ME01172B - (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so - Google Patents

(2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so

Info

Publication number
ME01172B
ME01172B MEP-2010-34A MEP3410A ME01172B ME 01172 B ME01172 B ME 01172B ME P3410 A MEP3410 A ME P3410A ME 01172 B ME01172 B ME 01172B
Authority
ME
Montenegro
Prior art keywords
heterocyclyl substituted
novel salts
derivatives
substituted hexahydrophenanthridine
hexahydrophenanthridine derivatives
Prior art date
Application number
MEP-2010-34A
Other languages
English (en)
French (fr)
Inventor
Rolf-Peter Hummel
Christian Scheufler
Ulrich Kautz
Matthias Webel
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of ME01172B publication Critical patent/ME01172B/me

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
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  • Psychiatry (AREA)
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MEP-2010-34A 2005-03-02 2006-03-01 (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so ME01172B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05101619 2005-03-02
EP05108442 2005-09-14
PCT/EP2006/060377 WO2006092422A1 (en) 2005-03-02 2006-03-01 Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP06708593A EP1856093B1 (en) 2005-03-02 2006-03-01 (2R,4aR,10bR)-6-(2,6-dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol, HCl salt

Publications (1)

Publication Number Publication Date
ME01172B true ME01172B (me) 2013-03-20

Family

ID=36295528

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MEP-2010-34A ME01172B (me) 2005-03-02 2006-03-01 (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so

Country Status (24)

Country Link
US (4) US7718668B2 (me)
EP (3) EP2189454B1 (me)
JP (2) JP5478828B2 (me)
KR (2) KR101421914B1 (me)
AT (1) ATE450524T1 (me)
AU (1) AU2006219867B2 (me)
BR (1) BRPI0607645A2 (me)
CA (1) CA2598860C (me)
CY (1) CY1109753T1 (me)
DE (1) DE602006010824D1 (me)
DK (1) DK1856093T3 (me)
EA (1) EA015376B1 (me)
ES (2) ES2440590T3 (me)
HR (1) HRP20100086T1 (me)
IL (2) IL185276A (me)
ME (1) ME01172B (me)
MX (1) MX2007010400A (me)
NO (1) NO339416B1 (me)
NZ (2) NZ589278A (me)
PL (1) PL1856093T3 (me)
PT (1) PT1856093E (me)
RS (1) RS51345B (me)
SI (1) SI1856093T1 (me)
WO (1) WO2006092422A1 (me)

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JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
RS52916B (en) 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
NZ549254A (en) * 2004-03-10 2010-06-25 Nycomed Gmbh Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
NZ589278A (en) 2005-03-02 2012-04-27 Nycomed Gmbh Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP2063890A1 (en) 2006-09-07 2009-06-03 Nycomed GmbH Combination treatment for diabetes mellitus
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
KR101996108B1 (ko) 2011-12-15 2019-10-01 엘커메스 파마 아일랜드 리미티드 부프레놀핀 및 뮤-오피오이드 수용체 길항물질의 조성물
CA2936332A1 (en) 2014-01-22 2015-07-30 Takeda Gmbh Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier)
CN110099686B (zh) 2016-08-26 2022-04-15 武田药品工业株式会社 非酒精性脂肪性肝病的治疗
AU2018234059A1 (en) 2017-03-16 2019-10-31 Takeda Gmbh Treatment of idiopathic pulmonary fibrosis

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AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
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JP2014040482A (ja) 2014-03-06
SI1856093T1 (sl) 2010-03-31
US7718668B2 (en) 2010-05-18
US8354535B2 (en) 2013-01-15
CA2598860A1 (en) 2006-09-08
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EP1856093B1 (en) 2009-12-02
WO2006092422A1 (en) 2006-09-08
US20130096152A1 (en) 2013-04-18
MX2007010400A (es) 2008-01-11
EP2189454A1 (en) 2010-05-26
IL185276A (en) 2013-10-31
DE602006010824D1 (de) 2010-01-14
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EP2295423B1 (en) 2013-10-02
HRP20100086T1 (hr) 2010-04-30
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AU2006219867B2 (en) 2012-09-13
US8829189B2 (en) 2014-09-09
KR20130108475A (ko) 2013-10-02
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US8754218B2 (en) 2014-06-17
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