EA015376B1 - СОЛИ ПРОИЗВОДНЫХ 6-ГЕТЕРОАРИЛ-(1,2,3,4,4a,10b)-ГЕКСАГИДРОФЕНАНТРИДИНА И ИХ ПРИМЕНЕНИЕ - Google Patents

СОЛИ ПРОИЗВОДНЫХ 6-ГЕТЕРОАРИЛ-(1,2,3,4,4a,10b)-ГЕКСАГИДРОФЕНАНТРИДИНА И ИХ ПРИМЕНЕНИЕ Download PDF

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Publication number
EA015376B1
EA015376B1 EA200701817A EA200701817A EA015376B1 EA 015376 B1 EA015376 B1 EA 015376B1 EA 200701817 A EA200701817 A EA 200701817A EA 200701817 A EA200701817 A EA 200701817A EA 015376 B1 EA015376 B1 EA 015376B1
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EA
Eurasian Patent Office
Prior art keywords
dimethoxypyridin
methoxy
ethoxy
compounds
hexahydrophenanthridin
Prior art date
Application number
EA200701817A
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English (en)
Russian (ru)
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EA200701817A1 (ru
Inventor
Ульрих Каутц
Маттиас Вебель
Кристиан Шойфлер
Рольф-Петер Хуммель
Original Assignee
Никомед Гмбх
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Application filed by Никомед Гмбх filed Critical Никомед Гмбх
Publication of EA200701817A1 publication Critical patent/EA200701817A1/ru
Publication of EA015376B1 publication Critical patent/EA015376B1/ru

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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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EA200701817A 2005-03-02 2006-03-01 СОЛИ ПРОИЗВОДНЫХ 6-ГЕТЕРОАРИЛ-(1,2,3,4,4a,10b)-ГЕКСАГИДРОФЕНАНТРИДИНА И ИХ ПРИМЕНЕНИЕ EA015376B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101619 2005-03-02
EP05108442 2005-09-14
PCT/EP2006/060377 WO2006092422A1 (en) 2005-03-02 2006-03-01 Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives

Publications (2)

Publication Number Publication Date
EA200701817A1 EA200701817A1 (ru) 2008-02-28
EA015376B1 true EA015376B1 (ru) 2011-08-30

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EA200701817A EA015376B1 (ru) 2005-03-02 2006-03-01 СОЛИ ПРОИЗВОДНЫХ 6-ГЕТЕРОАРИЛ-(1,2,3,4,4a,10b)-ГЕКСАГИДРОФЕНАНТРИДИНА И ИХ ПРИМЕНЕНИЕ

Country Status (24)

Country Link
US (4) US7718668B2 (https=)
EP (3) EP2189454B1 (https=)
JP (2) JP5478828B2 (https=)
KR (2) KR101352687B1 (https=)
AT (1) ATE450524T1 (https=)
AU (1) AU2006219867B2 (https=)
BR (1) BRPI0607645A2 (https=)
CA (1) CA2598860C (https=)
CY (1) CY1109753T1 (https=)
DE (1) DE602006010824D1 (https=)
DK (1) DK1856093T3 (https=)
EA (1) EA015376B1 (https=)
ES (2) ES2440590T3 (https=)
HR (1) HRP20100086T1 (https=)
IL (2) IL185276A (https=)
ME (1) ME01172B (https=)
MX (1) MX2007010400A (https=)
NO (1) NO339416B1 (https=)
NZ (2) NZ589278A (https=)
PL (1) PL1856093T3 (https=)
PT (1) PT1856093E (https=)
RS (1) RS51345B (https=)
SI (1) SI1856093T1 (https=)
WO (1) WO2006092422A1 (https=)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
EP1725534A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
WO2008028914A1 (en) 2006-09-07 2008-03-13 Nycomed Gmbh Combination treatment for diabetes mellitus
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
MX375348B (es) 2011-12-15 2025-03-06 Alkermes Pharma Ireland Ltd Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu.
WO2015110394A1 (en) 2014-01-22 2015-07-30 Takeda Gmbh Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier)
WO2018037109A1 (en) 2016-08-26 2018-03-01 Takeda Gmbh Treatment of nonalcoholic fatty liver disease
JP2020510071A (ja) 2017-03-16 2020-04-02 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング 特発性肺線維症の治療

Citations (5)

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Publication number Priority date Publication date Assignee Title
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