PH12012502057B1 - Compounds for inhibiting mitotic progression - Google Patents

Compounds for inhibiting mitotic progression Download PDF

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Publication number
PH12012502057B1
PH12012502057B1 PH12012502057A PH12012502057A PH12012502057B1 PH 12012502057 B1 PH12012502057 B1 PH 12012502057B1 PH 12012502057 A PH12012502057 A PH 12012502057A PH 12012502057 A PH12012502057 A PH 12012502057A PH 12012502057 B1 PH12012502057 B1 PH 12012502057B1
Authority
PH
Philippines
Prior art keywords
cancer
group
aliphatic
heteroaryl
aryl
Prior art date
Application number
PH12012502057A
Other languages
English (en)
Other versions
PH12012502057A1 (en
Inventor
Christopher F Claiborne
Todd B Sells
Stephen G Stroud
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39315133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH12012502057(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of PH12012502057A1 publication Critical patent/PH12012502057A1/en
Publication of PH12012502057B1 publication Critical patent/PH12012502057B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH12012502057A 2006-11-16 2012-10-12 Compounds for inhibiting mitotic progression PH12012502057B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16
PCT/US2007/023948 WO2008063525A1 (en) 2006-11-16 2007-11-14 Compounds for inhibiting mitotic progression

Publications (2)

Publication Number Publication Date
PH12012502057A1 PH12012502057A1 (en) 2015-09-14
PH12012502057B1 true PH12012502057B1 (en) 2018-10-24

Family

ID=39315133

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12012502057A PH12012502057B1 (en) 2006-11-16 2012-10-12 Compounds for inhibiting mitotic progression

Country Status (34)

Country Link
US (7) US8026246B2 (enExample)
EP (4) EP2497773B1 (enExample)
JP (3) JP5102839B2 (enExample)
KR (2) KR101342014B1 (enExample)
CN (2) CN101547924B (enExample)
AR (1) AR064246A1 (enExample)
AT (1) ATE556076T1 (enExample)
AU (1) AU2007322046B2 (enExample)
BR (1) BRPI0718803B8 (enExample)
CA (1) CA2669680C (enExample)
CL (1) CL2007003244A1 (enExample)
CR (3) CR10782A (enExample)
CY (1) CY1112828T1 (enExample)
DK (2) DK2497772T3 (enExample)
EA (1) EA015779B1 (enExample)
ES (3) ES2537451T3 (enExample)
GE (1) GEP20125459B (enExample)
HR (2) HRP20120490T1 (enExample)
IL (1) IL198690A0 (enExample)
MA (1) MA30988B1 (enExample)
MX (3) MX2009004670A (enExample)
MY (1) MY153243A (enExample)
NO (1) NO343338B1 (enExample)
NZ (3) NZ611898A (enExample)
PH (1) PH12012502057B1 (enExample)
PL (2) PL2497772T3 (enExample)
PT (2) PT2086981E (enExample)
RS (2) RS53788B1 (enExample)
SG (2) SG176443A1 (enExample)
SI (2) SI2497772T1 (enExample)
TW (1) TWI401255B (enExample)
UA (1) UA94129C2 (enExample)
WO (1) WO2008063525A1 (enExample)
ZA (1) ZA200903279B (enExample)

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JP5738196B2 (ja) * 2008-12-22 2015-06-17 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼ阻害剤および抗ｃｄ２０抗体の併用
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
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WO2016106357A1 (en) * 2014-12-23 2016-06-30 Millennnium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
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JP6955485B2 (ja) 2015-09-09 2021-10-27 アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ 抗がん剤としての複素環式の限定された三環系スルホンアミド
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JP6591036B2 (ja) 2016-02-26 2019-10-16 公益財団法人がん研究会 Ｈｐ１の機能に着目した抗癌剤のスクリーニング方法及び評価系
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Also Published As

