DK2759600T3 - Fremgangsmåde til fremstilling af et pulver indeholdende krystallinsk alpha,alpha-trehalose-dihydrat - Google Patents
Fremgangsmåde til fremstilling af et pulver indeholdende krystallinsk alpha,alpha-trehalose-dihydrat Download PDFInfo
- Publication number
- DK2759600T3 DK2759600T3 DK12834341.5T DK12834341T DK2759600T3 DK 2759600 T3 DK2759600 T3 DK 2759600T3 DK 12834341 T DK12834341 T DK 12834341T DK 2759600 T3 DK2759600 T3 DK 2759600T3
- Authority
- DK
- Denmark
- Prior art keywords
- thr
- asn
- gly
- ala
- ser
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1074—Cyclomaltodextrin glucanotransferase (2.4.1.19)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/20—Preparation of compounds containing saccharide radicals produced by the action of an exo-1,4 alpha-glucosidase, e.g. dextrose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01019—Cyclomaltodextrin glucanotransferase (2.4.1.19)
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
- C13K13/007—Separation of sugars provided for in subclass C13K
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Claims (4)
1. Fremgangsmåde til fremstilling af partikelformig sammensætning omfattende krystallinsk α,α-trehalose-dihydrat med et α,α-trehalose-indhold på 98,0 vægt-% eller mere, på tørstofbasis, og en grad af krystal I in itet for krystallinsk α,α-trehalose-dihydrat på 90,0 % eller højere, beregnet på basis af dens pulverrøntgendiffraktionsprofil, hvilken fremgangsmåde omfatter trinnene: at opnå en saccharidopløsning med et α,α-trehalose-indhold på over 86,0 vægt-%, på tørstofbasis, uden at gennemgå et fraktioneringstrin ved hjælp af søjlekromatografi, ved at lade et α-glycosyltrehalose-dannende enzym afledt af en mikroorganisme af arten Arthrobacter og et trehalose-frigivende enzym afledt af en mikroorganisme af arten Arthrobacter sammen med et stivelsesaf-greningsenzym og en cyclomaltodextrin-glucanotransferase indvirke på flydende stivelse, efterfulgt af at lade en glucoamylase indvirke på den resulterende blanding; at udfælde krystallinsk α,α-trehalose-dihydrat fra saccharidopløsningen; at opsamle det udfældede krystallinske α,α-trehalose-dihydrat ved hjælp af en centrifuge; og at ælde og tørre de opsamlede krystaller; hvor cyclomaltodextrin-glucanotransferasen er en naturlig eller rekombinant cyclomaltodextrin-glucanotransferase afledt afen mikroorganisme afarten Paenibacillus illinoisensis, Paenibacillus pabuli eller Paenibacillus amylolyticus, elleret enzym med aminosyresekvensen SEQ ID NO: 12 eller 13; hvor trinnet at udfælde krystallinsk α,α-trehalose-dihydrat udføres ved en kontrolleret afkølingsmetode eller semi-kontrolleret afkølingsmetode; og hvor den kontrollerede afkølingsmetode er en afkølingsmetode, hvor væsketemperaturen "T" på tidspunktet "t" er udtrykt ved følgende formel "T=To-(To-Tf) (t/r)3", hvor "r" er den fastslåede driftstid for et krystalliseringstrin, "To" er væsketemperaturen ved påbegyndelsen af krystalliseringen, og "Tf" er den tilstræbte væsketemperatur ved afslutningen af krystalliseringen.
2. Fremgangsmåde ifølge krav 1, hvor cyclomaltodextrin-glucanotransferasen er et enzym, der har følgende del-aminosyresekvens (a) til (d): (a) Gly-Ser-Xi-Ala-Ser-Asp; (b) Lys-Thr-Ser-Ala-Val-Asn-Asn; (c) Lys-Met-Pro-Ser-Phe-Ser-Lys ; og (d) Val-Asn-Ser-Asn-X2-Tyr; hvor Xi står for Ala eller Ser, og X2 står for henholdsvis Ala eller Thr.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor cyclomaltodextrin-glucanotrans-ferasen er den, der har en aminosyresekvens med SEQ ID NO: 1,2 eller 3.
4. Partikelformig sammensætning omfattende krystallinsk α,α-trehalose-dihy-drat, som omfatter α,α-trehalose i en mængde på 99,0 vægt-% eller mere, men ikke mere end 99,6 vægt-%, på tørstofbasis, og har en grad af krystal I in itet for krystallinsk α,α-trehalose-dihydrat på 90,0 % eller højere, men ikke højere end 96,0 %, beregnet på basis af dens pulverrøntgendiffraktionsprofil, hvor sammensætningen indeholder partikler med en størrelse i området 53 pm til 425 pm i en mængde på 70 % eller mere ud fra vægt af sammensætningen; og hvor sammensætningen indeholder partikler med en størrelse i området 53 pm til 300 pm i en mængde på 50 % eller mere ud fra vægt af sammensætningen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011206482 | 2011-09-21 | ||
| JP2012168474 | 2012-07-30 | ||
| PCT/JP2012/073266 WO2013042587A1 (ja) | 2011-09-21 | 2012-09-12 | α，α－トレハロース二含水結晶含有粉末の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2759600T3 true DK2759600T3 (da) | 2018-08-13 |
Family
ID=47914358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12834341.5T DK2759600T3 (da) | 2011-09-21 | 2012-09-12 | Fremgangsmåde til fremstilling af et pulver indeholdende krystallinsk alpha,alpha-trehalose-dihydrat |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9657045B2 (da) |
| EP (2) | EP2759600B1 (da) |
| JP (7) | JP5647354B2 (da) |
| KR (5) | KR20190006604A (da) |
| CN (4) | CN105218597B (da) |
| AU (2) | AU2012310757B2 (da) |
| BR (1) | BR112014006682B1 (da) |
| CA (1) | CA2849747C (da) |
| DK (1) | DK2759600T3 (da) |
| ES (1) | ES2674599T3 (da) |
| IN (1) | IN2014CN02872A (da) |
| MX (2) | MX2018007700A (da) |
| MY (2) | MY160496A (da) |
| PH (2) | PH12016501348A1 (da) |
| PL (1) | PL2759600T3 (da) |
| PT (1) | PT2759600T (da) |
| SG (3) | SG10201606201UA (da) |
| TW (4) | TWI675103B (da) |
| WO (1) | WO2013042587A1 (da) |
| ZA (1) | ZA201402839B (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201606201UA (en) * | 2011-09-21 | 2016-09-29 | Hayashibara Co | Process for producing a particulate composition comprising crystalline alpha, alpha-trehalose di-hydrate |
| CN103981233B (zh) * | 2014-05-29 | 2015-08-26 | 湖南尔康制药股份有限公司 | 一种以木薯淀粉为原料制备海藻糖的方法 |
| CN104531629B (zh) * | 2014-12-16 | 2017-07-21 | 江南大学 | 一种提高aa‑2g转化率的环糊精葡萄糖基转移酶突变体 |
| CN108779501A (zh) * | 2016-01-20 | 2018-11-09 | 株式会社林原 | 含有α,α-海藻糖二水合物晶体的粉末、其制造方法及用途 |
| CN107739745A (zh) * | 2017-10-10 | 2018-02-27 | 溧阳维信生物科技有限公司 | 采用膜分离技术制备α,α‑海藻糖二水合物的方法 |
| CN107488689B (zh) * | 2017-10-10 | 2021-04-27 | 溧阳维信生物科技有限公司 | 采用电渗析技术制备α,α-海藻糖二水合物的方法 |
| CN108130350B (zh) * | 2018-01-26 | 2021-08-24 | 通辽梅花生物科技有限公司 | 高含量海藻糖的制备方法 |
| CN108774273B (zh) * | 2018-08-24 | 2021-06-25 | 湖南汇升生物科技有限公司 | 一种海藻糖结晶工艺 |
| CN108624637B (zh) * | 2018-08-24 | 2021-10-19 | 湖南汇升生物科技有限公司 | 一种利用大米生产海藻糖的方法 |
| CN112244184B (zh) * | 2020-09-30 | 2022-08-12 | 广东省农业科学院蚕业与农产品加工研究所 | 一种变频超声辅助水合物浓缩液态食品的装置和方法 |
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| JPH05292986A (ja) | 1992-02-21 | 1993-11-09 | Takeda Chem Ind Ltd | トレハロースの製造法 |
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| ATE182359T1 (de) | 1992-12-28 | 1999-08-15 | Hayashibara Biochem Lab | Nichtreduzierendes saccharidbildendes enzym, und dessen herstellung und verwendungen |
| BR9400368A (pt) | 1993-02-02 | 1994-08-23 | Ajinomoto Kk | Processo para isolamento e purificação de trehalose |
| JPH06269289A (ja) * | 1993-02-02 | 1994-09-27 | Ajinomoto Co Inc | トレハロースの水晶析による単離精製法 |
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| SG10201606201UA (en) * | 2011-09-21 | 2016-09-29 | Hayashibara Co | Process for producing a particulate composition comprising crystalline alpha, alpha-trehalose di-hydrate |
| JP5993674B2 (ja) * | 2012-09-12 | 2016-09-14 | 株式会社林原 | α，α−トレハロース二含水結晶含有粉末の製造方法 |
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