CN101544592B - N-芳基磺酰-3-取代吲哚制备的替代方法 - Google Patents
N-芳基磺酰-3-取代吲哚制备的替代方法 Download PDFInfo
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- CN101544592B CN101544592B CN200910134498XA CN200910134498A CN101544592B CN 101544592 B CN101544592 B CN 101544592B CN 200910134498X A CN200910134498X A CN 200910134498XA CN 200910134498 A CN200910134498 A CN 200910134498A CN 101544592 B CN101544592 B CN 101544592B
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- Prior art keywords
- indole
- ylmethyl
- methylpiperazin
- bromo
- indol
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- 0 C*(C(*)(*)N(*)*(*)(*)c(c1c(*)c(*)c(*)c(*)c11)c(*)[n]1S(c1c(*)c(*)c(*)c(*)c1*)(=O)=O)N(*)* Chemical compound C*(C(*)(*)N(*)*(*)(*)c(c1c(*)c(*)c(*)c(*)c11)c(*)[n]1S(c1c(*)c(*)c(*)c(*)c1*)(=O)=O)N(*)* 0.000 description 2
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN884MA2002 | 2002-11-28 | ||
| IN884/MAS/2002 | 2002-11-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN038254883A Division CN1720225B (zh) | 2002-11-28 | 2003-06-05 | 具有5-羟色胺受体亲和性的n-芳基磺酰-3-取代吲哚及其制备方法和含有其的药物组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101544592A CN101544592A (zh) | 2009-09-30 |
| CN101544592B true CN101544592B (zh) | 2013-08-21 |
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ID=40184827
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910134498XA Expired - Lifetime CN101544592B (zh) | 2002-11-28 | 2003-06-05 | N-芳基磺酰-3-取代吲哚制备的替代方法 |
| CN038254883A Expired - Lifetime CN1720225B (zh) | 2002-11-28 | 2003-06-05 | 具有5-羟色胺受体亲和性的n-芳基磺酰-3-取代吲哚及其制备方法和含有其的药物组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN038254883A Expired - Lifetime CN1720225B (zh) | 2002-11-28 | 2003-06-05 | 具有5-羟色胺受体亲和性的n-芳基磺酰-3-取代吲哚及其制备方法和含有其的药物组合物 |
Country Status (21)
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| EP (1) | EP1581492B1 (enExample) |
| JP (1) | JP4559230B2 (enExample) |
| KR (1) | KR100818508B1 (enExample) |
| CN (2) | CN101544592B (enExample) |
| AT (1) | ATE401307T1 (enExample) |
| AU (1) | AU2003237599B2 (enExample) |
| BR (2) | BRPI0318799B8 (enExample) |
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| MX (1) | MXPA05005701A (enExample) |
| NO (2) | NO330341B1 (enExample) |
| NZ (2) | NZ540840A (enExample) |
| PT (1) | PT1581492E (enExample) |
| SI (1) | SI1581492T1 (enExample) |
| WO (1) | WO2004048330A1 (enExample) |
| ZA (1) | ZA200504043B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4694129B2 (ja) * | 2002-02-12 | 2011-06-08 | ナームローゼ・フエンノートチヤツプ・オルガノン | 中枢神経系疾患の治療において有用な1−アリールスルホニル−3−置換インドール及びインドリン誘導体 |
| WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
| MXPA06007415A (es) | 2004-01-02 | 2007-01-26 | Suven Life Sciences Ltd | Inden [2, 1a] indenos e isoindol [2,1-a] indoles novedosos. |
| RU2422442C2 (ru) | 2005-07-29 | 2011-06-27 | Ф. Хоффманн-Ля Рош Аг | Производные индол-3-ил-карбонил-пиперидина и пиперазина |
| CA2618636C (en) | 2005-08-12 | 2011-01-18 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands |
| WO2007020653A1 (en) * | 2005-08-12 | 2007-02-22 | Suven Life Sciences Limited | Thioether derivatives as functional 5-ht6 ligands |
| KR101250820B1 (ko) | 2005-08-16 | 2013-04-04 | 수벤 라이프 사이언시스 리미티드 | 개선된 로사르탄 제조 방법 |
| EP2121602B1 (en) * | 2007-01-08 | 2015-03-18 | Suven Life Sciences Limited | 4-(heterocyclyl)alkyl-n-(arylsulfonyl) indole compounds and their use as 5-ht6 ligands |
| JP2010515674A (ja) * | 2007-01-08 | 2010-05-13 | スベン ライフ サイエンシズ リミティド | 5−(ヘテロシクリル)アルキル−n−(アリールスルホニル)インドール化合物および5−ht6リガンドとしてのそれらの使用 |
| CA2683124C (en) | 2007-05-03 | 2012-09-25 | Suven Life Sciences Limited | Aminoalkoxy aryl sulfonamide compounds and their use as 5-ht6 ligands |
| WO2008144263A1 (en) * | 2007-05-18 | 2008-11-27 | The Ohio State University Research Foundation | Potent indole-3-carbinol-derived antitumor agents |
| AU2008315309B2 (en) | 2007-10-26 | 2011-06-09 | Suven Life Sciences Limited | Amino arylsulfonamide compounds and their use as 5-HT6 ligands |
| US8318725B2 (en) | 2008-09-17 | 2012-11-27 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands |
| ES2424036T3 (es) | 2008-09-17 | 2013-09-26 | Suven Life Sciences Limited | Compuestos de amina de arilsulfonamida y su uso como ligandos de 5-HT6 |
| US8912220B2 (en) * | 2009-08-10 | 2014-12-16 | Galenea Pharmaceuticals | Compounds and methods of use thereof |
| US8153680B2 (en) * | 2009-08-25 | 2012-04-10 | The Ohio State University Research Foundation | Alkyl indole-3-carbinol-derived antitumor agents |
| MX2012007783A (es) | 2010-01-05 | 2012-10-03 | Suven Life Sciences Ltd | Compuestos sulfona que actuan como ligandos del receptor 5-ht6. |
| CN102093149A (zh) * | 2010-12-08 | 2011-06-15 | 天津理工大学 | 一种促进氰基快速水解制备羧酸类化合物的方法 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| KR101534136B1 (ko) * | 2013-06-11 | 2015-07-07 | 이화여자대학교 산학협력단 | 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 5-ht6 수용체 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2015083179A1 (en) * | 2013-12-02 | 2015-06-11 | Suven Life Sciences Limited | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| EP3083588B1 (en) | 2013-12-20 | 2020-12-09 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| EP3166924B1 (en) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| BR112017002921B1 (pt) | 2014-08-16 | 2023-03-28 | Suven Life Sciences Limited | Composto metabólito ativo de monohidrato dimesilato de 1-[(2- bromofenil)sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)metil]-1h-indola,processo para a preparação do composto e composição farmacêutica |
| DK3458039T3 (da) * | 2016-05-18 | 2020-09-14 | Suven Life Sciences Ltd | Tripelkombination af rene 5-ht6-receptorantagonister, acetylcholinesterasehæmmere og nmda-receptorantagonist |
| DK3458040T3 (da) * | 2016-05-18 | 2021-05-03 | Suven Life Sciences Ltd | Kombination af rene 5-ht6-receptorantagonister med nmda-receptorantagonist |
| CA3023819C (en) * | 2016-05-18 | 2019-10-22 | Suven Life Sciences Limited | Combination of pure 5-ht6 receptor antagonists with acetylcholinesterase inhibitors |
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