DK476686A - Fremgangsmaade til udfoerelse af stedsspecifik rekombination af dna i gaer - Google Patents

Fremgangsmaade til udfoerelse af stedsspecifik rekombination af dna i gaer Download PDF

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Publication number
DK476686A
DK476686A DK476686A DK476686A DK476686A DK 476686 A DK476686 A DK 476686A DK 476686 A DK476686 A DK 476686A DK 476686 A DK476686 A DK 476686A DK 476686 A DK476686 A DK 476686A
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Prior art keywords
yeast
dna
specific recombination
procedure
performing location
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DK476686A
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Danish (da)
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DK476686D0 (da
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Brian Lee Sauer
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Du Pont
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK476686A 1985-10-07 1986-10-06 Fremgangsmaade til udfoerelse af stedsspecifik rekombination af dna i gaer DK476686A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78495185A 1985-10-07 1985-10-07

Publications (2)

Publication Number Publication Date
DK476686D0 DK476686D0 (da) 1986-10-06
DK476686A true DK476686A (da) 1987-04-08

Family

ID=25134033

Family Applications (1)

Application Number Title Priority Date Filing Date
DK476686A DK476686A (da) 1985-10-07 1986-10-06 Fremgangsmaade til udfoerelse af stedsspecifik rekombination af dna i gaer

Country Status (9)

Country Link
US (1) US4959317A (de)
EP (1) EP0220009B1 (de)
JP (1) JP2721666B2 (de)
AT (1) ATE85649T1 (de)
CA (1) CA1293460C (de)
DE (1) DE3687734T2 (de)
DK (1) DK476686A (de)
ES (1) ES2053438T3 (de)
IE (1) IE60421B1 (de)

Families Citing this family (271)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88556B (pt) * 1987-09-28 1992-11-30 Smithkline Biolog Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6291159B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
GB8920211D0 (en) * 1989-09-07 1989-10-18 Ici Plc Diagnostic method
US5658772A (en) * 1989-12-22 1997-08-19 E. I. Du Pont De Nemours And Company Site-specific recombination of DNA in plant cells
WO1991009957A1 (en) * 1989-12-22 1991-07-11 E.I. Du Pont De Nemours And Company Site-specific recombination of dna in plant cells
JPH05508547A (ja) * 1990-07-13 1993-12-02 トランスカリオティック　セラピーズ，インコーポレイテッド ライブラリースクリーニング法
US5580734A (en) * 1990-07-13 1996-12-03 Transkaryotic Therapies, Inc. Method of producing a physical map contigous DNA sequences
WO1992015694A1 (en) * 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
WO1992022650A1 (en) * 1991-06-17 1992-12-23 Life Technologies, Inc. Recombination-facilitated multiplex analysis of dna fragments
WO1993001283A1 (en) * 1991-07-08 1993-01-21 The United States Of America As Represented By The Secretary Of Agriculture Selection-gene-free transgenic plants
WO1993015191A1 (en) * 1992-01-24 1993-08-05 Life Technologies, Inc. Modulation of enzyme activities in the in vivo cloning of dna
AU4401993A (en) * 1992-06-04 1993-12-30 Exemplar Corporation Insertion of heterologous dna outside of known chromosomal genes
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5834202A (en) 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
GB9302798D0 (en) * 1993-02-12 1993-03-31 Medical Res Council Improvements in or relating to cloning dna
US5843744A (en) * 1993-07-08 1998-12-01 Ecogen Inc. Bacillus thuringiensis Tn5401 proteins
US5441884A (en) * 1993-07-08 1995-08-15 Ecogen Inc. Bacillus thuringiensis transposon TN5401
CA2117668C (en) * 1994-03-09 2005-08-09 Izumu Saito Recombinant adenovirus and process for producing the same
EG23907A (en) * 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US5723765A (en) * 1994-08-01 1998-03-03 Delta And Pine Land Co. Control of plant gene expression
