EA005593B1 - Способ получения циталопрама - Google Patents

Способ получения циталопрама Download PDF

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Publication number
EA005593B1
EA005593B1 EA200200900A EA200200900A EA005593B1 EA 005593 B1 EA005593 B1 EA 005593B1 EA 200200900 A EA200200900 A EA 200200900A EA 200200900 A EA200200900 A EA 200200900A EA 005593 B1 EA005593 B1 EA 005593B1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
citalopram
followed
alkylation
Prior art date
Application number
EA200200900A
Other languages
English (en)
Russian (ru)
Other versions
EA200200900A1 (ru
Inventor
Ханс Петерсен
Майкл Хэролд Рок
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159208&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA005593(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200200900A1 publication Critical patent/EA200200900A1/ru
Publication of EA005593B1 publication Critical patent/EA005593B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
EA200200900A 2000-02-24 2001-02-22 Способ получения циталопрама EA005593B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000296 2000-02-24
PCT/DK2001/000122 WO2001062754A1 (en) 2000-02-24 2001-02-22 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
EA200200900A1 EA200200900A1 (ru) 2003-02-27
EA005593B1 true EA005593B1 (ru) 2005-04-28

Family

ID=8159208

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200900A EA005593B1 (ru) 2000-02-24 2001-02-22 Способ получения циталопрама

Country Status (29)

Country Link
US (3) US20020004604A1 (enExample)
EP (1) EP1259500A1 (enExample)
JP (1) JP2003524009A (enExample)
KR (1) KR20020080438A (enExample)
CN (1) CN1161350C (enExample)
AU (1) AU2001235357A1 (enExample)
BE (1) BE1012921A6 (enExample)
BG (1) BG107015A (enExample)
BR (1) BR0108947A (enExample)
CA (1) CA2400682A1 (enExample)
EA (1) EA005593B1 (enExample)
FR (1) FR2805813A1 (enExample)
GR (1) GR20010100097A (enExample)
HK (1) HK1054378B (enExample)
HR (1) HRP20020743A2 (enExample)
HU (1) HUP0300078A3 (enExample)
IE (1) IES20010143A2 (enExample)
IL (1) IL151339A0 (enExample)
IS (1) IS6512A (enExample)
IT (1) ITMI20010385A1 (enExample)
MX (1) MXPA02008230A (enExample)
NL (1) NL1017414C1 (enExample)
NO (1) NO20024007L (enExample)
PL (1) PL357178A1 (enExample)
SK (1) SK13662002A3 (enExample)
TR (1) TR200202048T2 (enExample)
UA (1) UA71059C2 (enExample)
WO (1) WO2001062754A1 (enExample)
ZA (2) ZA200206255B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
HK1043129B (zh) 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
WO2001051477A1 (en) * 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
BR0109364A (pt) 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
SK14602002A3 (sk) * 2000-03-13 2003-02-04 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
TR200202168T2 (tr) 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
TR200201166T1 (tr) 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
DK1281707T3 (da) * 2001-08-02 2005-05-02 Infosint Sa Fremgangsmåde til fremstilling af 5-substituerede isobenzenfuraner
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US8539533B2 (en) * 2003-03-07 2013-09-17 Siemens Enterprise Communications, Inc. System and method for digital personal video stream manager
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
JP2006176490A (ja) * 2004-11-29 2006-07-06 Sumitomo Chemical Co Ltd ５−フタランカルボニトリル及びシタロプラムの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
CN1161350C (zh) 2004-08-11
MXPA02008230A (es) 2003-05-23
PL357178A1 (en) 2004-07-26
HRP20020743A2 (en) 2003-12-31
ITMI20010385A1 (it) 2002-08-26
EA200200900A1 (ru) 2003-02-27
EP1259500A1 (en) 2002-11-27
HUP0300078A2 (en) 2003-05-28
ZA200206255B (en) 2003-10-20
HK1054378A1 (en) 2003-11-28
NO20024007L (no) 2002-10-07
IL151339A0 (en) 2003-04-10
KR20020080438A (ko) 2002-10-23
CN1404475A (zh) 2003-03-19
JP2003524009A (ja) 2003-08-12
BE1012921A6 (fr) 2001-05-08
AU2001235357A1 (en) 2001-09-03
UA71059C2 (uk) 2004-11-15
CA2400682A1 (en) 2001-08-30
GR20010100097A (el) 2001-10-31
BR0108947A (pt) 2003-06-03
SK13662002A3 (sk) 2003-01-09
US20020004604A1 (en) 2002-01-10
IES20010143A2 (en) 2001-07-25
ZA200206699B (en) 2003-11-21
NO20024007D0 (no) 2002-08-22
BG107015A (bg) 2003-05-30
NL1017414C1 (nl) 2001-03-15
IS6512A (is) 2002-08-20
HK1054378B (zh) 2005-04-29
US20030114692A1 (en) 2003-06-19
FR2805813A1 (fr) 2001-09-07
HUP0300078A3 (en) 2005-02-28
US20030083508A1 (en) 2003-05-01
TR200202048T2 (tr) 2003-01-21
WO2001062754A1 (en) 2001-08-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU