DZ540A1 - Composés bicycliques. - Google Patents

Composés bicycliques.

Info

Publication number
DZ540A1
DZ540A1 DZ836846A DZ836846A DZ540A1 DZ 540 A1 DZ540 A1 DZ 540A1 DZ 836846 A DZ836846 A DZ 836846A DZ 836846 A DZ836846 A DZ 836846A DZ 540 A1 DZ540 A1 DZ 540A1
Authority
DZ
Algeria
Prior art keywords
bicyclic compounds
bicyclic
compounds
Prior art date
Application number
DZ836846A
Other languages
English (en)
French (fr)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DZ540A1 publication Critical patent/DZ540A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/650905Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DZ836846A 1982-05-12 1983-05-10 Composés bicycliques. DZ540A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (1)

Publication Number Publication Date
DZ540A1 true DZ540A1 (fr) 2004-09-13

Family

ID=26282820

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ836846A DZ540A1 (fr) 1982-05-12 1983-05-10 Composés bicycliques.

Country Status (32)

Country Link
US (3) US4512924A (pt)
EP (1) EP0094095B1 (pt)
KR (1) KR890002106B1 (pt)
AR (1) AR240940A1 (pt)
AU (1) AU567873B2 (pt)
BG (1) BG61123B2 (pt)
CA (1) CA1234568A (pt)
CS (2) CS249128B2 (pt)
CU (1) CU21532A3 (pt)
DE (2) DE3317290A1 (pt)
DK (1) DK160612C (pt)
DO (1) DOP1983004163A (pt)
DZ (1) DZ540A1 (pt)
ES (6) ES522291A0 (pt)
FI (1) FI77244C (pt)
FR (1) FR2531956B1 (pt)
GB (1) GB2128984B (pt)
GR (1) GR77462B (pt)
HK (1) HK91692A (pt)
HU (3) HU199842B (pt)
IE (1) IE56480B1 (pt)
IL (1) IL68620A (pt)
IT (1) IT1212738B (pt)
LU (2) LU84803A1 (pt)
MC (1) MC1515A1 (pt)
MY (1) MY102889A (pt)
NL (2) NL8301640A (pt)
NO (1) NO160368C (pt)
PT (1) PT76681B (pt)
SE (1) SE461792B (pt)
SG (1) SG81192G (pt)
ZW (1) ZW9883A1 (pt)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4940718A (en) * 1985-04-30 1990-07-10 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
US4826992A (en) * 1985-04-30 1989-05-02 Eli Lilly And Company 2,3-(Dihydro) bicyclic pyrazolidinones
US4902707A (en) * 1985-04-30 1990-02-20 Eli Lilly And Company Bicyclic pyrazolidinones, compositions and use
DE3677253D1 (de) * 1985-04-30 1991-03-07 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
US4832763A (en) * 1985-10-15 1989-05-23 Westinghouse Electric Corp. Method of stress-relief annealing a magnetic core containing amorphous material
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
US4956490A (en) * 1989-03-09 1990-09-11 Merck & Co., Inc. Process for preparing benzylpyruvic acids and esters
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
DE3917255A1 (de) * 1989-05-26 1990-11-29 Schopf Masch Verfahren und vorrichtung zum aufnehmen eines flugzeugbugfahrwerks durch einen flugzeugschlepper
US5011938A (en) * 1989-10-02 1991-04-30 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones
EP0502075A1 (en) * 1989-11-21 1992-09-09 Schering Corporation Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
WO1991009840A1 (en) * 1989-12-22 1991-07-11 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
DE59107840D1 (de) * 1990-11-21 1996-06-27 Ciba Geigy Ag Silylierte Acylphosphinoxide
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