CA2197242A1 (en) * 1994-08-18 1996-02-29 Joan S. Brugge Regulatable elimination of gene expression, gene product function and engineered host cells
JP4216350B2 (ja) * 1994-09-19 2009-01-28 大日本住友製薬株式会社 動物細胞感染用の組換えｄｎａウイルスベクター
JP3770333B2 (ja) * 1995-03-15 2006-04-26 大日本住友製薬株式会社 組換えｄｎａウイルスおよびその製造方法
US6091001A (en) * 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6720140B1 (en) * 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US5629159A (en) * 1995-06-07 1997-05-13 California Institute Of Technology Immortalization and disimmortalization of cells
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US20060110798A1 (en) * 1995-06-07 2006-05-25 Graham Frank L Cells expressing recombinase useful for adenovirus vector production and control of gene expression
NZ312332A (en) 1995-06-07 2000-01-28 Life Technologies Inc Recombinational cloning using engineered recombination sites
US6964861B1 (en) * 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6974694B2 (en) * 1995-06-07 2005-12-13 Advec, Inc. Adenoviruses for control of gene expression
US5801030A (en) * 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
US6051409A (en) 1995-09-25 2000-04-18 Novartis Finance Corporation Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
US6406847B1 (en) * 1995-10-02 2002-06-18 The Board Of Trustees Of The Leland Stanford Junior University Mismatch repair detection
US7153652B2 (en) * 1995-10-02 2006-12-26 The Board Of Trustees Of The Leland Stanford Junior University Mismatch repair detection
JP2000500341A (ja) * 1995-11-13 2000-01-18 ユニバーシティ・オブ・ロチェスター 組換え基質による哺乳類体細胞モザイク現象の生成
JP2000503534A (ja) * 1996-01-05 2000-03-28 ジェネティック セラピー，インコーポレイテッド アデノウイルスベクターのリコンビナーゼ媒介生成
US6087129A (en) * 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines
US6228646B1 (en) 1996-03-07 2001-05-08 The Regents Of The University Of California Helper-free, totally defective adenovirus for gene therapy
US6132989A (en) * 1996-06-03 2000-10-17 University Of Washington Methods and compositions for enhanced stability of non-adenoviral DNA
US6534314B1 (en) 1996-06-14 2003-03-18 Massachusetts Institute Of Technology Methods and compositions for transforming cells
US5928914A (en) * 1996-06-14 1999-07-27 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Methods and compositions for transforming cells
US6255071B1 (en) 1996-09-20 2001-07-03 Cold Spring Harbor Laboratory Mammalian viral vectors and their uses
US6025192A (en) * 1996-09-20 2000-02-15 Cold Spring Harbor Laboratory Modified retroviral vectors
US7332338B2 (en) 1996-10-04 2008-02-19 Lexicon Pharmaceuticals, Inc. Vectors for making genomic modifications
US20040072243A1 (en) * 1996-10-11 2004-04-15 Lexicon Genetics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6066778A (en) * 1996-11-06 2000-05-23 The Regents Of The University Of Michigan Transgenic mice expressing APC resistant factor V
US5994620A (en) * 1996-12-10 1999-11-30 The Jackson Laboratory Induced chromosomal deletion
US5851808A (en) * 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
US6787319B2 (en) * 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6774279B2 (en) * 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
US6284944B1 (en) * 1997-08-29 2001-09-04 Cephalon, Inc, Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
US7129390B2 (en) 1997-10-16 2006-10-31 Avigenics, Inc Poultry Derived Glycosylated Interferon Alpha 2b
US7511120B2 (en) * 1997-10-16 2009-03-31 Synageva Biopharma Corp. Glycosylated G-CSF obtained from a transgenic chicken
US20090074718A1 (en) * 1997-10-16 2009-03-19 Ivarie Robert D Avian derived erythropoietin
EP1023442B1 (de) 1997-10-16 2010-11-24 University Of Georgia Research Foundation, Inc. Transgene vögel und proteinproduktion
US20040019923A1 (en) * 1997-10-16 2004-01-29 Ivarie Robert D. Exogenous proteins expressed in avians and their eggs
US8563803B2 (en) * 1997-10-16 2013-10-22 Synageva Biopharma Corp. Method of making protein in an egg of a transgenic chicken
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
NZ520579A (en) 1997-10-24 2004-08-27 Invitrogen Corp Recombinational cloning using nucleic acids having recombination sites and methods for synthesizing double stranded nucleic acids
AU757930B2 (en) * 1997-12-01 2003-03-13 Roche Diagnostics Gmbh Optimization of cells for endogenous gene activation
US6436707B1 (en) * 1998-03-27 2002-08-20 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
US6808921B1 (en) 1998-03-27 2004-10-26 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
WO2000005355A1 (en) * 1998-07-24 2000-02-03 Baylor College Of Medicine Rapid subcloning using site-specific recombination
TWI255853B (en) * 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
DE69942782D1 (de) 1998-11-27 2010-10-28 Ucb Sa Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung
AU774643B2 (en) 1999-03-02 2004-07-01 Invitrogen Corporation Compositions and methods for use in recombinational cloning of nucleic acids
JP2002537800A (ja) * 1999-03-02 2002-11-12 インビトロゲン・コーポレーション 毒性遺伝子に対して耐性のある細胞およびその使用
US6890726B1 (en) 1999-04-06 2005-05-10 Oklahoma Medical Research Foundation Method for selecting recombinase variants with altered specificity
EP1194540A1 (de) 1999-07-14 2002-04-10 Clontech Laboratories Inc. Rekombinase-basierende methoden zur herstellung von expressionsvektoren und zusammensetzungen für ihre verwendung
WO2001005987A1 (fr) 1999-07-14 2001-01-25 Transgenic Inc. Vecteur piege et procede de piegeage de genes utilisant ledit vecteur
EP2278022A3 (de) 1999-11-01 2011-05-18 Novartis Vaccines and Diagnostics, Inc. Expressionsvektoren, Transfektionssysteme und Verfahren zu deren Verwendung
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
EP1250453B1 (de) 1999-12-10 2008-04-09 Invitrogen Corporation Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen
WO2001042442A2 (en) 1999-12-10 2001-06-14 Cytos Biotechnology Ag Activation of endogenous genes by genomic introduction of a replicon
DE10004996C2 (de) * 2000-02-04 2002-09-26 Infineon Technologies Ag Vorrichtung und Verfahren zur Selbstkalibrierung von Faltungs-Analog/Digitalwandlern
JP2004503207A (ja) * 2000-02-25 2004-02-05 ストラタジーン 核酸をライゲーションする方法および分子クローニング
US7517688B2 (en) * 2000-02-25 2009-04-14 Stratagene California Method for ligating nucleic acids and molecular cloning
US6580019B1 (en) 2000-03-09 2003-06-17 Dekalb Genetics Corporation Non-reciprocal recombination-mediated transgene deletion in transgenic plants
US6750379B2 (en) 2000-03-09 2004-06-15 Dekalb Genetics Corporation Homologous recombination-mediated transgene alterations in plants
WO2001068131A1 (en) 2000-03-13 2001-09-20 Cornell Research Foundation, Inc. Blocking leukocyte emigration and inflammation by interfering with cd99/hec2
US20040231006A1 (en) * 2000-04-12 2004-11-18 Silver Daniel P. Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
CA2405768A1 (en) 2000-04-12 2001-10-25 Dana-Farber Cancer Institute Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
CA2430013C (en) 2000-11-30 2011-11-22 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
US7491534B2 (en) * 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
EP1356035B1 (de) * 2000-12-22 2011-03-16 Kyowa Hakko Kirin Co., Ltd. Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen
EP1860199B1 (de) 2001-01-12 2014-03-05 Exelixis, Inc. Modulierte Signalisierung von Insulinrezeptoren
US7265262B2 (en) * 2001-03-21 2007-09-04 Roslin Institute (Edinburgh) Telomerizing nuclear donor cells and improving the efficiency on nuclear transfer
US7126039B2 (en) * 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
WO2002081711A1 (en) * 2001-04-06 2002-10-17 Cropdesign N.V. The use of double and opposite recombination sites for the single step cloning of two dna segments
WO2002086144A2 (en) * 2001-04-19 2002-10-31 Invitrogen Corporation Compositions and methods for recombinational cloning of nucleic acid molecules
US20020188965A1 (en) 2001-04-20 2002-12-12 Zou-Yu Zhao Methods of transforming plants
DK1391511T3 (da) * 2001-05-11 2008-09-29 Kirin Pharma Kk Humant kunstigt kromosom indeholdende human antistof lambda-let-kæde-gen
EP1451344A4 (de) * 2001-05-21 2005-03-23 Invitrogen Corp Zusammensetzungen und verfahren zur verwendung bei der isolierung von nukleinsäuremolekülen
NZ545697A (en) * 2001-05-30 2008-06-30 Glaxo Group Ltd A lambda-intR mutein comprising a glutamic acid to arginine change at position 174 of Wt lambda-intR
US20030092183A1 (en) * 2001-09-21 2003-05-15 Fisher Katherine E. Rapid creation of gene targeting vectors using homologous recombination in yeast
US20040023910A1 (en) * 2001-09-28 2004-02-05 Zhiming Zhang Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas
PT1298207E (pt) 2001-10-01 2010-11-08 Deutsches Krebsforsch Processo para a produção de bibliotecas de proteínas e para a selecção de proteínas a partir da mesma
DE10211063A1 (de) 2002-03-13 2003-10-09 Axaron Bioscience Ag Neue Verfahren zur Detektion und Analyse von Protein-Interaktionen in vivo
US8304233B2 (en) 2002-06-04 2012-11-06 Poetic Genetics, Llc Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same
EP1546395A4 (de) * 2002-07-26 2007-05-02 Genecopoeia Inc Verfahren und nukleinsäurevektoren zur schnellen expression und zum schnellen screening von cdna-klonen
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US20040229230A1 (en) * 2002-08-27 2004-11-18 Sleckman Barry P. Method for gene isolation by Cre-trap cloning
US7285699B2 (en) * 2002-10-07 2007-10-23 Stowers Institute For Medical Research Ends-out gene targeting method
US20040170614A1 (en) * 2002-10-30 2004-09-02 Gail Bishop Somatic cell gene targeting vectors and methods of use thereof
US20030175968A1 (en) * 2002-10-30 2003-09-18 Golic Kent G. Gene targeting method
AU2003290689A1 (en) 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
US7078234B2 (en) 2002-12-18 2006-07-18 Monsanto Technology Llc Maize embryo-specific promoter compositions and methods for use thereof
SI1583830T1 (sl) * 2003-01-07 2006-12-31 Symphogen As Postopek za pripravo rekombinantnih poliklonskih proteinov
US20060275766A1 (en) * 2003-01-07 2006-12-07 Haurum John S Method for manufacturing recombinant polyclonal proteins
US20040133944A1 (en) * 2003-01-08 2004-07-08 Delta And Pine Land Company Seed oil suppression to enhance yield of commercially important macromolecules
US7803362B2 (en) * 2003-01-24 2010-09-28 Synageva Biopharma Corp. Glycosylated interferon alpha
US7271313B2 (en) * 2003-04-09 2007-09-18 The Brigham And Women's Hospital, Inc. Presenilin-deficient mouse model of age-dependent neurodegeneration and cognitive loss
EP1881074B1 (de) 2003-05-05 2013-01-02 Monsanto Technology, LLC HRGP Promotorkonstrukte
US7304203B2 (en) * 2003-09-18 2007-12-04 Mayo Foundation For Medical Education And Research Transgenic TIEG non-human animals
US20050118710A1 (en) * 2003-09-30 2005-06-02 Gwenn Hansen Methods and compositions for defining gene function
EP1699928B9 (de) 2003-10-02 2010-11-03 Monsanto Technology, LLC Stapeln von merkmalen zur verbesserung von nutzpflanzen in transgenen pflanzen
WO2005054438A2 (en) 2003-12-01 2005-06-16 Invitrogen Corporation Nucleic acid molecules containing recombination sites and methods of using the same
US20050235370A1 (en) * 2003-12-12 2005-10-20 National Health Research Institutes Spatiotemporally controlled adult somatic mutagenesis system
DE602004018029D1 (de) 2003-12-30 2009-01-08 Ulleval Universitetssykehus Hf Nichtmenschliches säugetier mit modifiziertem serca2-gen sowie verfahren, zellen, gene und vektoren hierfür
US7683237B2 (en) 2004-02-10 2010-03-23 Monsanto Technology Llc Maize seed with synergistically enhanced lysine content
AR047598A1 (es) 2004-02-10 2006-01-25 Monsanto Technology Llc Semilla de maiz transgenica con mayor contenido de aminoacidos
US20060041961A1 (en) 2004-03-25 2006-02-23 Abad Mark S Genes and uses for pant improvement
CA2693280C (en) 2004-04-09 2017-09-12 Monsanto Technology Llc Compositions and methods for control of insect infestations in plants
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
PL1787126T3 (pl) 2004-07-20 2010-03-31 Symphogen As Sposób charakteryzowania poliklonalnej linii komórkowej
US7582741B2 (en) 2004-07-26 2009-09-01 University Of Massachusetts Conditional disruption of dicer1 in cell lines and non-human mammals
US20090035784A1 (en) * 2004-07-30 2009-02-05 Mount Sinai School Of Medicine Of New York University Npc1l1 and npc1l1 inhibitors and methods of use thereof
US20060075522A1 (en) 2004-07-31 2006-04-06 Jaclyn Cleveland Genes and uses for plant improvement
US20060117398A1 (en) * 2004-10-22 2006-06-01 Roland Buelow Suppression of endogenous immunoglobulin expression
US7501275B2 (en) * 2004-10-27 2009-03-10 The United States Of America As Represented By The Secretary Of Agriculture Yeast transformation system
WO2006058159A2 (en) * 2004-11-23 2006-06-01 The United States Of America As Represented By The Secretary Of Health And Human Services, Nih Methods and compositions for the ex vivo high-throughput detection of protein/protein interactions
US20080244765A1 (en) * 2004-12-16 2008-10-02 Pioneer Hi-Bred International, Inc. Methods and compositions for pollination disruption
PL1827078T3 (pl) 2004-12-21 2014-07-31 Monsanto Technology Llc Rośliny transgeniczne z ulepszonymi cechami agronomicznymi
AU2005337132B2 (en) 2004-12-21 2011-01-20 Monsanto Technology, Llc Transgenic plants with enhanced agronomic traits
US20060154285A1 (en) * 2004-12-29 2006-07-13 Robishaw Janet D Zebrafish heterotrimer G-protein gamma 2 subunit (GNG2)
WO2006074400A2 (en) 2005-01-07 2006-07-13 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Method to trigger rna interference
EP3059306A1 (de) 2005-01-12 2016-08-24 Monsanto Technology LLC Gene und verwendungen zur pflanzenverbesserung
US20060174362A1 (en) 2005-02-01 2006-08-03 Origen Therapeutics, Inc. Long-term culture of avian primordial germ cells (PGCs)
EP2478760A1 (de) 2005-05-10 2012-07-25 Monsanto Technology LLC Gene und ihre Verwendung zur Pflanzenverbesserung
US8124732B2 (en) 2005-06-24 2012-02-28 Synageva Biopharma Corp. Composition comprising isolated human CTLA4-Fc fusion protein produced in a transgenic chicken
US8088382B2 (en) * 2005-07-05 2012-01-03 Cornell Research Foundation, Inc. Methods of inhibiting transendothelial migration of neutrophils and monocytes with anti-CD99L2 antibodies
CN101611142A (zh) * 2005-07-07 2009-12-23 综合医院公司 用于控制干细胞分化的方法
US9121028B2 (en) * 2005-09-09 2015-09-01 Monsanto Technology Llc Selective gene expression in plants
ATE548459T1 (de) 2005-09-16 2012-03-15 Monsanto Technology Llc Verfahren zur genetischen kontrolle von insektenbefall bei pflanzen und zusammensetzungen
PT2295584E (pt) 2005-09-16 2015-09-22 Devgen Nv Métodos com base em plantas transgénicas para infestações em plantas utilizando arn de interferência
UA102367C2 (ru) 2005-10-03 2013-07-10 Монсанто Текнолоджи Ллс Семя трансгенной кукурузы с повышенным содержанием лизина
WO2007085906A2 (en) * 2005-10-13 2007-08-02 Bc Cancer Agency Functional mutant loxp sequences and uses thereof
US20070143881A1 (en) * 2005-12-16 2007-06-21 Pioneer Hi-Bred International, Inc. Methods and Compositions for Improving the Efficiency of Site-Specific Polynucleotide Exchange
EP2484769A3 (de) 2005-12-21 2012-09-19 Monsanto Technology LLC Transgene Pflanzen mit verbesserten agronomischen Merkmalen
PL2044109T3 (pl) 2006-02-10 2014-11-28 Monsanto Technology Llc Identyfikacja i zastosowanie genów docelowych do zwalczania nicieni pasożytów roślin
