UA99136C2 - Улучшенная фармацевтическая композиция, содержащая антагонист кальциевых каналов - лерканидипин, способ ее получения - Google Patents

Улучшенная фармацевтическая композиция, содержащая антагонист кальциевых каналов - лерканидипин, способ ее получения

Info

Publication number
UA99136C2
UA99136C2 UAA201000447A UAA201000447A UA99136C2 UA 99136 C2 UA99136 C2 UA 99136C2 UA A201000447 A UAA201000447 A UA A201000447A UA A201000447 A UAA201000447 A UA A201000447A UA 99136 C2 UA99136 C2 UA 99136C2
Authority
UA
Ukraine
Prior art keywords
lercanidipine
preparation
calcium channel
channel antagonist
pharmaceutical composition
Prior art date
Application number
UAA201000447A
Other languages
English (en)
Ukrainian (uk)
Inventor
Евангелос Каравас
Макис Коутрис
Вики Самара
Кристина Матсингоу
Атина Илиопоулоу
Original Assignee
Фарматен Са
Рекордати Ирланд Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39223083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99136(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Фарматен Са, Рекордати Ирланд Лимитед filed Critical Фарматен Са
Publication of UA99136C2 publication Critical patent/UA99136C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Данное изобретение относится к композициям твердых форм дозирования, содержащим терапевтически эффективное количество антагониста кальциевых каналов - производного дигидропиридина, такого как лерканидипин или его соль, в комбинации с коллоидным диоксидом кремния, таким как Аэросил™, для повышения биологической усвояемости и улучшения стойкости, и к способу их получения путем влажной грануляции.
UAA201000447A 2007-07-23 2008-07-23 Улучшенная фармацевтическая композиция, содержащая антагонист кальциевых каналов - лерканидипин, способ ее получения UA99136C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/006517 WO2009012791A1 (en) 2007-07-23 2007-07-23 Pharmaceutical composition containing dihydropyridine calcium channel antagonist and method for the preparation thereof

Publications (1)

Publication Number Publication Date
UA99136C2 true UA99136C2 (ru) 2012-07-25

Family

ID=39223083

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201001781A UA97161C2 (ru) 2007-07-23 2007-07-23 Фармацевтическая композиция, которая содержит дигидропиридиновый антагонист кальциевого канала лерканидипин и коллоидный диоксид кремния, способ ее приготовления
UAA201000447A UA99136C2 (ru) 2007-07-23 2008-07-23 Улучшенная фармацевтическая композиция, содержащая антагонист кальциевых каналов - лерканидипин, способ ее получения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201001781A UA97161C2 (ru) 2007-07-23 2007-07-23 Фармацевтическая композиция, которая содержит дигидропиридиновый антагонист кальциевого канала лерканидипин и коллоидный диоксид кремния, способ ее приготовления

Country Status (20)