JPH06506201A (ja) * 1991-03-19 1994-07-14 ノバルティス アクチエンゲゼルシャフト 新規な除草性、殺ダニ性および殺虫性活性化合物
TW216770B (pt) * 1991-07-23 1993-12-01 Hoffmann La Roche
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
JPH06107661A (ja) * 1991-10-24 1994-04-19 Upjohn Co:The イミダゾール誘導体およびこれを有効成分とする医薬組成物
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
DE69325904T2 (de) * 1992-05-15 1999-12-09 Merrell Pharma Inc MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN
EP0570764B1 (de) * 1992-05-18 2001-07-18 F.Hoffmann-La Roche & Co. Aktiengesellschaft Asymmetrische Hydrierung
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
WO1994010193A1 (en) * 1992-10-30 1994-05-11 Merrell Dow Pharmaceuticals Inc. Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
JPH072859A (ja) * 1993-01-28 1995-01-06 Upjohn Co:The ピラゾール誘導体およびこれを有効成分とする医薬組成物
US5476395A (en) * 1993-03-01 1995-12-19 Methode Electronics, Inc. Planar fuse panel
DK0634175T3 (da) * 1993-07-15 2001-04-30 Hoffmann La Roche Farmaceutisk kombination, der indeholder en hæmmer af renin-angiotensin-systemet og en endothelin-antagonist
DK0750631T3 (da) * 1994-02-14 2000-10-23 Merrell Pharma Inc Mercaptoacetylamido-1,3,4,5-tetrahydrobenzo[c]azepin-3-ondisulfidderivater som enkephalinase- og ACE-inhibitorer
CA2183320C (en) * 1994-02-14 1999-10-26 Gary A. Flynn Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
PT745081E (pt) * 1994-02-14 2002-04-29 Merrell Pharma Inc Derivados de dissulfureto de inda-2-mercaptoacetilamida uteis como inibidores da encefalinase
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
JPH09510476A (ja) * 1994-03-24 1997-10-21 メリル・フアーマシユウテイカルズ・インコーポレイテツド 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のアミノアセチルメルカプト誘導体
ATE246927T1 (de) * 1994-03-24 2003-08-15 Merrell Pharma Inc Cholesterin senkende mercaptoacetylamiddisulfidderivate
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
FR2777888B1 (fr) * 1998-04-27 2004-07-16 Hoechst Marion Roussel Inc Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
FR2777889B1 (fr) * 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
AU2003200034B2 (en) * 1998-04-27 2006-07-20 Aventis Pharma S.A. New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
FR2788276B1 (fr) * 1999-01-12 2001-02-16 Hoechst Marion Roussel Inc NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
WO2001021259A2 (en) * 1999-09-21 2001-03-29 Emory University Use and compositions for treating platelet-related disorders using anagrelide
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
US8101363B2 (en) 2000-12-14 2012-01-24 The Brigham And Women's Hospital, Inc. Inflammatory markers as tools in the detection and prevention of diabetes mellitus and as tools to aid in the selection of agents to be used for the prevention and treatment of diabetes
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
SI3072978T1 (sl) 2002-05-09 2018-11-30 The Brigham And Women's Hospital, Inc. 1L1RL-1 kot marker za kardiovaskularne bolezni
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
JP2006521287A (ja) * 2002-12-20 2006-09-21 エスティ.ジェイムス アソシエイト エルエルシー/フェイバー リサーチ シリーズ 医薬製剤用の高圧圧縮
