MX9308031A - Procedimiento para la produccion de polipeptidos. - Google Patents

Procedimiento para la produccion de polipeptidos.

Info

Publication number
MX9308031A
MX9308031A MX9308031A MX9308031A MX9308031A MX 9308031 A MX9308031 A MX 9308031A MX 9308031 A MX9308031 A MX 9308031A MX 9308031 A MX9308031 A MX 9308031A MX 9308031 A MX9308031 A MX 9308031A
Authority
MX
Mexico
Prior art keywords
production
polypeptides
procedure
polypeptide
functional
Prior art date
Application number
MX9308031A
Other languages
English (en)
Inventor
Peter Furst
Jutta Heim
Thomas Hottiger
Gabriele Pohlig
Original Assignee
Ciba Geigy
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy, Ucp Gen Pharma Ag filed Critical Ciba Geigy
Publication of MX9308031A publication Critical patent/MX9308031A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/102—Plasmid DNA for yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/15—Peptidyl-dipeptidases (3.4.15)
    • C12Y304/15001—Peptidyl-dipeptidase A (3.4.15.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención se relaciona con un método para la producción de un polipéptido, con ayuda de células de levadura, manipuladas por ingeniería genética, que contienen no más de un gene CUP1 funcional en la genoma, y que llevan un plásmido que comprende un gene que codifica para el polipéptido, y un gene CUP1 funcional; y las células de levadura y los plásmidos.
MX9308031A 1992-12-15 1993-12-15 Procedimiento para la produccion de polipeptidos. MX9308031A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92811005 1992-12-15

Publications (1)

Publication Number Publication Date
MX9308031A true MX9308031A (es) 1994-08-31

Family

ID=8212051

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9308031A MX9308031A (es) 1992-12-15 1993-12-15 Procedimiento para la produccion de polipeptidos.

Country Status (15)

Country Link
US (1) US5922569A (es)
EP (1) EP0603128A1 (es)
JP (1) JPH06343471A (es)
KR (1) KR940014784A (es)
AU (1) AU673384B2 (es)
CA (1) CA2111321A1 (es)
FI (1) FI935592A (es)
HU (1) HU218850B (es)
IL (1) IL108015A0 (es)
MX (1) MX9308031A (es)
NO (1) NO934602L (es)
NZ (1) NZ250442A (es)
SG (1) SG49865A1 (es)
TW (1) TW282490B (es)
ZA (1) ZA939359B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1660661A2 (en) * 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
CA2545855A1 (en) * 2003-11-14 2005-06-02 Baxter International Inc. Alpha 1-antitrypsin compositions and treatment methods using such compositions
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
KR100672745B1 (ko) * 2005-04-20 2007-01-24 재단법인 목암생명공학연구소 효모 발현시스템에서의 재조합 외래단백질의 분비효율을향상시키는 방법
EP2044203B1 (en) 2006-07-14 2013-10-09 Novozymes, Inc. Methods for increasing expression of genes in a fungal cell
JP5751609B2 (ja) * 2010-08-24 2015-07-22 株式会社豊田中央研究所 特性が改変された細胞の生産方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3163784A (en) * 1983-08-08 1985-02-14 Smithkline Beckman Corporation Yeast copper - metallothionein gene
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4940661A (en) * 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
US4935350A (en) * 1985-11-18 1990-06-19 Amgen Materials and methods for controlling plasmid copy number and stability
MC1834A1 (fr) * 1986-07-10 1988-06-03 Transgene Sa Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
PT88556B (pt) * 1987-09-28 1992-11-30 Smithkline Biolog Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche

Also Published As

Publication number Publication date
US5922569A (en) 1999-07-13
EP0603128A1 (en) 1994-06-22
IL108015A0 (en) 1994-04-12
FI935592A (fi) 1994-06-16
KR940014784A (ko) 1994-07-19
HU218850B (hu) 2000-12-28
CA2111321A1 (en) 1994-06-16
NZ250442A (en) 1995-12-21
AU673384B2 (en) 1996-11-07
HU9303580D0 (en) 1994-04-28
AU5207193A (en) 1994-06-30
JPH06343471A (ja) 1994-12-20
TW282490B (es) 1996-08-01
NO934602D0 (no) 1993-12-14
FI935592A0 (fi) 1993-12-13
HUT68578A (en) 1995-06-28
ZA939359B (en) 1994-06-15
NO934602L (no) 1994-06-16
SG49865A1 (en) 1999-10-19

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