EP1984511A2 (de) 2006-02-13 2008-10-29 Monsanto Technology LLP Auswahl und stabilisierung von dsrna-konstrukten
JP5301424B2 (ja) * 2006-03-15 2013-09-25 ブライアン アール． ソーパー， 細胞における表現型および遺伝型の変動のスクリーニングおよびマッピングの方法
US7812127B2 (en) 2006-03-17 2010-10-12 Synageva Biopharma Corp. Glycosylated human G-CSF
US20070250941A1 (en) * 2006-03-27 2007-10-25 Genentech, Inc. VEGF Receptor Conditional Knockout Animals and Methods of Use
US7919322B2 (en) * 2006-03-29 2011-04-05 Sigma-Aldrich Co. Targeted deletions using retroelement-mediated placement of recombination sites
EP2010226B1 (de) 2006-04-07 2014-01-15 The Research Foundation of State University of New York Transcobalaminrezeptor-Polypeptide, -Nukleinsäuren und -Modulatoren sowie entsprechende Verfahren zur Verwendung für die Modulation von Zellwachstum und die Behandlung von Krebs und Cobalaminmangel
AU2007249385B2 (en) 2006-05-09 2012-09-13 The Curators Of The University Of Missouri Plant artificial chromosome platforms via telomere truncation
EP2540831A3 (de) 2006-08-17 2013-04-10 Monsanto Technology, LLC Transgene Pflanzen mit erweiterten agronomischen Merkmalen
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US20090105462A1 (en) * 2006-11-09 2009-04-23 Ivarie Robert D Glycosylated erythropoietin
US8975068B2 (en) * 2007-01-25 2015-03-10 The General Hospital Corporation Isolated stem cell comprising a Xic flanking region transgene
EP2126071A4 (de) 2007-01-26 2010-12-08 Synageva Biopharma Corp Transgenexpression in vögeln
EP2113029A4 (de) * 2007-02-09 2010-06-02 Univ Utah Res Found In vivo genomweite mutagenese
US8603950B2 (en) 2007-02-20 2013-12-10 Anaptysbio, Inc. Methods of generating libraries and uses thereof
EP2120544A4 (de) * 2007-03-09 2010-12-15 Univ Missouri Verfahren für bedingte und induzierbare transgenexpression zur lenkung der entwicklung von stammzellen
DE102007041655A1 (de) 2007-09-03 2009-03-05 Medicyte Gmbh Vermehrung von primären Zellen und deren Verwendung
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
CA3187687A1 (en) 2007-09-14 2009-03-19 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
CN101998965B (zh) 2007-11-01 2014-03-12 安斯泰来制药有限公司 免疫抑制性多肽与核酸
FR2927089B1 (fr) 2008-02-05 2011-03-25 Inst Nat De La Rech Agronomique Inra Procede d'integration ciblee de multicopies d'un gene d'interet dans une souche de yarrowia
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
US8093043B2 (en) * 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
ES2575008T3 (es) * 2008-07-11 2016-06-23 Nstitut National De La Recherche Agronomique (Inra) Nuevas cepas de levadura mutantes capaces de acumular una gran cantidad de lípidos
WO2010017248A2 (en) 2008-08-04 2010-02-11 University Of Miami Sting (stimulator of interferon genes), a regulator of innate immune responses
WO2010042490A1 (en) * 2008-10-06 2010-04-15 Boston Medical Center Corporation A single lentiviral vector system for induced pluripotent (ips) stem cells derivation
WO2010075143A1 (en) 2008-12-22 2010-07-01 Monsanto Technology Llc Genes and uses for plant enhancement
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (de) 2009-01-12 2010-07-14 Bonas, Ulla Modulare DNA-bindende Domänen
RU2537264C2 (ru) 2009-04-03 2014-12-27 Медикал Рисерч Каунсил Мутанты индуцируемой активацией цитидиндеаминазы (aid) и способы их применения
CA2759291C (en) 2009-04-20 2020-09-15 Monsanto Technology Llc Multiple virus resistance in transgenic tomato plants
EP2449112A1 (de) 2009-07-01 2012-05-09 Transposagen Biopharmaceuticals, Inc. Genetisch modifizierte rattenmodelle für schwere kombinierte immundefizienz (scid)
EP2456876A2 (de) 2009-07-24 2012-05-30 Transposagen Biopharmaceuticals, Inc. Genetisch modifizierte rattenmodelle für zytokin-zytokin-signalwege
US20110145936A1 (en) * 2009-07-30 2011-06-16 Ostertag Eric M Genetically Modified Rat Models for Pharmacokinetics
