CA2400682A1 - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram Download PDF

Info

Publication number
CA2400682A1
CA2400682A1 CA002400682A CA2400682A CA2400682A1 CA 2400682 A1 CA2400682 A1 CA 2400682A1 CA 002400682 A CA002400682 A CA 002400682A CA 2400682 A CA2400682 A CA 2400682A CA 2400682 A1 CA2400682 A1 CA 2400682A1
Authority
CA
Canada
Prior art keywords
formula
compound
citalopram
fluorophenyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002400682A
Other languages
English (en)
French (fr)
Inventor
Hans Petersen
Michael Harold Rock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159208&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2400682(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2400682A1 publication Critical patent/CA2400682A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
CA002400682A 2000-02-24 2001-02-22 Method for the preparation of citalopram Abandoned CA2400682A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200000296 2000-02-24
DKPA200000296 2000-02-24
PCT/DK2001/000122 WO2001062754A1 (en) 2000-02-24 2001-02-22 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
CA2400682A1 true CA2400682A1 (en) 2001-08-30

Family

ID=8159208

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002400682A Abandoned CA2400682A1 (en) 2000-02-24 2001-02-22 Method for the preparation of citalopram

Country Status (29)

Country Link
US (3) US20020004604A1 (enExample)
EP (1) EP1259500A1 (enExample)
JP (1) JP2003524009A (enExample)
KR (1) KR20020080438A (enExample)
CN (1) CN1161350C (enExample)
AU (1) AU2001235357A1 (enExample)
BE (1) BE1012921A6 (enExample)
BG (1) BG107015A (enExample)
BR (1) BR0108947A (enExample)
CA (1) CA2400682A1 (enExample)
EA (1) EA005593B1 (enExample)
FR (1) FR2805813A1 (enExample)
GR (1) GR20010100097A (enExample)
HK (1) HK1054378B (enExample)
HR (1) HRP20020743A2 (enExample)
HU (1) HUP0300078A3 (enExample)
IE (1) IES20010143A2 (enExample)
IL (1) IL151339A0 (enExample)
IS (1) IS6512A (enExample)
IT (1) ITMI20010385A1 (enExample)
MX (1) MXPA02008230A (enExample)
NL (1) NL1017414C1 (enExample)
NO (1) NO20024007L (enExample)
PL (1) PL357178A1 (enExample)
SK (1) SK13662002A3 (enExample)
TR (1) TR200202048T2 (enExample)
UA (1) UA71059C2 (enExample)
WO (1) WO2001062754A1 (enExample)
ZA (2) ZA200206255B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
HK1043129B (zh) 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
WO2001051477A1 (en) * 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
BR0109364A (pt) 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
SK14602002A3 (sk) * 2000-03-13 2003-02-04 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
TR200202168T2 (tr) 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
TR200201166T1 (tr) 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
DK1281707T3 (da) * 2001-08-02 2005-05-02 Infosint Sa Fremgangsmåde til fremstilling af 5-substituerede isobenzenfuraner
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US8539533B2 (en) * 2003-03-07 2013-09-17 Siemens Enterprise Communications, Inc. System and method for digital personal video stream manager
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
JP2006176490A (ja) * 2004-11-29 2006-07-06 Sumitomo Chemical Co Ltd ５−フタランカルボニトリル及びシタロプラムの製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
CN1161350C (zh) 2004-08-11
MXPA02008230A (es) 2003-05-23
PL357178A1 (en) 2004-07-26
HRP20020743A2 (en) 2003-12-31
ITMI20010385A1 (it) 2002-08-26
EA200200900A1 (ru) 2003-02-27
EP1259500A1 (en) 2002-11-27
HUP0300078A2 (en) 2003-05-28
ZA200206255B (en) 2003-10-20
HK1054378A1 (en) 2003-11-28
NO20024007L (no) 2002-10-07
IL151339A0 (en) 2003-04-10
KR20020080438A (ko) 2002-10-23
CN1404475A (zh) 2003-03-19
JP2003524009A (ja) 2003-08-12
BE1012921A6 (fr) 2001-05-08
AU2001235357A1 (en) 2001-09-03
UA71059C2 (uk) 2004-11-15
GR20010100097A (el) 2001-10-31
BR0108947A (pt) 2003-06-03
SK13662002A3 (sk) 2003-01-09
US20020004604A1 (en) 2002-01-10
IES20010143A2 (en) 2001-07-25
ZA200206699B (en) 2003-11-21
NO20024007D0 (no) 2002-08-22
BG107015A (bg) 2003-05-30
NL1017414C1 (nl) 2001-03-15
EA005593B1 (ru) 2005-04-28
IS6512A (is) 2002-08-20
HK1054378B (zh) 2005-04-29
US20030114692A1 (en) 2003-06-19
FR2805813A1 (fr) 2001-09-07
HUP0300078A3 (en) 2005-02-28
US20030083508A1 (en) 2003-05-01
TR200202048T2 (tr) 2003-01-21
WO2001062754A1 (en) 2001-08-30

Similar Documents

Publication Publication Date Title
US20020004604A1 (en) Method for the preparation of citalopram
AU2001100440B4 (en) Method for the preparation of citalopram
JP3813820B2 (ja) シタロプラムの製造方法
CA2291129C (en) Method for the preparation of citalopram
AU746664B2 (en) Crystalline base of citalopram
EP1228056B1 (en) Method for the preparation of citalopram
AU2001258239B2 (en) Method for the preparation of citalopram
AU2001258239A1 (en) Method for the preparation of citalopram
ZA200107956B (en) Method for the preparation of citalopram.

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued