UA99136C2 - Improved pharmaceutical composition comprising a calcium channel antagonist such as lercanidipine, process for the preparation thereof - Google Patents

Improved pharmaceutical composition comprising a calcium channel antagonist such as lercanidipine, process for the preparation thereof

Info

Publication number
UA99136C2
UA99136C2 UAA201000447A UAA201000447A UA99136C2 UA 99136 C2 UA99136 C2 UA 99136C2 UA A201000447 A UAA201000447 A UA A201000447A UA A201000447 A UAA201000447 A UA A201000447A UA 99136 C2 UA99136 C2 UA 99136C2
Authority
UA
Ukraine
Prior art keywords
lercanidipine
preparation
calcium channel
channel antagonist
pharmaceutical composition
Prior art date
Application number
UAA201000447A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Евангелос Каравас
Макис Коутрис
Вики Самара
Кристина Матсингоу
Атина Илиопоулоу
Original Assignee
Фарматен Са
Рекордати Ирланд Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39223083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99136(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Фарматен Са, Рекордати Ирланд Лимитед filed Critical Фарматен Са
Publication of UA99136C2 publication Critical patent/UA99136C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The present invention relates to the formulation of solid dosage forms comprising a therapeutically effective amount of a dihydropyridine calcium channel antagonist such as Lercanidipine or salt thereof, in combination with colloidal silicon dioxide such as Aerosil to enhance bioavailability and improve solubility, and a process for the preparation thereof by wet granulation.
UAA201000447A 2007-07-23 2008-07-23 Improved pharmaceutical composition comprising a calcium channel antagonist such as lercanidipine, process for the preparation thereof UA99136C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2007/006517 WO2009012791A1 (en) 2007-07-23 2007-07-23 Pharmaceutical composition containing dihydropyridine calcium channel antagonist and method for the preparation thereof

Publications (1)

Publication Number Publication Date
UA99136C2 true UA99136C2 (en) 2012-07-25

Family

ID=39223083

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201001781A UA97161C2 (en) 2007-07-23 2007-07-23 Normal;heading 1;heading 2;heading 3;PHARMACEUTICAL COMPOSITION CONTAINING DIHYDROPYRIDINE CALCIUM CHANNEL ANTAGONIST AND METHOD FOR THE PREPARATION THEREOF
UAA201000447A UA99136C2 (en) 2007-07-23 2008-07-23 Improved pharmaceutical composition comprising a calcium channel antagonist such as lercanidipine, process for the preparation thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201001781A UA97161C2 (en) 2007-07-23 2007-07-23 Normal;heading 1;heading 2;heading 3;PHARMACEUTICAL COMPOSITION CONTAINING DIHYDROPYRIDINE CALCIUM CHANNEL ANTAGONIST AND METHOD FOR THE PREPARATION THEREOF

Country Status (20)

Country Link
EP (2) EP2180883B1 (en)
JP (2) JP5769963B2 (en)
KR (2) KR101632079B1 (en)
CN (3) CN101784260A (en)
AU (2) AU2007356942B2 (en)
BR (2) BRPI0721883A2 (en)
CA (2) CA2691752C (en)
CO (1) CO6290639A2 (en)
CR (1) CR11285A (en)
EA (2) EA021645B1 (en)
EC (1) ECSP109984A (en)
ES (2) ES2622495T3 (en)
MA (1) MA31684B1 (en)
MX (2) MX2010000856A (en)
MY (1) MY153857A (en)
NZ (2) NZ582648A (en)
TN (2) TN2010000011A1 (en)
UA (2) UA97161C2 (en)
WO (2) WO2009012791A1 (en)
ZA (2) ZA201000586B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
BRPI0814423B1 (en) 2007-07-17 2022-04-19 Plexxikon, Inc Kinase modulating compounds and pharmaceutical composition comprising the same
ES2622495T3 (en) * 2007-07-23 2017-07-06 Pharmathen S.A. Pharmaceutical composition containing a dihydropyridine calcium channel antagonist and method for its preparation
AR078033A1 (en) 2009-04-03 2011-10-12 Plexxikon Inc A SOLID DISPERSION, CONTAINING THE COMPOUND {3- [5- (4- (CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDA OF PROPANE-1-SULPHONIC ACID, COMPOSITIONS AND FORMULATIONS THAT INCLUDE SUCH SOLID DISPERSION; METHODS FOR MANUFACTURING SUCH SOLID DISPERSION, FORMS 1 AND 2
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (en) 2009-11-06 2017-09-20 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications for it
MA34948B1 (en) 2011-02-07 2014-03-01 Plexxikon Inc COMPOUNDS AND METHODS FOR MODULATING KINASE, AND INDICATIONS THEREOF
TWI558702B (en) 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
ES2821528T3 (en) 2012-11-14 2021-04-26 Grace W R & Co Compositions containing a biologically active material and an unordered inorganic oxide
GR1008554B (en) * 2014-06-12 2015-09-03 ΦΑΡΜΑΤΕΝ ΑΝΩΝΥΜΟΣ ΒΙΟΜΗΧΑΝΙΚΗ ΚΑΙ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΙΑΤΡΙΚΩΝ ΚΑΙ ΚΑΛΛΥΝΤΙΚΩΝ ΠΡΟΪΟΝΤΩΝ με δ.τ. ΦΑΡΜΑΤΕΝ, Pharmaceutical preparation containing an antifugal trizol factor - preparation method of the same
CN104069500A (en) * 2014-06-20 2014-10-01 湖南天地恒一制药有限公司 Pharmaceutical composition containing lercanidipine
CN105168165B (en) * 2015-08-28 2018-06-26 江苏福邦药业有限公司 A kind of Lercanidipine hydrochloride piece and preparation method thereof
WO2018004379A1 (en) * 2016-07-01 2018-01-04 Общество С Ограниченной Ответственностью "Гиостин" Medication in capsule form for the treatment of joint diseases
CN114533686B (en) * 2022-02-15 2023-10-20 湖南普道医药技术有限公司 Oral solid preparation of dihydropyridines medicine and preparation method thereof
KR20240040407A (en) * 2022-09-21 2024-03-28 주식회사 종근당 Pharmaceutical composition comprising sacubitril valsartan calcium salt

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3720757A1 (en) * 1987-06-24 1989-01-05 Bayer Ag DHP COAT TABLET
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
GB9025251D0 (en) * 1990-11-20 1991-01-02 Solomon Montague C Nifedipine dosage forms
BR9903490A (en) * 1998-12-15 2000-09-26 Oscar Gold Process for the preparation of programmed-release pharmaceutical compositions containing nimodipine, which allow for the gradual release and maintenance of therapeutic action
DE19944803A1 (en) * 1999-09-20 2001-03-29 Bayer Ag Combination of dihydropyridine compounds and HMG-CoA reductase inhibitors and their use in drugs
US20040185097A1 (en) * 2003-01-31 2004-09-23 Glenmark Pharmaceuticals Ltd. Controlled release modifying complex and pharmaceutical compositions thereof
ZA200605290B (en) * 2003-12-01 2007-10-31 Lifecycle Pharma As Pharmaceutical compositions comprising lercanidipine
BRPI0417043A (en) * 2003-12-01 2007-02-06 Lifecycle Pharma As pharmaceutical composition, solid dosage form, manufacturing method of solid dosage form, and, use of the composition
KR101575679B1 (en) * 2006-08-30 2015-12-08 자고텍 아게 Controlled release oral dosage formulations comprising a core and one or more barrier layers
WO2008068777A2 (en) * 2006-12-06 2008-06-12 Torrent Pharmaceuticals Limited Stable lercanidipine formulation
ES2622495T3 (en) * 2007-07-23 2017-07-06 Pharmathen S.A. Pharmaceutical composition containing a dihydropyridine calcium channel antagonist and method for its preparation

Also Published As

Publication number Publication date
EP2180883B1 (en) 2017-01-11
WO2009013306A1 (en) 2009-01-29
EP2170295A1 (en) 2010-04-07
MX2010000801A (en) 2010-07-05
KR101512404B1 (en) 2015-04-21
TN2010000022A1 (en) 2011-09-26
BRPI0721883A2 (en) 2014-02-18
EP2180883A1 (en) 2010-05-05
WO2009012791A1 (en) 2009-01-29
AU2008280106A2 (en) 2010-02-25
ECSP109984A (en) 2010-04-30
EA021645B1 (en) 2015-08-31
ES2622495T3 (en) 2017-07-06
NZ582648A (en) 2012-06-29
CN103976968A (en) 2014-08-13
EP2170295B1 (en) 2015-04-22
AU2007356942B2 (en) 2011-12-15
MX2010000856A (en) 2010-04-30
AU2007356942A1 (en) 2009-01-29
EA201070160A1 (en) 2010-06-30
JP2010534220A (en) 2010-11-04
KR20100047848A (en) 2010-05-10
ZA201000586B (en) 2011-03-30
ZA201001176B (en) 2010-11-24
AU2008280106B2 (en) 2014-03-20
CR11285A (en) 2010-04-27
AU2008280106A1 (en) 2009-01-29
CA2693233A1 (en) 2009-01-29
JP5769963B2 (en) 2015-08-26
JP2010534211A (en) 2010-11-04
CN101801347A (en) 2010-08-11
BRPI0814666A2 (en) 2017-05-09
NZ582690A (en) 2011-12-22
CA2691752C (en) 2016-01-26
MA31684B1 (en) 2010-09-01
AU2008280106B9 (en) 2014-08-07
KR101632079B1 (en) 2016-06-20
TN2010000011A1 (en) 2011-09-26
CA2691752A1 (en) 2009-01-29
CN101784260A (en) 2010-07-21
ES2537063T3 (en) 2015-06-02
UA97161C2 (en) 2012-01-10
KR20100045456A (en) 2010-05-03
CO6290639A2 (en) 2011-06-20
EA019614B1 (en) 2014-05-30
EA201000220A1 (en) 2010-08-30
MY153857A (en) 2015-03-31

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