AR066000A1 - Procedimiento para preparar comprimidos de dihidrocloruro de pramipexol - Google Patents

Procedimiento para preparar comprimidos de dihidrocloruro de pramipexol

Info

Publication number
AR066000A1
AR066000A1 ARP080101470A ARP080101470A AR066000A1 AR 066000 A1 AR066000 A1 AR 066000A1 AR P080101470 A ARP080101470 A AR P080101470A AR P080101470 A ARP080101470 A AR P080101470A AR 066000 A1 AR066000 A1 AR 066000A1
Authority
AR
Argentina
Prior art keywords
tablets
ingredients
tablet
intragranular
dihydrochloride
Prior art date
Application number
ARP080101470A
Other languages
English (en)
Inventor
Noel Cotton
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR066000A1 publication Critical patent/AR066000A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Abstract

Un proceso para preparar comprimidos de dihidrocloruro de pramipexol. En particular, la presente se refiere a un proceso para preparar comprimidos de dihidrocloruro de pramipexol, en el que los comprimidos muestran propiedades mejoradas deestabilidad de conservacion. Reivindicacion 1: Un proceso para preparar comprimidos de dihidrocloruro de pramipexol que comprenden ingredientes de formacion de comprimidos intragranulares, dihidrocloruro de pramipexol o una sal farmacéuticamenteaceptable del mismo, una suspension de ligante, y agentes de formacion de comprimidos extragranulares, en el que al menos una porcion del proceso se realiza en un sistema cerrado, caracterizado porque comprende las etapas de: (a) ajustar el tamanode los ingredientes de formacion de comprimidos intragranulares para formar partículas de tamano uniforme de ingredientes de formacion de comprimidos intragranulares, (b) mezclar las partículas de ingredientes de formacion de comprimidosintragranulares en un granulador-mezclador, (c) disolver el dihidrocloruro de pramipexol, o una sal farmacéuticamente aceptable, en agua para formar una disolucion acuosa de dihidrocloruro de pramipexol, y anadir la disolucion de dihidrocloruro depramipexol sobre las partículas de los ingredientes de formacion de comprimidos intragranulares en el granulador-mezclador, (d) preparar una suspension de ligante y anadir la suspension de ligante al granulador-mezclador, (e) mezclar las partículasde los ingredientes de formacion de comprimidos intragranulares, la disolucion de dihidrocloruro de pramipexol y la suspension de ligante en el granulador-mezclador para formar una premezcla, (f) granular dicha premezcla para formar una premezclagranulada, (g) secar dicha premezcla granulada hasta un contenido en humedad final de aproximadamente 1,5% a aproximadamente 2,5, (h) mezclar dicha premezcla granulada de la etapa (g) con los agentes de formacion de comprimidos extragranulares ymezclar para formar una mezcla final, (i) comprimir la mezcla final en comprimidos utilizando una prensa de comprimidos.
ARP080101470A 2007-04-10 2008-04-09 Procedimiento para preparar comprimidos de dihidrocloruro de pramipexol AR066000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/733,602 US20080254117A1 (en) 2007-04-10 2007-04-10 Process for preparing pramipexole dihydrochloride tablets

Publications (1)

Publication Number Publication Date
AR066000A1 true AR066000A1 (es) 2009-07-15

Family

ID=39791070

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101470A AR066000A1 (es) 2007-04-10 2008-04-09 Procedimiento para preparar comprimidos de dihidrocloruro de pramipexol

Country Status (5)

Country Link
US (4) US20080254117A1 (es)
AR (1) AR066000A1 (es)
CL (1) CL2008001014A1 (es)
TW (1) TW200906397A (es)
WO (1) WO2008122638A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200906997A1 (tr) 2009-09-11 2011-03-21 Sanovel �La� San. Ve T�C. A. �. Pramipeksol farmasötik bileşimleri.
JP2013526601A (ja) 2010-05-24 2013-06-24 ルピン・リミテッド プラミペキソールの徐放性製剤
WO2012140604A1 (en) * 2011-04-15 2012-10-18 Sandoz Ag Stable formulations of pramipexole hydrochloride
WO2013034173A1 (en) * 2011-09-06 2013-03-14 Synthon Bv Pramipexole extended release tablets
JP7271437B2 (ja) 2017-04-10 2023-05-11 チェイス セラピューティクス コーポレイション Ｎｋ１拮抗薬組み合わせおよびシヌクレイノパチーを治療する方法
US11266633B2 (en) 2017-06-30 2022-03-08 Chase Therapeutics Corporation NK-1 antagonist compositions and methods for use in treating depression

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3572485D1 (en) * 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
DE3937271A1 (de) * 1989-11-09 1991-05-16 Boehringer Ingelheim Kg Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol
DE19830201A1 (de) * 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
CA2301899C (en) * 1998-07-27 2008-11-18 Boehringer Ingelheim Pharma Kg Agent with an antidepressant activity
JP2004505917A (ja) * 2000-08-08 2004-02-26 テバ　ファーマシューティカル　インダストリーズ　リミティド 安定なペルゴリドメシラート及びその作成の方法
DE10148233A1 (de) * 2001-09-28 2003-04-10 Boehringer Ingelheim Pharma Verbindungen zur Reduzierung übermäßiger Nahrungsaufnahme
MXPA04006163A (es) * 2001-12-20 2004-11-01 Pharmacia Corp Formas de dosis de liberacion sostenida del orden-cero y metodo de fabricacion de las mismas.
US20030215498A1 (en) * 2002-05-17 2003-11-20 Harland Ronald S. Rapidly disintegrating comressed tablets comprising biologically active compounds
ES2199061B1 (es) * 2002-06-10 2005-02-16 Laboratorios Vita, S.A. Comprimidos bucodispersables y procedimiento para su obtencion.
CN101780080B (zh) * 2003-01-16 2014-06-04 阿卡蒂亚药品公司 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂
CN1819819B (zh) * 2003-05-07 2011-03-09 株式会社三养社 用于制备速熔片的高度可塑性颗粒
DE10333393A1 (de) * 2003-07-23 2005-02-24 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit dem Wirkstoff Pramipexol
RS51527B2 (sr) * 2004-08-13 2018-02-28 Boehringer Ingelheim Int Tabletna formulacija sa produženim otpuštanjem koja sadrži pramipeksol ili njegovu farmaceutski prihvatljivu so, postupak za proizvodnju iste i njena primena
US20070148238A1 (en) * 2005-06-23 2007-06-28 Spherics, Inc. Dosage forms for movement disorder treatment
WO2008023027A2 (en) * 2006-08-24 2008-02-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing pramipexole dihydrochloride tablets with high storage stability
US20080254118A1 (en) * 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets

Also Published As

Publication number Publication date
US20080254117A1 (en) 2008-10-16
US20130221561A1 (en) 2013-08-29
TW200906397A (en) 2009-02-16
WO2008122638A2 (en) 2008-10-16
WO2008122638A3 (en) 2008-12-04
US20100252949A1 (en) 2010-10-07
US20120267817A1 (en) 2012-10-25
CL2008001014A1 (es) 2009-01-16

Similar Documents

Publication Publication Date Title
AR062509A1 (es) Proceso para preparar comprimidos de dihidrocloruro de pramipexol
AR066000A1 (es) Procedimiento para preparar comprimidos de dihidrocloruro de pramipexol
HRP20200046T1 (hr) Formulacije apiksabana
BRPI0606187A2 (pt) comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
EP1893176B1 (de) Herstellung von festen lösungen schwerlöslicher wirkstoffe durch kurzzeitüberhitzung und schnelle trocknung
ES2875966T3 (es) Preparación de formas farmacéuticas estables
BRPI0707044B8 (pt) comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais
UY32127A (es) Granulado conteniendo nicotina con muy reducida o nula producción de polvo en procesos donde se utilice y procedimientos de preparación
HRP20120719T1 (hr) Kruti oblik doziranja koji sadrži inhibitor protonske pumpe i od njega dobivena suspenzija
HRP20100674T1 (hr) Farmaceutski pripravak koji sadrzi omega-karboksiaril supstituirani difenil ureu za lijecenje raka
BRPI0621789A2 (pt) composições farmacêuticas com memantina
MX2010005087A (es) Formulacion solida de liberacion rapida, preparacion y uso de la misma.
JO3762B1 (ar) حبيبات للمستحضرات الدوائية وطرق أجهزة لإنتاجها
AR095159A2 (es) Una composición farmacéutica en forma de cápsula para administración oral
ES2624231T3 (es) Coadyuvante de formación de comprimidos a base de lactosa y celulosa
AR055953A1 (es) Formulaciones de acido hidroxamico suberoilanilida y procedimientos para la producion de las mismas
NO20054417L (no) Fremgangsmate for fremstilling av farmasoytiske preperater i form av fibratholdige tabletter og de derved fremstilte tabletter
Liu et al. Gastric floating pill enhances the bioavailability and drug efficacy of dihydromyricetin in vivo
AR025879A1 (es) Granulaciones de celulosa hidrolizada de sales de farmacos
RU2016106328A (ru) Противотуберкулезная стабильная фармацевтическая композиция в форме диспергируемой таблетки, содержащей гранулированный изониазид и гранулированный рифапентин, и способ ее приготовления
ATE526961T1 (de) Pharmazeutische zusammensetzung mit atorvastatin als wirkstoff
Nawale et al. Formulation and evaluation of domperidone orodispersible tablet
Garala Kevin et al. Fast-disintegrating aceclofenac tablets: formulation development using simplex lattice design
HRP20191669T1 (hr) Farmaceutski sastav koji sadrži polimer koji veže fosfate
Dineshmohan Effect of hydrophilic and hydrophobic polymer combinations in vildagliptin sustained release tablets: Fabrication and in vitro characterization