HRP20100086T1 - (2R,4aR,10bR)-6-(2,6-DIMETOKSIPIRIDIN-3-IL)-9-ETOKSI-8-METOKSI-1,2,3,4,4a,10b-HEKSAHIDROFENANTRIDIN-2-ol, HCI SOL - Google Patents

(2R,4aR,10bR)-6-(2,6-DIMETOKSIPIRIDIN-3-IL)-9-ETOKSI-8-METOKSI-1,2,3,4,4a,10b-HEKSAHIDROFENANTRIDIN-2-ol, HCI SOL Download PDF

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Publication number
HRP20100086T1
HRP20100086T1 HR20100086T HRP20100086T HRP20100086T1 HR P20100086 T1 HRP20100086 T1 HR P20100086T1 HR 20100086 T HR20100086 T HR 20100086T HR P20100086 T HRP20100086 T HR P20100086T HR P20100086 T1 HRP20100086 T1 HR P20100086T1
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Croatia
Prior art keywords
salt according
hexahydrophenanthridin
dimethoxypyridin
ethoxy
methoxy
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HR20100086T
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English (en)
Inventor
Kautz Ulrich
Webel Matthias
Scheufler Christian
Hummel Rolf-Peter
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Nycomed Gmbh
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Publication of HRP20100086T1 publication Critical patent/HRP20100086T1/hr

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Abstract

Spoj, naznačen time, da je (2R,4aR,10bR)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol hidroklorid. Patent sadrži još 8 patentnih zahtjeva.

Claims (9)

1. Spoj, naznačen time, da je (2R,4aR,10bR)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol hidroklorid.
2. Spoj, naznačen time, da je solvatni oblik soli u skladu sa zahtjevom 1.
3. Spoj, naznačen time, da je hidratni oblik soli u skladu sa zahtjevom 1.
4. Sol u skladu s bilo kojim zahtjevom 1 do 3, naznačena time, da je u kristaliničnom obliku.
5. Sol u skladu s bilo kojim zahtjevom 1 do 4, naznačena time, da je u krutom dozirnom obliku.
6. Sol u skladu s bilo kojim zahtjevom 1 do 4, naznačena time, da je za uporabu u liječenju bolesti.
7. Farmaceutski pripravak, naznačen time, da sadrži sol u skladu s bilo kojim zahtjevom 1 do 4 zajedno s farmaceutskim pomoćnim tvarima i/ili punilima.
8. Uporaba soli u skladu s bilo kojim zahtjevom 1 do 4, naznačena time, da se koristi za pripremu farmaceutskih pripravaka za liječenje PDE4 posredovanih poremećaja.
9. Uporaba soli u skladu s bilo kojim zahtjevom 1 do 4, naznačena time, da se koristi za pripremu farmaceutskih pripravaka za liječenje diabetes mellitus-a.
HR20100086T 2005-03-02 2010-02-18 (2R,4aR,10bR)-6-(2,6-DIMETOKSIPIRIDIN-3-IL)-9-ETOKSI-8-METOKSI-1,2,3,4,4a,10b-HEKSAHIDROFENANTRIDIN-2-ol, HCI SOL HRP20100086T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101619 2005-03-02
EP05108442 2005-09-14
PCT/EP2006/060377 WO2006092422A1 (en) 2005-03-02 2006-03-01 Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives

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HRP20100086T1 true HRP20100086T1 (hr) 2010-04-30

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HR20100086T HRP20100086T1 (hr) 2005-03-02 2010-02-18 (2R,4aR,10bR)-6-(2,6-DIMETOKSIPIRIDIN-3-IL)-9-ETOKSI-8-METOKSI-1,2,3,4,4a,10b-HEKSAHIDROFENANTRIDIN-2-ol, HCI SOL

