DK3009449T3 - Humane cytomegalovirusneutraliserende antistoffer og anvendelse deraf - Google Patents
Humane cytomegalovirusneutraliserende antistoffer og anvendelse deraf Download PDFInfo
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- DK3009449T3 DK3009449T3 DK15194590.4T DK15194590T DK3009449T3 DK 3009449 T3 DK3009449 T3 DK 3009449T3 DK 15194590 T DK15194590 T DK 15194590T DK 3009449 T3 DK3009449 T3 DK 3009449T3
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Claims (13)
1. Isoleret antistof, eller et antigenbindende fragment deraf, der binder til en epitop dannet af begge humane cytomegalovirus- (hCMV) proteiner UL130 og UL131A, hvor antistoffet eller fragmentet neutraliserer infektion af humane epitelceller med hCMV og omfatter tung- og letkæde-variable regioner med aminosyresekvenser, der er mindst 85 % identiske med henholdsvis SEQ ID NO: 61 og 62.
2. Antistof eller antigenbindende fragment ifølge krav 1, hvor antistoffet omfatter tungekæde-CDR1-, CDR2- og CDR3-sekvenser ifølge henholdsvis SEQ ID NO: 49, 50 og 51, og letkæde-CDR1-, CDR2- og CDR3-sekvenser ifølge henholdsvis SEQ ID NO: 52, 53 og 54.
3. Antistof eller antigenbindende fragment ifølge krav 1 eller krav 2, hvor antistoffet omfatter tung- og letkæde-variabel-region-sekvenser ifølge henholdsvis SEQ ID NO: 61 og 62.
4. Antistof eller fragment ifølge et hvilket som helst af de foregående krav, hvor antistoffet er et monoklonalt antistof, et humant monoklonalt antistof, et enkeltkæde-, Fab, Fab', F(ab')2, Fv eller scFV.
5. Isoleret nukleinsyremolekyle, der omfatter en nukleotidsekvens, der koder for antistoffet eller antistoffragmentet ifølge et hvilket som helst af de foregående krav.
6. Ekspressionsvektor, der omfatter en nukleinsyre ifølge krav 5.
7. Celle transformeret med en ekspressionsvektor ifølge krav 6.
8. Farmaceutisk sammensætning, der omfatter antistoffet eller det antigenbindende fragment ifølge et hvilket som helst af kravene 1 til 4 og en farmaceutisk acceptabel fortynder eller bærer.
9. Farmaceutisk sammensætning ifølge krav 8, der endvidere omfatter et andet antistof, eller et antigenbindende fragment deraf, der neutraliserer hCMV-infektion.
10. Farmaceutisk sammensætning ifølge krav 9, hvor det andet antistof eller antigenbindende fragment deraf binder til et hCMV gFI-protein, et hCMV gB-protein, et hCMV UL128-protein, en anden epitop dannet af begge hCMV-proteiner UL130 og UL131A, en epitop dannet af hCMV-proteinerne UL128, UL130 og UL131A, en epitop dannet af hCMV-proteinerne gH, gL, UL128 og UL130, eller en epitop dannet af hCMV-proteinerne gM og gN.
11. Antistof eller antigenbindende fragment ifølge et hvilket som helst af kravene 1 til 4 eller farmaceutisk sammensætning ifølge et hvilket som helst af kravene 8 til 10 til anvendelse i en fremgangsmåde til behandling eller forebyggelse af hCMV-infektion.
12. Anvendelse af antistoffet eller den antigenbindende del deraf ifølge et hvilket som helst af kravene 1 til 4 i fremstilling af et lægemiddel til behandling eller forebyggelse af hCMV-infektion.
13. Fremgangsmåde til fremstilling af antistoffer ifølge et hvilket som helst af kravene 1 til 4, der omfatter (i) dyrkning af en celle ifølge krav 7 og (ii) isolering af antistoffer.
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