Publication number Publication date
DK2086981T3 (da) 2012-08-06
US20210214361A1 (en) 2021-07-15
CN103483343B (zh) 2016-06-01
BRPI0718803B8 (pt) 2021-05-25
US20240400567A1 (en) 2024-12-05
NZ611898A (en) 2015-01-30
JP5102839B2 (ja) 2012-12-19
HK1217699A1 (en) 2017-01-20
EP2497773B1 (en) 2015-02-25
CN101547924B (zh) 2013-09-25
JP2014055166A (ja) 2014-03-27
CL2007003244A1 (es) 2008-04-04
UA94129C2 (ru) 2011-04-11
KR101342014B1 (ko) 2013-12-19
CR20140154A (es) 2014-07-23
HRP20150047T1 (en) 2015-03-13
MX348568B (es) 2017-06-20
SI2086981T1 (sl) 2012-12-31
NO20091864L (no) 2009-06-15
EP2497772B1 (en) 2014-10-29
CN103483343A (zh) 2014-01-01
MX343391B (es) 2016-11-04
US10836766B2 (en) 2020-11-17
RS52313B (sr) 2012-12-31
ES2384123T3 (es) 2012-06-29
US20080167292A1 (en) 2008-07-10
ES2537451T3 (es) 2015-06-08
MA30988B1 (fr) 2009-12-01
RS53788B1 (sr) 2015-06-30
ZA200903279B (en) 2010-07-28
AU2007322046A1 (en) 2008-05-29
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
EP2497772A1 (en) 2012-09-12
JP2010510215A (ja) 2010-04-02
MY153243A (en) 2015-01-29
CA2669680A1 (en) 2008-05-29
EP2944639B1 (en) 2017-01-04
AR064246A1 (es) 2009-03-25
US9765076B2 (en) 2017-09-19
SG176443A1 (en) 2011-12-29
NZ577042A (en) 2012-03-30
HK1134672A1 (en) 2010-05-07
NO343338B1 (no) 2019-02-04
EP2086981B1 (en) 2012-05-02
KR20090091173A (ko) 2009-08-26
CA2669680C (en) 2012-04-10
SG10201503350TA (en) 2015-06-29
US8026246B2 (en) 2011-09-27
US20110312942A1 (en) 2011-12-22
DK2497772T3 (en) 2015-01-19
SI2497772T1 (sl) 2015-03-31
US20150166545A1 (en) 2015-06-18
US11958855B2 (en) 2024-04-16
EA015779B1 (ru) 2011-12-30
ES2528793T3 (es) 2015-02-12
HK1175778A1 (en) 2013-07-12
PL2086981T3 (pl) 2012-09-28
BRPI0718803B1 (pt) 2020-11-17
JP5452811B2 (ja) 2014-03-26
EP2497773A1 (en) 2012-09-12
JP2012006965A (ja) 2012-01-12
US20110312943A1 (en) 2011-12-22
NZ597252A (en) 2013-06-28
CR10782A (es) 2009-06-24
EA200970486A1 (ru) 2009-10-30
HK1175777A1 (en) 2013-07-12
PH12012502057A1 (en) 2015-09-14
BRPI0718803A2 (pt) 2013-12-03
CN101547924A (zh) 2009-09-30
EP2944639A1 (en) 2015-11-18
WO2008063525A1 (en) 2008-05-29
US9988384B2 (en) 2018-06-05
ATE556076T1 (de) 2012-05-15
CY1112828T1 (el) 2016-02-10
US20190031662A1 (en) 2019-01-31
KR20110113210A (ko) 2011-10-14
GEP20125459B (en) 2012-03-26
IL198690A0 (en) 2010-02-17
PT2497772E (pt) 2015-02-05
PL2497772T3 (pl) 2015-05-29
HRP20120490T1 (hr) 2012-07-31
EP2086981A1 (en) 2009-08-12
CR20140544A (es) 2015-01-12
TWI401255B (zh) 2013-07-11
TW200829589A (en) 2008-07-16
AU2007322046B2 (en) 2012-04-05
KR101110458B1 (ko) 2012-03-13

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