2008-07-10
EP2086981B1 (en) 2012-05-02
CN103483343B (zh) 2016-06-01
SG10201503350TA (en) 2015-06-29
NZ597252A (en) 2013-06-28
ES2384123T3 (es) 2012-06-29
CR20140544A (es) 2015-01-12
JP2014055166A (ja) 2014-03-27
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
EP2497772B1 (en) 2014-10-29
AU2007322046B2 (en) 2012-04-05
TWI401255B (zh) 2013-07-11
CA2669680C (en) 2012-04-10
US11958855B2 (en) 2024-04-16
HK1175778A1 (en) 2013-07-12
CA2669680A1 (en) 2008-05-29
ATE556076T1 (de) 2012-05-15
CN101547924A (zh) 2009-09-30
TW200829589A (en) 2008-07-16
UA94129C2 (ru) 2011-04-11
EP2944639B1 (en) 2017-01-04
CN103483343A (zh) 2014-01-01
US20110312942A1 (en) 2011-12-22
DK2497772T3 (en) 2015-01-19
EA015779B1 (ru) 2011-12-30
CY1112828T1 (el) 2016-02-10
BRPI0718803A2 (pt) 2013-12-03
HRP20150047T1 (en) 2015-03-13
JP2012006965A (ja) 2012-01-12
KR20110113210A (ko) 2011-10-14
JP2010510215A (ja) 2010-04-02
CR20140154A (es) 2014-07-23
HK1217699A1 (en) 2017-01-20
SG176443A1 (en) 2011-12-29
ES2537451T3 (es) 2015-06-08
PH12012502057B1 (en) 2018-10-24
US9988384B2 (en) 2018-06-05
CN101547924B (zh) 2013-09-25

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