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US (4) US7718668B2 (hr)
EP (3) EP2189454B1 (hr)
JP (2) JP5478828B2 (hr)
KR (2) KR101421914B1 (hr)
AT (1) ATE450524T1 (hr)
AU (1) AU2006219867B2 (hr)
BR (1) BRPI0607645A2 (hr)
CA (1) CA2598860C (hr)
CY (1) CY1109753T1 (hr)
DE (1) DE602006010824D1 (hr)
DK (1) DK1856093T3 (hr)
EA (1) EA015376B1 (hr)
ES (2) ES2440590T3 (hr)
HR (1) HRP20100086T1 (hr)
IL (2) IL185276A (hr)
ME (1) ME01172B (hr)
MX (1) MX2007010400A (hr)
NO (1) NO339416B1 (hr)
NZ (2) NZ589278A (hr)
PL (1) PL1856093T3 (hr)
PT (1) PT1856093E (hr)
RS (1) RS51345B (hr)
SI (1) SI1856093T1 (hr)
WO (1) WO2006092422A1 (hr)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
RS52916B (en) 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
NZ549254A (en) * 2004-03-10 2010-06-25 Nycomed Gmbh Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
NZ589278A (en) 2005-03-02 2012-04-27 Nycomed Gmbh Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP2063890A1 (en) 2006-09-07 2009-06-03 Nycomed GmbH Combination treatment for diabetes mellitus
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
KR101996108B1 (ko) 2011-12-15 2019-10-01 엘커메스 파마 아일랜드 리미티드 부프레놀핀 및 뮤-오피오이드 수용체 길항물질의 조성물
CA2936332A1 (en) 2014-01-22 2015-07-30 Takeda Gmbh Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier)
CN110099686B (zh) 2016-08-26 2022-04-15 武田药品工业株式会社 非酒精性脂肪性肝病的治疗
AU2018234059A1 (en) 2017-03-16 2019-10-31 Takeda Gmbh Treatment of idiopathic pulmonary fibrosis

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027055D0 (en) 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
SI0882021T1 (en) 1996-01-31 2003-10-31 Altana Pharma Ag New phenanthridines
ATE224386T1 (de) 1996-03-26 2002-10-15 Altana Pharma Ag Neue in 6-position substituierte phenanthridine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
NZ334976A (en) 1996-11-11 2000-10-27 Byk Gulden Lomberg Chem Fab Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses
AU6825898A (en) 1997-03-07 1998-09-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
US6384047B1 (en) 1997-06-03 2002-05-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
JP2001510827A (ja) 1997-07-25 2001-08-07 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 置換６−フェニルフェナントリジン
PL190685B1 (pl) 1997-07-25 2005-12-30 Altana Pharma Ag Nowe pochodne tetrazolu, środek farmaceutyczny oraz zastosowanie
DK1000034T3 (da) 1997-07-25 2003-01-27 Altana Pharma Ag Substituerede 6-alkylphenanthridiner
PT1075477E (pt) 1998-05-05 2003-07-31 Altana Pharma Ag Novos n-oxidos de benzonaftiridina
CA2342245A1 (en) 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
ES2242594T3 (es) 1999-01-15 2005-11-16 Altana Pharma Ag N-oxidos de fenantridinas con una acitvidad inhidora de pde-iv.
CN1152864C (zh) 1999-01-15 2004-06-09 奥坦纳医药公司 具有pde-iv抑制活性的苯基菲啶类化合物
EP1163226B1 (en) 1999-01-15 2007-03-14 ALTANA Pharma AG Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
AU2289400A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh 6-arylphenanthridines with pde-iv inhibiting activity
CA2359449A1 (en) 1999-01-15 2000-07-20 Beate Gutterer Phenanthridine-n-oxides with pde-iv inhibiting activity
AU782908B2 (en) 2000-01-11 2005-09-08 Altana Pharma Ag Phenanthridine-N-oxides
CA2404226A1 (en) 2000-03-23 2001-09-27 Takeda Chemical Industries, Ltd. Furoisoquinoline derivatives, process for producing the same and use thereof
WO2002006238A1 (en) 2000-07-14 2002-01-24 Altana Pharma Ag Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
WO2002006270A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-heteroarylphenanthridines
AU2001281965A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Novel 6-phenylphenanthridines
ES2236504T3 (es) 2001-02-21 2005-07-16 Altana Pharma Ag 6-fenilbenzonaftiridinas.
RS20050117A (en) 2002-08-17 2007-06-04 Altana Pharma Ag., Novel benzonaphthyridines
PL374014A1 (en) 2002-08-17 2005-09-19 Altana Pharma Ag Novel phenanthridines having pde 3/4 inhibiting properties
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
JP4587294B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン
JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
RS52916B (en) * 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
AR049419A1 (es) 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CA2558375A1 (en) 2004-03-09 2005-09-15 Altana Pharma Ag Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
WO2005087744A1 (en) 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
NZ549254A (en) 2004-03-10 2010-06-25 Nycomed Gmbh Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
JP2007527898A (ja) 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト ジフルオロエトキシ置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
NZ589278A (en) 2005-03-02 2012-04-27 Nycomed Gmbh Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives

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