US20110035816A1 (en) * 2009-08-05 2011-02-10 Ostertag Eric M Genetically Modified Rat Models for Drug Metabolism
US20120151609A1 (en) 2009-08-20 2012-06-14 Ostertag Eric M Genetically Modified Rat Models for Pain
WO2011053957A2 (en) 2009-11-02 2011-05-05 Gen9, Inc. Compositions and methods for the regulation of multiple genes of interest in a cell
EP2510096B2 (de) 2009-12-10 2018-02-07 Regents of the University of Minnesota Tal-effektorvermittelte dna-modifizierung
CA2798988C (en) 2010-05-17 2020-03-10 Sangamo Biosciences, Inc. Tal-effector (tale) dna-binding polypeptides and uses thereof
RU2580017C2 (ru) 2010-07-26 2016-04-10 Трианни, Инк. Трансгенные животные и способы применения
DE102010041958A1 (de) 2010-10-04 2012-04-05 Medicyte Gmbh Geeignete Hepatozyten für in-vitro Genotoxitätstests
JP6118725B2 (ja) 2010-11-12 2017-04-19 ジェン９・インコーポレイテッドＧｅｎ９，ＩＮＣ． 核酸合成のための方法およびデバイス
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
JP6092782B2 (ja) 2010-11-16 2017-03-08 エクセリミューン， インコーポレイテッド 組換えタンパク質の製造方法
WO2012129198A1 (en) 2011-03-23 2012-09-27 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for obesity and diabetes
EP2734632A1 (de) 2011-07-21 2014-05-28 The Regents of the University of California Transkriptionsfaktoren zur herstellung von zelluloseabbauenden enzymen
LT3594340T (lt) 2011-08-26 2021-10-25 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
EP3715365A1 (de) 2012-03-26 2020-09-30 Axcella Health Inc. Nährmittelfragmente, proteine damit und verfahren
CA2871505C (en) 2012-04-24 2021-10-12 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
US20150225734A1 (en) 2012-06-19 2015-08-13 Regents Of The University Of Minnesota Gene targeting in plants using dna viruses
AU2013280661A1 (en) 2012-06-25 2015-01-22 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
EP2690177B1 (de) 2012-07-24 2014-12-03 Technische Universität Dresden Protein mit Rekombinase-Aktivität zur ortspezifischen DNA-Rekombination
CN104968193B (zh) 2012-11-01 2021-02-09 塞尔克蒂斯股份有限公司 用于生成治疗性蛋白质的植物
WO2014096972A2 (en) 2012-12-21 2014-06-26 Cellectis Potatoes with reduced cold-induced sweetening
AU2014207618A1 (en) 2013-01-16 2015-08-06 Emory University Cas9-nucleic acid complexes and uses related thereto
US10113162B2 (en) 2013-03-15 2018-10-30 Cellectis Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
EP2810952A1 (de) 2013-06-03 2014-12-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Neuartige Schädlingsbekämpfungsverfahren
EP2927685A1 (de) 2014-04-02 2015-10-07 Medicyte GmbH Geeignete Hepatozyten für In-vitro-Hepatitistests
CA2952906A1 (en) 2014-06-20 2015-12-23 Cellectis Potatoes with reduced granule-bound starch synthase
WO2015200281A1 (en) 2014-06-24 2015-12-30 The Regents Of The University Of California Methods for production of xylosyl-xylitol oligomers
FR3028527A1 (fr) 2014-11-13 2016-05-20 Pivert Identification de facteurs de transcription de yarrowia lipolytica
US20180105832A1 (en) 2015-04-13 2018-04-19 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Novel aflatoxin and fungal infection control methods
CN106191041B (zh) * 2015-04-30 2020-12-29 杭州菁因康生物科技有限公司 基因打靶方法
US20180291353A1 (en) 2015-05-28 2018-10-11 The Regents Of The University Of California Monofunctional aldehyde and alcohol dehydrogenases for production of fuels and commodity chemicals
WO2016210373A2 (en) 2015-06-24 2016-12-29 Synlogic, Inc. Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof
US10837024B2 (en) 2015-09-17 2020-11-17 Cellectis Modifying messenger RNA stability in plant transformations
WO2017128039A1 (zh) * 2016-01-26 2017-08-03 浙江大学 基因组合及其用途
EP3410843A1 (de) 2016-02-02 2018-12-12 Cellectis Modifizierung von sojaölzusammensetzung durch gezieltes knockout der fad3a/1b-gene
BR112019002238A2 (pt) 2016-08-05 2019-05-14 Cargill, Incorporated polipeptídeo e célula manipulados, e, método de fermentação.