Country Link
EP (2) EP2180883B1 (ru)
JP (2) JP5769963B2 (ru)
KR (2) KR101632079B1 (ru)
CN (3) CN101784260A (ru)
AU (2) AU2007356942B2 (ru)
BR (2) BRPI0721883A2 (ru)
CA (2) CA2691752C (ru)
CO (1) CO6290639A2 (ru)
CR (1) CR11285A (ru)
EA (2) EA021645B1 (ru)
EC (1) ECSP109984A (ru)
ES (2) ES2622495T3 (ru)
MA (1) MA31684B1 (ru)
MX (2) MX2010000856A (ru)
MY (1) MY153857A (ru)
NZ (2) NZ582648A (ru)
TN (2) TN2010000011A1 (ru)
UA (2) UA97161C2 (ru)
WO (2) WO2009012791A1 (ru)
ZA (2) ZA201000586B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
EA021645B1 (ru) * 2007-07-23 2015-08-31 Фарматен С.А. Твердая дозированная форма в виде таблетки и способ её приготовления
CR20170089A (es) 2009-04-03 2017-07-17 Plexxikon Inc Composiciones del acido propano-1--sulfonico {3-[5-(4-cloro-fenil)-1h-pirrolo [2,3-b] piridina-3-carbonil] -2,4-difluoro-fenil}-amida y el uso de las mismas
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011057022A1 (en) 2009-11-06 2011-05-12 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
RS58455B1 (sr) 2011-02-07 2019-04-30 Plexxikon Inc Jedinjenja i postupci za modulaciju kinaze, i indikacije za njih
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
KR102237799B1 (ko) 2012-11-14 2021-04-08 더블유.알. 그레이스 앤드 캄파니-콘. 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물
GR1008554B (el) * 2014-06-12 2015-09-03 ΦΑΡΜΑΤΕΝ ΑΝΩΝΥΜΟΣ ΒΙΟΜΗΧΑΝΙΚΗ ΚΑΙ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΙΑΤΡΙΚΩΝ ΚΑΙ ΚΑΛΛΥΝΤΙΚΩΝ ΠΡΟΪΟΝΤΩΝ με δ.τ. ΦΑΡΜΑΤΕΝ, Φαρμακευτικο σκευασμα περιεχον εναν αντιμυκητιασικο παραγοντα τριaζολης και μεθοδος για την παρασκευη αυτου
CN104069500A (zh) * 2014-06-20 2014-10-01 湖南天地恒一制药有限公司 一种包含乐卡地平的药物组合物
CN105168165B (zh) * 2015-08-28 2018-06-26 江苏福邦药业有限公司 一种盐酸乐卡地平片及其制备方法
WO2018004379A1 (ru) * 2016-07-01 2018-01-04 Общество С Ограниченной Ответственностью "Гиостин" Средство в виде капсулы для лечения заболеваний суставов
CN114533686B (zh) * 2022-02-15 2023-10-20 湖南普道医药技术有限公司 一种二氢吡啶类药物的口服固体制剂及其制备方法
KR20240040407A (ko) * 2022-09-21 2024-03-28 주식회사 종근당 사쿠비트릴ㆍ발사르탄 칼슘염을 포함하는 약제학적 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
GB9025251D0 (en) * 1990-11-20 1991-01-02 Solomon Montague C Nifedipine dosage forms
BR9903490A (pt) * 1998-12-15 2000-09-26 Oscar Gold Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica
DE19944803A1 (de) * 1999-09-20 2001-03-29 Bayer Ag Kombination von Dihydropyridinverbindungen und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
US20040185097A1 (en) * 2003-01-31 2004-09-23 Glenmark Pharmaceuticals Ltd. Controlled release modifying complex and pharmaceutical compositions thereof
WO2005053689A2 (en) * 2003-12-01 2005-06-16 Lifecycle Pharma A/S Pharmaceutical compositions comprising lercanidipine
UA89177C2 (ru) * 2003-12-01 2010-01-11 Рекордати Айрленд Лимитед Фармацевтическая композиция с контролируемым высвобождением, которая содержит лерканидипин
AU2007291509B2 (en) * 2006-08-30 2013-05-02 Jagotec Ag Controlled release oral dosage formulations comprising a core and one or more barrier layers
WO2008068777A2 (en) * 2006-12-06 2008-06-12 Torrent Pharmaceuticals Limited Stable lercanidipine formulation
EA021645B1 (ru) * 2007-07-23 2015-08-31 Фарматен С.А. Твердая дозированная форма в виде таблетки и способ её приготовления

Also Published As

Publication number Publication date
MX2010000801A (es) 2010-07-05
NZ582690A (en) 2011-12-22
ES2537063T3 (es) 2015-06-02
EA021645B1 (ru) 2015-08-31
JP5769963B2 (ja) 2015-08-26
EP2170295B1 (en) 2015-04-22
CR11285A (es) 2010-04-27
WO2009013306A1 (en) 2009-01-29
AU2007356942A1 (en) 2009-01-29
AU2008280106B2 (en) 2014-03-20
AU2007356942B2 (en) 2011-12-15
MY153857A (en) 2015-03-31
EA201000220A1 (ru) 2010-08-30
KR101512404B1 (ko) 2015-04-21
WO2009012791A1 (en) 2009-01-29
EP2180883B1 (en) 2017-01-11
ZA201001176B (en) 2010-11-24
KR20100045456A (ko) 2010-05-03
CA2691752C (en) 2016-01-26
MX2010000856A (es) 2010-04-30
JP2010534211A (ja) 2010-11-04
UA97161C2 (ru) 2012-01-10
TN2010000011A1 (en) 2011-09-26
ZA201000586B (en) 2011-03-30
ES2622495T3 (es) 2017-07-06
TN2010000022A1 (en) 2011-09-26
BRPI0721883A2 (pt) 2014-02-18
AU2008280106A2 (en) 2010-02-25
EP2180883A1 (en) 2010-05-05
CN101801347A (zh) 2010-08-11
AU2008280106A1 (en) 2009-01-29
KR20100047848A (ko) 2010-05-10
EA019614B1 (ru) 2014-05-30
KR101632079B1 (ko) 2016-06-20
CO6290639A2 (es) 2011-06-20
EP2170295A1 (en) 2010-04-07
ECSP109984A (es) 2010-04-30
MA31684B1 (fr) 2010-09-01
CN101784260A (zh) 2010-07-21
AU2008280106B9 (en) 2014-08-07
BRPI0814666A2 (pt) 2017-05-09
CA2693233A1 (en) 2009-01-29
NZ582648A (en) 2012-06-29
EA201070160A1 (ru) 2010-06-30
CA2691752A1 (en) 2009-01-29
JP2010534220A (ja) 2010-11-04
CN103976968A (zh) 2014-08-13

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