ME01172B - (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so - Google Patents

(2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so

Info

Publication number
ME01172B
ME01172B MEP-2010-34A MEP3410A ME01172B ME 01172 B ME01172 B ME 01172B ME P3410 A MEP3410 A ME P3410A ME 01172 B ME01172 B ME 01172B
Authority
ME
Montenegro
Prior art keywords
heterocyclyl substituted
novel salts
derivatives
substituted hexahydrophenanthridine
hexahydrophenanthridine derivatives
Prior art date
Application number
MEP-2010-34A
Other languages
English (en)
French (fr)
Inventor
Rolf-Peter Hummel
Christian Scheufler
Ulrich Kautz
Matthias Webel
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of ME01172B publication Critical patent/ME01172B/me

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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MEP-2010-34A 2005-03-02 2006-03-01 (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so ME01172B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05101619 2005-03-02
EP05108442 2005-09-14
EP06708593A EP1856093B1 (en) 2005-03-02 2006-03-01 (2R,4aR,10bR)-6-(2,6-dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol, HCl salt
PCT/EP2006/060377 WO2006092422A1 (en) 2005-03-02 2006-03-01 Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives

Publications (1)

Publication Number Publication Date
ME01172B true ME01172B (me) 2013-03-20

Family

ID=36295528

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MEP-2010-34A ME01172B (me) 2005-03-02 2006-03-01 (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so

Country Status (24)

Country Link
US (4) US7718668B2 (me)
EP (3) EP2295423B1 (me)
JP (2) JP5478828B2 (me)
KR (2) KR101352687B1 (me)
AT (1) ATE450524T1 (me)
AU (1) AU2006219867B2 (me)
BR (1) BRPI0607645A2 (me)
CA (1) CA2598860C (me)
CY (1) CY1109753T1 (me)
DE (1) DE602006010824D1 (me)
DK (1) DK1856093T3 (me)
EA (1) EA015376B1 (me)
ES (2) ES2337083T3 (me)
HR (1) HRP20100086T1 (me)
IL (2) IL185276A (me)
ME (1) ME01172B (me)
MX (1) MX2007010400A (me)
NO (1) NO339416B1 (me)
NZ (2) NZ589278A (me)
PL (1) PL1856093T3 (me)
PT (1) PT1856093E (me)
RS (1) RS51345B (me)
SI (1) SI1856093T1 (me)
WO (1) WO2006092422A1 (me)

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JP4587295B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての３−ヒドロキシ−６−フェニルフェナントリジン
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
EA017282B1 (ru) 2004-03-03 2012-11-30 Никомед Гмбх Производное гидрокси-6-гетероарилфенантридина и его применение в качестве ингибитора pde4
US20070185149A1 (en) * 2004-03-10 2007-08-09 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors
ME01172B (me) 2005-03-02 2013-03-20 Takeda Gmbh (2r,4ar,10br)-6-(2,6-dimetoksipiridin-3-il)-9-etoksi-8-metoksi-1,2,3,4,4a,10b-heksahidrofenantridin-2-ol, hci so
EA200900392A1 (ru) 2006-09-07 2010-06-30 Никомед Гмбх Комбинированное лечение сахарного диабета
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
US8822488B2 (en) 2011-12-15 2014-09-02 Alkermes Pharma Ireland Limited Compositions of buprenorphine and μ antagonists
EP3096760A1 (en) 2014-01-22 2016-11-30 Takeda GmbH Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier)
JP7048863B2 (ja) 2016-08-26 2022-04-06 武田薬品工業株式会社 非アルコール性脂肪肝疾患の治療法
CN110573148A (zh) 2017-03-16 2019-12-13 武田有限公司 特发性肺纤维化的治疗

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GB9027055D0 (en) 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
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