WO2004078761A1 (en) * 2003-03-06 2004-09-16 Ranbaxy Laboratories Limited Enantiomerically pure cilazapril,process for preparation
AU2003247159A1 (en) * 2003-07-07 2005-01-21 Hetero Drugs Limited A novel process for the preparation of cilazapril
ES2567135T3 (es) 2003-08-29 2016-04-20 The Brigham And Women's Hospital, Inc. Derivados de hidantoína como inhibidores de necrosis celular
CA2549236C (en) 2003-12-05 2017-06-13 The Cleveland Clinic Foundation Risk markers for cardiovascular disease
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
WO2005122682A2 (en) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Process for the preparation of esters of piperazic acid
JP5020086B2 (ja) 2004-10-06 2012-09-05 ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド 治療後の全身炎症性マーカーの達成レベルの関連性
JP2008528507A (ja) * 2005-01-21 2008-07-31 ニトロメッド インコーポレーティッド 複素環式の酸化窒素供与体基を含む心血管化合物、組成物および使用方法
EP1848424B1 (en) * 2005-01-31 2017-04-05 Mylan Laboratories, Inc Pharmaceutical composition comprising hydroxylated nebivolol
KR101310037B1 (ko) 2005-05-31 2013-09-24 밀란 인크. 네비볼롤을 함유하는 조성물
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
DE602006000402T8 (de) 2006-06-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Stabile Zubereitung enthaltend eine feuchtigkeitsempfindliche aktive Substanz und Verfahren zur Herstellung der Zubereitung.
US20070281000A1 (en) * 2006-06-02 2007-12-06 Michael Fox Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
CA2659082A1 (en) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
US20080008751A1 (en) * 2006-07-10 2008-01-10 Michael Fox Stable formulation comprising a combination of a moisture sensitive drug and a second drug and manufacturing procedure thereof
WO2008131224A2 (en) 2007-04-18 2008-10-30 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
EP2221299A3 (en) 2009-02-11 2010-11-03 Dr. Reddy's Laboratories Ltd. Preparation of cilazapril intermediates
JP2013518618A (ja) 2010-02-01 2013-05-23 ザ・ホスピタル・フォー・シック・チルドレン 再狭窄を治療および予防するための遠隔虚血コンディショニング
KR20190000368A (ko) 2010-03-31 2019-01-02 더 호스피탈 포 식 칠드런 심근 경색 후 결과를 개선시키기 위한 원격 허혈 처치의 사용
AU2011237461B2 (en) 2010-04-08 2015-11-26 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
WO2012049646A1 (en) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of cilazapril
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.
BR112014001283A2 (pt) 2011-07-18 2017-02-21 Critical Care Diagnostics Inc métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício
RU2654484C1 (ru) 2012-05-11 2018-05-21 Ресет Терапьютикс, Инк. Карбазолсодержащие сульфонамиды в качестве модуляторов криптохрома
AU2013296803B2 (en) 2012-08-01 2018-03-08 Eric Ostertag Free flowing, frozen compositions comprising a therapeutic agent
JP2016514693A (ja) 2013-03-15 2016-05-23 プレジデント アンド フェローズ オブ ハーバード カレッジ ハイブリッド型ネクロトーシス阻害剤
RU2015144689A (ru) 2013-03-21 2017-04-25 ЮПРАКСИЯ ФАРМАСЬЮТИКАЛЗ ЮЭсЭй ЭлЭлСи Композиция для инъекций с замедленным высвобождением и способ ее применения для лечения воспаления в суставах и связанной с такими воспалениями боли
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
PT3206672T (pt) 2015-10-27 2018-06-20 Eupraxia Pharmaceuticals Inc Formulações de libertação prolongada de anestésicos locais

