EA012875B1 - ПРОИЗВОДНЫЕ ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ CSBP/RK/p38 - Google Patents

ПРОИЗВОДНЫЕ ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ CSBP/RK/p38 Download PDF

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Publication number
EA012875B1
EA012875B1 EA200702071A EA200702071A EA012875B1 EA 012875 B1 EA012875 B1 EA 012875B1 EA 200702071 A EA200702071 A EA 200702071A EA 200702071 A EA200702071 A EA 200702071A EA 012875 B1 EA012875 B1 EA 012875B1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
aryl
heterocyclyl
heteroaryl
optionally substituted
Prior art date
Application number
EA200702071A
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English (en)
Russian (ru)
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EA200702071A1 (ru
Inventor
Джеймс Фрэнсис Каллахан
Джеффри С. Боэм
Энтони Уилльям Джеймс Купер
Стефано Ливия
Нейса Невинс
Цзехун Вань
Бет А. Нортон
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA200702071A1 publication Critical patent/EA200702071A1/ru
Publication of EA012875B1 publication Critical patent/EA012875B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
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  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
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  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
EA200702071A 2005-03-25 2006-03-24 ПРОИЗВОДНЫЕ ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ CSBP/RK/p38 EA012875B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66531505P 2005-03-25 2005-03-25
PCT/US2006/010855 WO2006104915A2 (en) 2005-03-25 2006-03-24 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS

Publications (2)

Publication Number Publication Date
EA200702071A1 EA200702071A1 (ru) 2008-02-28
EA012875B1 true EA012875B1 (ru) 2009-12-30

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EA200702071A EA012875B1 (ru) 2005-03-25 2006-03-24 ПРОИЗВОДНЫЕ ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ CSBP/RK/p38

Country Status (24)

Country Link
US (3) US8207176B2 (OSRAM)
EP (3) EP2436686A1 (OSRAM)
JP (1) JP5037487B2 (OSRAM)
KR (1) KR101235497B1 (OSRAM)
CN (4) CN102746299A (OSRAM)
AR (1) AR053346A1 (OSRAM)
AU (1) AU2006229993B2 (OSRAM)
BR (1) BRPI0609437A2 (OSRAM)
CA (1) CA2602553C (OSRAM)
EA (1) EA012875B1 (OSRAM)
ES (2) ES2398246T3 (OSRAM)
IL (1) IL185870A (OSRAM)
MA (1) MA29341B1 (OSRAM)
MX (1) MX2007011856A (OSRAM)
MY (2) MY145281A (OSRAM)
NO (1) NO20075275L (OSRAM)
NZ (1) NZ561237A (OSRAM)
PE (2) PE20061351A1 (OSRAM)
SG (1) SG166771A1 (OSRAM)
TW (1) TWI389690B (OSRAM)
UA (1) UA95444C2 (OSRAM)
UY (1) UY29440A1 (OSRAM)
WO (1) WO2006104915A2 (OSRAM)
ZA (1) ZA200707564B (OSRAM)

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WO2012158197A2 (en) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Compounds useful as akt/pkb modulators and uses thereof
SMT201700528T1 (it) * 2011-08-25 2018-01-11 Medicines For Malaria Venture Mmv 2-alchil-1-osso-n-fenil-3-eteroaril-1,2,3,4-tetraidroisochinolin-4-carbossammidi sostituite per le terapie antimalariche
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
EP3692144A1 (en) 2017-10-05 2020-08-12 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of dux4

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