BR9903490A - Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica - Google Patents

Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica

Info

Publication number
BR9903490A
BR9903490A BR9903490-5A BR9903490A BR9903490A BR 9903490 A BR9903490 A BR 9903490A BR 9903490 A BR9903490 A BR 9903490A BR 9903490 A BR9903490 A BR 9903490A
Authority
BR
Brazil
Prior art keywords
substances
release
preparation
nimodipine
maintenance
Prior art date
Application number
BR9903490-5A
Other languages
English (en)
Inventor
Oscar Gold
Original Assignee
Oscar Gold
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oscar Gold filed Critical Oscar Gold
Publication of BR9903490A publication Critical patent/BR9903490A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

''PROCESSO PARA A PREPARAçãO DE COMPOSIçõES FARMACEUTICAS DE LIBERAçãO PROGRAMADA CONTENDO NIMODIPINE, QUE PERMITEM A LIBERAçãO GRADUAL E A MANUTENçãO DA AçãO TERAPEUTICA" Trata-se de um processo para obtenção de preparações de liberação programada de Nimodipine, compreendendo essencialmente: I - preparação de uma substância granulada em que a característica de solubilidade de Nimodipine é modificada, dita solução da droga sendo preparada com substâncias que modificam a solubilidade dessa droga, essas substâncias sendo capazes de formarem uma solução sólida com essa droga, dita solução sendo embebida em substâncias desintegrantes e este pó úmido sendo misturado, granulado através de uma malha de aço inoxidável (abertura de 1,5 a 2 mm) e em seguida sêca; II - as partículas da substâncias granulada sêca sendo colocadas numa vasilha grande rasa onde é aplicada uma cobertura com substâncias poliméricas em solução por aspersão e em seguida sêca por sopro de ar quente; III - prensagem dos grânulos revestidos a fim de se obter comprimidos contendo 60 e 90mg de Nimodipine.
BR9903490-5A 1998-12-15 1999-08-13 Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica BR9903490A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR9801063 1998-12-15

Publications (1)

Publication Number Publication Date
BR9903490A true BR9903490A (pt) 2000-09-26

Family

ID=3461075

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9903490-5A BR9903490A (pt) 1998-12-15 1999-08-13 Processo para a preparação de composições farmacêuticas de liberação programada contendo nimodipine, que permitem a liberação gradual e a manuntenção da ação terapeutica

Country Status (2)

Country Link
EP (1) EP1013271A3 (pt)
BR (1) BR9903490A (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101784260A (zh) * 2007-07-23 2010-07-21 法尔玛赞公司 包含二氢吡啶钙通道拮抗剂的药物组合物及其制备方法
DE102010051890A1 (de) 2010-11-22 2012-05-24 Wilhelm Schauerte Gmbh & Co. Kg Be-/Entlüftungsautomat mit Elasto-mer-Membran
CN112206214A (zh) * 2020-11-06 2021-01-12 迪沙药业集团有限公司 一种用于治疗高血压的药物组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3270785D1 (en) * 1981-10-29 1986-05-28 Bayer Ag Process for preparing solid fast-releasing drug formulations of dihydropyridines
DK0386440T3 (da) * 1989-02-11 1992-09-14 Bayer Ag Lægemidler med kontrolleret afgivelse af virksomt stof

Also Published As

Publication number Publication date
EP1013271A3 (en) 2000-11-22
EP1013271A2 (en) 2000-06-28

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Legal Events

Date Code Title Description
B25C Requirement related to requested transfer of rights

Owner name: OSCAR GOLD (AR)

Free format text: A FIM DE ATENDER O SOLICITADO NA PETICAO DE TRANSFERENCIA NO 018060013911/SP, DE 14/02/06, QUEIRA APRESENTAR A PROCURACAO DA CESSIONARIA, BEM COMO A TRADUCAO DO DOCUMENTO DE CESSAO.

B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: DESCONHECIDA A PETICAO DE TRANSFERENCIA NO 018060013912/SP DE 14/02/2006, POR FALTA DE FUNDAMENTACAO LEGAL.

B25B Requested transfer of rights rejected

Owner name: OSCAR GOLD (AR)

Free format text: INDEFERIDO O PEDIDO DE TRANSFERENCIA DE TITULARIDADE POR FALTA DE CUMPRIMENTO DE EXIGENCIA, PUBLICADA NA RPI 1856 DE 01/08/2006.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1914 DE 11/09/2007.