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
DE3169261D1 (en) * 1980-09-10 1985-04-18 Beecham Group Plc Aryl diazabicyclyl amides, a process for their preparation and use
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds

Also Published As

Publication number Publication date
PT76681A (en) 1983-06-01
ES528627A0 (es) 1985-11-16
DK194783D0 (da) 1983-05-02
IL68620A (en) 1987-11-30
FI77244B (fi) 1988-10-31
NO160368C (no) 1989-04-12
ZW9883A1 (en) 1984-11-21
DK160612B (da) 1991-04-02
AR240940A2 (es) 1991-03-27
ES8407049A1 (es) 1984-08-16
NO160368B (no) 1989-01-02
IT8321000A0 (it) 1983-05-09
EP0094095A3 (en) 1984-11-21
PT76681B (en) 1986-05-20
US4772701A (en) 1988-09-20
SE8302716L (sv) 1983-11-13
HU198935B (en) 1989-12-28
DE3381884D1 (de) 1990-10-25
ES8607970A1 (es) 1986-06-16
AU567873B2 (en) 1987-12-10
SE461792B (sv) 1990-03-26
DK194783A (da) 1983-11-13
CS402191A3 (en) 1992-10-14
IE56480B1 (en) 1991-08-14
FR2531956A1 (fr) 1984-02-24
BG61123B2 (bg) 1996-11-29
MC1515A1 (fr) 1984-02-10
US4512924A (en) 1985-04-23
NL930055I2 (nl) 1993-10-01
FI831661A0 (fi) 1983-05-12
CU21532A3 (en) 1987-06-09
ES8505173A1 (es) 1985-05-16
GB8305505D0 (en) 1983-03-30
NO831675L (no) 1983-11-14
GB2128984A (en) 1984-05-10
IE831084L (en) 1983-11-12
LU84803A1 (fr) 1985-03-21
SG81192G (en) 1993-01-29
ES8601994A1 (es) 1985-11-16
AR240940A1 (es) 1991-03-27
ES8800170A1 (es) 1987-11-01
HU199842B (en) 1990-03-28
LU88299I2 (fr) 1994-09-09
CA1234568A (en) 1988-03-29
AU1436483A (en) 1983-11-17
FI77244C (fi) 1989-02-10
ES8706672A1 (es) 1987-07-16
KR890002106B1 (ko) 1989-06-19
FI831661L (fi) 1983-11-13
GB2128984B (en) 1985-05-22
EP0094095B1 (de) 1990-09-19
KR840004754A (ko) 1984-10-24
DOP1983004163A (es) 1988-09-20
GR77462B (pt) 1984-09-24
DE3317290A1 (de) 1983-11-17
ES528630A0 (es) 1986-06-16
NL8301640A (nl) 1983-12-01
HU195965B (en) 1988-08-29
FR2531956B1 (fr) 1987-02-20
ES528628A0 (es) 1987-07-16
IT1212738B (it) 1989-11-30
SE8302716D0 (sv) 1983-05-11
NL930055I1 (nl) 1993-09-01
US4658024A (en) 1987-04-14
MY102889A (en) 1993-03-31
CS249128B2 (en) 1987-03-12
IL68620A0 (en) 1983-09-30
ES522291A0 (es) 1984-08-16
ES554935A0 (es) 1987-11-01
ES528625A0 (es) 1985-05-16
EP0094095A2 (de) 1983-11-16
DK160612C (da) 1991-09-23
HK91692A (en) 1992-11-27

Similar Documents

Publication Publication Date Title
DZ540A1 (fr) Composés bicycliques.
FI834235A (fi) Anordning foer placering av koniska foeremaol i en laoda.
FI834261A (fi) Paosliknande saeckar foer foervaring av vaetskor.
FI824215L (fi) Foerfarande foer upploesning av cellulosakarbamat.
FI841294A0 (fi) Foerfarande foer aostadkommande av foerbaettringar i boskapskoetsel.
FI834454A (fi) Foerfarande foer upparbetning av komplexa sulfidiska malmkoncentrat.
FI834397A (fi) Lindning av cellulosabanor.
FI823929L (fi) Odlingsgrupp foer skolning av plantor.
FI842596A (fi) Foerfarande foer bildande av permanentvaogor i haoret.
FI834238A (fi) Foerfarande foer framstaellning av citrussaftkoncentrat.
FI834231A (fi) Enzymatisk syntes av l-serin.
FI834372A (fi) Foerbindning av skidsko.
FI833864A (fi) Staell foer lagring av kaernbraensle- element.
FI834382A (fi) Foerfarande foer delignifierande blekning av cellulosamassa.
FI834259A (fi) Foerfarande foer framstaellning av optiskt aktiva cyanometylestrar.
IT8219187A0 (it) Composti biciclici.
FI73996B (fi) Foerfarande foer framstaellning av ergolinderivat.
FI74015B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla vinyltioacetamidooxakefalosporinderivat.
FI834849A0 (fi) Foerfarande foer framstaellning av en behaollare, saerskilt foer transformatorer
FI73491B (fi) Foerbindelsedel foer tvao byggnadselement av staolbetong.
FI74022B (fi) Foerfarande foer framstaellning av terapeutiskt aktiva antracyklinglykosider.
FI834340A (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara svavelhaltiga bensylidenderivat.
FI842860A (fi) Anlaeggning foer buntning av tidningar.
FI834627A (fi) Foerfarande foer haerdning av jaernlegeringar i vattenhaltig omgivning.
FI834409A (fi) Foerfarande foer framstaellning av pyridonderivat.