CA3035084A1 (en) 2016-08-26 2018-03-01 Board Of Trustees Of Michigan State University Transcription factors to improve resistance to environmental stress in plants
CA3042857A1 (en) 2016-11-16 2018-05-24 Cellectis Methods for altering amino acid content in plants through frameshift mutations
WO2018198049A1 (en) 2017-04-25 2018-11-01 Cellectis Alfalfa with reduced lignin composition
US11046969B2 (en) 2017-05-24 2021-06-29 Epiplanta Biotech Ltd. Transgenic plant and the method for producing the same
WO2018228961A1 (en) 2017-06-12 2018-12-20 Johann Wolfgang Goethe-Universität Frankfurt am Main Genetic tools and procedure for the phenotypic identification of the genotype of transgenic diploid organisms
CA3066047A1 (en) 2017-06-14 2018-12-20 Technische Universitat Dresden Methods and means for genetic alteration of genomes utilizing designer dna recombining enzymes
HRP20220615T1 (hr) 2017-06-30 2022-06-24 Inscripta, Inc. Postupci, moduli, instrumenti i sustavi za automatiziranu obradu stanica
US10738327B2 (en) 2017-08-28 2020-08-11 Inscripta, Inc. Electroporation cuvettes for automation
CA3074927A1 (en) 2017-09-30 2019-04-04 Inscripta, Inc. Flow through electroporation instrumentation
US11359208B2 (en) 2018-01-09 2022-06-14 Cibus Us Llc Shatterproof genes and mutations
AU2019241967A1 (en) 2018-03-29 2020-11-19 Inscripta, Inc. Automated control of cell growth rates for induction and transformation
US10376889B1 (en) 2018-04-13 2019-08-13 Inscripta, Inc. Automated cell processing instruments comprising reagent cartridges
US10557216B2 (en) 2018-04-24 2020-02-11 Inscripta, Inc. Automated instrumentation for production of T-cell receptor peptide libraries
WO2019209926A1 (en) 2018-04-24 2019-10-31 Inscripta, Inc. Automated instrumentation for production of peptide libraries
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
WO2020005383A1 (en) 2018-06-30 2020-01-02 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US10532324B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
AU2019363487A1 (en) 2018-08-30 2021-04-15 Inscripta, Inc. Improved detection of nuclease edited sequences in automated modules and instruments
US10920189B2 (en) 2019-06-21 2021-02-16 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in E. coli
US10927385B2 (en) 2019-06-25 2021-02-23 Inscripta, Inc. Increased nucleic-acid guided cell editing in yeast
KR20220025838A (ko) 2019-07-01 2022-03-03 트리아니, 인코포레이티드 유전자이식 포유동물 및 사용 방법
AU2020298458A1 (en) 2019-07-01 2022-01-20 Trianni, Inc. Transgenic mammals and methods of use thereof
CA3138188A1 (en) 2019-07-02 2021-01-07 Fred Hutchinson Cancer Research Center Recombinant ad35 vectors and related gene therapy improvements
US11939588B2 (en) 2019-10-17 2024-03-26 Board Of Trustees Of Michigan State University Elevated resistance to insects and plant pathogens without compromising seed production
EP3825408A1 (de) 2019-11-19 2021-05-26 FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. Verfahren zur insektenschädlingsbekämpfung für mehrere arten
US10689669B1 (en) 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
JP2024503719A (ja) 2021-01-19 2024-01-26 ザ ジェイ． デビッド グラッドストーン インスティテューツ、 ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デビッド グラッドストーン ヒトｔ細胞の機能を強化するための遺伝子活性化標的
CN117440753A (zh) 2021-05-05 2024-01-23 特里安尼公司 表达嵌合马科动物-啮齿动物抗体的转基因啮齿动物及其使用方法
WO2023086815A1 (en) 2021-11-10 2023-05-19 Trianni, Inc. Transgenic mammals and methods of use thereof
WO2023150393A2 (en) 2022-02-07 2023-08-10 Ensoma, Inc. Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids
WO2023156906A1 (en) 2022-02-15 2023-08-24 Futuragene Israel Ltd A bacillus thuringiensis pesticidal protein (bt pp) combination useful for plant protection
WO2024097418A2 (en) 2022-11-03 2024-05-10 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Gene activation and interference targets for exhaustion/dysfunction-resistant t cell products and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626505A (en) * 1984-02-24 1986-12-02 E. I. Du Pont De Nemours And Company Selectable markers for yeast transformation
US4673640A (en) * 1984-04-30 1987-06-16 Biotechnica International, Inc. Regulated protein production using site-specific recombination

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