BRPI0607645A2 - sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila - Google Patents

sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila

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Publication number
BRPI0607645A2
BRPI0607645A2 BRPI0607645-9A BRPI0607645A BRPI0607645A2 BR PI0607645 A2 BRPI0607645 A2 BR PI0607645A2 BR PI0607645 A BRPI0607645 A BR PI0607645A BR PI0607645 A2 BRPI0607645 A2 BR PI0607645A2
Authority
BR
Brazil
Prior art keywords
salts
heterocyclyl substituted
derivatives
substituted hexahydrophenanthridine
hexahydrophenanthridine derivatives
Prior art date
Application number
BRPI0607645-9A
Other languages
English (en)
Inventor
Ulrich Kautz
Matthias Webel
Christian Scheufler
Rolf-Peter Hummel
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of BRPI0607645A2 publication Critical patent/BRPI0607645A2/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

SAIS DE DERIVADOS DE HEXAIDROFENANTRIDINA SUBSTITUìDOS COM 6-HETEROCICLILA. A presente invenção refere-se a sais de compostos de hexaidrofenantridina substituidos com 6-heteroarila inibidores, ou PDE4, que podem ser usados na indústria farmacêutica para a produção de composições farmacêuticas para o uso, por exemplo, no tratamento de distúrbios das vias aéreas.
BRPI0607645-9A 2005-03-02 2006-03-01 sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila BRPI0607645A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101619 2005-03-02
EP05108442 2005-09-14
PCT/EP2006/060377 WO2006092422A1 (en) 2005-03-02 2006-03-01 Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives

Publications (1)

Publication Number Publication Date
BRPI0607645A2 true BRPI0607645A2 (pt) 2009-09-22

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ID=36295528

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BRPI0607645-9A BRPI0607645A2 (pt) 2005-03-02 2006-03-01 sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila

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US (4) US7718668B2 (pt)
EP (3) EP1856093B1 (pt)
JP (2) JP5478828B2 (pt)
KR (2) KR101352687B1 (pt)
AT (1) ATE450524T1 (pt)
AU (1) AU2006219867B2 (pt)
BR (1) BRPI0607645A2 (pt)
CA (1) CA2598860C (pt)
CY (1) CY1109753T1 (pt)
DE (1) DE602006010824D1 (pt)
DK (1) DK1856093T3 (pt)
EA (1) EA015376B1 (pt)
ES (2) ES2440590T3 (pt)
HR (1) HRP20100086T1 (pt)
IL (2) IL185276A (pt)
ME (1) ME01172B (pt)
MX (1) MX2007010400A (pt)
NO (1) NO339416B1 (pt)
NZ (2) NZ560268A (pt)
PL (1) PL1856093T3 (pt)
PT (1) PT1856093E (pt)
RS (1) RS51345B (pt)
SI (1) SI1856093T1 (pt)
WO (1) WO2006092422A1 (pt)

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ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
CN104817534A (zh) 2004-03-03 2015-08-05 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
US20070185149A1 (en) * 2004-03-10 2007-08-09 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors
WO2006092422A1 (en) 2005-03-02 2006-09-08 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
JP2010502670A (ja) 2006-09-07 2010-01-28 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 真性糖尿病のための組合せ治療
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
MX2014007042A (es) 2011-12-15 2015-01-22 Alkermes Pharma Ireland Ltd Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu.
WO2015110394A1 (en) 2014-01-22 2015-07-30 Takeda Gmbh Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier)
CN110099686B (zh) 2016-08-26 2022-04-15 武田药品工业株式会社 非酒精性脂肪性肝病的治疗
WO2018167142A1 (en) 2017-03-16 2018-09-20 Takeda Gmbh Treatment of idiopathic pulmonary fibrosis

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IL227565A (en) 2015-05-31
IL185276A0 (en) 2008-02-09
NO20074843L (no) 2007-09-24
JP2008531655A (ja) 2008-08-14
ATE450524T1 (de) 2009-12-15
PT1856093E (pt) 2010-02-08
US20080194587A1 (en) 2008-08-14
ES2337083T3 (es) 2010-04-20
US8354535B2 (en) 2013-01-15
US8754218B2 (en) 2014-06-17
JP5478828B2 (ja) 2014-04-23
WO2006092422A1 (en) 2006-09-08
SI1856093T1 (sl) 2010-03-31
EP1856093A1 (en) 2007-11-21
US20140039001A1 (en) 2014-02-06
HRP20100086T1 (hr) 2010-04-30
DK1856093T3 (da) 2010-03-15
EP2189454A1 (en) 2010-05-26
MX2007010400A (es) 2008-01-11
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AU2006219867B2 (en) 2012-09-13
IL185276A (en) 2013-10-31
EA200701817A1 (ru) 2008-02-28
EA015376B1 (ru) 2011-08-30
KR101421914B1 (ko) 2014-07-22
KR20130108475A (ko) 2013-10-02
JP2014040482A (ja) 2014-03-06
CY1109753T1 (el) 2014-09-10
DE602006010824D1 (de) 2010-01-14
US20130096152A1 (en) 2013-04-18
US7718668B2 (en) 2010-05-18
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NO339416B1 (no) 2016-12-12
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