EA011320B1 - N-арилсульфонил-3-замещенные индолы, обладающие афинностью к серотониновому рецептору, способ их получения и содержащая их фармацевтическая композиция - Google Patents

N-арилсульфонил-3-замещенные индолы, обладающие афинностью к серотониновому рецептору, способ их получения и содержащая их фармацевтическая композиция Download PDF

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Publication number
EA011320B1
EA011320B1 EA200500881A EA200500881A EA011320B1 EA 011320 B1 EA011320 B1 EA 011320B1 EA 200500881 A EA200500881 A EA 200500881A EA 200500881 A EA200500881 A EA 200500881A EA 011320 B1 EA011320 B1 EA 011320B1
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EA
Eurasian Patent Office
Prior art keywords
indole
methylpiperazin
methyl
ylmethyl
bromo
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Application number
EA200500881A
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English (en)
Russian (ru)
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EA200500881A1 (ru
Inventor
Венката Сатья Нироги Рамакришна
Викас Шрикришна Ширсатх
Рама Састри Камбхампати
Венката Сатья Веерабхадра Вадламуди Рао
Венкатесварлу Джасти
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Сувен Лайф Сайенсиз Лимитед
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Publication of EA200500881A1 publication Critical patent/EA200500881A1/ru
Publication of EA011320B1 publication Critical patent/EA011320B1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
EA200500881A 2002-11-28 2003-06-05 N-арилсульфонил-3-замещенные индолы, обладающие афинностью к серотониновому рецептору, способ их получения и содержащая их фармацевтическая композиция EA011320B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN884MA2002 2002-11-28
PCT/IN2003/000209 WO2004048330A1 (en) 2002-11-28 2003-06-05 N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them

Publications (2)

Publication Number Publication Date
EA200500881A1 EA200500881A1 (ru) 2005-12-29
EA011320B1 true EA011320B1 (ru) 2009-02-27

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EA200500881A EA011320B1 (ru) 2002-11-28 2003-06-05 N-арилсульфонил-3-замещенные индолы, обладающие афинностью к серотониновому рецептору, способ их получения и содержащая их фармацевтическая композиция

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US (1) US7875605B2 (enExample)
EP (1) EP1581492B1 (enExample)
JP (1) JP4559230B2 (enExample)
KR (1) KR100818508B1 (enExample)
CN (2) CN101544592B (enExample)
AT (1) ATE401307T1 (enExample)
AU (1) AU2003237599B2 (enExample)
BR (2) BRPI0318799B8 (enExample)
CA (1) CA2509982C (enExample)
CY (1) CY1108786T1 (enExample)
DE (1) DE60322266D1 (enExample)
DK (1) DK1581492T3 (enExample)
EA (1) EA011320B1 (enExample)
ES (1) ES2310243T3 (enExample)
MX (1) MXPA05005701A (enExample)
NO (2) NO330341B1 (enExample)
NZ (2) NZ540840A (enExample)
PT (1) PT1581492E (enExample)
SI (1) SI1581492T1 (enExample)
WO (1) WO2004048330A1 (enExample)
ZA (1) ZA200504043B (enExample)

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RU2422442C2 (ru) 2005-07-29 2011-06-27 Ф. Хоффманн-Ля Рош Аг Производные индол-3-ил-карбонил-пиперидина и пиперазина
CA2618636C (en) 2005-08-12 2011-01-18 Suven Life Sciences Limited Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands
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KR101250820B1 (ko) 2005-08-16 2013-04-04 수벤 라이프 사이언시스 리미티드 개선된 로사르탄 제조 방법
EP2121602B1 (en) * 2007-01-08 2015-03-18 Suven Life Sciences Limited 4-(heterocyclyl)alkyl-n-(arylsulfonyl) indole compounds and their use as 5-ht6 ligands
JP2010515674A (ja) * 2007-01-08 2010-05-13 スベン ライフ サイエンシズ リミティド ５−（ヘテロシクリル）アルキル−ｎ−（アリールスルホニル）インドール化合物および５−ｈｔ６リガンドとしてのそれらの使用
CA2683124C (en) 2007-05-03 2012-09-25 Suven Life Sciences Limited Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands
WO2008144263A1 (en) * 2007-05-18 2008-11-27 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
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ES2424036T3 (es) 2008-09-17 2013-09-26 Suven Life Sciences Limited Compuestos de amina de arilsulfonamida y su uso como ligandos de 5-HT6
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WO2015083179A1 (en) * 2013-12-02 2015-06-11 Suven Life Sciences Limited Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
EP3083588B1 (en) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
EP3166924B1 (en) 2014-07-08 2019-02-20 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
BR112017002921B1 (pt) 2014-08-16 2023-03-28 Suven Life Sciences Limited Composto metabólito ativo de monohidrato dimesilato de 1-[(2- bromofenil)sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1h-indola,processo para a preparação do composto e composição farmacêutica
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DK3458040T3 (da) * 2016-05-18 2021-05-03 Suven Life Sciences Ltd Kombination af rene 5-ht6-receptorantagonister med nmda-receptorantagonist
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