DE602006010824D1 - (2R,4aR,10bR)-6-(2,6-Dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol Hydrochloridsalz - Google Patents

(2R,4aR,10bR)-6-(2,6-Dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol Hydrochloridsalz

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Publication number
DE602006010824D1
DE602006010824D1 DE602006010824T DE602006010824T DE602006010824D1 DE 602006010824 D1 DE602006010824 D1 DE 602006010824D1 DE 602006010824 T DE602006010824 T DE 602006010824T DE 602006010824 T DE602006010824 T DE 602006010824T DE 602006010824 D1 DE602006010824 D1 DE 602006010824D1
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Germany
Prior art keywords
hexahydrophenanthridine
dimethoxypyridin
ethoxy
methoxy
hydrochloride salt
Prior art date
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Active
Application number
DE602006010824T
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English (en)
Inventor
Ulrich Kautz
Matthias Webel
Christian Scheufler
Rolf-Peter Hummel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
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Publication of DE602006010824D1 publication Critical patent/DE602006010824D1/de
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DE602006010824T 2005-03-02 2006-03-01 (2R,4aR,10bR)-6-(2,6-Dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol Hydrochloridsalz Active DE602006010824D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101619 2005-03-02
EP05108442 2005-09-14
PCT/EP2006/060377 WO2006092422A1 (en) 2005-03-02 2006-03-01 Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives

Publications (1)

Publication Number Publication Date
DE602006010824D1 true DE602006010824D1 (de) 2010-01-14

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DE602006010824T Active DE602006010824D1 (de) 2005-03-02 2006-03-01 (2R,4aR,10bR)-6-(2,6-Dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol Hydrochloridsalz

Country Status (24)

Country Link
US (4) US7718668B2 (de)
EP (3) EP2295423B1 (de)
JP (2) JP5478828B2 (de)
KR (2) KR101352687B1 (de)
AT (1) ATE450524T1 (de)
AU (1) AU2006219867B2 (de)
BR (1) BRPI0607645A2 (de)
CA (1) CA2598860C (de)
CY (1) CY1109753T1 (de)
DE (1) DE602006010824D1 (de)
DK (1) DK1856093T3 (de)
EA (1) EA015376B1 (de)
ES (2) ES2440590T3 (de)
HR (1) HRP20100086T1 (de)
IL (2) IL185276A (de)
ME (1) ME01172B (de)
MX (1) MX2007010400A (de)
NO (1) NO339416B1 (de)
NZ (2) NZ589278A (de)
PL (1) PL1856093T3 (de)
PT (1) PT1856093E (de)
RS (1) RS51345B (de)
SI (1) SI1856093T1 (de)
WO (1) WO2006092422A1 (de)

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DE60311662T2 (de) 2002-08-29 2007-10-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
KR101152488B1 (ko) 2004-03-03 2012-07-02 니코메드 게엠베하 신규 히드록시-6-헤테로아릴페난트리딘 및 ｐｄｅ4 억제제로서의 이의 용도
WO2005087745A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
SI1856093T1 (sl) * 2005-03-02 2010-03-31 Nycomed Gmbh Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
US20100179131A1 (en) 2006-09-07 2010-07-15 Nycomed Gmbh Combination treatment for diabetes mellitus
WO2009109525A1 (en) * 2008-03-03 2009-09-11 Nycomed Gmbh Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease
EP3415148A1 (de) 2011-12-15 2018-12-19 Alkermes Pharma Ireland Limited Zusammensetzungen aus buprenorphin und mu-opioid-rezeptorantagonisten
JP2017503814A (ja) 2014-01-22 2017-02-02 タケダ ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ 部分的コントロール状態の重症喘息またはコントロール不良状態の重症喘息のｐｄｅ４インヒビターを用いた（およびロイコトリエン調節薬と組み合わせて用いた）治療
CN110099686B (zh) 2016-08-26 2022-04-15 武田药品工业株式会社 非酒精性脂肪性肝病的治疗
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